Effect of chemical modification of histidine and tyrosine residues in toxic shock syndrome toxin 1 on the serologic and mitogenic activities of the toxin.

abstract：:The ocular surface is continuously exposed to potential pathogens, including free-living amoebae. Acanthamoeba species are among the most ubiquitous amoebae, yet Acanthamoeba keratitis is remarkably rare. The pathogenesis of Acanthamoeba keratitis is a complex, sequential process. Here we show that Acanthamoeba kerati...

journal_title：Infection and immunity

authors： Alizadeh H,Neelam S,Hurt M,Niederkorn JY

更新日期：2005-02-01 00:00:00

abstract：:The microfilament inhibitors cytochalasins B and D have been traditionally used to indirectly evaluate the requirement for actin in the uptake of invasive bacterial pathogens by nonprofessional phagocytes. Through their effects on microfilaments, both cytochalasins also impart profound alterations in cellular morpholo...

journal_title：Infection and immunity

authors： Ewanowich CA,Peppler MS

更新日期：1990-10-01 00:00:00

abstract：:Immunologically competent mice and mice with defined immunological deficiencies were infected with Plasmodium yoelii. Splenomegaly, enhanced phagocytosis, and anemia were most marked in infected mice having intact thymic tissue. Whereas the spleens of infected nude mice increased minimally in size, the relative blood ...

journal_title：Infection and immunity

authors： Roberts DW,Weidanz WP

更新日期：1978-06-01 00:00:00

abstract：:Chronic helminth infections are known to be associated with the modulation of antigen-specific T-cell responses. Strongyloides stercoralis infection is characterized by the downmodulation of antigen-specific Th1 and Th17 responses and the upregulation of Th2 and Th9 responses. Immune homeostasis is partially maintaine...

journal_title：Infection and immunity

authors： Rajamanickam A,Munisankar S,Dolla C,Nutman TB,Babu S

更新日期：2019-11-18 00:00:00

abstract：:The phenotypic and functional changes of glycolipid presented by CD1d(glycolipid/CD1d) specific Valpha14+ T cells in the liver of mice at early stages of bacterial infection were investigated. After Listeria monocytogenes infection or interleukin-12 (IL-12) treatment, alpha-galactosylceramide/CD1d tetramer-reactive (a...

journal_title：Infection and immunity

authors： Emoto M,Yoshizawa I,Emoto Y,Miamoto M,Hurwitz R,Kaufmann SH

更新日期：2006-10-01 00:00:00

abstract：:The tetraspanins are a superfamily of transmembrane proteins with diverse functions and can form extended microdomains within the plasma membrane in conjunction with partner proteins, which probably includes receptors for bacterial adhesins. Neisseria meningitidis, the causative agent of meningococcal disease, attache...

journal_title：Infection and immunity

authors： Green LR,Monk PN,Partridge LJ,Morris P,Gorringe AR,Read RC

更新日期：2011-06-01 00:00:00

abstract：:Humans infected with the dimorphic fungus Blastomyces dermatitidis develop strong T-lymphocyte responses to WI-1, an immunodominant antigen that has been shown to elicit protective immunity in mice. In the present study, the T-cell epitopes of WI-1 and human leukocyte antigen (HLA) restricting elements that display th...

journal_title：Infection and immunity

authors： Chang WL,Audet RG,Aizenstein BD,Hogan LH,DeMars RI,Klein BS

更新日期：2000-02-01 00:00:00

abstract：:A Mycobacterium tuberculosis strain disrupted in the AraC homologue Rv1931c was isolated. The mutant strain exhibited reduced survival both in macrophages and in a mouse infection model, with survival being restored on complementation with the Rv1931c gene. These results suggest that Rv1931c regulates genes important ...

journal_title：Infection and immunity

authors： Frota CC,Papavinasasundaram KG,Davis EO,Colston MJ

更新日期：2004-09-01 00:00:00

abstract：:Group A streptococci isolated from skin adhere in greater numbers to human skin epithelial cells than to cells obtained from buccal mucosa whereas streptococci isolated from a throat tend to adhere in greater numbers to buccal epithelial cells than to skin epithelial cells in vitro. M protein-producing strains of grou...

journal_title：Infection and immunity

authors： Alkan M,Ofek I,Beachey EH

更新日期：1977-11-01 00:00:00

abstract：:Nitric oxide (NO) produced by inducible NO synthase (iNOS) mediates hypotension in endotoxemia. In this study, NO induction by a toxin-producing Streptococcus pyogenes isolate, H250, and by recombinant streptococcal pyrogenic exotoxin A (rSPEA) has been examined, both in vitro and in vivo. Streptococcal supernatants, ...

journal_title：Infection and immunity

authors： Sriskandan S,Moyes D,Buttery LK,Wilkinson J,Evans TJ,Polak J,Cohen J

更新日期：1997-05-01 00:00:00

abstract：:Understanding the extent to which genetic factors influence the immune response is important in the development of subunit vaccines. Associations with HLA gene polymorphisms appear insufficient to explain the range of variation in immune responses to vaccines and to infections by major pathogens. In this study of Gamb...

journal_title：Infection and immunity

authors： Jepson A,Banya W,Sisay-Joof F,Hassan-King M,Nunes C,Bennett S,Whittle H

更新日期：1997-03-01 00:00:00

abstract：:Proteus mirabilis, a common agent of nosocomially acquired and catheter-associated urinary tract infection, is the most frequent cause of infection-induced bladder and kidney stones. Urease-catalyzed urea hydrolysis initiates stone formation in urine and can be inhibited by acetohydroxamic acid and other structural an...

journal_title：Infection and immunity

authors： Nicholson EB,Concaugh EA,Mobley HL

更新日期：1991-10-01 00:00:00

abstract：:Oral inoculation of 5-day-old gnotobiotic pigs with Salmonella enterica serovar Typhimurium strain F98 resulted in severe enteritis and invasive disease. Preinoculation 24 h earlier with an avirulent mutant of Salmonella enterica serovar Infantis (1326/28) completely prevented disease for up to 14 days (when the exper...

journal_title：Infection and immunity

authors： Foster N,Lovell MA,Marston KL,Hulme SD,Frost AJ,Bland P,Barrow PA

更新日期：2003-04-01 00:00:00

abstract：:The yield of infectious Chlamydia trachomatis was analyzed in human (HeLa) and mouse (McCoy) cell lines treated with the human interferon (IFN) subtypes IFN-alpha A and IFN-alpha D, with their hybrids [IFN-alpha AD (BglII), IFN-alpha AD (PvuII), and IFN-alpha DA (BglII)] constructed in vitro from their expression plas...

journal_title：Infection and immunity

authors： de la Maza LM,Peterson EM,Goebel JM,Fennie CW,Czarniecki CW

更新日期：1985-03-01 00:00:00

abstract：:Intracellular multiplication of virulent Legionella pneumophila serogroup 1 was inhibited by human monocyte-derived macrophages activated by a glycoprotein extract of Klebsiella pneumoniae, RU 41.740. Macrophage cultures were infected with L. pneumophila in the presence of immune antibodies on day 7 of culture. Extrac...

journal_title：Infection and immunity

authors： Rajagopalan P,Dournon E,Vildé JL,Pocidalo JJ

更新日期：1987-09-01 00:00:00

abstract：:Hamster respiratory epithelial cells were cultured in a monolayer format, and 20% of the cells were ciliated. Mycoplasma pneumoniae attached to the epithelial cells in a neuraminidase-specific fashion and induced ciliostasis and cytonecrosis. ...

journal_title：Infection and immunity

authors： Gabridge MG,Gunderson H,Schaeffer SL,Barden-Stahl YD

更新日期：1978-07-01 00:00:00

abstract：:The enteric pathogen Shigella is one of the leading causes of moderate-to-severe diarrhea and death in young children in developing countries. Transformed cell lines and animal models have been widely used to study Shigella pathogenesis. In addition to altered physiology, transformed cell lines are composed of a singl...

journal_title：Infection and immunity

authors： Ranganathan S,Doucet M,Grassel CL,Delaine-Elias B,Zachos NC,Barry EM

更新日期：2019-03-25 00:00:00

abstract：:Studies of meningococcal pathogenesis have been severely restricted due to the absence of an adequate animal model. Given the significance of iron in meningococcal pathogenesis, we developed a model of Neisseria meningitidis colonization in outbred adult mice that included daily administration of iron dextran. While r...

journal_title：Infection and immunity

authors： Yi K,Stephens DS,Stojiljkovic I

更新日期：2003-04-01 00:00:00

abstract：:The major antigenic determinants of the lipoglycans from Acholeplasma granularum and Acholeplasma axanthum were found to be the oligosaccharide sequences Glcp(beta 1 leads to 2)-Glcp(alpha 1 leads to 4)-Glcp and Glcp(beta 1 leads to 2)-Glcp(beta 1 leads to 2)-Glcp, respectively. The disaccharides sophorose and maltose...

journal_title：Infection and immunity

authors： Al-Samarrai TH,Smith PF,Lynn RJ

更新日期：1983-05-01 00:00:00

abstract：:A murine model system was established to study immune responses to the Pnu-Imune vaccine, which is made up of 23 different pneumococcal capsular polysaccharides. In this animal model, antibody-forming cell responses to 21 of 23 individual polysaccharides in the vaccine were detected. The Pnu-Imune vaccine elicited goo...

journal_title：Infection and immunity

authors： Garg M,Subbarao B

更新日期：1992-06-01 00:00:00

abstract：:Ring-necked pheasant virus, an avian leukosis virus, when injected into 10-day old chick embryos, caused angiosarcomas in the lungs of infected chickens within a short time. Angiosarcomas appeared as localized foci of proliferating cells in the lungs as early as 2 weeks posthatch, and by 6 weeks, the lungs of the infe...

journal_title：Infection and immunity

authors： Carter JK,Proctor SJ,Smith RE

更新日期：1983-04-01 00:00:00

abstract：:Immune responses of mice to Streptococcus mutans serotype c were analyzed by means of the enzyme-linked immunospot assay to determine the predominant specificities of the antibodies developed. In general, the numbers of splenic antibody-secreting cells correlated with serum antibody levels. A low dose (10(8) CFU) of k...

journal_title：Infection and immunity

authors： Russell MW,Czerkinsky C,Moldoveanu Z

更新日期：1986-08-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is an amphipathic macromolecule that is highly aggregated in aqueous preparations. LPS-binding protein (LBP) catalyzes the transfer of single LPS molecules, segregated from an LPS aggregate, to high-density lipoproteins (HDL), which results in the neutralization of LPS. When fluorescein isothi...

journal_title：Infection and immunity

authors： de Haas CJ,Poppelier MJ,van Kessel KP,van Strijp JA

更新日期：2000-09-01 00:00:00

abstract：:Engerotoxins isolated from Vibrio cholerae and toxigenic Escherichia coli cause permeability alterations in rabbit skin. Firm induration and erythema are observed within 18 to 24 h, and visualization of the reaction may be enhanced by intravenous injection of Pontamine sky blue dye. Two skin permeability factors (PF) ...

journal_title：Infection and immunity

authors： Sandefur PD,Peterson JW

更新日期：1976-09-01 00:00:00

abstract：:An alkali-soluble water-soluble extract of Blastomyces dermatitidis yeast-phase cell walls was tested for its ability to elicit a response in lymphocytes isolated from the peripheral blood of Blastomyces-infected guinea pigs. Sequential preparations of the antigen were reproducible and specific in the in vitro lymphoc...

journal_title：Infection and immunity

authors： Hall NK,Deighton F,Larsh HW

更新日期：1978-02-01 00:00:00

abstract：:The influence of the growth medium on the ability of strains of Streptococcus mutans, Actinomyces viscosus and A. naeslundii to attach to saliva-treated hydroxyapatite (S-HA) surfaces was studied. Preliminary experiments indicated that cells of each species harvested in lag, log, and early stationary phases of growth ...

journal_title：Infection and immunity

authors： Peros WJ,Gibbons RJ

更新日期：1981-04-01 00:00:00

abstract：:Immunofluorescence microscopy demonstrated that laminin bound to the surface of Penicillium marneffei conidia. Attachment of P. marneffei conidia in an adherence assay was inhibited by soluble laminin and anti-laminin antibody. N-Acetylneuraminic acid abolished adherence, indicating an interaction mediated by a sialic...

journal_title：Infection and immunity

authors： Hamilton AJ,Jeavons L,Youngchim S,Vanittanakom N,Hay RJ

更新日期：1998-12-01 00:00:00

abstract：:The 25-kb linear plasmid lp25 and one of the 28-kb linear plasmids (lp28-1) are required for experimental infection in Borrelia burgdorferi, the etiologic agent of Lyme disease. The loss of these plasmids either eliminates infectivity (lp25) or significantly increases the 50% infective dose during a 2-week infection p...

journal_title：Infection and immunity

authors： Labandeira-Rey M,Seshu J,Skare JT

更新日期：2003-08-01 00:00:00

abstract：:Filifactor alocis is a recently recognized periodontal pathogen; however, little is known regarding its interactions with the immune system. As the first-responder phagocytic cells, neutrophils are recruited in large numbers to the periodontal pocket, where they play a crucial role in the innate defense of the periodo...

journal_title：Infection and immunity

authors： Armstrong CL,Miralda I,Neff AC,Tian S,Vashishta A,Perez L,Le J,Lamont RJ,Uriarte SM

更新日期：2016-11-18 00:00:00

abstract：:Bioluminescent reporter assays have been widely used to study the effect of Toxoplasma gondii on host gene expression. In the present study, we extend these studies by engineering novel reporter cell lines containing a gamma-activated sequence (GAS) element driving firefly luciferase (FLUC). In RAW264.7 macrophages, T...

journal_title：Infection and immunity

authors： Olias P,Sibley LD

更新日期：2016-06-23 00:00:00