Critical role of neutrophils in eliminating Listeria monocytogenes from the central nervous system during experimental murine listeriosis.

abstract：:In the present study, we have investigated the evolution and impact on virulence of a 350-kb genomic duplication present in the most recently evolved members of the Mycobacterium tuberculosis East Asian lineage. In a mouse model of infection, comparing HN878 subclones HN878-27 (no duplication) and HN878-45 (with the 3...

journal_title：Infection and immunity

authors： Domenech P,Rog A,Moolji JU,Radomski N,Fallow A,Leon-Solis L,Bowes J,Behr MA,Reed MB

更新日期：2014-07-01 00:00:00

abstract：:The comparative immunogenicity of the two cross-reacting group 6 pneumococcal capsular polysaccharides, type 6A(6) and type 6B(26), was studied with hyperimmune rabbit typing antisera and with sera from adult volunteers injected with polyvalent pneumococcal vaccines containing either 50 mug of type 6A (U.S. designatio...

journal_title：Infection and immunity

authors： Robbins JB,Lee CJ,Rastogi SC,Schiffman G,Henrichsen J

更新日期：1979-12-01 00:00:00

abstract：:We demonstrate that a mucoid, alginate-producing strain of Pseudomonas aeruginosa isolated from the lungs of a cystic fibrosis (CF) patient secretes multiple enzymes with nucleoside diphosphate kinase (Ndk), ATPase, adenylate kinase, 5'-nucleotidase, and ATP-modifying enzymatic activities. The secretion is triggered a...

journal_title：Infection and immunity

authors： Zaborina O,Misra N,Kostal J,Kamath S,Kapatral V,El-Idrissi ME,Prabhakar BS,Chakrabarty AM

更新日期：1999-10-01 00:00:00

abstract：:The innate immune response in human tuberculosis is not completely understood. To improve our knowledge regarding the role of cathelicidin hCAP-18/LL37 in the innate immune response to tuberculosis infection, we used immunohistochemistry, immunoelectron microscopy, and gene expression to study the induction and produc...

journal_title：Infection and immunity

authors： Rivas-Santiago B,Hernandez-Pando R,Carranza C,Juarez E,Contreras JL,Aguilar-Leon D,Torres M,Sada E

更新日期：2008-03-01 00:00:00

abstract：:An anti-glucosyltransferase serum was prepared against a pure enzyme preparation from Streptococcus sanguis OMZ 9, which synthesized both soluble and insoluble dextran. Sera, crude gamma globulins, and antibody fractions obtained after gel filtration on a Bio-Gel P200 column were used to study enzyme-antibody interact...

journal_title：Infection and immunity

authors： Klein JP,Schöller M,Frank RM

更新日期：1978-06-01 00:00:00

abstract：:GNA33 is a membrane-bound lipoprotein with murein hydrolase activity that is present in all Neisseria species and well conserved in different meningococcal isolates. The protein shows 33% identity to a lytic transglycolase (MltA) from Escherichia coli and has been shown to be involved in the degradation of both insolu...

journal_title：Infection and immunity

authors： Adu-Bobie J,Lupetti P,Brunelli B,Granoff D,Norais N,Ferrari G,Grandi G,Rappuoli R,Pizza M

更新日期：2004-04-01 00:00:00

abstract：:One aspect in a broad spectrum of possible mechanisms of cariostatic reactions of fluoride is its interaction with the metabolism of oral bacteria. Information on the mechanisms and kinetics of fluoride inhibition of essential enzymes of the glycolytic pathway of the relevant bacteria is lacking. In this work, the iso...

journal_title：Infection and immunity

authors： Hüther FJ,Psarros N,Duschner H

更新日期：1990-04-01 00:00:00

abstract：:Intestinal segmented filamentous bacteria (SFB) protect from ameba infection, and protection is transferable with bone marrow dendritic cells (BMDCs). SFB cause an increase in serum amyloid A (SAA), suggesting that SAA might mediate SFB's effects on BMDCs. Here we further explored the role of bone marrow in SFB-mediat...

journal_title：Infection and immunity

authors： Burgess SL,Saleh M,Cowardin CA,Buonomo E,Noor Z,Watanabe K,Abhyankar M,Lajoie S,Wills-Karp M,Petri WA Jr

更新日期：2016-09-19 00:00:00

abstract：:Efficient utilization of heme as an iron (Fe) source by Bordetella avium requires bhuR, an Fe-regulated gene which encodes an outer membrane heme receptor. Upstream of bhuR is a 507-bp open reading frame, hereby designated rhuI (for regulator of heme uptake), which codes for a 19-kDa polypeptide. Whereas the 19-kDa po...

journal_title：Infection and immunity

authors： Kirby AE,Metzger DJ,Murphy ER,Connell TD

更新日期：2001-11-01 00:00:00

abstract：:The she gene of Shigella flexneri 2a, which also harbors the internal enterotoxin genes set1A and set1B (F. R. Noriega, GenBank accession no. U35656, 1995) encodes a homolog of the virulence-related immunoglobulin A (IgA) protease-like family of secreted proteins, Tsh, EspC, SepA, and Hap, from an avian pathogenic Esc...

journal_title：Infection and immunity

authors： Rajakumar K,Sasakawa C,Adler B

更新日期：1997-11-01 00:00:00

abstract：:Female guinea pigs were immunized with viable or UV light-inactivated chlamydiae (agent of guinea pig inclusion conjunctivitis), belonging to the species Chlamydia psittaci, by intravenous, subcutaneous, oral, or ocular routes. All animals were then inoculated vaginally with viable chlamydiae to determine the extent o...

journal_title：Infection and immunity

authors： Rank RG,Batteiger BE,Soderberg LS

更新日期：1990-08-01 00:00:00

abstract：:Endotoxin may cause abnormal deposition of platelet-endotoxin aggregates, and this event could have damaging effects. We compared the aggregation characteristics of platelets from rabbits made tolerant to the lethal effects of endotoxin with those of platelets from normal rabbits. Platelets from tolerant rabbits aggre...

journal_title：Infection and immunity

authors： Walker RI,Shields LJ,Fletcher JR

更新日期：1978-03-01 00:00:00

abstract：:Immunization with live Plasmodium sporozoites under chloroquine prophylaxis (Spz plus CQ) induces sterile immunity against sporozoite challenge in rodents and, more importantly, in humans. Full protection is obtained with substantially fewer parasites than with the classic immunization with radiation-attenuated sporoz...

journal_title：Infection and immunity

authors： Mauduit M,Tewari R,Depinay N,Kayibanda M,Lallemand E,Chavatte JM,Snounou G,Rénia L,Grüner AC

更新日期：2010-05-01 00:00:00

abstract：:The present study was performed to determine whether Histoplasma capsulatum (yeast phase) is able to activate the alternative complement pathway. H. capsulatum yeasts were shown to consume C3 in C4-deficient guinea pig serum. Immunoelectrophoretic conversion of alternative pathway component factor B confirmed that C3 ...

journal_title：Infection and immunity

authors： Ratnoff WD,Pepple JM,Winkelstein JA

更新日期：1980-10-01 00:00:00

abstract：:Gamma interferon (IFN-γ) drives antiparasite responses and immunopathology during infection with Plasmodium species. Immunity-related GTPases (IRGs) are a class of IFN-γ-dependent proteins that are essential for cell autonomous immunity to numerous intracellular pathogens. However, it is currently unknown whether IRGs...

journal_title：Infection and immunity

authors： Guo J,McQuillan JA,Yau B,Tullo GS,Long CA,Bertolino P,Roediger B,Weninger W,Taylor GA,Hunt NH,Ball HJ,Mitchell AJ

更新日期：2015-04-01 00:00:00

abstract：:The absolute requirement for elemental iron and the porphyrin nucleus for growth of Haemophilus influenzae led us to investigate the role of iron and hemin in regulation of expression of the H. influenzae transferrin receptor. H. influenzae type b strain H1689 was grown in brain heart infusion broth supplemented with ...

journal_title：Infection and immunity

authors： Morton DJ,Musser JM,Stull TL

更新日期：1993-10-01 00:00:00

abstract：:Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA fragmentation characteristic of apoptosis. Macrophage lysis was dependent on a subset of caspases and an intact sipB gene...

journal_title：Infection and immunity

authors： Watson PR,Gautier AV,Paulin SM,Bland AP,Jones PW,Wallis TS

更新日期：2000-06-01 00:00:00

abstract：:The data presented indicate that in experimental Pseudomonas aeruginosa infection of mice, protease enhances the virulence of the organism. Anesthetized CBA/Lü mice were subjected to a 15-s flame burn and infected with a wild-type protease-producing strain and two of its protease-deficient mutants. The average bacteri...

journal_title：Infection and immunity

authors： Pavlovskis OR,Wretlind B

更新日期：1979-04-01 00:00:00

abstract：:Several previous findings have suggested that the cationic nature of lysozyme is a major factor in its bactericidal activity. Since a number of cationic proteins or peptides have been reported to cause membrane damage in bacteria, we investigated the effect of lysozyme on glucose fermentation and intracellular pH and ...

journal_title：Infection and immunity

authors： Wang YB,Germaine GR

更新日期：1991-02-01 00:00:00

abstract：:Vibrio vulnificus is an oyster-associated bacterial pathogen that causes life-threatening fulminating septicemia and necrotizing wound infections in humans. The capsular polysaccharide of V. vulnificus (VvPS) is critical for virulence. Previously we showed that active immunization of mice with a VvPS-tetanus toxoid (V...

journal_title：Infection and immunity

authors： Devi SJ,Hayat U,Powell JL,Morris JG Jr

更新日期：1996-06-01 00:00:00

abstract：:Trypanosoma cruzi is a protozoan parasite that can initiate mucosal infection after conjunctival exposure. The anatomical route of T. cruzi invasion and spread after conjunctival parasite contamination remains poorly characterized. In the present work we have identified the sites of initial invasion and replication af...

journal_title：Infection and immunity

authors： Giddings OK,Eickhoff CS,Smith TJ,Bryant LA,Hoft DF

更新日期：2006-10-01 00:00:00

abstract：:Exposure of mycobacterial growth inhibitory factor (MycoIF) to trypsin, chymotrypsin, or neuraminidase decrease its ability to produce intracellular inhibition of mycobacterial growth within macrophages, suggesting that MycoIF was a glycoprotein. MycoIF was unaffected by deoxyribonuclease or ribonuclease. Supernatant ...

journal_title：Infection and immunity

authors： Cahall DL,Youmans GP

更新日期：1975-10-01 00:00:00

abstract：:Lymphocytes derived from 72- to 90-day-old fetal piglet thymuses respond in vitro to phytohemagglutinin quantitatively greater than do spleen cell lymphocytes. ...

journal_title：Infection and immunity

authors： Rodey GE,Day N,Holmes-Gray B,Good RA

更新日期：1972-03-01 00:00:00

abstract：:Many of the virulence factors associated with fulminant group A streptococci (GAS) infection are expressed under in vitro exponential growth conditions. However, the survival of GAS in tissue and intracellularly, as well as colonization of asymptomatic carriers, has been reported for GAS. The bacteria associated with ...

journal_title：Infection and immunity

authors： Leonard BA,Woischnik M,Podbielski A

更新日期：1998-08-01 00:00:00

abstract：:Neuronal dysfunction can occur in the course of sepsis without meningitis. Sepsis-associated neuronal damage (SAND) was observed in the hippocampus within hours in experimental pneumococcal bacteremia. Intravascular challenge with purified bacterial cell wall recapitulated SAND. SAND persisted in PAFr(-/-) mice but wa...

journal_title：Infection and immunity

authors： Orihuela CJ,Fillon S,Smith-Sielicki SH,El Kasmi KC,Gao G,Soulis K,Patil A,Murray PJ,Tuomanen EI

更新日期：2006-07-01 00:00:00

abstract：:Many pathogenic Escherichia coli produce the toxin alpha-hemolysin (Hly), and lipopolysaccharide (LPS), interleukin-1 (IL-1), and tumor necrosis factor (TNF) have all been recognized as important effector molecules during infections by gram-negative organisms. Despite the characterization of many in vitro effects of h...

journal_title：Infection and immunity

authors： Gleason TG,Houlgrave CW,May AK,Crabtree TD,Sawyer RG,Denham W,Norman JG,Pruett TL

更新日期：1998-09-01 00:00:00

abstract：:The three most abundant extracellular proteins of Mycobacterium tuberculosis, the 30-, 32-, and 16-kDa major extracellular proteins, are particularly promising vaccine candidates. We have mapped T-cell epitopes of these three proteins in outbred guinea pigs by immunizing the animals with each protein and assaying sple...

journal_title：Infection and immunity

authors： Lee BY,Horwitz MA

更新日期：1999-05-01 00:00:00

abstract：:Thrombin-induced platelet microbicidal protein 1 (tPMP-1) is a small, cationic peptide generated from rabbit platelets when they are exposed to thrombin in vitro. It has potent microbicidal activity against a broad spectrum of bacterial and fungal pathogens, including Staphylococcus aureus. Previous in vitro studies i...

journal_title：Infection and immunity

authors： Koo SP,Bayer AS,Kagan BL,Yeaman MR

更新日期：1999-05-01 00:00:00

abstract：:Bartonella henselae is a recently recognized pathogenic bacterium associated with cat scratch disease, bacillary angiomatosis, and bacillary peliosis. This study describes the cloning, sequencing, and characterization of an antigenic autotransporter gene from B. henselae. A cloned 6.0-kb BclI-EcoRI DNA fragment expres...

journal_title：Infection and immunity

authors： Litwin CM,Rawlins ML,Swenson EM

更新日期：2007-11-01 00:00:00

abstract：:We have previously demonstrated the existence of Klebsiella pneumoniae clinical isolates deficient in the lipopolysaccharide O side chain, the major factor for resistance to complement-mediated killing in this bacterial species. These isolates are complement resistant, and their mechanisms to resist complement were in...

journal_title：Infection and immunity

authors： Alvarez D,Merino S,Tomás JM,Benedí VJ,Albertí S

更新日期：2000-02-01 00:00:00