Abstract:
:The innate immune response in human tuberculosis is not completely understood. To improve our knowledge regarding the role of cathelicidin hCAP-18/LL37 in the innate immune response to tuberculosis infection, we used immunohistochemistry, immunoelectron microscopy, and gene expression to study the induction and production of the antimicrobial peptide in A549 epithelial cells, alveolar macrophages (AM), neutrophils, and monocyte-derived macrophages (MDM) after infection with Mycobacterium tuberculosis. We demonstrated that mycobacterial infection induced the expression and production of LL-37 in all cells studied, with AM being the most efficient. We did not detect peptide expression in tuberculous granulomas, suggesting that LL-37 participates only during early infection. Through the study of Toll-like receptors (TLR) in MDM, we showed that LL-37 can be induced by stimulation through TLR-2, TLR-4, and TLR-9. This last TLR was strongly stimulated by M. tuberculosis DNA. We concluded that LL-37 may have an important role in the innate immune response against M. tuberculosis.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Rivas-Santiago B,Hernandez-Pando R,Carranza C,Juarez E,Contreras JL,Aguilar-Leon D,Torres M,Sada Edoi
10.1128/IAI.01218-07subject
Has Abstractpub_date
2008-03-01 00:00:00pages
935-41issue
3eissn
0019-9567issn
1098-5522pii
IAI.01218-07journal_volume
76pub_type
杂志文章abstract::A murine monoclonal antibody was raised against the B95-8 strain of Epstein-Barr virus (EBV), which was isolated from a case of mononucleosis after blood transfusion (Hoffman et al. Proc. Natl. Acad. Sci. U.S.A. 77:2979, 1980). We provide evidence that neutralization of immortalization by this monoclonal antibody is v...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.37.3.1028-1031.1982
更新日期:1982-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/IAI.01515-07
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.6.1663-1667.1989
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.1.65-69.1998
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.9.3768-3773.1997
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pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.50.3.738-744.1985
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.3.799-806.1977
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journal_title:Infection and immunity
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/IAI.69.7.4242-4247.2001
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.3.1100-1105.1991
更新日期:1991-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.22.3.740-745.1978
更新日期:1978-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.21.1.59-63.1978
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.6.2776-2782.1999
更新日期:1999-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.24.3.793-797.1979
更新日期:1979-06-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2010-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.4.721-725.1988
更新日期:1988-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1976-10-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.1.356-358.1982
更新日期:1982-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1986-06-01 00:00:00