Effects of Mycobacterium bovis BCG infection on regulation of L-arginine uptake and synthesis of reactive nitrogen intermediates in J774.1 murine macrophages.

abstract：:Mice immunized with a killed vaccine of phase I Bordetella bronchiseptica were challenged with various numbers of virulent B. bronchiseptica by intraperitoneal, intracerebral, or intranasal routes. The course of infection was compared among these routes, and the protective effect of vaccination was quantitatively anal...

journal_title：Infection and immunity

authors： Sekiya K,Kawahira M,Nakase Y

更新日期：1983-08-01 00:00:00

abstract：:Toll-like receptor (TLR)-based signaling pathways in the host may be modulated by pathogens during the course of infection. We describe a novel immunomodulatory mechanism in which Aspergillus fumigatus conidia induce attenuation of TLR2- and TLR4-mediated interleukin (IL)-6 and IL-1beta proinflammatory responses in hu...

journal_title：Infection and immunity

authors： Chai LY,Kullberg BJ,Vonk AG,Warris A,Cambi A,Latgé JP,Joosten LA,van der Meer JW,Netea MG

更新日期：2009-05-01 00:00:00

abstract：:The development and course of normally lethal parasitemias in mice inoculated intraperitoneally with erythrocytic stages of Plasmodium yoelii or Plasmodium berghei were markedly affected by treatment with the antilymphoid drug cyclosporin A (CS-A). When the first of four daily subcutaneous 25-mg/kg doses of CS-A was g...

journal_title：Infection and immunity

authors： Nickell SP,Scheibel LW,Cole GA

更新日期：1982-09-01 00:00:00

abstract：:The porcine immunoglobulins M (IgM), A (IgA), and G (IgG) were isolated and purified and some of the properties of the porcine milk IgA were examined. Monospecific antisera which were prepared against these immunoglobulins in rabbits were then used to absorb a particular class of immunoglobulin from sow serum, colostr...

journal_title：Infection and immunity

authors： Saif LJ,Bohl EH,Gupta RK

更新日期：1972-10-01 00:00:00

abstract：:The development of chronic and recurrent Staphylococcus aureus infections is associated with the emergence of slow-growing mutants known as small-colony variants (SCVs), which are highly tolerant of antibiotics and can survive inside host cells. However, the host and bacterial factors which underpin SCV emergence duri...

journal_title：Infection and immunity

authors： Painter KL,Strange E,Parkhill J,Bamford KB,Armstrong-James D,Edwards AM

更新日期：2015-05-01 00:00:00

abstract：:Culture filtrate from Mycobacterium tuberculosis contains protective antigens of relevance for the generation of a new antituberculosis vaccine. We have identified two previously uncharacterized M. tuberculosis proteins (TB7.3 and TB10.4) from the highly active low-mass fraction of culture filtrate. The molecules were...

journal_title：Infection and immunity

authors： Skjøt RL,Oettinger T,Rosenkrands I,Ravn P,Brock I,Jacobsen S,Andersen P

更新日期：2000-01-01 00:00:00

abstract：:The bactericidal activity of guinea pig and human polymorphonuclear leukocytes (PMNs) against a smooth-intermediate strain (45/0) and a rough strain (45/20) of Brucella abortus has been examined. After incubation for 120 min, guinea pig PMNs incubated with either the smooth strain 45/0 or the rough strain 45/20 exhibi...

journal_title：Infection and immunity

authors： Kreutzer DL,Dreyfus LA,Robertson DC

更新日期：1979-03-01 00:00:00

abstract：:Immune cytolysis was measured by release of absorbed radioactive chromium from infected cells that were incubated with antiviral antibody and complement. The presence of virus-specific antigens detected in this manner on the surface of several types of cells infected with Japanese encephalitis (JE) virus did not corre...

journal_title：Infection and immunity

authors： Brandt WE,Russell PK

更新日期：1975-02-01 00:00:00

abstract：:Lymphocytes derived from 72- to 90-day-old fetal piglet thymuses respond in vitro to phytohemagglutinin quantitatively greater than do spleen cell lymphocytes. ...

journal_title：Infection and immunity

authors： Rodey GE,Day N,Holmes-Gray B,Good RA

更新日期：1972-03-01 00:00:00

abstract：:Virulent strains of Pseudomonas aeruginosa are either of a nonmucoid, lipopolysaccharide (LPS)-smooth or mucoid, LPS-rough phenotype, and immunity to these different variants is efficiently mediated by antibodies specific to O antigens or mucoid exopolysaccharide (also called alginate), respectively. In addition to O ...

journal_title：Infection and immunity

authors： Hatano K,Goldberg JB,Pier GB

更新日期：1995-01-01 00:00:00

abstract：:Most vaccines are still given parenterally. Mucosal vaccination would offer different advantages over parenteral immunization, including blocking of the pathogens at the portal of entry. In this paper, nontoxic Escherichia coli heat-labile enterotoxin (LT) mutants and Supramolecular Biovector systems (SMBV) were evalu...

journal_title：Infection and immunity

authors： Baudner BC,Balland O,Giuliani MM,Von Hoegen P,Rappuoli R,Betbeder D,Del Giudice G

更新日期：2002-09-01 00:00:00

abstract：:Immunity to reinfection in the genital tract of female guinea pigs with the agent of guinea pig inclusion conjunctivitis was found to be dependent upon an intact humoral immune response. Cell-mediated immunity in the absence of humoral immunity had no apparent role in resistance to challenge infection. ...

journal_title：Infection and immunity

authors： Rank RG,Barron AL

更新日期：1983-01-01 00:00:00

abstract：:Salmonella enterica, a gram-negative pathogen, causes a spectrum of human infections including enterocolitis and typhoid fever. We previously showed that Salmonella flagellin played a role in suppressing intestinal mucosal inflammation in a murine model of acute enterocolitis. In this study, we examined the role of fl...

journal_title：Infection and immunity

authors： Fournier B,Williams IR,Gewirtz AT,Neish AS

更新日期：2009-09-01 00:00:00

abstract：:Peptidoglycans of Leptotrichia buccalis ATCC 14201 and ATCC 19616 were isolated by extraction with sodium dodecyl sulfate and subsequent digestion of the sodium dodecyl sulfate-insoluble residue with proteases and alpha-amylase. Cell wall fractions obtained by sodium dodecyl sulfate extraction and protease digestion w...

journal_title：Infection and immunity

authors： Fukuhara H,Umemoto T,Sagawa H,Kato K,Kotani S

更新日期：1983-01-01 00:00:00

abstract：:Infection with Trypanosoma cruzi, the agent of Chagas' disease, may induce antibodies and T cells reactive with self antigens (autoimmunity). Because autoimmunity is generally thought to develop during the chronic phase of infection, one hypothesis is that autoimmunity develops only after long-term, low-level stimulat...

journal_title：Infection and immunity

authors： Leon JS,Godsel LM,Wang K,Engman DM

更新日期：2001-09-01 00:00:00

abstract：:Experiments were performed to investigate the usefulness of an enzyme-linked immunosorbent assay utilizing avidin-biotin interaction as a diagnostic tool for detection of Toxoplasma antigen in blood. The lower limit of sensitivity of the assay by this method was ca. 4 ng/ml, and standard assays provided a linear plot ...

journal_title：Infection and immunity

authors： Ise Y,Iida T,Sato K,Suzuki T,Shimada K,Nishioka K

更新日期：1985-04-01 00:00:00

abstract：:Help from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address th...

journal_title：Infection and immunity

authors： Ekkens MJ,Shedlock DJ,Jung E,Troy A,Pearce EL,Shen H,Pearce EJ

更新日期：2007-05-01 00:00:00

abstract：:Protein-malnourished rats had greater numbers of bacteria in their livers and spleens compared with numbers in control rats following a sublethal intraperitoneal dose of Salmonella typhimurium. However, the febrile responses of both groups of rats to infection were similar. The ability to mount a normal febrile respon...

journal_title：Infection and immunity

authors： Bradley SF,Kauffman CA

更新日期：1988-04-01 00:00:00

abstract：:Helicobacter pylori infection of the stomach causes an active immune response that includes stimulation of inducible nitric oxide (NO) synthase (iNOS) expression. Although NO can kill H. pylori, the bacterium persists indefinitely, suggesting that NO production is inadequate. We determined if the NO derived from iNOS ...

journal_title：Infection and immunity

authors： Chaturvedi R,Asim M,Lewis ND,Algood HM,Cover TL,Kim PY,Wilson KT

更新日期：2007-09-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) against herpes simplex virus (HSV) were induced in vitro from human peripheral blood lymphocytes by stimulation with HSV antigen. CTL generated by HSV type 1 (HSV-1) antigen stimulation killed not only HSV-1-infected target cells but also HSV type 2 (HSV-2)-infected target cells, though a...

journal_title：Infection and immunity

authors： Yasukawa M,Shiroguchi T,Kobayashi Y

更新日期：1983-04-01 00:00:00

abstract：:Sporothrix schenckii is a human pathogen that causes sporotrichosis, an important cutaneous mycosis with a worldwide distribution. It produces dark-brown conidia, which infect the host. We found that S. schenckii synthesizes melanin via the 1,8-dihydroxynaphthalene pentaketide pathway. Melanin biosynthesis in the wild...

journal_title：Infection and immunity

authors： Romero-Martinez R,Wheeler M,Guerrero-Plata A,Rico G,Torres-Guerrero H

更新日期：2000-06-01 00:00:00

abstract：:Bartonella bacilliformis is the etiologic agent of Oroya fever in humans. Flagellum-mediated motility has been postulated as a major virulence factor for invasion of host cells. To address this hypothesis, we purified and characterized flagella from strain KC584 and then assessed their role in human erythrocyte associ...

journal_title：Infection and immunity

authors： Scherer DC,DeBuron-Connors I,Minnick MF

更新日期：1993-12-01 00:00:00

abstract：:The in vivo induction of colony-stimulating activity (CSA) by N-acetylmuramyl-L-alanine-D-isoglutamine has been demonstrated recently. In this study we increased our understanding of this property by testing muramyl peptides of several structures and activities for their capacity to induce CSA in vivo. A comparison of...

journal_title：Infection and immunity

authors： Galelli A,Lefrancier P,Chedid L

更新日期：1984-11-01 00:00:00

abstract：:To look for a possible correlation between the virulence of Rhodococcus equi and its cytokine-inducing capacity, we evaluated intracellular survival and measured cytokine induction by mouse macrophages infected with a virulent strain containing an 85-kb plasmid and expressing VapA (103+), its avirulent plasmid-cured d...

journal_title：Infection and immunity

authors： Giguère S,Prescott JF

更新日期：1998-05-01 00:00:00

abstract：:Cholera enterotoxin and the related heat-labile enterotoxins of Escherichia coli enter their target cells through noncoated vesicles, but how the toxins are processed intracellularly and how they get to their targeted enzyme, adenylate cyclase, remain to be defined. Brefeldin A, an inhibitor of the trans-Golgi network...

journal_title：Infection and immunity

authors： Donta ST,Beristain S,Tomicic TK

更新日期：1993-08-01 00:00:00

abstract：:Burkholderia cenocepacia strain K56-2 typically has rough colony morphology on agar medium; however, shiny colony variants (shv) can appear spontaneously. These shv all had a minimum of 50% reduction in biomass formation and were generally avirulent in an alfalfa seedling infection model. Three shv-K56-2 S15, K56-2 S7...

journal_title：Infection and immunity

authors： Bernier SP,Nguyen DT,Sokol PA

更新日期：2008-01-01 00:00:00

abstract：:The type III capsular polysaccharide of group B streptococci (GBS) consists of a linear backbone with short side chains ending in residues of N-acetylneuraminic acid, or sialic acid. The presence of sialic acid on the surface of the organism inhibits activation of the alternative pathway of complement and is thought t...

journal_title：Infection and immunity

authors： Wessels MR,Haft RF,Heggen LM,Rubens CE

更新日期：1992-02-01 00:00:00

abstract：:Borrelia burgdorferi synthesizes a variety of differentially regulated outer surface lipoproteins in the tick vector and in vertebrate hosts. Among these is OspD, a protein that is highly induced in vitro by conditions that mimic the tick environment. Using genetically engineered strains in which ospD is deleted, we d...

journal_title：Infection and immunity

authors： Stewart PE,Bestor A,Cullen JN,Rosa PA

更新日期：2008-05-01 00:00:00

abstract：:Escherichia coli heat-labile enterotoxin (LT) is an extensively studied adjuvant of mucosal responses. Nevertheless, its mode of action as an adjuvant remains incompletely understood. In this study, we describe a simplified in vitro model with which to look at some aspects of immunoregulation by LT. The interaction of...

journal_title：Infection and immunity

authors： Lopes LM,Maroof A,Dougan G,Chain BM

更新日期：2000-12-01 00:00:00

abstract：:Klebsiella pneumoniae is a leading cause of both community-acquired and nosocomial gram-negative-bacterial pneumonia. A further clinical complication of pulmonary K. pneumoniae infection is dissemination of bacteria from the lung into the peripheral blood, resulting in bacteremia concurrent with the localized pulmonar...

journal_title：Infection and immunity

authors： Moore TA,Perry ML,Getsoian AG,Newstead MW,Standiford TJ

更新日期：2002-11-01 00:00:00