Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes.

abstract：:Conventional dendritic cells (cDCs) are critical for protection against pulmonary infection with the opportunistic fungal pathogen Cryptococcus neoformans; however, the role of plasmacytoid dendritic cells (pDCs) is unknown. We show for the first time that murine pDCs have direct activity against C. neoformans via rea...

journal_title：Infection and immunity

authors： Hole CR,Leopold Wager CM,Mendiola AS,Wozniak KL,Campuzano A,Lin X,Wormley FL Jr

更新日期：2016-08-19 00:00:00

abstract：:Stools from a patient with antibiotic-associated colitis and cecal contents from a hamster with clindamycin-induced enterocolitis were compared in a cytotoxicity assay to determine common properties. Both specimens produced actinomorphic changes in human amnion cells at 10(-7) dilutions. The toxin was acid labile, hea...

journal_title：Infection and immunity

authors： Chang TW,Bartlett JG,Gorbach SL,Onderdonk AB

更新日期：1978-05-01 00:00:00

abstract：:The appearance of lymphotoxin in the culture fluid of phytohemagglutinin (PHA)-stimulated mouse spleen cells required two cell fractions that were separated by adherence to plastic. Upon stimulation with PHA, neither cell fraction alone produced significant amounts of lymphotoxin; however, when the cell fractions were...

journal_title：Infection and immunity

authors： Aksamit RR,Leonard EJ

更新日期：1982-06-01 00:00:00

abstract：:The concept of translational research, which aims to facilitate the application of basic scientific discoveries in clinical and community settings, is currently in vogue. While there are powerful forces driving this trend, support for translational research must be accompanied by a robust investment in basic science, ...

journal_title：Infection and immunity

authors： Fang FC,Casadevall A

更新日期：2010-02-01 00:00:00

abstract：:Specific pathogen-free guinea pigs were infected via the respiratory route with viable, attenuated Mycobacterium tuberculosis H37Ra and maintained on purified isocaloric diets. The control diet contained 30% protein (ovalbumin) and 50 ppm of added zinc (50 micrograms/g), the low protein diet contained 10% protein and ...

journal_title：Infection and immunity

authors： McMurray DN,Carlomagno MA,Cumberland PA

更新日期：1983-02-01 00:00:00

abstract：:Vitamin E protects nonimmunized and immunized mice against fatal Diplococcus pneumoniae type I (DpI) infection. A dietary supplementation of 180 mg of dl-alpha-tocopheryl acetate per kg of diet increased survival of nonimmunized mice from 20 to 80% when challenged with 20 organisms, and of mice immunized with 0.5 ng o...

journal_title：Infection and immunity

authors： Heinzerling RH,Tengerdy RP,Wick LL,Lueker DC

更新日期：1974-12-01 00:00:00

abstract：:Active immunization of mice with high doses of heat-killed and autoclaved vaccine of unencapsulated strains of Staphylococcus aureus, which was grown in brain heart infusion media, protected against challenge with the Smith diffuse strain of Staphylococcus aureus. These organisms were capable of absorbing the protecti...

journal_title：Infection and immunity

authors： Yoshida K,Ichiman Y,Otomo T

更新日期：1975-11-01 00:00:00

abstract：:Radial immunodiffusion procedures have been developed for testing bovine sera for the presence of antibody activity against three foot-and-mouth disease virus types and a virus infection-associated antigen. Reactions with virus antigens were obtained as early as 4 days after infection, and the virus type causing the r...

journal_title：Infection and immunity

authors： Wagner GG,Cowan KM,McVicar JW

更新日期：1972-02-01 00:00:00

abstract：:The within-host dynamics of an infection with the malaria parasite Plasmodium falciparum are the result of a complex interplay between the host immune system and parasite. Continual variation of the P. falciparum erythrocyte membrane protein (PfEMP1) antigens displayed on the surface of infected red blood cells enable...

journal_title：Infection and immunity

authors： Klein EY,Graham AL,Llinás M,Levin S

更新日期：2014-01-01 00:00:00

abstract：:The antiinflammatory cytokine response during urosepsis was determined by measurement of concentrations of soluble tumor necrosis factor receptor (sTNFR) types I and II, interleukin 1 receptor antagonist (IL-1ra), soluble IL-1 receptor type II (sIL-1RII), and interleukin 10 in sera and urine of 30 patients with cultur...

journal_title：Infection and immunity

authors： Olszyna DP,Prins JM,Buis B,van Deventer SJ,Speelman P,van der Poll T

更新日期：1998-08-01 00:00:00

abstract：:Migration of the fungal pathogen Candida albicans across the endothelial cell layer is considered a prerequisite for the invasion of multiple organs occurring in systemic candidiasis. We developed an experimental system in which C. albicans migrates from a luminal compartment across a monolayer of bovine aortic endoth...

journal_title：Infection and immunity

authors： Zink S,Nass T,Rösen P,Ernst JF

更新日期：1996-12-01 00:00:00

abstract：:Glucose has previously been shown to increase the in vitro phagocytosis of unopsonized Pseudomonas aeruginosa by freshly explanted murine peritoneal macrophages (PM) and cultivated alveolar macrophages (AM). This study examined the effect of glucose on the same phagocytosis process in human AM in order to determine wh...

journal_title：Infection and immunity

authors： Wong SY,Guerdoud LM,Cantin A,Speert DP

更新日期：1999-01-01 00:00:00

abstract：:Protection against colibacillosis in neonatal piglets was obtained by immunization of pregnant dams with procholeragenoid. Procholeragenoid is a stable high-molecular-weight aggregate of cholera toxin formed during the heating of cholera toxin. Procholeragenoid retained approximately 1% of the toxicity of native toxin...

journal_title：Infection and immunity

authors： Fürer E,Cryz SJ Jr,Dorner F,Nicolet J,Wanner M,Germanier R

更新日期：1982-03-01 00:00:00

abstract：:In this study we tested the in vitro and in vivo anti-Cryptococcus neoformans activity of an antilaminarin (anti-beta-glucan) monoclonal antibody (MAb 2G8) (immunoglobulin G2b) which was previously shown to inhibit the growth of beta-glucan-exposing Candida albicans cells. Here we show that MAb 2G8 binds to the cell w...

journal_title：Infection and immunity

authors： Rachini A,Pietrella D,Lupo P,Torosantucci A,Chiani P,Bromuro C,Proietti C,Bistoni F,Cassone A,Vecchiarelli A

更新日期：2007-11-01 00:00:00

abstract：:We tested the hypothesis that the intensity of specific antichlamydial T cell-mediated immunity in the genital tract of female guinea pigs infected intravaginally with the chlamydial agent of guinea pig inclusion conjunctivitis would determine the resistance or susceptibility to reinfection after a primary chlamydial ...

journal_title：Infection and immunity

authors： Igietseme JU,Rank RG

更新日期：1991-04-01 00:00:00

abstract：:Fusobacterium nucleatum is a common oral anaerobe involved in periodontitis that is known to translocate and cause intrauterine infections. In the oral environment, F. nucleatum adheres to a large diversity of species, facilitating their colonization and creating biological bridges that stabilize the multispecies dent...

journal_title：Infection and immunity

authors： Coppenhagen-Glazer S,Sol A,Abed J,Naor R,Zhang X,Han YW,Bachrach G

更新日期：2015-03-01 00:00:00

abstract：:Antibodies against mumps virus have been studied by using immunoglobulin class-specific indicators labeled with (125)I in the radioimmunoassay (RIA) procedure. The immunoglobulins in paired acute and convalescent sera were allowed to react with mumps virus in a solid-phase RIA system. Class-specific immunoglobulin ind...

journal_title：Infection and immunity

authors： Daugharty H,Warfield DT,Hemingway WD,Casey HL

更新日期：1973-03-01 00:00:00

abstract：:Strains of Cryptococcus neoformans vary in resistance to phagocytosis in vitro. The binding of isolated capsular polysaccharide (CPS) to a capsule-free mutant of C. neoformans confers resistance to phagocytosis. The importance of capsule composition to differences among strains in susceptibility to phagocytosis was ev...

journal_title：Infection and immunity

authors： Small JM,Mitchell TG

更新日期：1989-12-01 00:00:00

abstract：:The protozoan parasite Cryptosporidium parvum is a significant cause of diarrheal disease worldwide. Attachment to and invasion of host intestinal epithelial cells by C. parvum sporozoites are crucial steps in the pathogenesis of cryptosporidiosis. The molecular basis of these initial interactions is unknown. In order...

journal_title：Infection and immunity

authors： Cevallos AM,Bhat N,Verdon R,Hamer DH,Stein B,Tzipori S,Pereira ME,Keusch GT,Ward HD

更新日期：2000-09-01 00:00:00

abstract：:Gram-negative organisms incorporate hydroxy fatty acids into the lipid A moiety of lipopolysaccharide (LPS), and in the case of some members of the family Enterobacteriaceae, hydroxy fatty acids are incorporated exclusively into lipid A. However, a limited number of Bacteroides species have been shown to incorporate s...

journal_title：Infection and immunity

authors： Nichols FC

更新日期：1994-09-01 00:00:00

abstract：:Intracellular bacterial infections affect all vertebrates. Cultured fish are particularly vulnerable because no effective protection measures have been established since such infections emerged approximately 50 years ago. As in other vertebrates, the induction of cell-mediated immunity (CMI) plays an important role in...

journal_title：Infection and immunity

authors： Matsumoto M,Kubota T,Fujita S,Shiozaki K,Kishida S,Yamamoto A

更新日期：2019-10-18 00:00:00

abstract：:Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes to shorten drug regimens. Pimonidazole hydrochloride (Hypoxyprobe) is an imaging agent that is bioreductively activated only unde...

journal_title：Infection and immunity

authors： Via LE,Lin PL,Ray SM,Carrillo J,Allen SS,Eum SY,Taylor K,Klein E,Manjunatha U,Gonzales J,Lee EG,Park SK,Raleigh JA,Cho SN,McMurray DN,Flynn JL,Barry CE 3rd

更新日期：2008-06-01 00:00:00

abstract：:By using the powerful separation technique of capillary gas chromatography combined with the selectivity of mass spectrometric detection, muramic acid was not detectable in purified elementary bodies of Chlamydia psittaci Cal 10 (less than or equal to 0.006%) or C. trachomatis serovar E (less than or equal to 0.02%). ...

journal_title：Infection and immunity

authors： Fox A,Rogers JC,Gilbart J,Morgan S,Davis CH,Knight S,Wyrick PB

更新日期：1990-03-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a critical role in early immune recognition of Aspergillus, which can regulate host defense during invasive pulmonary Aspergillosis (IPA). However, the role of TLR7 in the pathogenesis of IPA remains unknown. In this study, an in vivo model of IPA was established to investigate the cont...

journal_title：Infection and immunity

authors： Xu B,Luo Q,Gong Y,Li J,Cao J

更新日期：2021-01-25 00:00:00

abstract：:Escherichia coli O157:H7, a major Shiga toxin-producing pathogen, has a low infectious dose and causes serious illness in humans. The gastrointestinal tract of cattle is the primary reservoir of E. coli O157:H7, and thus, it is critical to eliminate or reduce E. coli O157:H7 gut colonization. Given that E. coli O157:H...

journal_title：Infection and immunity

authors： Xue Y,Zhang H,Wang H,Hu J,Du M,Zhu MJ

更新日期：2014-05-01 00:00:00

abstract：:Tuberculosis is one of the most important infectious diseases worldwide. The susceptibility to this disease depends to a great extent on the innate immune response against mycobacteria. Host defense peptides (HDP) are one of the first barriers to counteract infection. Cathelicidin (LL-37) is an HDP that has many immun...

journal_title：Infection and immunity

authors： Torres-Juarez F,Cardenas-Vargas A,Montoya-Rosales A,González-Curiel I,Garcia-Hernandez MH,Enciso-Moreno JA,Hancock RE,Rivas-Santiago B

更新日期：2015-12-01 00:00:00

abstract：:Bovine mastitis continues to be the most detrimental factor for profitable dairying. Recent research conducted within our laboratory has identified a genetic marker in the CXCR2 gene associated with mastitis susceptibility. The objective of the present study was to evaluate the migratory ability of neutrophils from co...

journal_title：Infection and immunity

authors： Rambeaud M,Pighetti GM

更新日期：2005-08-01 00:00:00

abstract：:Fourteen freshly isolated strains of Streptococcus sanguis were obtained from the dental plaque of five healthy adults. Whole saliva was collected concomitant with the plaque isolates from the five subjects, and a second whole saliva sample was collected 10 weeks later. All possible combinations of the first five sali...

journal_title：Infection and immunity

authors： Liljemark WF,Bloomquist CG,Ofstehage JC

更新日期：1979-12-01 00:00:00

abstract：:Vibrio cholerae, the pathogen that causes cholera, also survives in aqueous reservoirs, probably in the form of biofilms. Quorum sensing negatively regulates V. cholerae biofilm formation through HapR, whose expression is induced at a high cell density. In this study, we show that the concentration of the quorum-sensi...

journal_title：Infection and immunity

authors： Liu Z,Stirling FR,Zhu J

更新日期：2007-01-01 00:00:00

abstract：:The initial encounter of Leishmania cells and cells from the immune system is fundamentally important in the outcome of infection and determines disease development or resistance. We evaluated the anti-Leishmania amazonensis response of naive volunteers by using an in vitro priming (IVP) system and comparing the respo...

journal_title：Infection and immunity

authors： Pompeu MM,Brodskyn C,Teixeira MJ,Clarêncio J,Van Weyenberg J,Coelho IC,Cardoso SA,Barral A,Barral-Netto M

更新日期：2001-12-01 00:00:00