Abstract:
:Minor salivary glands of the oral mucosa in healthy monkeys (Macaca fascicularis and Macaca mulatta) contain organized structural units suitable for recognizing and processing antigens. A previous study of M. fascicularis monkeys provided experimental evidence of retrograde access of oral antigens deep into the minor salivary glands. The present study aimed at exploring the possible immune response of simian oral mucosa to repeated topical application of a chemically defined antigenic solution at the labial and gut mucosa. Ten female M. fascicularis animals were challenged topically at the lower lip mucosa at weekly intervals for a variable period of 4 to 8 weeks with a solution consisting of horseradish peroxidase, ferritin, and special India ink. Transmission electron microscopic examination of immunohistochemically treated sections of the labial glands revealed the presence of plasma cells containing specific anti-horseradish peroxidase antibody. These cells resided in the interacinar regions. Enteric and gut priming with the same antigen in four other monkeys, bypassing the oral mucosa, failed to reveal the presence of horseradish peroxidase-positive plasma cells in the labial mucosa of any of the four animals, although in one animal such cells could be identified in a mesenteric lymph node. This is suggestive of the existence, at least in primates, of a local immune response of the oral mucosa independent of systemic involvement.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Nair PN,Schroeder HEdoi
10.1128/IAI.41.1.399-409.1983subject
Has Abstractpub_date
1983-07-01 00:00:00pages
399-409issue
1eissn
0019-9567issn
1098-5522journal_volume
41pub_type
杂志文章abstract::Elevated levels of immunoglobulin E anti-Candida antibodies were observed in the sera of patients with systemic and vaginal candidiasis and in cervicovaginal washings of the latter. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.18.1.257-259.1977
更新日期:1977-10-01 00:00:00
abstract::Vibrio vulnificus is an oyster-associated bacterial pathogen that causes life-threatening fulminating septicemia and necrotizing wound infections in humans. The capsular polysaccharide of V. vulnificus (VvPS) is critical for virulence. Previously we showed that active immunization of mice with a VvPS-tetanus toxoid (V...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.6.2220-2224.1996
更新日期:1996-06-01 00:00:00
abstract::Mice injected intravenously with a commercially available extract of Coxiella burnetii prepared for use as the antigen in the complement fixation diagnostic test for Q fever were subsequently resistant to infection with Babesia microti, Babesia rodhaini, and Plasmodium vinckei petteri. The parasites appeared to die in...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.24.2.319-325.1979
更新日期:1979-05-01 00:00:00
abstract::Interactions between bacteria and salivary components are thought to be important in the establishment and ecology of the oral microflora. alpha-Amylase, the predominant salivary enzyme in humans, binds to Streptococcus gordonii, a primary colonizer of the tooth. Previous studies have implicated this interaction in ad...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.11.7046-7056.2001
更新日期:2001-11-01 00:00:00
abstract::Several immunological, hematological, and pathological responses associated with Marek's disease were determined. Four-week-old Marek's disease-infected and control chickens were injected with Salmonella pullorum antigen. About one-half of all infected chickens tested were unresponsive to antigenic challenge. Antibody...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.4.5.567-574.1971
更新日期:1971-11-01 00:00:00
abstract::The nonacylated form of protein D (PDm) of Haemophilus influenzae has been shown to induce the production of antibodies that are bactericidal to homologous and heterologous nontypeable H. influenzae (NTHi) strains. In this study, immunization of rats with lipoprotein D (LPD) induced higher levels of anti-protein D imm...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.12.5010-5016.1997
更新日期:1997-12-01 00:00:00
abstract::Depletion of dendritic cells (DC) in secondary lymphoid organs is a hallmark of sepsis-induced immune dysfunction. In this setting, we investigated if Toll-like receptor (TLR)-dependent signaling might modulate the maturation process and the survival of DC. Using a model of sublethal polymicrobial sepsis induced by ce...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00238-09
更新日期:2009-12-01 00:00:00
abstract::Vaccination with recombinant outer surface protein A (OspA) has been shown to protect mice from infection with Borrelia burgdorferi, the Lyme disease agent. To determine whether antibodies to B. burgdorferi proteins other than OspA are involved in protective immunity, antibodies to OspA were removed from protective an...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.2.657-661.1992
更新日期:1992-02-01 00:00:00
abstract::Clostridium perfringens delta toxin was selectively cytotoxic for various rabbit leukocyte populations. The sensitivity of these populations to the toxin varied, depending on the tissue from which they were derived, from 28% (appendix) to 41% (bone marrow) and 32% (spleen). Macrophages were uniformly killed by delta t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.3.860-864.1982
更新日期:1982-12-01 00:00:00
abstract::Previous experimentation has highlighted a number of difficulties in the development of carrier-based bivalent vaccines (J.-F. Viret and D. Favre, Biologicals 22:361-372, 1994) In an attempt to obviate these carrier strains. Toward this aim, a series of defined rfbInaba deletion (delta rfbInaba) mutants of the cholera...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.2.576-584.1996
更新日期:1996-02-01 00:00:00
abstract::A recent study found that group A Streptococcus (GAS) expresses a cell surface protein with similarity to human collagen (S. Lukomski, K. Nakashima, I. Abdi, V. J. Cipriano, R. M. Ireland, S. R. Reid, G. G. Adams, and J. M. Musser, Infect. Immun. 68:6542-6553, 2000). This streptococcal collagen-like protein (Scl) cont...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.3.1729-1738.2001
更新日期:2001-03-01 00:00:00
abstract::Neutrophils are the main inflammatory cell present in lesions involving the central nervous system (CNS) during human and murine listeriosis. In this study, administration of the neutrophil-depleting monoclonal antibody RB6-8C5 during experimental murine listeriosis facilitated the multiplication of Listeria monocytog...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.8.4789-4791.2000
更新日期:2000-08-01 00:00:00
abstract::The opportunistic pathogen Pseudomonas aeruginosa is a major cause of sepsis in severely burned patients. If it is not eradicated from the wound, it translocates to the bloodstream, causing sepsis, multiorgan failure, and death. We recently described the P. aeruginosa heparinase-encoding gene, hepP, whose expression w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00755-17
更新日期:2017-12-19 00:00:00
abstract::Yersinia pestis is a highly pathogenic Gram-negative organism and the causative agent of bubonic and pneumonic plague. Y. pestis is capable of causing major epidemics; thus, there is a need for vaccine targets and a greater understanding of the role of these targets in pathogenesis. Two prime Y. pestis vaccine candida...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00981-10
更新日期:2011-02-01 00:00:00
abstract::Ehrlichia chaffeensis, a tick-transmitted rickettsial, is the causative agent of human monocytic ehrlichiosis. To examine protein expression patterns, we analyzed total, membrane, and immunogenic proteomes of E. chaffeensis originating from macrophage and tick cell cultures. Total proteins resolved by one-dimensional ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00484-08
更新日期:2008-11-01 00:00:00
abstract::Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxificatio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.1.729-733.2006
更新日期:2006-01-01 00:00:00
abstract::Archived sera (collected in 1946) from acute rheumatic fever (ARF) and untreated scarlet fever and/or pharyngitis patients were reacted with streptococcal M protein, cardiac myosin, and cardiac tropomyosin. Except for very low levels to tropomyosin, antibodies to other antigens were not elevated in the sera of ARF pat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.12.7132-7136.2000
更新日期:2000-12-01 00:00:00
abstract::The pac gene of the serotype c strain Streptococcus mutans MT8148 encodes a cell surface protein antigen (PAc) of approximate 190 kilodaltons. The serotype c strain S. mutans GS-5 does not produce the 190-kilodalton PAc but produces a lower-molecular-weight protein that reacts with anti-PAc serum. The SphI-BamHI fragm...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.2.289-296.1990
更新日期:1990-02-01 00:00:00
abstract::Apical membrane antigen 1 (AMA1) is expressed on the surfaces of Plasmodium falciparum merozoites and is thought to play an important role in the invasion of erythrocytes by malaria parasites. To select for peptides that mimic conformational B-cell epitopes on AMA1, we screened a phage display library of >10(8) indivi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.2.1126-1134.2004
更新日期:2004-02-01 00:00:00
abstract::No effective therapy exists for Cryptosporidium parvum, a coccidial protozoan parasite that causes severe diarrhea in patients with AIDS. The role of microtubules in parasite invasion of host cells was investigated by incubating 10(7) oocysts with a HT 29.74 cell line for 24 h in the presence of microtubule-disrupting...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.11.4888-4890.1993
更新日期:1993-11-01 00:00:00
abstract::Bovine tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) cDNAs were generated by reverse transcription and then by PCR amplification from lipopolysaccharide (LPS)-stimulated alveolar macrophage RNA. The amplified cDNAs were cloned into pPow and expressed in Escherichia coli DH5 alpha. The expr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.2.381-388.1995
更新日期:1995-02-01 00:00:00
abstract::The Corynebacterium diphtheriae hmuO gene encodes a heme oxygenase that is involved in the utilization of heme as an iron source. Transcription of hmuO is activated by heme or hemoglobin and repressed by iron and DtxR. Previous studies with Escherichia coli showed that heme-dependent transcriptional activation of an h...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.11.7406-7412.2005
更新日期:2005-11-01 00:00:00
abstract::Humoral immunity does not play a prominent role during experimental cryptococcosis. However, previous studies have shown that immunoglobulin G (IgG) anti-Cryptococcus neoformans antibodies can mediate cell-dependent yeast killing in vitro. Therefore, the protective effect of a previously described monoclonal IgG1 anti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.3.749-752.1987
更新日期:1987-03-01 00:00:00
abstract::Three dominant proteins (41, 48, and 49 kDa) were detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in purified preparations of the extracellular aspartyl proteinase (AP) of Candida albicans. All three proteins bound to the specific carboxyl proteinase ligand, pepstatin A, and were assoc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.5.2030-2036.1993
更新日期:1993-05-01 00:00:00
abstract::Hydrogen peroxide (H2O2) is a by-product of glycerol metabolism in mycoplasmas and has been shown to cause cytotoxicity for cocultured eukaryotic cells. There appears to be selective pressure for mycoplasmas to retain the genes needed for glycerol metabolism. This has generated interest and speculation as to their fun...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02208-14
更新日期:2014-12-01 00:00:00
abstract::This study was designed to evaluate the immunogenicity and the protective efficacy of a divalent fusion DNA vaccine encoding both the Brucella abortus L7/L12 protein (ribosomal protein) and Omp16 protein (outer membrane lipoprotein), designated pcDNA3.1-L7/L12-Omp16. Intramuscular injection of this divalent DNA vaccin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.5.2734-2741.2006
更新日期:2006-05-01 00:00:00
abstract::Severe combined immunodeficient beige mice were inoculated orally and intraperitoneally with a bovine strain of Mycobacterium paratuberculosis to explore their potential as laboratory animal models in the study of paratuberculosis (Johne's disease). Control animals were similarly inoculated with heat-killed M. paratub...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.10.4074-4079.1992
更新日期:1992-10-01 00:00:00
abstract::Previously, we reported that mutants of Legionella pneumophila lacking a type II secretion (T2S) system elicit higher levels of cytokines (e.g., interleukin-6 [IL-6]) following infection of U937 cells, a human macrophage-like cell line. We now show that this effect of T2S is also manifest upon infection of human THP-1...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00897-16
更新日期:2017-03-23 00:00:00
abstract::A cytotoxigenic Clostridium difficile strain that fails to produce toxin A but causes hemorrhage and bloody fluid accumulation in ligated ileal loops of rabbits and hemorrhage and diarrhea in hamsters is described. The lack of reaction of DNA from this strain in hybridization studies with a toxin A gene-specific 4.5-k...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.10.4192-4199.1992
更新日期:1992-10-01 00:00:00
abstract::Citrobacter rodentium, a murine model pathogen for enteropathogenic Escherichia coli, colonizes the surface of intestinal epithelial cells and causes mucosal inflammation. This bacterium is an ideal model for investigating pathogen-host immune interactions in the gut. It is well known that gene transcripts for Th1 cyt...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01343-09
更新日期:2010-06-01 00:00:00