Abstract:
:Borrelia burgdorferi synthesizes a variety of differentially regulated outer surface lipoproteins in the tick vector and in vertebrate hosts. Among these is OspD, a protein that is highly induced in vitro by conditions that mimic the tick environment. Using genetically engineered strains in which ospD is deleted, we demonstrate that this protein is not required for B. burgdorferi survival and infectivity in either the mouse or the tick. However, examination of both transcript levels and protein expression indicates that OspD expression is limited to a discrete window of time during B. burgdorferi replication within the tick. This time frame corresponds to tick detachment from the host following feeding, and expression of OspD continues during tick digestion of the blood meal but is low or undetectable after the tick has molted. The high level of OspD production correlates to the highest cell densities that B. burgdorferi is known to reach in vivo. Although OspD is nonessential to the infectious cycle of B. burgdorferi, the tight regulation of expression suggests a beneficial contribution of OspD to the spirochete during bacterial replication within the tick midgut.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Stewart PE,Bestor A,Cullen JN,Rosa PAdoi
10.1128/IAI.00714-07subject
Has Abstractpub_date
2008-05-01 00:00:00pages
1970-8issue
5eissn
0019-9567issn
1098-5522pii
IAI.00714-07journal_volume
76pub_type
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.1.128-134.1996
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journal_title:Infection and immunity
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doi:10.1128/IAI.02572-14
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journal_title:Infection and immunity
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doi:10.1128/IAI.31.1.136-143.1981
更新日期:1981-01-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/iai.71.12.6915-6920.2003
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.4.764-765.1974
更新日期:1974-04-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2007-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.3.1650-1660.2001
更新日期:2001-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.12.5298-5301.1992
更新日期:1992-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02785-14
更新日期:2015-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01388-08
更新日期:2009-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.25.1.127-132.1979
更新日期:1979-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.5.1985-1989.1998
更新日期:1998-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.7.3782-3786.2003
更新日期:2003-07-01 00:00:00
abstract::Previous studies have shown that tumor necrosis factor alpha (TNF-alpha) plays a pathophysiologic role in sepsis induced in rat pups by group B streptococci (GBS). In this model, TNF-alpha is also partially responsible for the induction of interleukin-6 (IL-6). The present study was undertaken to investigate the role ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.11.4997-5002.1994
更新日期:1994-11-01 00:00:00
abstract::Virulent strains of Yersinia enterocolitica and their plasmidless, avirulent derivatives were examined for their cell surface properties. Increased surface charge and hydrophobicity of Y. enterocolitica were found to be associated with the possession of a 40- to 48-megadalton plasmid. These surface properties were exp...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.2.540-543.1984
更新日期:1984-05-01 00:00:00
abstract::We previously showed that cytotoxic necrotizing factor 1 (CNF1) contributes to Escherichia coli K1 invasion of human brain microvascular endothelial cells (HBMEC) and interacts with the receptor on the surface of HBMEC. CNF1 is the cytoplasmic protein, and it remains incompletely understood how CNF1 is secreted across...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00674-09
更新日期:2010-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00972-06
更新日期:2007-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.8.4124-4131.2002
更新日期:2002-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Infection and immunity
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doi:10.1128/IAI.00144-18
更新日期:2018-06-21 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.6.1182-1186.1975
更新日期:1975-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00348-19
更新日期:2019-07-23 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.10.6822-6830.2005
更新日期:2005-10-01 00:00:00
abstract::Kinetic, microscopic, and biochemical studies show that virulent Ti (tumor inducing)-plasmid-containing strains of Agrobacterium attach to normal tobacco and carrot tissue culture cells. Kinetic studies showed that virulent strains of A. tumefaciens attach to the plant tissue culture cells in increasing numbers during...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.22.2.516-522.1978
更新日期:1978-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.8.2560-2566.1991
更新日期:1991-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1997-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.4.669-673.1973
更新日期:1973-10-01 00:00:00
abstract::Haemophilus influenzae type b (Hib) is a significant pathogen for young children, and three Hib vaccines (named PRP-OMPC, HbOC, and PRP-T) are currently available for young children. Extensive studies of anti-Hib polysaccharide (PS) antibodies (Abs) have shown that the V regions of Abs against the Hib PS comprise a VH...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.11.4219-4223.1995
更新日期:1995-11-01 00:00:00