Abstract:
:We studied interleukin-1 (IL-1) secretion by rat peritoneal exudate macrophages stimulated with purified toxic shock syndrome toxin-1 (TSST-1). TSST-1 was observed to be a more potent inducer of IL-1 than was endotoxin. The induction of IL-1 secretion by TSST-1 was not blocked by polymyxin B but could be blocked by monoclonal antibodies directed against TSST-1. Synergistic induction of IL-1 was observed when the cells were stimulated with TSST-1 and endotoxin. The sequence of addition was found to be important for the synergistic response. Enhanced IL-1 production was observed only when macrophages were exposed to endotoxin before or simultaneously with TSST-1. Prior exposure of macrophages to TSST-1 had no enhancing effect on endotoxin-induced IL-1 secretion. We conclude that stimulation of the macrophage by endotoxin enhances the responsiveness of the cells to TSST-1 and may thereby play a role in the pathogenesis of toxic shock syndrome.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Beezhold DH,Best GK,Bonventre PF,Thompson Mdoi
10.1128/IAI.55.12.2865-2869.1987subject
Has Abstractpub_date
1987-12-01 00:00:00pages
2865-9issue
12eissn
0019-9567issn
1098-5522journal_volume
55pub_type
杂志文章abstract::The growth of Eimeria vermiformis within cultured murine fibroblastlike (L-929) or rat epithelial-like (RATEC) cells was inhibited by treatment of the cells with the appropriate recombinant gamma interferon. The effect was apparent as a reduction in both the initial numbers of intracellular sporozoites and, to a much ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.2.580-586.1991
更新日期:1991-02-01 00:00:00
abstract::The pac gene of the serotype c strain Streptococcus mutans MT8148 encodes a cell surface protein antigen (PAc) of approximate 190 kilodaltons. The serotype c strain S. mutans GS-5 does not produce the 190-kilodalton PAc but produces a lower-molecular-weight protein that reacts with anti-PAc serum. The SphI-BamHI fragm...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.2.289-296.1990
更新日期:1990-02-01 00:00:00
abstract::Escherichia coli O157:H7 causes food and waterborne enteric infections that can result in hemorrhagic colitis and life-threatening hemolytic uremic syndrome. Intimate adherence of the bacteria to intestinal epithelial cells is mediated by intimin, but E. coli O157:H7 also possess several other putative adhesins, inclu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05945-11
更新日期:2012-03-01 00:00:00
abstract::The gram-negative gastric pathogen Helicobacter pylori is equipped with an extraordinarily large set of outer membrane proteins (OMPs), whose role in the infection process is not well understood. The Hop (Helicobacter outer membrane porins) and Hor (Hop-related proteins) groups constitute a large paralogous family con...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00364-09
更新日期:2009-09-01 00:00:00
abstract::The virulence of Neisseria gonorrhoeae for chicken embryos can be modified in a predictable manner by the addition of microbial siderophores to the inoculum. "Meningobactin" and "gonobactin," siderophores isolated from iron-limited cultures of meningococci and gonococci, respectively, enhance the virulence of the rela...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.2.609-613.1981
更新日期:1981-05-01 00:00:00
abstract::Salmonella is a widespread zoonotic enteropathogen that causes gastroenteritis and fatal typhoidal disease in mammals. During systemic infection of mice, Salmonella enterica serovar Typhimurium resides and replicates in macrophages within the "Salmonella-containing vacuole" (SCV). It is surprising that the substrates ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00093-09
更新日期:2009-07-01 00:00:00
abstract::In contrast to infection of superficial tissues, Streptococcus pyogenes infection of deeper tissue can be associated with a significantly diminished inflammatory response, suggesting that this bacterium has the ability to both promote and suppress inflammation. To examine this, we analyzed the behavior of an S. pyogen...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00420-09
更新日期:2009-11-01 00:00:00
abstract::The adhesion of K21a, K26, K36, and K50 capsulated Klebsiella strains to ileocecal (HCT-8) and bladder (T24) epithelial cell lines was significantly lower than that of their corresponding spontaneous noncapsulated variants K21a/3, K26/1, K36/3, and K50/3, respectively. Internalization of the bacteria by both epithelia...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.12.6744-6749.2000
更新日期:2000-12-01 00:00:00
abstract::The immune mechanism by which hamsters acquire resistance to infection with Treponema pertenue, the causative agent of frambesia, or yaws, has not been elucidated. Serum or cells (spleen or lymph node) obtained from hamsters resistant to frambesial infection were transferred to normal syngenic recipients, who are subs...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.21.2.430-435.1978
更新日期:1978-08-01 00:00:00
abstract::Brucellosis is a bacterial disease of animals and humans. Brucella abortus barely activates the innate immune system at the onset of infection, and this bacterium is resistant to the microbicidal action of complement. Since complement stands as the first line of defense during bacterial invasions, we explored the role...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00567-18
更新日期:2018-09-21 00:00:00
abstract::Studies on the innate immune response against microbial infections in Drosophila melanogaster involve mutant strains and their reference strains that act as experimental controls. We used five standard D. melanogaster laboratory reference strains (Oregon R, w1118, Canton-S, Cinnabar Brown, and Yellow White [YW]) and i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02318-14
更新日期:2014-10-01 00:00:00
abstract::For the first time, hepatitis A viral antigen (HAAg) was shown in liver biopsy tissue from a patient in the acute phase of hepatitis type A by light and electron microscopy, using the peroxidase-antibody technique. Under light microscopy, the staining for HAAg appeared as a fine, granular reaction product, scattered t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.36.1.320-324.1982
更新日期:1982-04-01 00:00:00
abstract::The role of macrophages in protecting mice from murine cytomegalovirus (MCMV) was studied in Swiss, CBA/J, and C57BL/6J mice. CBA/J mice were more resistant to virus than were C57BL/6J mice at all ages tested. Prior treatment of adult Swiss mice with 60 mg of silica, a dose selectively toxic to macrophages, increased ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.6.1383-1390.1974
更新日期:1974-12-01 00:00:00
abstract::The antigenically conserved proteins of Treponema pallidum subsp. pallidum and four nonpathogenic cultivatable treponemes were investigated by phase partitioning with the nonionic detergent Triton X-114 and immunoblot analysis. None of the T. pallidum integral membrane proteins identified by phase partitioning (deterg...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.7.1825-1828.1988
更新日期:1988-07-01 00:00:00
abstract::The suspected correlation between cessation of type C virus production and halt in immunoglobulin secretion by murine myeloma cells was studied. Employing two variants of the murine myeloma MOPC-315, immunoglobulin A-producing and nonproducing cells, we demonstrated that the two myelomas release similar levels of type...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.25.2.569-573.1979
更新日期:1979-08-01 00:00:00
abstract::Lipopolysaccharide (LPS) has recently been shown to facilitate macrophage foam cell formation and has been suggested to be a proatherogenic factor. The mechanism of LPS induced cholesterol accumulation, however, is unclear. In this report, using the macrophage-like RAW 264.7 cell line, we provide experimental evidence...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.6.2995-3003.2002
更新日期:2002-06-01 00:00:00
abstract::Citrate is a ubiquitous compound and can be utilized by many bacterial species, including enteric pathogens, as a carbon and energy source. Genes involved in citrate utilization have been extensively studied in some enteric bacteria, such as Klebsiella pneumoniae; however, their role in pathogenesis is still not clear...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00746-18
更新日期:2019-02-21 00:00:00
abstract::We investigated the mechanisms that lead to the production of proinflammatory mediators by human monocytes when these cells are exposed in vitro to live Borrelia burgdorferi spirochetes. We first focused on myeloid differentiation primary response protein 88 (MyD88), an adapter molecule that is essential in the Toll-l...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01078-08
更新日期:2009-03-01 00:00:00
abstract::Infection of mice with the murine sarcoma virus (Moloney) markedly suppressed the humoral antibody response to sheep erythrocyte antigen injected 10 days after infection, when tumor size was maximal, and on day 26, when primary tumors had partially regressed. Humoral antibody response was also inhibited when antigen w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1970-03-01 00:00:00
abstract::Anti-CD4 antibodies, which cause CD4(+) T-cell depletion, have been shown to increase susceptibility to infections in mice. Thus, development of anti-CD4 antibodies for clinical use raises potential concerns about suppression of host defense mechanisms against pathogens and tumors. The anti-human CD4 antibody kelixima...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.2.1032-1043.2001
更新日期:2001-02-01 00:00:00
abstract::Recent reports have demonstrated that Bordetella pertussis has invasive behavior in vivo and in vitro. In this study, we investigated the ability of a virulent strain, avirulent mutants, and mutants deficient in specific virulence factors to enter and survive intracellularly in human macrophages in vitro. Uptake of vi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.11.4578-4585.1992
更新日期:1992-11-01 00:00:00
abstract::Vibrio parahaemolyticus is the leading cause of bacterial seafood-borne gastroenteritis worldwide, yet little is known about how this pathogen colonizes the human intestine. The alternative sigma factor RpoN/sigma-54 is a global regulator that controls flagellar synthesis, as well as a wide range of nonflagellar genes...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01210-13
更新日期:2014-02-01 00:00:00
abstract::Infection with tissue-migrating helminths is frequently associated with intense granulocyte infiltrations. Several host-derived factors are known to mediate granulocyte recruitment to the tissues, but less attention has been paid to how parasite-derived products trigger this process. Parasite-derived chemotactic facto...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.6.4007-4018.2001
更新日期:2001-06-01 00:00:00
abstract::A canine distemper virus (CDV), DESIGNATED R252, originally recovered from a dog with demyelinating encephalomyelitis was shown to reproduce this disease in gnotobiotic dogs with a high incidence as compared to other CDV strains, which produced an acute fatal infection. In this investigation, R252 was propagated for t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.4.835-844.1975
更新日期:1975-04-01 00:00:00
abstract::In this study we tested the in vitro and in vivo anti-Cryptococcus neoformans activity of an antilaminarin (anti-beta-glucan) monoclonal antibody (MAb 2G8) (immunoglobulin G2b) which was previously shown to inhibit the growth of beta-glucan-exposing Candida albicans cells. Here we show that MAb 2G8 binds to the cell w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00278-07
更新日期:2007-11-01 00:00:00
abstract::The biological response to endotoxin mediated through the Toll-like receptor 4 (TLR4)-MD-2 receptor complex is directly related to lipid A structure or configuration. Endotoxin structure may also influence activation of the MyD88-dependent and -independent signaling pathways of TLR4. To address this possibility, human...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.5.2940-2950.2005
更新日期:2005-05-01 00:00:00
abstract::An experimental model of "chronic" diphtheria intoxication in the guinea pig was developed. Adult guinea pigs, subjected to a regimen of multiple sublethal doses of purified diphtheria toxin (total of 1.4 minimum lethal doses divided equally in four daily doses), developed a toxemia which terminated in death between 6...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.4.556-560.1973
更新日期:1973-04-01 00:00:00
abstract::Immunization of BALB/c mice with a plasmid containing the gene for Trypanosoma cruzi trans-sialidase (TS) induced antibodies that inhibited TS enzymatic activity, CD4+ Th1 and CD8+ Tc1 cells, and protective immunity against infection. We used this model to obtain basic information on the requirement of CD4 or CD8 or B...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.69.9.5477-5486.2001
更新日期:2001-09-01 00:00:00
abstract::The innate and the adaptive arms of the mucosal immune system must be coordinated to facilitate the control of pathogenic invasion while maintaining immune homeostasis. Toll-like receptors, able to activate the cell to produce bactericidal and inflammatory cytokines but also able to upregulate antigen (Ag)-presenting ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00100-07
更新日期:2008-02-01 00:00:00
abstract::Streptococcus suis capsular type 2 is an important etiological agent of swine meningitis, and it is also a zoonotic agent. Since one hypothesis of the pathogenesis of S. suis infection is that bacteria enter the bloodstream and invade the meninges and other tissues in close association with mononuclear phagocytes, the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.8.4312-4322.2002
更新日期:2002-08-01 00:00:00