Absence of a prominent Th2 cytokine response in human tuberculosis.


:Depressed Th1 responses are a prominent feature of human tuberculosis, but an enhanced Th2 response has not been detected in peripheral blood T cells stimulated in vitro with Mycobacterium tuberculosis. In disease due to Mycobacterium leprae, Th2 cells predominate in tissue lesions of patients with extensive disease but are absent from peripheral blood. To determine if Th2 cells are present in tissue lesions of tuberculosis patients, we evaluated patterns of cytokine expression in lymph nodes from tuberculosis patients with or without human immunodeficiency virus infection and in controls without tuberculosis. Gamma interferon and interleukin-10 (IL-10) mRNA expression in tuberculosis patients with or without human immunodeficiency virus infection was high, whereas IL-4 expression in the same patients was low. Immunolabeling studies showed that macrophage production of IL-12 was increased in lymph nodes from tuberculosis patients, that gamma interferon was produced by T cells, and that IL-10 was produced by macrophages rather than Th2 cells. These results indicate that Th2 responses are not enhanced either systemically or at the site of disease in human tuberculosis.


Infect Immun


Infection and immunity


Lin Y,Zhang M,Hofman FM,Gong J,Barnes PF




Has Abstract


1996-04-01 00:00:00












  • Ultrastructural-immunohistochemical evidence for a maturation defect of temperature-sensitive G31 vesicular stomatitis virus in murine spinal cord neurons.

    abstract::Ultrastructural immunoperoxidase studies were done in spinal cords of mice infected with wild type vesicular stomatitis virus or its temperature-sensitive (ts) mutant G31. Infected neurons showed subplasmalemmal staining of viral antigen and staining of viral particles budding from the neuronal membrane in wild-type v...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Dal Canto MC,Rabinowitz SG,Johnson TC,Hughes JV

    更新日期:1979-04-01 00:00:00

  • DNA microarray assessment of putative Borrelia burgdorferi lipoprotein genes.

    abstract::A DNA microarray containing fragments of 137 Borrelia burgdorferi B31 putative lipoprotein genes was used to examine Lyme disease spirochetes. DNA from B. burgdorferi sensu stricto B31, 297, and N40; Borrelia garinii IP90; and Borrelia afzelii P/Gau was fluorescently labeled and hybridized to the microarray, demonstra...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Liang FT,Nelson FK,Fikrig E

    更新日期:2002-06-01 00:00:00

  • Bacterial adherence and hemolysin production from Escherichia coli induces histamine and leukotriene release from various cells.

    abstract::We investigated the role of bacterial adherence and hemolysin production from Escherichia coli parent and genetically cloned strains as to their effects on histamine release from rat mast cells and leukotriene generation from human polymorphonuclear granulocytes. These mediators were involved in the induction of infla...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Scheffer J,König W,Hacker J,Goebel W

    更新日期:1985-10-01 00:00:00

  • Influence of monocytes and antibiotic treatment on tissue factor activity of endocardial vegetations in rabbits infected with Streptococcus sanguis.

    abstract::A main feature in the pathogenesis of bacterial endocarditis is the activation of the coagulation system via the extrinsic pathway, resulting in the formation of infected endocardial vegetations. Earlier studies gave indirect evidence that monocytes play an important role in the procoagulant response during the course...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Bancsi MJ,Veltrop MH,Bertina RM,Thompson J

    更新日期:1996-02-01 00:00:00

  • Mitogenic activities of synthetic Escherichia coli lipid A and a synthetic partial structure (tripalmitoyl pentapeptide) of E. coli lipoprotein.

    abstract::Synthetic Escherichia coli lipid A and synthetic S-[2,3-bis-(palmitoyloxy)propyl]-N-palmitoylpentapeptide (tripalmitoyl pentapeptide [TPP]), representing the mitogenically active principles of bacterial lipopolysaccharide (LPS) and lipoprotein, respectively, were compared for their mitogenic activities on splenocytes ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Brade L,Bessler WG,Brade H

    更新日期:1988-05-01 00:00:00

  • Amyloidosis and the serum amyloid A protein response to muramyl dipeptide analogs and different mycobacterial species.

    abstract::Serum amyloid A protein (SAA) elevation accompanies induction of secondary amyloidosis in mice given Mycobacterium butyricum in Freund adjuvant. The synthesis of SAA by cultured hepatocytes is induced by a macrophage-derived mediator, which has been identified as interleukin 1. In these studies, SAA synthesis has been...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: McAdam KP,Foss NT,Garcia C,DeLellis R,Chedid L,Rees RJ,Wolff SM

    更新日期:1983-03-01 00:00:00

  • T-Cell epitopes and human leukocyte antigen restriction elements of an immunodominant antigen of Blastomyces dermatitidis.

    abstract::Humans infected with the dimorphic fungus Blastomyces dermatitidis develop strong T-lymphocyte responses to WI-1, an immunodominant antigen that has been shown to elicit protective immunity in mice. In the present study, the T-cell epitopes of WI-1 and human leukocyte antigen (HLA) restricting elements that display th...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Chang WL,Audet RG,Aizenstein BD,Hogan LH,DeMars RI,Klein BS

    更新日期:2000-02-01 00:00:00

  • Systemic Th1 immunization of mice against Helicobacter pylori infection with CpG oligodeoxynucleotides as adjuvants does not protect from infection but enhances gastritis.

    abstract::Recent reports have suggested that oral vaccination of mice against Helicobacter pylori is dependent on a Th1-mediated immune response. However, oral vaccination in mice neither induces sterilizing immunity nor leads to complete protection from disease. Therefore, in this study we investigated whether a systemic subcu...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sommer F,Wilken H,Faller G,Lohoff M

    更新日期:2004-02-01 00:00:00

  • Effect of Porphyromonas gingivalis on epithelial cell MMP-9 type IV collagenase production.

    abstract::Porphyromonas gingivalis is reportedly capable of stimulating the expression of host cell matrix metalloproteinases (MMP), contributing to tissue destruction. However, the impact of this bacterium on specific molecules remains to be determined. In this study, we evaluate the effect of P. gingivalis on regulation of MM...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Fravalo P,Ménard C,Bonnaure-Mallet M

    更新日期:1996-12-01 00:00:00

  • Effect of minerals on staphylococcal enterotoxin B production.

    abstract::Raising the magnesium level from 0.4 to 1.5 mM in a medium containing only amino acids (2.08%), salts, and vitamins increased enterotoxin B production by Staphylococcus aureus S-6 by about 80%. The level of phosphates in the medium was lowered to one-tenth (to 2.87 mM) the original amount without adversely affecting g...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Keller GM,Hanson RS,Bergdoll MS

    更新日期:1978-04-01 00:00:00

  • Identification of a Fusobacterium nucleatum PK1594 galactose-binding adhesin which mediates coaggregation with periopathogenic bacteria and hemagglutination.

    abstract::Attachment of Fusobacterium nucleatum to various oral surfaces is mediated by several adhesins anchored on its outer surface. Monoclonal antibodies (MAbs) were prepared and used to identify the putative galactose-binding adhesin of F. nucleatum PK1594. Four unique MAbs, 8G7, 26B9, 28G11, and 29D4, were isolated on the...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Shaniztki B,Hurwitz D,Smorodinsky N,Ganeshkumar N,Weiss EI

    更新日期:1997-12-01 00:00:00

  • Genome-based identification of chromosomal regions specific for Salmonella spp.

    abstract::Acquisition of genomic elements by horizontal gene transfer represents an important mechanism in the evolution of bacterial species. Pathogenicity islands are a subset of horizontally acquired elements present in various pathogens. These elements are frequently located adjacent to tRNA genes. We performed a comparativ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Hansen-Wester I,Hensel M

    更新日期:2002-05-01 00:00:00

  • Pathogenicity of stable L-phase variants of Staphylococcus aureus: failure to colonize experimental endocarditis in rabbits.

    abstract::Endocarditis was induced in the rabbit by the placement of a polyethylene catheter in the right heart. The catheter was filled with stable L-phase variants of Staphylococcus aureus to determine if the variant form would colonize the damaged endocardium and produce further tissue injury similar to that produced by the ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Linnemann CC Jr,Watanakunakorn C,Bakie C

    更新日期:1973-05-01 00:00:00

  • Analysis of Pneumocystis carinii introns.

    abstract::Pneumocystis carinii is an ascomycete phylogenetically related to Schizosaccharomyces pombe. Little is known about gene regulation in P. carinii. The removal of introns from pre-mRNA requires spliceosomal recognition of the intron-exon boundary. In S. pombe and higher eukaryotes, this boundary and a branch site within...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Thomas CF Jr,Leof EB,Limper AH

    更新日期:1999-11-01 00:00:00

  • Redundant and Cooperative Roles for Yersinia pestis Yop Effectors in the Inhibition of Human Neutrophil Exocytic Responses Revealed by Gain-of-Function Approach.

    abstract::Yersinia pestis causes a rapid, lethal disease referred to as plague. Y. pestis actively inhibits the innate immune system to generate a noninflammatory environment during early stages of infection to promote colonization. The ability of Y. pestis to create this early noninflammatory environment is in part due to the ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Pulsifer AR,Vashishta A,Reeves SA,Wolfe JK,Palace SG,Proulx MK,Goguen J,Bodduluri SR,Haribabu B,Uriarte SM,Lawrenz MB

    更新日期:2020-02-20 00:00:00

  • The type III secretion effector NleF of enteropathogenic Escherichia coli activates NF-κB early during infection.

    abstract::The enteric pathogens enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli employ a type 3 secretion system (T3SS) to manipulate the host inflammatory response during infection. Previously, it has been reported that EPEC, in a T3SS-dependent manner, induces an early proinflammatory response through a...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Pallett MA,Berger CN,Pearson JS,Hartland EL,Frankel G

    更新日期:2014-11-01 00:00:00

  • Chemotactic behavior of Campylobacter jejuni.

    abstract::The chemotactic behavior of Campylobacter jejuni was determined in the presence of different amino acids, carbohydrates, organic acids, and preparations and constituents of mucin and bile. L-Fucose was the only carbohydrate and L-aspartate, L-cysteine, L-glutamate, and L-serine were the only amino acids producing a ch...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Hugdahl MB,Beery JT,Doyle MP

    更新日期:1988-06-01 00:00:00

  • Novel role for albumin in innate immunity: serum albumin inhibits the growth of Blastomyces dermatitidis yeast form in vitro.

    abstract::In this study we found that serum inhibitory activity against Blastomyces dermatitidis was principally mediated by albumin. This was confirmed in experiments using albumin from several mammalian species. Analbuminemic rat serum did not inhibit B. dermatitidis growth in vivo; however, the addition of albumin restored i...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Giles S,Czuprynski C

    更新日期:2003-11-01 00:00:00

  • Mycobacterium bovis BCG immunization induces protective immunity against nine different Mycobacterium tuberculosis strains in mice.

    abstract::Recent preclinical and epidemiologic studies have suggested that certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity. To investigate the strain specificity of BCG-induced protective respon...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Jeon BY,Derrick SC,Lim J,Kolibab K,Dheenadhayalan V,Yang AL,Kreiswirth B,Morris SL

    更新日期:2008-11-01 00:00:00

  • Influence of oxygen on respiration and glucose catabolism by Treponema pallidum.

    abstract::Oxygen consumption by Treponema pallidum was observed to be glucose dependent. Treponemes consumed O2 to a low dissolved O2 concentration of 0.01 mumol of O2 per ml when respiration ceased. A fermentative degradation of glucose occurred during the maintenance of treponemes at 0.01 mumol of O2 per ml. Although the init...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Barbieri JT,Cox CD

    更新日期:1981-03-01 00:00:00

  • Control of Leishmania infantum infection is associated with CD8(+) and gamma interferon- and interleukin-5-producing CD4(+) antigen-specific T cells.

    abstract::Visceral leishmaniasis is a severe and lethal disease caused by the protozoan parasites of the genus Leishmania. In areas where leishmaniasis is endemic, most infected individuals control the infection and remain asymptomatic; chemotherapy of visceral leishmaniasis restores some immunity which protects against relapse...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Mary C,Auriault V,Faugère B,Dessein AJ

    更新日期:1999-11-01 00:00:00

  • Association of protein with the cell wall of Streptococcus mutans.

    abstract::Cell walls from Streptococcus mutans were prepared by conventional technique and subjected to a series of extraction procedures involving classical protein solvents. The extracted walls contained several non-peptidoglycan amino acids and were also amenable to radiolabeling with [125I]sodium iodide and chloramine T. Th...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Nesbitt WE,Staat RH,Rosan B,Taylor KG,Doyle RJ

    更新日期:1980-04-01 00:00:00

  • Cloning and expression in Escherichia coli of a protective antigen of Erysipelothrix rhusiopathiae.

    abstract::Erysipelothrix rhusiopathiae is a primary pathogen of swine and turkeys and sporadic cause of disease in a variety of other hosts, including humans. A genomic library of the highly virulent strain of E. rhusiopathiae E1-6P was constructed in the expression-cloning vector lambda gt11 and screened with serum from a pig ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Galán JE,Timoney JF

    更新日期:1990-09-01 00:00:00

  • Further study on neutralization of biochemical activity of cord factor by anti-cord factor antibody.

    abstract::The action of trehalose-6, 6'-dimycolate (cord factor) of Mycobacterium tuberculosis to induce site II-specific inhibition of mitochondrial oxidative phosphorylation and to stimulate adenosine triphosphatase activity was neutralized by its specific antibody. The activity was restored after dissociation of cord factor ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kato M

    更新日期:1974-07-01 00:00:00

  • Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection.

    abstract::Toll-like receptors (TLRs) are a group of highly conserved molecules that initiate the innate immune response to pathogens by recognizing structural motifs expressed by microbes. We have identified a novel TLR, TLR15, by bioinformatic analysis of the chicken genome, which is distinct from any known vertebrate TLR and ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Higgs R,Cormican P,Cahalane S,Allan B,Lloyd AT,Meade K,James T,Lynn DJ,Babiuk LA,O'farrelly C

    更新日期:2006-03-01 00:00:00

  • Acquired resistance and expression of a protective humoral immune response in guinea pigs infected with Treponema pallidum Nichols.

    abstract::Resistance to cutaneous syphilitic reinfection in strain 2 and strain 13 guinea pigs developed gradually 3 to 7 months after primary infection and reached maximum levels at 6 to 7 months after the induction of primary cutaneous disease. Associated with this acquired resistance was the occurrence of Arthus reactions an...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Pavia CS,Niederbuhl CJ

    更新日期:1985-10-01 00:00:00

  • In vivo production of neuraminidase by Pasteurella haemolytica A1 in goats after transthoracic challenge.

    abstract::Nine goats were injected transthoracically with Pasteurella haemolytica A1 to determine if an extracellular bacterial enzyme, neuraminidase, was produced in vivo during infection with this organism. The principal group of goats (n = 9) each received 1 ml of 7.25 x 10(5) live P. haemolytica A1 cells in polyacrylate bea...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Straus DC,Purdy CW

    更新日期:1994-10-01 00:00:00

  • PLC/PRF/5 (Alexander) hepatoma cell line: further characterization and studies of infectivity.

    abstract::The Alexander hepatoma cell line, PLC/PRF/5, was studied for evidence of hepatitis B virus markers and alpha-fetoprotein. Only hepatitis B surface antigen and alpha-fetoprotein were detected. Induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did n...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Daemer RJ,Feinstone SM,Alexander JJ,Tully JG,London WT,Wong DC,Purcell RH

    更新日期:1980-11-01 00:00:00

  • Vaccination with an attenuated strain of Francisella novicida prevents T-cell depletion and protects mice infected with the wild-type strain from severe sepsis.

    abstract::Francisella tularensis is the causative agent of zoonotic tularemia, a severe pneumonia in humans, and Francisella novicida causes a similarly severe tularemia in mice upon inhalation. The correlates of protective immunity, as well as the virulence mechanisms of this deadly pathogen, are not well understood. In the pr...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sharma J,Li Q,Mishra BB,Georges MJ,Teale JM

    更新日期:2009-10-01 00:00:00

  • Relationship of pili to colonial morphology among pathogenic and nonpathogenic species of Neisseria.

    abstract::Growth in colonies with type 1 morphology and the presence of pili are characteristics that have been associated with virulence of gonococci for humans. To determine whether the presence of pili per se might be responsible for colony type 1 morphology, the relationship of pili to colony type was examined in various sp...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: McGee ZA,Dourmashkin RR,Gross JG,Clark JB,Taylor-Robinson D

    更新日期:1977-02-01 00:00:00