Abstract:
:Guinea pig peritoneal or alveolar macrophages were inoculated with Mycoplasma pneumoniae cells. Extracellular mycoplasms were killed by complement treatment, and the effect of macrophage action on the number of the remaining viable mycoplasmas was observed. The complement killing was to some extent inhibited by the presence of the macrophages, but the mechanism of this protection remains unknown. Opsonized mycoplasmas were ingested, and approximately 98% were killed within 4 h. The killing rate was somewhat lower than comparable data for bacteria, but lack of cell wall and high lipid content of the membrane apparently do not cause a significant delay in intracellular destruction.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Erb P,Bredt Wdoi
10.1128/IAI.25.1.11-15.1979keywords:
subject
Has Abstractpub_date
1979-07-01 00:00:00pages
11-5issue
1eissn
0019-9567issn
1098-5522journal_volume
25pub_type
杂志文章abstract::Rickettsia rickettsii infection of endothelial cells is manifested in very distinctive changes in cell morphology, consisting of extensive dilatation of the membranes of the endoplasmic reticulum and outer nuclear envelope and blebbing of the plasma membrane, as seen by transmission electron microscopy (D. J. Silverma...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.5.2290-2299.1998
更新日期:1998-05-01 00:00:00
abstract::The effect of splenectomy on animals infected with Trypanosoma lewisi is unclear, and previous reports are inconclusive or conflictive. We splenectomized rats of different ages after they had been infected with T. lewisi. Female Sprague-Dawley rats, Hemobartonella-free, were assigned to four groups according to weight...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.3.1127-1133.1983
更新日期:1983-06-01 00:00:00
abstract::A 95-kDa protein was isolated from Staphylococcus saprophyticus 7108 grown on dialysis membranes placed on the surface of brain heart infusion agar. Strain CCM883 did not produce this protein. Ultrathin sections revealed the presence of very thin, tuftlike, 50- to 75-nm-long structures on the surface of strain 7108, w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.3.1055-1060.1992
更新日期:1992-03-01 00:00:00
abstract::Early-onset periodontitis (EOP) is characterized by rapidly progressive alveolar bone loss, chemotactic defects of neutrophils, and significant familial aggregation. We found immature myeloid lineage cells, defined as promyelocytes, in the peripheral blood in patients with EOP. A hematological examination of periphera...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.9.3906-3912.1997
更新日期:1997-09-01 00:00:00
abstract::Expression of ace (adhesin to collagen of Enterococcus faecalis), encoding a virulence factor in endocarditis and urinary tract infection models, has been shown to increase under certain conditions, such as in the presence of serum, bile salts, urine, and collagen and at 46 °C. However, the mechanism of ace/Ace regula...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02587-14
更新日期:2015-01-01 00:00:00
abstract::Theileria parasites infect and transform bovine leukocytes. We have analyzed laboratory-established Theileria sp.-infected leukocyte lines and observed that transformed macrophages express CD5. Low-level expression of CD5 by macrophages was further confirmed on three independent Theileria annulata clinical isolates fr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::The role of capsule in the adherence of Haemophilus influenzae type b to human epithelial cells in vitro was examined. A group of 30 nonadherent isolates did not differ in degree of encapsulation compared with their respective adherent variants. Furthermore, capsule-deficient mutants of both nonadherent and adherent v...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.9.2308-2310.1987
更新日期:1987-09-01 00:00:00
abstract::The mig gene of Streptococcus dysgalactiae, a major bovine mastitis pathogen, encodes two plasma protein-binding receptors, alpha2-macroglobulin (alpha2-M) and immunoglobulin G (IgG). In this study, the mig gene from one S. dysgalactiae isolate was cloned and expressed in Escherichia coli. The IgG receptor region enco...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.10.6030-6037.2001
更新日期:2001-10-01 00:00:00
abstract::The interaction of the first component of complement with two serum-sensitive strains of Escherichia coli and Klebsiella pneumoniae was studied. It could be demonstrated that highly purified C1, free of immunoglobulin G and immunoglobulin M, binds to E. coli or K. pneumoniae. C1 binding was also found with specificall...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.22.1.5-9.1978
更新日期:1978-10-01 00:00:00
abstract::γ9δ2 T cells provide a natural bridge between innate and adaptive immunity, rapidly and potently respond to pathogen infection in mucosal tissues, and are prominently induced by both tuberculosis (TB) infection and bacillus Calmette Guérin (BCG) vaccination. Mycobacterium-expanded γ9δ2 T cells represent only a subset ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01322-15
更新日期:2016-08-19 00:00:00
abstract::The genes of the lic1 operon (lic1A to lic1D) are responsible for incorporation of phosphocholine (PCho) into the lipopolysaccharide (LPS) of Haemophilus influenzae. PCho plays a multifaceted role in the commensal and pathogenic lifestyles of a range of mucosal pathogens, including H. influenzae. Structural studies of...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00748-07
更新日期:2008-02-01 00:00:00
abstract::The mechanisms by which Mycobacterium tuberculosis elicits disease are complex, involving a large repertoire of bacterial genes that are required for in vivo growth and survival. To identify such genes, we utilized a high-throughput microarray detection method to rapidly screen hundreds of unique, genotypically define...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.4.2533-2540.2005
更新日期:2005-04-01 00:00:00
abstract::The enteric pathogens enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli employ a type 3 secretion system (T3SS) to manipulate the host inflammatory response during infection. Previously, it has been reported that EPEC, in a T3SS-dependent manner, induces an early proinflammatory response through a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02131-14
更新日期:2014-11-01 00:00:00
abstract::Antibody responses against proteins located on the surface or in the apical organelles of merozoites are presumed to be important components of naturally acquired protective immune responses against the malaria parasite Plasmodium falciparum. However, many merozoite antigens are highly polymorphic, and antibodies indu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.1.422-430.2005
更新日期:2005-01-01 00:00:00
abstract::Fimbriae are colonization factors of the human pathogen Haemophilus influenzae in that they mediate bacterial adherence to human eukaryotic cells. The contribution of the major (HifA) and putative minor (HifD and HifE) subunits of H. influenzae fimbriae to fimbria-specific adherence was studied by using mutants that w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.12.4883-4889.1995
更新日期:1995-12-01 00:00:00
abstract::During the course of infection of rabbits with vaccinia virus, macrophages obtained from the peritoneal cavity develop bactericidal activity and the replication of vaccinia virus becomes restricted in these cells. The abortive replication of vaccinia virus in the activated macrophages was characterized in the present ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.1.328-338.1979
更新日期:1979-10-01 00:00:00
abstract::F1651 and the pyelonephritis-associated pili (Pap) are two members of the type P family of adhesive factors. They play a key role in establishing disease caused by extraintestinal pathogenic Escherichia coli (ExPEC) strains in animals and humans. Both F1651 and Pap are under the control of an epigenetic and reversible...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02510-14
更新日期:2015-05-01 00:00:00
abstract::Lipopolysaccharide (LPS) from three human and four monkey isolates of Campylobacter jejuni was extracted in high yields that revealed ladder-like structures in polyacrylamide gels by direct silver staining. These observations demonstrate that C. jejuni possesses LPS with O-chain repeating units typical of the family E...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.12.5384-5387.1993
更新日期:1993-12-01 00:00:00
abstract::Two inbred mouse strains, derived from feral founders, are susceptible to experimental leishmaniasis due to Leishmania major and support a disease of a severity intermediate between those observed in strains C57BL/6 and BALB/c. Mice of the MAI strain develop a severe, nonhealing, but nonfatal disease with no resistanc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.8.4603-4611.2004
更新日期:2004-08-01 00:00:00
abstract::In the enteric pathogen Vibrio cholerae, expression of the major virulence factors is controlled by the hierarchical expression of several regulatory proteins comprising the ToxR regulon. In this study, we demonstrate that disruption of the fadD gene encoding a long-chain fatty acyl coenzyme A ligase has marked effect...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00663-10
更新日期:2011-01-01 00:00:00
abstract::The adherence of Trichomonas vaginalis NYH 286 to host cells was evaluated by using monolayer cultures of HeLa and HEp-2 epithelial cells and human fibroblast cell lines. Saturation of sites on HeLa cells was achieved, yielding a maximal T. vaginalis NYH 286-to-cell ratio of two. The ability of radiolabeled NYH 286 to...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.50.3.701-708.1985
更新日期:1985-12-01 00:00:00
abstract::Recent work has demonstrated that the polyketide natural product Aurodox from Streptomyces goldiniensis is able to block the pathogenesis of the murine pathogen Citrobacter rodentium In this work, we aimed to gain a better understanding of the mechanism of action of the compound. We show that Aurodox downregulates the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00595-18
更新日期:2019-01-24 00:00:00
abstract::Borrelia burgdorferi resembles gram-negative bacteria in having both cellular and outer membranes. We previously showed that a lipopolysaccharide (LPS)-like material could be extracted from B. burgdorferi with phenol-chloroform-petroleum ether (PCP). The PCP extract of B. burgdorferi exhibited biological activity in s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.12.4995-5003.1992
更新日期:1992-12-01 00:00:00
abstract::Deciphering the mechanisms by which Borrelia burgdorferi controls the synthesis of proteins associated with mammalian infection will be an important step toward understanding the pathogenic properties of Lyme disease-causing bacteria. We present results of studies indicating that B. burgdorferi senses a wide variety o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.6.4146-4153.2001
更新日期:2001-06-01 00:00:00
abstract::Yersinia enterocolitica, Yersinia pseudotuberculosis, and Yersinia pestis deliver different Yop (Yersinia outer proteins) effector proteins into mammalian cells by a type III secretion mechanism. Recently, it was shown that Yersinia producing YopT leads to disruption of the actin cytoskeleton of HeLa cells (M. Iriarte...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.12.7535-7543.2001
更新日期:2001-12-01 00:00:00
abstract::Campylobacter rectus is a putative periodontopathogen which expresses a proteinaceous surface layer (S-layer) external to the outer membrane. S-layers are considered to play a protective role for the microorganism in hostile environments. The S-layer proteins from six different C. rectus strains (five human isolates a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.2.478-483.1997
更新日期:1997-02-01 00:00:00
abstract::The properties of two candidate Salmonella typhi-based live oral typhoid vaccine strains, BRD691 (S. typhi Ty2 harboring mutations in aroA and aroC) and BRD1116 (S. typhi Ty2 harboring mutations in aroA, aroC, and htrA), were compared in a number of in vitro and in vivo assays. BRD1116 exhibited an increased susceptib...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.2.700-707.1999
更新日期:1999-02-01 00:00:00
abstract::We have cloned chromosomal genes mediating the aerobactin iron transport system from the enteroinvasive strain Escherichia coli 978-77. The physical map of the region spanning the siderophore biosynthesis genes and the upstream portion of the receptor gene in strain 978-77-derived clones was identical to the correspon...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.1.357-364.1991
更新日期:1991-01-01 00:00:00
abstract::We examined the immunobiological responses to Histoplasma capsulatum in lungs of gamma interferon (IFN-gamma) knockout mice (GKO mice). Naive GKO mice succumbed by day 9 to intranasal challenge with 2.5 x 10(6) yeasts, whereas all wild-type (WT) mice survived for 45 days. Compared to lungs of WT mice, the lungs of acu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.7.2564-2569.1997
更新日期:1997-07-01 00:00:00
abstract::C57BL/6 mice were infected intravenously with 6 X 10(3) Listeria monocytogenes organisms. As early as day 3 of infection, there was a marked reduction in the number of lymphocytes recovered from the peripheral blood, bone marrow, and thymuses of infected animals. Concomitantly, there was an increase in the number of s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.2.372-377.1984
更新日期:1984-08-01 00:00:00