Microtubule inhibitors block Cryptosporidium parvum infection of a human enterocyte cell line.

abstract：:Resistance against acute and chronic infection with Taxoplasma gondii in BALB/c and CBA/Ca mice was compared. Intraperitoneal inoculation of either 20, 40, or 80 cysts of the ME49 strain resulted in mortality rates in BALB/c mice of 12% (2 of 17), 50% (6 of 12), and 75% (9 of 12), respectively, within 3 weeks after in...

journal_title：Infection and immunity

authors： Suzuki Y,Orellana MA,Wong SY,Conley FK,Remington JS

更新日期：1993-06-01 00:00:00

abstract：:Differences in susceptibility to persistent cryptosporidial infection between two strains of adult athymic nude mice prompted us to investigate the immune mechanism(s) that may control resistance to infection in these T-cell-deficient mice. We studied fecal oocyst shedding, serum and fecal parasite-specific antibody r...

journal_title：Infection and immunity

authors： Adjei AA,Jones JT,Riggs MW,Enriquez FJ

更新日期：1999-08-01 00:00:00

abstract：:Serum was necessary for optimal phagocytosis of Aspergillus fumigatus spores by human leukocytes, and its opsonic capacity was greatly diminished by heat inactivation (56 C, 30 min). A germination assay, described in this report, was developed to study the fate of phagocytized spores. After incubation for 3 hr with no...

journal_title：Infection and immunity

authors： Lehrer RI,Jan RG

更新日期：1970-04-01 00:00:00

abstract：:Experiments were conducted in which rhesus monkeys were infected with mumps virus by inoculation into the parotid gland. Virus was isolated from buccal swab specimens from animals up to 6 days after inoculation. Immunofluorescence staining for mumps antigen was positive, and infectious virus was recovered from tissue ...

journal_title：Infection and immunity

authors： Flanagan TD,Andrada JA,Barron AL,Witebsky E

更新日期：1971-05-01 00:00:00

abstract：:Mutation of purR was previously shown to enhance the virulence of Staphylococcus aureus in a murine sepsis model, and this cannot be fully explained by increased expression of genes within the purine biosynthesis pathway. Rather, the increased production of specific S. aureus virulence factors, including alpha toxin a...

journal_title：Infection and immunity

authors： Alkam D,Jenjaroenpun P,Ramirez AM,Beenken KE,Spencer HJ,Smeltzer MS

更新日期：2021-01-19 00:00:00

abstract：:A major ceramide monohexoside (CMH) was purified from lipidic extracts of Cryptococcus neoformans. This molecule was analyzed by high-performance thin-layer chromatography (HPTLC), gas chromatography coupled with mass spectrometry, and fast atom bombardment-mass spectrometry. The cryptococcal CMH is a beta-glucosylcer...

journal_title：Infection and immunity

authors： Rodrigues ML,Travassos LR,Miranda KR,Franzen AJ,Rozental S,de Souza W,Alviano CS,Barreto-Bergter E

更新日期：2000-12-01 00:00:00

abstract：:Lipid X, a precursor in the biosynthesis of lipid A, has been claimed to possess most of the immunostimulatory activity but none of the toxicity of endotoxin. However, recent work shows that synthetic lipid X can be contaminated with small amounts of N,O-acylated disaccharide-1-phosphate (H. Aschauer, A. Grob, J. Hild...

journal_title：Infection and immunity

authors： Lam C,Hildebrandt J,Schütze E,Rosenwirth B,Proctor RA,Liehl E,Stütz P

更新日期：1991-07-01 00:00:00

abstract：:High-density oligonucleotide microarrays are widely used to study gene expression in cells exposed to a variety of pathogens. This study addressed the global genome-wide transcriptional activation of genes in hosts infected in vivo, which result in radically different clinical outcomes. We present an analysis of the g...

journal_title：Infection and immunity

authors： Schaecher K,Kumar S,Yadava A,Vahey M,Ockenhouse CF

更新日期：2005-09-01 00:00:00

abstract：:The surface antigen makeup of metacyclic trypomastigote forms of strain G of Trypanosoma cruzi, which produce a subpatent infection in mice, differed from those of the virulent strains Y and CL. A 100,000-molecular-weight protein, barely detectable on the Y or CL cell surface, appeared as the main surface antigen of t...

journal_title：Infection and immunity

authors： Yoshida N

更新日期：1983-05-01 00:00:00

abstract：:The Fcγ receptor IIIb (FcγRIIIb) is a low-affinity receptor of IgG and is essential in neutrophil-mediated effector functions. Different allelic forms of FcγRIIIb carrying human neutrophil antigen (HNA-1a, -1b, -1c, and -1d) have been identified. Here, we have generated stable transfected HEK293 cell lines expressing ...

journal_title：Infection and immunity

authors： Simtong P,Romphruk AV,Traum A,Burg-Roderfeld M,Bein G,Jakubowski K,Dominik A,Theisen M,Kana IH,Sachs UJ,Santoso S

更新日期：2018-07-23 00:00:00

abstract：:Guinea pig and mouse peritoneal macrophages in culture transport glucose by a specific, saturable system with characteristics compatible with facilitated diffusion. Phagocytosis of killed staphylococci or polystyrene latex spheres results in a significant increase in uptake of 2-deoxy-d-glucose. Reciprocal plot analys...

journal_title：Infection and immunity

authors： Bonventre PF,Mukkada AJ

更新日期：1974-12-01 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a noninvasive food-borne pathogen that colonizes the distal ileum and colon. Proteins encoded in the EHEC locus of enterocyte effacement (LEE) pathogenicity island are known to contribute to this pathogen's adherence to epithelial cells and intestinal colonization. The role...

journal_title：Infection and immunity

authors： Ho TD,Davis BM,Ritchie JM,Waldor MK

更新日期：2008-05-01 00:00:00

abstract：:Using pharmacologic and biochemical criteria, we evaluated whether uptake of four different Chlamydia trachomatis serovars, D, E, K, and L2, was dependent upon lipid rafts. Our data suggest that lipid raft-mediated entry is not required for C. trachomatis infection of cultured epithelial cells. ...

journal_title：Infection and immunity

authors： Gabel BR,Elwell C,van Ijzendoorn SC,Engel JN

更新日期：2004-12-01 00:00:00

abstract：:Pneumonic tularemia is a life-threatening disease caused by inhalation of the highly infectious intracellular bacterium Francisella tularensis. The most serious form of the disease associated with the type A strains can be prevented in experimental animals through vaccination with the attenuated live vaccine strain (L...

journal_title：Infection and immunity

authors： Mara-Koosham G,Hutt JA,Lyons CR,Wu TH

更新日期：2011-04-01 00:00:00

abstract：:Several immunological, hematological, and pathological responses associated with Marek's disease were determined. Four-week-old Marek's disease-infected and control chickens were injected with Salmonella pullorum antigen. About one-half of all infected chickens tested were unresponsive to antigenic challenge. Antibody...

journal_title：Infection and immunity

authors： Evans DL,Patterson LT

更新日期：1971-11-01 00:00:00

abstract：:Fimbriae, lipopolysaccharide (LPS), and extracellular polymeric substance (EPS) all contribute to biofilm formation by the periodontopathogen Aggregatibacter actinomycetemcomitans. To understand how individual biofilm determinants respond to changing environmental conditions, the transcription of genes responsible for...

journal_title：Infection and immunity

authors： Amarasinghe JJ,Scannapieco FA,Haase EM

更新日期：2009-07-01 00:00:00

abstract：:Immunization with the B oligomer of pertussis toxin protected neonatal mice from a lethal respiratory challenge with Bordetella pertussis. All mice immunized with 8 micrograms of B oligomer survived aerosol challenge and had peripheral leukocyte counts and weight gains similar to those of mice immunized with pertussis...

journal_title：Infection and immunity

authors： Shahin RD,Witvliet MH,Manclark CR

更新日期：1990-12-01 00:00:00

abstract：:The 18-kilodalton (kDa) antigen of Mycobacterium leprae was expressed as a fusion protein with a 2-kDa leader peptide and used in proliferation assays with peripheral blood cells. Fifty percent of untreated tuberculoid leprosy patients and 93% of long-term leprosy contacts responded to the recombinant protein in lymph...

journal_title：Infection and immunity

authors： Dockrell HM,Stoker NG,Lee SP,Jackson M,Grant KA,Jouy NF,Lucas SB,Hasan R,Hussain R,McAdam KP

更新日期：1989-07-01 00:00:00

abstract：:A monoclonal antibody (MAb) was raised against Shiga toxin 2 (Stx2) of Escherichia coli O157:H7. MAb VTm1.1 belonged to the immunoglobulin G1 subclass and had a kappa light chain, and it could neutralize the cytotoxic activity of Stx2 and variants derived from patient strains but not that of variants derived from anim...

journal_title：Infection and immunity

authors： Nakao H,Kiyokawa N,Fujimoto J,Yamasaki S,Takeda T

更新日期：1999-11-01 00:00:00

abstract：:Immunization with ribosomal preparations from Haemophilus influenzae type b elicited protective immunity in mice. Ribosomes from disrupted cells where isolated by differential centrifugation using sodium dodecyl sulfate. The washed ribosomes contained 25% protein and 75% ribonucleic acid and sedimented as a single pea...

journal_title：Infection and immunity

authors： Lynn M,Tewari RP,Solotorovsky M

更新日期：1977-02-01 00:00:00

abstract：:In vitro experimentation indicates that periodontitis-associated bacteria contain potent polyclonal B-cell activators (PBA). We reasoned that if PBA were operative in vivo, plasma cells specific for nonoral antigens should be present in the inflamed gingival tissues, which are characterized by a plasma cell infiltrate...

journal_title：Infection and immunity

authors： Mallison SM 3rd,Szakal AK,Ranney RR,Tew JG

更新日期：1988-04-01 00:00:00

abstract：:Shiga toxin type 1 (Stx1) belongs to the Shiga family of bipartite AB toxins that inactivate eukaryotic 60S ribosomes. The A subunit of Stxs are N-glycosidases that share structural and functional features in their catalytic center and in an internal hydrophobic region that shows strong transmembrane propensity. Both ...

journal_title：Infection and immunity

authors： Suhan ML,Hovde CJ

更新日期：1998-11-01 00:00:00

abstract：:The effects of heat and chemical inactivation on the antigenicity and immunogenicity of Vibrio cholerae 1418 in rabbits were studied. V. cholerae 1418 was inactivated with heat and chemical inactivants (phenol or Formalin) alone or in combination. Enzyme-linked immunoassay systems employing whole cells of V. cholerae ...

journal_title：Infection and immunity

authors： Cryz SJ Jr,Fürer E,Germanier R

更新日期：1982-10-01 00:00:00

abstract：:The capacity of Candida albicans to switch reversibly between the white phenotype and the opaque phenotype is required for the fungus to mate. It also influences virulence during hematogenously disseminated candidiasis. We investigated the roles of the mating type loci (MTL) and white-opaque switching in the capacity ...

journal_title：Infection and immunity

authors： Solis NV,Park YN,Swidergall M,Daniels KJ,Filler SG,Soll DR

更新日期：2018-05-22 00:00:00

abstract：:Borrelia burgdorferi, an agent of Lyme disease, establishes persistent infection in immunocompetent animals and humans. Although the infection in humans can be cleared by antibiotic therapy, persistence in reservoir animals is necessary for the maintenance of the bacterium in the natural reservoir host⇔tick vector inf...

journal_title：Infection and immunity

authors： LaFrance ME,Pierce JV,Antonara S,Coburn J

更新日期：2011-08-01 00:00:00

abstract：:This study investigates the role of CD4+ T cells in host defense against cholera enterotoxin-induced diarrhea. Antitoxin immunoglobulin A formation and gut protection against cholera toxin (CT) following oral immunizations with CT were evaluated in normal mice and mice that had been depleted of CD4+ T cells by in vivo...

journal_title：Infection and immunity

authors： Hörnqvist E,Goldschmidt TJ,Holmdahl R,Lycke N

更新日期：1991-10-01 00:00:00

abstract：:Three open reading frames (ORFs) were identified by a genome walking strategy in the genomes of serotype M49 group A streptococcal (GAS) strains CS101 and 591. These ORFs were located between the mga core regulon and the dipeptide permease operon. The deduced amino acid (aa) sequences contained signature sequences ind...

journal_title：Infection and immunity

authors： Elsner A,Kreikemeyer B,Braun-Kiewnick A,Spellerberg B,Buttaro BA,Podbielski A

更新日期：2002-09-01 00:00:00

abstract：:Parasite antigens which bind to host cell molecules of approximately 32 and 34 kilodaltons (kDa) were identified in supernatant fluids obtained from axenic cultures of Trypanosoma cruzi. These parasite components were first detected in culture supernatants obtained after 2 weeks in culture. Immunoblot analysis of cult...

journal_title：Infection and immunity

authors： Davis CD,Kuhn RE

更新日期：1990-06-01 00:00:00

abstract：:Human and rat C-reactive proteins, major acute-phase reactants, bind to sporozoites and inhibit their in vitro development in hepatocytes (A. Nussler, S. Pied, M. Pontet, F. Miltgen, L. Renia, M. Gentilini, and D. Mazier, Exp. Parasitol. 72:1-7, 1991, and S. Pied, A. Nussler, M. Pontet, F. Miltgen, H. Matile, P.-H. La...

journal_title：Infection and immunity

authors： Rénia L,Xia D,Samols D,Nussenzweig V

更新日期：1993-01-01 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) is a leading diarrheagenic bacterial pathogen among travelers and children in resource-limited regions. Adherence to host intestinal cells mediated by ETEC fimbriae is believed to be a critical first step in ETEC pathogenesis. These fimbriae are categorized into related classes ...

journal_title：Infection and immunity

authors： Liu Y,Shahabudin S,Farid S,Lee LH,McVeigh AL,Maciel M Jr.,,Poole ST,Broadman M,Prouty MG,Savarino SJ

更新日期：2020-10-19 00:00:00