Absence of a prominent Th2 cytokine response in human tuberculosis.


:Depressed Th1 responses are a prominent feature of human tuberculosis, but an enhanced Th2 response has not been detected in peripheral blood T cells stimulated in vitro with Mycobacterium tuberculosis. In disease due to Mycobacterium leprae, Th2 cells predominate in tissue lesions of patients with extensive disease but are absent from peripheral blood. To determine if Th2 cells are present in tissue lesions of tuberculosis patients, we evaluated patterns of cytokine expression in lymph nodes from tuberculosis patients with or without human immunodeficiency virus infection and in controls without tuberculosis. Gamma interferon and interleukin-10 (IL-10) mRNA expression in tuberculosis patients with or without human immunodeficiency virus infection was high, whereas IL-4 expression in the same patients was low. Immunolabeling studies showed that macrophage production of IL-12 was increased in lymph nodes from tuberculosis patients, that gamma interferon was produced by T cells, and that IL-10 was produced by macrophages rather than Th2 cells. These results indicate that Th2 responses are not enhanced either systemically or at the site of disease in human tuberculosis.


Infect Immun


Infection and immunity


Lin Y,Zhang M,Hofman FM,Gong J,Barnes PF




Has Abstract


1996-04-01 00:00:00












  • Protective role of D-amino acid oxidase against Staphylococcus aureus infection.

    abstract::D-Amino acid oxidase (DAO) is a hydrogen peroxide-generating enzyme that uses a D-amino acid as a substrate. We hypothesized that DAO may protect against bacterial infection, because hydrogen peroxide is one of the most important molecules in the antibacterial defense systems in mammals. We show here that DAO suppress...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Nakamura H,Fang J,Maeda H

    更新日期:2012-04-01 00:00:00

  • YAPI, a new Yersinia pseudotuberculosis pathogenicity island.

    abstract::Pathogenicity islands (PAIs) are chromosomal clusters of pathogen-specific virulence genes often found at tRNA loci. In the Yersinia pseudotuberculosis 32777 chromosome, we characterized a 98-kb segment that has all of the characteristic features of a PAI, including insertion in a (phenylalanine) tRNA gene, the presen...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Collyn F,Billault A,Mullet C,Simonet M,Marceau M

    更新日期:2004-08-01 00:00:00

  • Predominant gram-positive bacteria in human feces: numbers, variety, and persistence.

    abstract::The predominant gram-positive bacteria in 47 fecal specimens from 10 healthy men were studied by microscopic and cultural counts, by the characterization and tentative identification of isolates, and by the use of fluorescein isothiocyanate (FITC)-conjugated globulins prepared using some of the isolates. Gram-positive...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Gossling J,Slack JM

    更新日期:1974-04-01 00:00:00

  • Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection.

    abstract::Since secondary Streptococcus pneumoniae infections greatly increase the mortality of influenza infections, we determined the relative roles of neutrophil-dependent and -independent mechanisms in increased susceptibility to S. pneumoniae during influenza infection. Mice infected with influenza for 6 days, but not 3 da...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: McNamee LA,Harmsen AG

    更新日期:2006-12-01 00:00:00

  • Inhibition of bactericidal activity of anticapsular antibody by nonspecific antibodies reactive with surface-exposed antigenic determinants on Actinobacillus pleuropneumoniae.

    abstract::In an attempt to understand the mechanism of serum resistance in Actinobacillus pleuropneumoniae, in the present study we examined various interactions among the bacterial surface constituents, serum antibodies, and complement. Analysis of swine sera revealed the presence of anticapsular antibodies in convalescent-pha...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Udeze FA,Kadis S

    更新日期:1992-09-01 00:00:00

  • Cell-mediated immunity to herpes simplex virus: recognition of type-specific and type-common surface antigens by cytotoxic T cell populations.

    abstract::In this communication, we examine the specificity of anti-herpes simplex virus (HSV) cytotoxic T lymphocytes (CTL). Serological studies of the two related HSV serotypes (HSV-1 and HSV-2) have revealed both type-specific and cross-reactive antigenic determinants in the viral envelope and on the surface of infected cell...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Eberle R,Russell RG,Rouse BT

    更新日期:1981-12-01 00:00:00

  • Use of monoclonal antibodies to identify phospholipase C as the enterotoxic factor of the bifunctional hemolysin-phospholipase C molecule of Vibrio cholerae O139.

    abstract::Two hybrid clones producing monoclonal antibodies (MAbs) raised against the purified enterotoxic hemolysin-phospholipase C (HlyPC) bifunctional molecule of a Vibrio cholerae O139 strain were used to study its enterotoxicity in relation to its hemolytic and enzymatic activities. Fab fragments of MAbs from ascites produ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Pal S,Datta A,Nair GB,Guhathakurta B

    更新日期:1998-08-01 00:00:00

  • Proteomic analysis of Vibrio cholerae in human stool.

    abstract::An effective vaccine for Vibrio cholerae is not yet available for use in the developing world, where the burden of cholera disease is highest. Characterizing the proteins that are expressed by V. cholerae in the human host environment may provide insight into the pathogenesis of cholera and assist with the development...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: LaRocque RC,Krastins B,Harris JB,Lebrun LM,Parker KC,Chase M,Ryan ET,Qadri F,Sarracino D,Calderwood SB

    更新日期:2008-09-01 00:00:00

  • Chlamydia trachomatis infection of human mesothelial cells alters proinflammatory, procoagulant, and fibrinolytic responses.

    abstract::In this study we demonstrate the capability of Chlamydia trachomatis to infect cultured human mesothelial cell (MC) monolayers and to induce the production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-8. Seventy-two hours after initial infection, both the procoagulant activity of MC and the act...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: van Westreenen M,Pronk A,Diepersloot RJ,de Groot PG,Leguit P

    更新日期:1998-05-01 00:00:00

  • Production and partial characterization of a Vibrio fluvialis cytotoxin.

    abstract::Conditions are described for the production of an extracellular cytotoxin or CHO cell-killing factor by Vibrio fluvialis, a recently recognized enteric pathogen. The cell-killing factor was ammonium sulfate precipitable, heat labile, and inactivated by proteases, and had an isoelectric point (estimated by sucrose dens...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Wall VW,Kreger AS,Richardson SH

    更新日期:1984-12-01 00:00:00

  • Localization of immunogenic regions on the flagellin proteins of Campylobacter jejuni 81116.

    abstract::The purpose of this study was to localize antigenic regions on the flagellin protein of Campylobacter jejuni 81116. This strain has two flagellin genes, flaA and flaB, which are 95% identical; only flaA seems to be expressed in motile C. jejuni 81116 cells. Fragments of flaA and flaB were cloned in the bacterial expre...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Nuijten PJ,van der Zeijst BA,Newell DG

    更新日期:1991-03-01 00:00:00

  • Regulation of hemolysin expression in Actinobacillus pleuropneumoniae serotype 1 by Ca2+.

    abstract::Actinobacillus pleuropneumoniae, the causative agent of swine pleuropneumonia, secretes a hemolytic activity which is thought to be a factor involved in the pathogenesis of the disease. The biosynthesis of hemolysin by serotype 1 strain 4074 was strongly dependent on the activity of free Ca2+ in the growth medium. At ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Frey J,Nicolet J

    更新日期:1988-10-01 00:00:00

  • Bacterial adherence and hemolysin production from Escherichia coli induces histamine and leukotriene release from various cells.

    abstract::We investigated the role of bacterial adherence and hemolysin production from Escherichia coli parent and genetically cloned strains as to their effects on histamine release from rat mast cells and leukotriene generation from human polymorphonuclear granulocytes. These mediators were involved in the induction of infla...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Scheffer J,König W,Hacker J,Goebel W

    更新日期:1985-10-01 00:00:00

  • Identification of a surrogate marker for infection in the African green monkey model of inhalation anthrax.

    abstract::In 2001, a bioterrorism attack involving Bacillus anthracis spore-laced letters resulted in 22 cases of inhalation anthrax, with five fatalities. This incident identified gaps in our health care system and precipitated a renewed interest in identifying both therapeutics and rapid diagnostic assays. To address those ga...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Rossi CA,Ulrich M,Norris S,Reed DS,Pitt LM,Leffel EK

    更新日期:2008-12-01 00:00:00

  • Role of viremia in the suppression of T-cell function during murine cytomegalovirus infection.

    abstract::The suppression of T-cell deoxyribonucleic acid (DNA) synthesis by serum from mice acutely with murine cytomegalovirus (MCMV) was investigated. Spleen cells from uninfected mice were exposed to concanavalin A in the presence of serum taken from mice at various times after infection with MCMV. The capacity of the serum...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Booss J,Wheelock EF

    更新日期:1977-08-01 00:00:00

  • An msbB homologue carried in plasmid pO157 encodes an acyltransferase involved in lipid A biosynthesis in Escherichia coli O157:H7.

    abstract::Escherichia coli O157:H7 carries a chromosomal msbB1 and a plasmid-encoded msbB2 gene. We characterized msbB2 function as a homologue of msbB1 by examination of wild-type organisms and mutant strains that lacked functional msbB1, msbB2, and both msbB1 and msbB2. The msbB double-mutant strain generated pentaacyl lipid ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kim SH,Jia W,Bishop RE,Gyles C

    更新日期:2004-02-01 00:00:00

  • Heparinase Is Essential for Pseudomonas aeruginosa Virulence during Thermal Injury and Infection.

    abstract::The opportunistic pathogen Pseudomonas aeruginosa is a major cause of sepsis in severely burned patients. If it is not eradicated from the wound, it translocates to the bloodstream, causing sepsis, multiorgan failure, and death. We recently described the P. aeruginosa heparinase-encoding gene, hepP, whose expression w...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Dzvova N,Colmer-Hamood JA,Griswold JA,Hamood AN

    更新日期:2017-12-19 00:00:00

  • Role of tumor necrosis factor alpha in pathogenesis of pneumococcal pneumonia in mice.

    abstract::The production and role of tumor necrosis factor alpha (TNF-alpha) in pneumococcal pneumonia were investigated in a mouse pneumonia model. When approximately 10(6) CFU of Streptococcus pneumoniae TUM19 were used to inoculate CBA/J mice intranasally, TNF-alpha levels in the lungs and serum began to increase from 1 and ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Takashima K,Tateda K,Matsumoto T,Iizawa Y,Nakao M,Yamaguchi K

    更新日期:1997-01-01 00:00:00

  • Differential patterns of liver proteins in experimental murine hepatosplenic schistosomiasis.

    abstract::Schistosoma mansoni eggs produced by adult worms in the mesenteric vasculature become trapped in the liver, where they induce granulomatous lesions and strong immune responses. Infected individuals suffer from intestinal schistosomiasis (INT) in 90% of cases, whereas the remaining 10% present with severe hepatosplenic...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Manivannan B,Rawson P,Jordan TW,Secor WE,La Flamme AC

    更新日期:2010-02-01 00:00:00

  • In vitro resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein is associated with alterations in cytoplasmic membrane fluidity.

    abstract::Platelet microbicidal proteins (PMPs) are small, cationic peptides which possess potent microbicidal activities against common bloodstream pathogens, such as Staphylococcus aureus. We previously showed that S. aureus strains exhibiting resistance to thrombin-induced PMP (tPMP-1) in vitro have an enhanced capacity to c...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Bayer AS,Prasad R,Chandra J,Koul A,Smriti M,Varma A,Skurray RA,Firth N,Brown MH,Koo SP,Yeaman MR

    更新日期:2000-06-01 00:00:00

  • Differential role of CbpA and PspA in modulation of in vitro CXC chemokine responses of respiratory epithelial cells to infection with Streptococcus pneumoniae.

    abstract::Respiratory epithelial cells play an active part in the host response to respiratory pathogens, such as Streptococcus pneumoniae, by releasing chemokines responsible for neutrophil recruitment. In order to investigate the role of specific pneumococcal virulence factors in eliciting CXC chemokine responses, type II pne...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Graham RM,Paton JC

    更新日期:2006-12-01 00:00:00

  • Bordetella pertussis risA, but not risS, is required for maximal expression of Bvg-repressed genes.

    abstract::Expression of virulence determinants by Bordetella pertussis, the primary etiological agent of whooping cough, is regulated by the BvgAS two-component regulatory system. The role of a second two-component regulatory system, encoded by risAS, in this process is not defined. Here, we show that mutation of B. pertussis r...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Stenson TH,Allen AG,Al-Meer JA,Maskell D,Peppler MS

    更新日期:2005-09-01 00:00:00

  • Protective and immunochemical activities of monoclonal antibodies reactive with the Bacillus anthracis polypeptide capsule.

    abstract::Bacillus anthracis is surrounded by a polypeptide capsule composed of poly-gamma-d-glutamic acid (gammaDPGA). In a previous study, we reported that a monoclonal antibody (MAb F26G3) reactive with the capsular polypeptide is protective in a murine model of pulmonary anthrax. The present study examined a library of six ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kozel TR,Thorkildson P,Brandt S,Welch WH,Lovchik JA,AuCoin DP,Vilai J,Lyons CR

    更新日期:2007-01-01 00:00:00

  • Microscopic characterization of ocular damage produced by Pseudomonas aeruginosa toxin A.

    abstract::The ocular damage in young adult mice produced by purified Pseudomonas aeruginosa exotoxin A was microscopically characterized at 1 and 5 h and at 1, 3, 5, 7, 10, 14, and 21 days after toxin A challenge, using light, transmission, and scanning electron microscopic techniques. Similarly to previously described infectio...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Hazlett LD,Berk RS,Iglewski BH

    更新日期:1981-12-01 00:00:00

  • Immunogenic properties of Klebsiella pneumoniae type 2 capsular polysaccharide.

    abstract::The immunoprotective activity of Klebsiella pneumoniae K2 cell surface preparations and purified capsular polysaccharide was tested in mice. The 50% protective dose (PD50), expressed as capsular polysaccharide content, was 2 ng for cell surface preparations and 50 ng for purified capsular polysaccharide. Both preparat...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Robert A,Jouin H,Fournier JM

    更新日期:1986-11-01 00:00:00

  • Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock.

    abstract::We investigated the ability of interleukin 10 (IL-10) to protect mice against lethal shock induced by staphylococcal enterotoxin B (SEB). Treatment of mice with IL-10 prevented the death of mice injected with SEB in a dose-dependent manner. IL-10-mediated protection was apparent when administered either prior to or co...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Bean AG,Freiberg RA,Andrade S,Menon S,Zlotnik A

    更新日期:1993-11-01 00:00:00

  • Increased expression of interleukin-5 (IL-5), IL-13, and tumor necrosis factor alpha genes in intestinal lymph cells of sheep selected for enhanced resistance to nematodes during infection with Trichostrongylus colubriformis.

    abstract::Cytokine gene expression in cells migrating in afferent and efferent intestinal lymph was monitored for extended time periods in individual sheep experimentally infected with the nematode Trichostrongylus colubriformis. Animals from stable selection lines with increased levels of either genetic resistance (R) or susce...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Pernthaner A,Cole SA,Morrison L,Hein WR

    更新日期:2005-04-01 00:00:00

  • Inhibition by cyclosporin A of rodent malaria in vivo and human malaria in vitro.

    abstract::The development and course of normally lethal parasitemias in mice inoculated intraperitoneally with erythrocytic stages of Plasmodium yoelii or Plasmodium berghei were markedly affected by treatment with the antilymphoid drug cyclosporin A (CS-A). When the first of four daily subcutaneous 25-mg/kg doses of CS-A was g...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Nickell SP,Scheibel LW,Cole GA

    更新日期:1982-09-01 00:00:00

  • Potentiation of human natural killer cell cytotoxicity by Salmonella bacteria is an interferon- and interleukin-2-independent process that utilizes CD2 and CD18 structures in the effector phase.

    abstract::Incubation of large granular lymphocytes (LGL) with glutaraldehyde-fixed bacteria stimulated in the supernatant the production of interferon (IFN), which proved to be mainly IFN-gamma. Even though IFN-gamma was produced upon exposure of LGL to bacteria, anti-IFN-gamma antibodies failed to interfere with induction of c...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Tarkkanen J,Saksela E

    更新日期:1991-08-01 00:00:00

  • Involvement of the Haemophilus ducreyi gmhA gene product in lipooligosaccharide expression and virulence.

    abstract::The lipooligosaccharide (LOS) present in the outer membrane of Haemophilus ducreyi is likely a virulence factor for this sexually transmitted pathogen. An open reading frame in H. ducreyi 35000 was found to encode a predicted protein that had 87% identity with the protein product of the gmhA (isn) gene of Haemophilus ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Bauer BA,Stevens MK,Hansen EJ

    更新日期:1998-09-01 00:00:00