Abstract:
:Haemophilus influenzae type b (Hib) is a significant pathogen for young children, and three Hib vaccines (named PRP-OMPC, HbOC, and PRP-T) are currently available for young children. Extensive studies of anti-Hib polysaccharide (PS) antibodies (Abs) have shown that the V regions of Abs against the Hib PS comprise a VH gene in the VH3 gene family and a VL gene from various K kappa and V lambda subgroups. To study immunogenic properties of the three vaccines in young children, we determined the VL subgroups and avidities of anti-Hib-PS Abs induced by the three clinically available conjugate vaccines. Ab avidity was measured by determining the concentration of a Hib-PS oligomer that abrogates half of the binding of immunoglobulin G anti-Hib-PS Abs to microwells. The PRP-OMPC vaccine induced lower-avidity Abs than the prelicensure HbOC vaccine (P = 0.05). When we compared anti-Hib-PS Abs expressing V kappa Ia, V kappa II, and V lambda subgroups, a greater Ab response was induced by the prelicensure HbOC vaccine than other vaccines (P < 0.05). When anti-Hib-PS Abs with the V kappa III subgroup were compared, however, both PRP-T and prelicensure HbOC vaccines induced a comparable response, which in turn was greater than those induced by the PRP-OMPC or the postlicensure HbOC vaccine (P < 0.001). The VL repertoire of Abs induced with the prelicensure HbOC or PRP-T vaccine in young children is dominated (about 80%) by anti-Hib-PS Abs using subgroup V kappa II. However, anti-Hib-PS using V kappa II VL accounts for only about 40% of the total anti-Hib-PS Abs induced with the PRP-OMPC vaccine or the postlicensure HbOC. Our data suggest that immunogenic properties of Hib vaccines in young children vary depending on the vaccine preparations as well as the vaccine types.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Chung GH,Kim KH,Daum RS,Insel RA,Siber GR,Sood S,Gupta RK,Marchant C,Nahm MHdoi
10.1128/IAI.63.11.4219-4223.1995subject
Has Abstractpub_date
1995-11-01 00:00:00pages
4219-23issue
11eissn
0019-9567issn
1098-5522journal_volume
63pub_type
杂志文章abstract::Enterohemorrhagic Escherichia coli (EHEC) is a noninvasive food-borne pathogen that colonizes the distal ileum and colon. Proteins encoded in the EHEC locus of enterocyte effacement (LEE) pathogenicity island are known to contribute to this pathogen's adherence to epithelial cells and intestinal colonization. The role...
journal_title:Infection and immunity
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abstract::Fasciola hepatica is a prevalent helminth parasite of livestock. Infection results in polarization of the host's immune response and generation of type 2 helper (Th2) immune responses, which are known to be inhibitory to Th1 responses. Bovine tuberculosis (BTB) is a bacterial disease of economic and zoonotic importanc...
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doi:10.1128/IAI.01445-06
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.10.5901-5907.2000
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.1.218-225.1982
更新日期:1982-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.3.916-924.1977
更新日期:1977-03-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.00132-06
更新日期:2006-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.6.2079-2087.1996
更新日期:1996-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.2.1126-1134.2004
更新日期:2004-02-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2004-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.2.703-709.1998
更新日期:1998-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.11.3637-3645.1989
更新日期:1989-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.3.6.756-761.1971
更新日期:1971-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.4.1351-1356.1996
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journal_title:Infection and immunity
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更新日期:1987-07-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1990-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1980-03-01 00:00:00
abstract::Enterohemorrhagic Escherichia coli (EHEC) is a prominent, food-borne cause of diarrhea, bloody diarrhea, and the hemolytic uremic syndrome in industrialized countries. Most strains of EHEC carry the locus for enterocyte effacement (LEE) pathogenicity island, but a proportion of isolates from patients with severe disea...
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journal_title:Infection and immunity
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doi:10.1128/IAI.51.1.204-208.1986
更新日期:1986-01-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-08-01 00:00:00
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更新日期:1993-06-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2017-01-26 00:00:00
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pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.1.169-172.1981
更新日期:1981-04-01 00:00:00