Abstract:
:Human and rat C-reactive proteins, major acute-phase reactants, bind to sporozoites and inhibit their in vitro development in hepatocytes (A. Nussler, S. Pied, M. Pontet, F. Miltgen, L. Renia, M. Gentilini, and D. Mazier, Exp. Parasitol. 72:1-7, 1991, and S. Pied, A. Nussler, M. Pontet, F. Miltgen, H. Matile, P.-H. Lambert, and D. Mazier, Infect. Immun. 57:278-282, 1989). We show here that rabbit C-reactive protein has identical properties. Nevertheless, infection by Plasmodium yoelii sporozoites was not prevented in transgenic mice engineered to express rabbit C-reactive protein following induction of gluconeogenesis.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Rénia L,Xia D,Samols D,Nussenzweig Vdoi
10.1128/IAI.61.1.348-349.1993subject
Has Abstractpub_date
1993-01-01 00:00:00pages
348-9issue
1eissn
0019-9567issn
1098-5522journal_volume
61pub_type
杂志文章abstract::Subunits of a proline-rich coccidioidal antigen (Ag2/PRA) of Coccidioides immitis were analyzed by comparison as vaccines in mice. The optimal dose of plasmid vaccine encoding full-length Ag2/PRA was determined to be between 10 and 100 microg. Mice vaccinated with plasmids encoding amino acids (aa) 1 to 106 were as pr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.7.3330-3335.2002
更新日期:2002-07-01 00:00:00
abstract::We found that when group A streptococci are cocultured with human pharyngeal cells, they upregulate and secrete a 25-kDa toxin, determined to be the bacteriophage-encoded streptococcal pyrogenic exotoxin C (SpeC). This prompted us to determine if the bacteriophage themselves are induced during coculture conditions. We...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.3.1440-1443.2001
更新日期:2001-03-01 00:00:00
abstract::Group A streptococcal pyrogenic exotoxins types A, B, and C and staphylococcal pyrogenic exotoxin were shown to be potent nonspecific T-lymphocyte mitogens. Adherent cell populations did not significantly affect the nonspecific mitogenicity. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.25.3.1075-1077.1979
更新日期:1979-09-01 00:00:00
abstract::Expression of ace (adhesin to collagen of Enterococcus faecalis), encoding a virulence factor in endocarditis and urinary tract infection models, has been shown to increase under certain conditions, such as in the presence of serum, bile salts, urine, and collagen and at 46 °C. However, the mechanism of ace/Ace regula...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02587-14
更新日期:2015-01-01 00:00:00
abstract::Minicells are small, anucleate cells resulting from aberrant cell divisions at the polar ends of bacilli. We have isolated minicell-producing mutant strains of Shigella flexneri 2a (MC-I) and Shigella dysenteriae 1 (MC-V) after mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine. Microscopically, broth cultures of M...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.30.1.297-302.1980
更新日期:1980-10-01 00:00:00
abstract::One major outer membrane protein (P1) of Haemophilus influenzae type b (Hib), with an apparent molecular weight of 34,000 (34K) as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), has been shown to be heat modifiable. After heating at 100 degrees C for 5 min in 2% SDS, the P1 protein...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.12.2993-3000.1987
更新日期:1987-12-01 00:00:00
abstract::Bordetella pertussis extract that contained adenylate cyclase toxin produced large increases in human neutrophil cyclic AMP levels and inhibited their oxidative burst, as reflected by luminol-enhanced chemiluminescence and superoxide release. The adenylate cyclase toxin-containing extract blocked neutrophil-mediated i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.4.751-755.1988
更新日期:1988-04-01 00:00:00
abstract::The role of type 1 pili in promoting bladder colonization was examined by constructing two mutant strains of a clinical Escherichia coli isolate. One mutant was isogenic to the parental strain save for a lesion in a gene required for pilus receptor binding; the other mutant was isogenic save for a lesion in the gene e...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.53.3.693-696.1986
更新日期:1986-09-01 00:00:00
abstract::Cronobacter sakazakii is an opportunistic pathogen that causes neonatal meningitis and necrotizing enterocolitis. Its interaction with intestinal epithelium is important in the pathogenesis of enteric infections. In this study, we investigated the involvement of the inv gene in the virulence of C. sakazakii ATCC 29544...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01397-13
更新日期:2014-05-01 00:00:00
abstract::Alveolar bone destruction is a characteristic feature of periodontitis. Treponema denticola is known to be involved in periodontitis. To elucidate the role of T. denticola in alveolar bone destruction in periodontitis, the effects of lipooligosaccharide (LOS) from T. denticola on osteoclast formation and on expression...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.1.226-233.2003
更新日期:2003-01-01 00:00:00
abstract::A number of polymorphonuclear leukocyte (PMN) chemotactic factors derived from complement components have been described. We sought to determine which of these factors accounted for the majority of PMN chemotactic activity in rabbit serum and guinea pig serum treated with preformed immune complexes. Normal rabbit sera...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.1.6.521-525.1970
更新日期:1970-06-01 00:00:00
abstract::It was previously demonstrated that avirulent Mycoplasma gallisepticum strain R(high) (passage 164) is lacking three proteins that are expressed in its virulent progenitor, strain R(low) (passage 15). These proteins were identified as the cytadhesin molecule GapA, the putative cytadhesin-related molecule CrmA, and a c...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.12.6839-6845.2002
更新日期:2002-12-01 00:00:00
abstract::Pneumolysin is a 471-amino-acid toxin produced by Streptococcus pneumoniae which has both cytolytic and complement activation properties. We have constructed a derivative of the type 2 S. pneumoniae strain D39 in which the portion of the pneumolysin gene encoding amino acids 55 to 437 has been deleted in-frame. The vi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.2.981-985.1999
更新日期:1999-02-01 00:00:00
abstract::Cryptosporidium parvum is a coccidian parasite that causes diarrheal disease in many vertebrate species, including young (less than or equal to 1 month old) calves. Older calves and adult cattle are resistant to infection. In this study, newborn calves were raised in isolation from C. parvum for 1 week to 3 months bef...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.7.2237-2240.1990
更新日期:1990-07-01 00:00:00
abstract::Defensins are antibiotic peptides expressed in human and animal myeloid and epithelial cells. Due to the limited availability of natural peptides, the properties of human epithelial defensins have not been studied. We assayed the microbicidal activity of recombinant human intestinal defensin 5 (rHD-5) in the presence ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.6.2396-2401.1997
更新日期:1997-06-01 00:00:00
abstract::Neisseria gonorrhoeae is an obligate human pathogen that causes the common sexually transmitted infection gonorrhea. Gonococcal infections cause significant morbidity, particularly among women, as the organism ascends to the upper reproductive tract, resulting in pelvic inflammatory disease, ectopic pregnancy, and inf...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05806-11
更新日期:2011-12-01 00:00:00
abstract::We previously identified a cell wall-associated protein from Fusobacterium nucleatum, a Gram-negative bacterium of the oral cavity, that induces human beta defensin 2 (hBD-2) in primary human oral epithelial cells (HOECs) and designated it FAD-I (Fusobacterium-associated defensin inducer). Here, we report differential...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01311-15
更新日期:2016-04-22 00:00:00
abstract::We identified a T-cell determinant of the 35-kDa antigen of Mycobacterium leprae which is discriminatory against cross-sensitization by its closely related homologue in Mycobacterium avium. From synthetic peptides covering the entire sequence, those with the highest affinity and permissive binding to purified HLA-DR m...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.3.1501-1504.1999
更新日期:1999-03-01 00:00:00
abstract::Isoelectric focusing and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with acrylamide copolymerized with gelatin (substrate-SDS-PAGE) were combined to evaluate the proteinases of both long-term-grown and fresh isolates of Trichomonas vaginalis. This two-dimensional substrate-SDS-PAGE resolved a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.1.157-162.1990
更新日期:1990-01-01 00:00:00
abstract::Susceptibility to Coccidioides spp. varies widely in humans and other mammals and also among individuals within a species. Among strains of mice with various susceptibilities, immunohistopathology revealed that C57BL/6 mice were highly susceptible to the disease following intranasal infection, DBA/2n mice were interme...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00885-08
更新日期:2008-12-01 00:00:00
abstract::Once in the cytoplasm of mammalian cells, Shigella flexneri expresses a motile phenotype caused by polar directional assembly of actin. This process depends on accumulation of IcsA (VirG), a 120-kDa protein with ATPase activity, at the pole of the bacterium opposite to that at which ongoing septation occurs. IcsA is a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.2.511-517.1996
更新日期:1996-02-01 00:00:00
abstract::Chronic pulmonary infection with Pseudomonas aeruginosa is a feature of cystic fibrosis (CF) and other chronic lung diseases. Cytokines of the interleukin-17 (IL-17) family have been proposed as important in the host response to P. aeruginosa infection through their role in augmenting antibacterial immune responses, a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00717-16
更新日期:2016-11-18 00:00:00
abstract::The filarial nematode Onchocerca volvulus is the causative organism of river blindness. Our previous studies demonstrated an essential role for endosymbiotic Wolbachia bacteria in corneal disease, which is characterized by neutrophil infiltration into the corneal stroma and the development of corneal haze. To determin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00991-07
更新日期:2007-12-01 00:00:00
abstract::The gene products from an 8-kb region adjacent to the 3' end of the ptx operon are required by Bordetella pertussis for the export of pertussis holotoxin. At least one of these gene products (PtlC) is specifically required for the export of assembled holotoxin from the periplasmic space. ptlC mutants exhibit a 20-fold...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.10.3920-3926.1995
更新日期:1995-10-01 00:00:00
abstract::Lymphocyte blastogenesis assays and immunoblotting were used to investigate and compare murine B-cell responses to preparations of extracellular membrane blebs (BAg) and spirochetes (Ag) of Borrelia burgdorferi. Immunoblotting BAg, Ag, and medium control preparations with serum from naive and infected C57BL/10 mice re...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.4.1460-1467.1993
更新日期:1993-04-01 00:00:00
abstract::Temperate bacteriophage can transfer toxin-encoding genes between bacteria, often resulting in acquired pathogenicity. However, little is known regarding the effects of the eukaryotic host on the phage-pathogen interaction. Using Streptococcus pyogenes as a model, we demonstrate, both in vitro and in vivo, that the eu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.7.3782-3786.2003
更新日期:2003-07-01 00:00:00
abstract::It was previously determined that the type II secretion system (T2SS) promotes the ability of Legionella pneumophila to grow in coculture with amoebae. Here, we discerned the stage of intracellular infection that is potentiated by comparing the wild-type and T2SS mutant legionellae for their capacity to parasitize Aca...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00374-19
更新日期:2019-10-18 00:00:00
abstract::Urease from ureaplasmas was purified by immunoaffinity chromatography, and the N-terminal amino acid sequence was determined for two of the three subunits. These sequences were used to design primers for a polymerase chain reaction (PCR) that amplified most of the gene coding for one of the subunits. By using a novel ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.7.2463-2469.1991
更新日期:1991-07-01 00:00:00
abstract::A single intradermal administration of recombinant interleukin-7 (IL-7) has been shown to aggravate the course of murine schistosomiasis, to favor the development of Th2-associated antibodies specific for the parasite, and to alter migration kinetics and/or migratory route of the parasite within its vertebrate host. H...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.8.4183-4190.1999
更新日期:1999-08-01 00:00:00
abstract::Infection with the intracellular protozoan parasite Toxoplasma gondii causes serious public health problems and is of great economic importance worldwide. The micronemal protein MIC3, which is a potent adhesin of T. gondii, could be a significant candidate vaccine against toxoplasmosis. In this study, all CBA/J mice i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.11.6222-6228.2003
更新日期:2003-11-01 00:00:00