Identification of lipoprotein homologues of pneumococcal PsaA in the equine pathogens Streptococcus equi and Streptococcus zooepidemicus.

Abstract:

:Streptococcus equi and Streptococcus zooepidemicus are major etiological agents of upper and lower airway disease in horses. Despite the considerable animal suffering and economic burden associated with these diseases, the factors that contribute to the virulence of these equine pathogens have not been extensively investigated. Here we demonstrate the presence of a homologue of the Streptococcus pneumoniae PsaA protein in both of these equine pathogens. Inhibition of signal peptide processing by the antibiotic globomycin confirmed the lipoprotein nature of the mature proteins, and surface exposure was confirmed by their release from intact cells by mild trypsinolysis.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Harrington DJ,Greated JS,Chanter N,Sutcliffe IC

doi

10.1128/iai.68.10.6048-6051.2000

keywords:

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

6048-51

issue

10

eissn

0019-9567

issn

1098-5522

journal_volume

68

pub_type

杂志文章
  • Effects of a phagocytosis-stimulating factor derived from polymorphonuclear neutrophils on the functions of macrophages.

    abstract::The effects of phagocytosis-stimulating factor (PSF) derived from polymorphonuclear neutrophils on macrophage functions were studied. PSF enhanced the initial rate of phagocytosis of serum-opsonized zymosan particles by macrophages, whereas it did not affect the phagocytosis of immunoglobulin G-sensitized and inert zy...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.55.8.1762-1766.1987

    authors: Ishibashi Y,Yamashita T

    更新日期:1987-08-01 00:00:00

  • Response to experimental infection with mumps virus in rhesus monkeys.

    abstract::Experiments were conducted in which rhesus monkeys were infected with mumps virus by inoculation into the parotid gland. Virus was isolated from buccal swab specimens from animals up to 6 days after inoculation. Immunofluorescence staining for mumps antigen was positive, and infectious virus was recovered from tissue ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.3.5.642-647.1971

    authors: Flanagan TD,Andrada JA,Barron AL,Witebsky E

    更新日期:1971-05-01 00:00:00

  • Growth within macrophages increases the efficiency of Mycobacterium avium in invading other macrophages by a complement receptor-independent pathway.

    abstract::Infections caused by organisms of the Mycobacterium avium complex occur in approximately 50 to 60% of patients with AIDS. M. avium is an intracellular pathogen that survives and multiplies within mononuclear phagocytes. In this study, we investigated the uptake of M. avium grown within macrophages (intracellular growt...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.65.5.1916-1925.1997

    authors: Bermudez LE,Parker A,Goodman JR

    更新日期:1997-05-01 00:00:00

  • Bacteriological and histopathological evaluation of guinea pigs after infection with Listeria monocytogenes.

    abstract::Randomly bred guinea pigs were infected with Listeria monocytogenes using the intracardial, intravenous and intraperitoneal routes of infection. Doses of Listeria ranged from 5 to 1,000 x the 50% lethal dose based on the 50% lethal dose for intracardially injected Listeria. A complete necropsy was performed on all ani...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.15.3.916-924.1977

    authors: Dustoor M,Croft W,Fulton A,Blazkovec A

    更新日期:1977-03-01 00:00:00

  • Immunodominance in mouse and human CD4+ T-cell responses specific for the Bordetella pertussis virulence factor P.69 pertactin.

    abstract::P.69 pertactin (P.69 Prn), an adhesion molecule from the causative agent of pertussis, Bordetella pertussis, is present in cellular and most acellular vaccines that are currently used worldwide. Although both humoral immunity and cellular immunity directed against P.69 Prn have been implicated in protective immune mec...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00769-08

    authors: Stenger RM,Poelen MC,Moret EE,Kuipers B,Bruijns SC,Hoogerhout P,Hijnen M,King AJ,Mooi FR,Boog CJ,van Els CA

    更新日期:2009-02-01 00:00:00

  • Preliminary characterization of "immunogenic" ribonucleic acid derived from rat peritoneal exudate cells.

    abstract::An "immunogenic" ribonucleic acid (Im-RNA) has been extracted from peritoneal exudate (PE) cells of rats that were immunized with sheep erythrocytes (SRBC). Following multiple phenol extractions and deoxyribonuclease treatment, the material obtained from PE cells was eluted from diethylaminoethyl-cellulose at 0.55 M N...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.8.2.215-221.1973

    authors: Archer SJ,Wust CJ

    更新日期:1973-08-01 00:00:00

  • Quantification of the relative contribution of major histocompatibility complex (MHC) and non-MHC genes to human immune responses to foreign antigens.

    abstract::Understanding the extent to which genetic factors influence the immune response is important in the development of subunit vaccines. Associations with HLA gene polymorphisms appear insufficient to explain the range of variation in immune responses to vaccines and to infections by major pathogens. In this study of Gamb...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.65.3.872-876.1997

    authors: Jepson A,Banya W,Sisay-Joof F,Hassan-King M,Nunes C,Bennett S,Whittle H

    更新日期:1997-03-01 00:00:00

  • Glucosyltransferases of viridans streptococci are modulins of interleukin-6 induction in infective endocarditis.

    abstract::The glucosyltransferases (GTFs) of viridans streptococci, common pathogens of infective endocarditis, are extracellular proteins that convert sucrose into exopolysaccharides and glucans. GTFs B, C, and D of Streptococcus mutans are modulins that induce, in vitro and in vivo, the production of cytokines, in particular ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.73.6.3261-3270.2005

    authors: Shun CT,Lu SY,Yeh CY,Chiang CP,Chia JS,Chen JY

    更新日期:2005-06-01 00:00:00

  • Specificity of Legionella pneumophila and Coxiella burnetii vacuoles and versatility of Legionella pneumophila revealed by coinfection.

    abstract::Legionella pneumophila and Coxiella burnetii are phylogenetically related intracellular bacteria that cause aerosol-transmitted lung infections. In host cells both pathogens proliferate in vacuoles whose biogenesis displays some common features. To test the functional similarity of their respective intracellular niche...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.73.8.4494-4504.2005

    authors: Sauer JD,Shannon JG,Howe D,Hayes SF,Swanson MS,Heinzen RA

    更新日期:2005-08-01 00:00:00

  • Influence of growth temperature on virulence of Legionella pneumophila.

    abstract::The effect of growth temperature on the virulence of a strain of broth-grown serogroup 1 Legionella pneumophila (Wadsworth F889) was examined by growing the bacterium at different temperatures and then infecting guinea pigs (by intratracheal injection) and guinea pig alveolar macrophages. The 50% lethal dose for guine...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.55.11.2701-2705.1987

    authors: Edelstein PH,Beer KB,DeBoynton ED

    更新日期:1987-11-01 00:00:00

  • Potential Immunological Biomarkers for Detection of Mycobacterium tuberculosis Infection in a Setting Where M. tuberculosis Is Endemic, Ethiopia.

    abstract::Accurate diagnosis and early treatment of tuberculosis (TB) and latent TB infection (LTBI) are vital to prevent and control TB. The lack of specific biomarkers hinders these efforts. This study's purpose was to screen immunological markers that discriminate Mycobacterium tuberculosis infection outcomes in a setting wh...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00759-17

    authors: Teklu T,Kwon K,Wondale B,HaileMariam M,Zewude A,Medhin G,Legesse M,Pieper R,Ameni G

    更新日期:2018-03-22 00:00:00

  • Salmonella flagellin is not a dominant protective antigen in oral immunization with attenuated live vaccine strains.

    abstract::We found that oral immunization with flagellum-defective mutant strains of Salmonella enterica serovar Typhimurium with the ClpXP-deficient background protected mice against oral challenge with the virulent strain. These data indicate that Salmonella flagellin is not a dominant protective antigen in oral immunization ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.72.4.2449-2451.2004

    authors: Kodama C,Matsui H

    更新日期:2004-04-01 00:00:00

  • Identification and characterization of an autolysin-encoding gene of Streptococcus mutans.

    abstract::We identified a gene (atlA) encoding autolytic activity from Streptococcus mutans Xc. The AtlA protein predicted to be encoded by atlA is composed of 979 amino acids with a molecular weight of 107,279 and has a conserved beta-1,4-N-acetylmuramidase (lysozyme) domain in the C-terminal portion. Sodium dodecyl sulfate ex...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.73.6.3512-3520.2005

    authors: Shibata Y,Kawada M,Nakano Y,Toyoshima K,Yamashita Y

    更新日期:2005-06-01 00:00:00

  • Investigation of a novel DNase of Streptococcus suis serotype 2.

    abstract::A secreted nuclease, SsnA, was identified in the virulent Streptococcus suis isolate SX332 and subsequently in each of the type strains of capsular serotypes 1 through 9. Screening of 258 porcine clinical isolates from surface (nasal mucosa or palatine tonsil) or internal (joint, brain or other internal organ) locatio...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.72.2.774-781.2004

    authors: Fontaine MC,Perez-Casal J,Willson PJ

    更新日期:2004-02-01 00:00:00

  • Characterization of the Pasteurella multocida hgbA gene encoding a hemoglobin-binding protein.

    abstract::Reverse transcriptase PCR analyses have demonstrated that open reading frames (ORFs) PM0298, PM0299, and PM0300 of the animal pathogen Pasteurella multocida constitute a single transcriptional unit. By cloning and overexpression studies in Escherichia coli cells, the product of ORF PM0300 was shown to bind hemoglobin ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.70.11.5955-5964.2002

    authors: Bosch M,Garrido ME,Llagostera M,Pérez De Rozas AM,Badiola I,Barbé J

    更新日期:2002-11-01 00:00:00

  • Innate immune gene polymorphisms in tuberculosis.

    abstract::Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single infectious agent. Recent studies targeting candidate genes and "case-control" association have revealed numerous polymorphisms implicated in host susceptibility to TB. Here, we review current progress in the understanding of cau...

    journal_title:Infection and immunity

    pub_type: 杂志文章,评审

    doi:10.1128/IAI.00443-12

    authors: Azad AK,Sadee W,Schlesinger LS

    更新日期:2012-10-01 00:00:00

  • Identification of two bvg-repressed surface proteins of Bordetella pertussis.

    abstract::Bordetella pertussis, the etiological agent of whooping cough, has the ability to modulate its phenotype in response to environmental conditions by using the BvgAS sensory transduction system which is encoded by the vir locus (now known as bvg). The BvgAS system is part of a large family of two-component sensory trans...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.63.10.3780-3789.1995

    authors: Stenson TH,Peppler MS

    更新日期:1995-10-01 00:00:00

  • Molecular weight and other characteristics of mycobacterial growth inhibitory factor produced by spleen cells obtained from mice immunized with viable attenuated mycobacterial cells.

    abstract::Exposure of mycobacterial growth inhibitory factor (MycoIF) to trypsin, chymotrypsin, or neuraminidase decrease its ability to produce intracellular inhibition of mycobacterial growth within macrophages, suggesting that MycoIF was a glycoprotein. MycoIF was unaffected by deoxyribonuclease or ribonuclease. Supernatant ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.12.4.841-850.1975

    authors: Cahall DL,Youmans GP

    更新日期:1975-10-01 00:00:00

  • Scavenger receptor A dampens induction of inflammation in response to the fungal pathogen Pneumocystis carinii.

    abstract::Alveolar macrophages are the effector cells largely responsible for clearance of Pneumocystis carinii from the lungs. Binding of organisms to beta-glucan and mannose receptors has been shown to stimulate phagocytosis of the organisms. To further define the mechanisms used by alveolar macrophages for clearance of P. ca...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00393-07

    authors: Hollifield M,Bou Ghanem E,de Villiers WJ,Garvy BA

    更新日期:2007-08-01 00:00:00

  • Predominant outer membrane antigens of Bartonella henselae.

    abstract::A hallmark of Bartonella henselae is persistent bacteremia in cats despite the presence of a vigorous host immune response. To understand better the long-term survival of B. henselae in cats, we examined the feline humoral immune response to B. henselae outer membrane (OM) proteins in naturally and experimentally infe...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.72.6.3097-3105.2004

    authors: Chenoweth MR,Greene CE,Krause DC,Gherardini FC

    更新日期:2004-06-01 00:00:00

  • Replication of rubella virus in human mononuclear blood cells.

    abstract::Rubella virus was capable of replicating in both unstimulated and phytohemagglutinin-stimulated cultures of human mononuclear blood cells. Monocyte-derived macrophages were the main cell type responsible for viral replication. The susceptibility of macrophages increased during cultivation. Phytohemagglutinin-stimulate...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.27.2.309-314.1980

    authors: van der Logt JT,van Loon AM,van der Veen J

    更新日期:1980-02-01 00:00:00

  • Production of Biologically Active Substances by Two Strains of Vibrio cholerae.

    abstract::Strains Inaba 569B and Ogawa B1307 of Vibrio cholerae were grown in shaken Casamino Acids-yeast extract-glucose medium at 30 and 37 C for 4 days. Time courses of production of neuraminidase (NM), mucinase (MC), proteinase (PR), lytic factor (LF), and vascular permeability factor (PF) were compared by examining culture...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:

    authors: Kusama H,Craig JP

    更新日期:1970-01-01 00:00:00

  • Chromosomal synthesis of staphylococcal exfoliative toxin.

    abstract::Tox-+ staphylococcal strains, as opposed to Tox-minus strains, produce epidermal exfoliation within 18 h after direct subcutaneous or intraperitoneal injection into newborn mice. The extracellular product responsible for exfoliation is termed exfoliative toxin (ET). When culture supernatant fluid from the plasmid-cure...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.12.1.193-197.1975

    authors: Keyhani M,Rogolsky M,Wiley BB,Glasgow LA

    更新日期:1975-07-01 00:00:00

  • A fadD mutant of Vibrio cholerae is impaired in the production of virulence factors and membrane localization of the virulence regulatory protein TcpP.

    abstract::In the enteric pathogen Vibrio cholerae, expression of the major virulence factors is controlled by the hierarchical expression of several regulatory proteins comprising the ToxR regulon. In this study, we demonstrate that disruption of the fadD gene encoding a long-chain fatty acyl coenzyme A ligase has marked effect...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00663-10

    authors: Ray S,Chatterjee E,Chatterjee A,Paul K,Chowdhury R

    更新日期:2011-01-01 00:00:00

  • Production and Properties of Antisera to Membrane Glycolipids of Mycoplasma pneumoniae.

    abstract::The glycolipid haptens of Mycoplasma pneumoniae became immunogenic when bound to membrane proteins of Acholeplasma laidlawii by reaggregation. This process consisted of the solubilization of lipid-depleted A. laidlawii membranes and M. pneumoniae glycolipids in 20 mm sodium dodecyl sulfate and dialysis of the mixed so...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.3.3.420-423.1971

    authors: Razin S,Prescott B,James WD,Caldes G,Valdesuso J,Chanock RM

    更新日期:1971-03-01 00:00:00

  • Nitric oxide levels regulate the immune response of Drosophila melanogaster reference laboratory strains to bacterial infections.

    abstract::Studies on the innate immune response against microbial infections in Drosophila melanogaster involve mutant strains and their reference strains that act as experimental controls. We used five standard D. melanogaster laboratory reference strains (Oregon R, w1118, Canton-S, Cinnabar Brown, and Yellow White [YW]) and i...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.02318-14

    authors: Eleftherianos I,More K,Spivack S,Paulin E,Khojandi A,Shukla S

    更新日期:2014-10-01 00:00:00

  • Protective humoral immunity elicited by a needle-free malaria vaccine comprised of a chimeric Plasmodium falciparum circumsporozoite protein and a Toll-like receptor 5 agonist, flagellin.

    abstract::Immunization with Plasmodium sporozoites can elicit high levels of sterile immunity, and neutralizing antibodies from protected hosts are known to target the repeat region of the circumsporozoite (CS) protein on the parasite surface. CS-based subunit vaccines have been hampered by suboptimal immunogenicity and the req...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00263-13

    authors: Carapau D,Mitchell R,Nacer A,Shaw A,Othoro C,Frevert U,Nardin E

    更新日期:2013-12-01 00:00:00

  • Occurrences, specificities, and functions of ubiquitous antibodies in human serum that are reactive with the Cryptococcus neoformans cell wall.

    abstract::Previous studies found that normal human serum (NHS) contains an immunoglobulin G (IgG) antibody that mediates initiation of the classical complement pathway by nonencapsulated Cryptococcus neoformans. The present study used an enzyme-linked immunosorbent assay with whole nonencapsulated yeast cells as solid-phase ant...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.62.1.215-220.1994

    authors: Keller RG,Pfrommer GS,Kozel TR

    更新日期:1994-01-01 00:00:00

  • Transcriptional and translational analysis of biofilm determinants of Aggregatibacter actinomycetemcomitans in response to environmental perturbation.

    abstract::Fimbriae, lipopolysaccharide (LPS), and extracellular polymeric substance (EPS) all contribute to biofilm formation by the periodontopathogen Aggregatibacter actinomycetemcomitans. To understand how individual biofilm determinants respond to changing environmental conditions, the transcription of genes responsible for...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00126-09

    authors: Amarasinghe JJ,Scannapieco FA,Haase EM

    更新日期:2009-07-01 00:00:00

  • Immunization of virgin cows with surface antigen TF1.17 of Tritrichomonas foetus.

    abstract::Protection by surface antigen TF1.17 of Tritrichomonas foetus was investigated because it reacted with a monoclonal antibody which immobilized and mediated complement killing of the organism and prevented adherence to vaginal epithelial cells. This monoclonal antibody was used to demonstrate conservation of the antige...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.61.4.1385-1394.1993

    authors: BonDurant RH,Corbeil RR,Corbeil LB

    更新日期:1993-04-01 00:00:00