Abstract:
:Two inbred mouse strains, derived from feral founders, are susceptible to experimental leishmaniasis due to Leishmania major and support a disease of a severity intermediate between those observed in strains C57BL/6 and BALB/c. Mice of the MAI strain develop a severe, nonhealing, but nonfatal disease with no resistance to a secondary parasite challenge. The immunological responses showed a TH2 dominance characterized by an early peak of interleukin-4 (IL-4) and IL-13. However, neutralization of IL-4, which leads to a resistance phenotype in BALB/c mice, has no effect on disease progression in MAI mice. Mice of strain PWK develop a protracted but self-healing disease, characterized by a mixed TH1-plus-TH2 pattern of immune responses in which IL-10 plays an aggravating role, and acquire resistance to a secondary challenge. These features are close to those observed in human cutaneous leishmaniasis due to L. major and make PWK mice a suitable model for the human disease.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Babay BE,Louzir H,Kebaïer C,Boubaker S,Dellagi K,Cazenave PAdoi
10.1128/IAI.72.8.4603-4611.2004keywords:
subject
Has Abstractpub_date
2004-08-01 00:00:00pages
4603-11issue
8eissn
0019-9567issn
1098-5522pii
72/8/4603journal_volume
72pub_type
杂志文章abstract::Cutaneous leishmaniasis is characterized by vascular remodeling. Following infection with Leishmania parasites, the vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 (VEGFR-2) signaling pathway mediates lymphangiogenesis, which is critical for lesion resolution. Therefore, we investigated the cellular and ...
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更新日期:1988-11-01 00:00:00
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更新日期:1987-12-01 00:00:00
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更新日期:1983-07-01 00:00:00