Specific and nonspecific responses of murine B cells to membrane blebs of Borrelia burgdorferi.

abstract：:The American opossum is the only experimental animal that regularly develops bacterial endocarditis spontaneously. There was no relation between the ability of opossums to clear bacteria from the bloodstream and the subsequent development of endocarditis. ...

journal_title：Infection and immunity

authors： Musher DM,Richie Y

更新日期：1974-06-01 00:00:00

abstract：:The hallmarks of pulmonary Mycobacterium tuberculosis infection are lung granulomas. These organized structures are composed of host immune cells whose purpose is to contain or clear infection, creating a complex hub of immune and bacterial cell activity, as well as limiting pathology in the lungs. Yet, given cellular...

journal_title：Infection and immunity

authors： Wong EA,Joslyn L,Grant NL,Klein E,Lin PL,Kirschner DE,Flynn JL

更新日期：2018-08-22 00:00:00

abstract：:Fab fragments prepared from the immunoglobulin G monoclonal antibody (MAb) 4C12, which reacts with a determinant expressed on the hyphal extension of germ tubes of Candida albicans, inhibited germ tube formation, but intact MAb 4C12 did not. Indirect immunofluorescence showed a punctate binding pattern on cells incuba...

journal_title：Infection and immunity

authors： Casanova M,Martínez JP,Chaffin WL

更新日期：1990-11-01 00:00:00

abstract：:Two distinct types of granulomas were produced in the draining lymph nodes by immunizing guinea pigs with Mycobacterium bovis BCG or Mycobacterium leprae, as reported earlier (Narayanan et al., J. Pathol. 134:253-265, 1981). In the BCG-induced granuloma there is successful containment, killing, and degradation of the ...

journal_title：Infection and immunity

authors： Mathew RC,Katayama I,Gupta SK,Curtis J,Turk JL

更新日期：1983-01-01 00:00:00

abstract：:The mechanism of in vitro synergistic lysis of sheep erythrocytes by Corynebacterium ovis and Corynebacterium equi was investigated. Hemolysis required (i) the action of phospholipase D from C. ovis, (ii) the action of an extracellular protein of C. equi, and (iii) Mg2+. Maximum lysis required imposition on the system...

journal_title：Infection and immunity

authors： Bernheimer AW,Linder R,Avigad LS

更新日期：1980-07-01 00:00:00

abstract：:The Lyme disease spirochete Borrelia burgdorferi reduces the expression of outer surface protein C (OspC) in response to the development of an anti-OspC humoral response, leading to the hypothesis that the ability to repress OspC expression is critical for the pathogen to proceed to chronic infection. B. burgdorferi w...

journal_title：Infection and immunity

authors： Xu Q,Seemanapalli SV,McShan K,Liang FT

更新日期：2006-09-01 00:00:00

abstract：:Saccharomyces boulardii, a nonpathogenic yeast, is effective in treating some patients with Clostridium difficile diarrhea and colitis. We have previously reported that S. boulardii inhibits rat ileal secretion in response to C. difficile toxin A possibly by releasing a protease that digests the intestinal receptor fo...

journal_title：Infection and immunity

authors： Castagliuolo I,LaMont JT,Nikulasson ST,Pothoulakis C

更新日期：1996-12-01 00:00:00

abstract：:Cell surface protein SSP-5 in the oral bacterium Streptococcus gordonii M5 binds human salivary agglutinin in a Ca(2+)-dependent reaction (D.R. Demuth, E.E. Golub, and D. Malamud, J. Biol. Chem. 265:7120-7126, 1990). The region of the gene encoding an N-terminal segment of a related polypeptide (SspA) in S. gordonii D...

journal_title：Infection and immunity

authors： Jenkinson HF,Terry SD,McNab R,Tannock GW

更新日期：1993-08-01 00:00:00

abstract：:Polymicrobial intra-abdominal infections (IAIs) are a significant cause of morbidity and mortality, particularly when fungal pathogens are involved. Our experimental murine model of IAI involving intraperitoneal inoculation of Candida albicans and Staphylococcus aureus results in synergistic lethality (∼80%) due to ex...

journal_title：Infection and immunity

authors： Ikeh MAC,Fidel PL Jr,Noverr MC

更新日期：2018-06-21 00:00:00

abstract：:Genomic DNA fingerprint analysis was performed on 39 Staphylococcus aureus and 28 Enterococcus faecalis endophthalmitis isolates collected from multiple clinical centers. Among 21 S. aureus genomic DNA fingerprint patterns identified, five clonotypes were recovered from multiple unrelated patients and accounted for 58...

journal_title：Infection and immunity

authors： Booth MC,Hatter KL,Miller D,Davis J,Kowalski R,Parke DW,Chodosh J,Jett BD,Callegan MC,Penland R,Gilmore MS

更新日期：1998-01-01 00:00:00

abstract：:Group A streptococci isolated from skin adhere in greater numbers to human skin epithelial cells than to cells obtained from buccal mucosa whereas streptococci isolated from a throat tend to adhere in greater numbers to buccal epithelial cells than to skin epithelial cells in vitro. M protein-producing strains of grou...

journal_title：Infection and immunity

authors： Alkan M,Ofek I,Beachey EH

更新日期：1977-11-01 00:00:00

abstract：:Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1beta (IL-1beta), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. ...

journal_title：Infection and immunity

authors： Vecchiarelli A,Retini C,Monari C,Casadevall A

更新日期：1998-03-01 00:00:00

abstract：:Polymicrobial intra-abdominal infections (IAI) are clinically prevalent and cause significant morbidity and mortality, especially those involving fungi. Our laboratory developed a mouse model of polymicrobial IAI and demonstrated that coinfection with Candida albicans and Staphylococcus aureus (C. albicans/S. aureus) ...

journal_title：Infection and immunity

authors： Lilly EA,Yano J,Esher SK,Hardie E,Fidel PL Jr,Noverr MC

更新日期：2019-07-23 00:00:00

abstract：:Lipopolysaccharide (LPS) is an amphipathic macromolecule that is highly aggregated in aqueous preparations. LPS-binding protein (LBP) catalyzes the transfer of single LPS molecules, segregated from an LPS aggregate, to high-density lipoproteins (HDL), which results in the neutralization of LPS. When fluorescein isothi...

journal_title：Infection and immunity

authors： de Haas CJ,Poppelier MJ,van Kessel KP,van Strijp JA

更新日期：2000-09-01 00:00:00

abstract：:Nontypeable Haemophilus influenzae (NTHI) has four loci, lic-1 to lic-3 and lgtC, that generate phase-variable lipooligosaccharide (LOS) structures. lic-1, which is required for the expression of phosphorylcholine (ChoP), is the best characterized and is associated with an enhanced ability of H. influenzae to persist ...

journal_title：Infection and immunity

authors： Tong HH,Blue LE,James MA,Chen YP,DeMaria TF

更新日期：2000-08-01 00:00:00

abstract：:Bacteria utilize type III secretion systems (T3SS) to deliver effectors directly into host cells. Hence, it is very important to identify the functions of bacterial (T3SS) effectors to understand host-pathogen interactions. Edwardsiella piscicida encodes a functional T3SS effector, EseK, which can be translocated into...

journal_title：Infection and immunity

authors： Cao H,Han F,Tan J,Hou M,Zhang Y,Yang D,Liu Q

更新日期：2018-08-22 00:00:00

abstract：:Various factors affecting the aggregation of Actinomyces naeslundii strain 12104 were studied. When the pH of glucose-supplemented growth medium fell below 5.5, the cells aggregated and formed microbial masses which tenaciously adhered to the culture vessels. When the organism was cultured in the same medium in the ab...

journal_title：Infection and immunity

authors： Miller CH,Palenik CJ,Stamper KE

更新日期：1978-09-01 00:00:00

abstract：:Previous studies have noted that the prevalence of certain gonococcal colony types is influenced by the physiological state of the human host. Consequently eight different gonococcal strains were passed on clear typing medium, and opaque (Op) and transparent (Tr) variants of heavily pilated (P++) bacteria were selecte...

journal_title：Infection and immunity

authors： Salit IE,Gotschlich EC

更新日期：1978-11-01 00:00:00

abstract：:Bacterial strains of Haemophilus species and Streptococcus pneumoniae were examined for synthesis of the enzyme immunoglobulin A1 (IgA1) protease. Of 36 H. influenzae strains examined, 35 produced IgA1 protease; strains included all six capsular types, unencapsulated variants of types b and d, and untypable H. influen...

journal_title：Infection and immunity

authors： Male CJ

更新日期：1979-10-01 00:00:00

abstract：:The level of type-specific antigen (that covalently associated with the cell wall peptidoglycan and that released extracellularly) synthesized by virulent and avirulent strains of type III group B streptococci was quantitated and compared. Additionally, the effect of the physiological age of the cells and the influenc...

journal_title：Infection and immunity

authors： Yeung MK,Mattingly SJ

更新日期：1984-05-01 00:00:00

abstract：:A murine respiratory infection model was used to study the mechanism of protective immunity to Bordetella pertussis. We found that nude mice, which are deficient in T cells, developed a persistent infection and failed to clear the bacteria after aerosol inoculation. In contrast, normal adult nonimmune mice cleared a r...

journal_title：Infection and immunity

authors： Mills KH,Barnard A,Watkins J,Redhead K

更新日期：1993-02-01 00:00:00

abstract：:The ApxIIA protein secreted from Actinobacillus pleuropneumoniae is both hemolytic and cytotoxic. However, when the cloned apxII operon is expressed in Escherichia coli, two forms of the ApxIIA protein can be recovered. Toxin which remains intracellular has hemolytic and cytotoxic activities, while toxin that is secre...

journal_title：Infection and immunity

authors： Tu AH,Hausler C,Young R,Struck DK

更新日期：1994-05-01 00:00:00

abstract：:We identified nonhemolytic mutants of Listeria monocytogenes that were severely deficient in their ability to invade mammalian nonprofessional phagocytes. These mutants were generated spontaneously or by means of transposon Tn916 mutagenesis. In terms of their extracellular proteins, the noninvasive mutants were defic...

journal_title：Infection and immunity

authors： Kathariou S,Pine L,George V,Carlone GM,Holloway BP

更新日期：1990-12-01 00:00:00

abstract：:Screening of a Mycobacterium tuberculosis genomic DNA library in the lambda gt11 expression vector was carried out by using, as probes, sera from tuberculous patients and murine monoclonal antibody H61.3 recognizing a mycobacterial 35-kilodalton protein present only on the M. tuberculosis complex. The recombinant beta...

journal_title：Infection and immunity

authors： Vismara D,Mezzopreti MF,Gilardini Montani MS,Del Porto P,Lombardi G,Piccolella E,Damiani G,Rappuoli R,Colizzi V

更新日期：1990-01-01 00:00:00

abstract：:Encapsulated Streptococcus pneumoniae of serotypes 2, 9N, 14, 21, and 23F and an unencapsulated variant of type 2 pneumococci were efficiently phagocytosed by both aerobically and anaerobically incubated human leukocytes. In the presence of O2, the pneumococci rapidly lost their viability, whereas during anaerobiosis,...

journal_title：Infection and immunity

authors： Thore M,Löfgren S,Tärnvik A,Monsen T,Selstam E,Burman LG

更新日期：1985-01-01 00:00:00

abstract：:Lipopolysaccharides obtained from Brucella abortus, B. melitensis, and B. suis, but not B. canis, were found to contain amino sugars identified as glucosamine and quinovosamine by cation exchange and thin-layer cellulose chromatography and ninhydrin degradation. ...

journal_title：Infection and immunity

authors： Bowser DV,Wheat RW,Foster JW,Leong D

更新日期：1974-04-01 00:00:00

abstract：:We explored the role of urokinase and tissue-type plasminogen activators (uPA and tPA), as well as the uPA receptor (uPAR; CD87) in mouse severe malaria (SM), using genetically deficient (-/-) mice. The mortality resulting from Plasmodium berghei ANKA infection was delayed in uPA(-/-) and uPAR(-/-) mice but was simila...

journal_title：Infection and immunity

authors： Piguet PF,Da Laperrousaz C,Vesin C,Tacchini-Cottier F,Senaldi G,Grau GE

更新日期：2000-07-01 00:00:00

abstract：:Membrane and soluble fractions of Mycoplasma pneumoniae, M. pulmonis, and M. laidlawii B were prepared by hypotonic lysis of whole cells. The membranes of M. pneumoniae and M. laidlawii B contained, as percentage of dry weight: 34 to 37% protein, 59 to 61% lipid, 3 to 4% carbohydrate as hexose, and 0.2% ribonucleic ac...

journal_title：Infection and immunity

authors： Pollack JD,Somerson NL,Senterfit LB

更新日期：1970-09-01 00:00:00

abstract：:In experimentally infected human volunteers, the cutaneous immune response to Haemophilus ducreyi is orchestrated by serum, polymorphonuclear leukocytes, macrophages, T cells, and myeloid dendritic cells (DC). This response either leads to spontaneous resolution of infection or progresses to pustule formation, which i...

journal_title：Infection and immunity

authors： Humphreys TL,Li L,Li X,Janowicz DM,Fortney KR,Zhao Q,Li W,McClintick J,Katz BP,Wilkes DS,Edenberg HJ,Spinola SM

更新日期：2007-12-01 00:00:00

abstract：:Streptococcus pneumoniae is a leading cause of bacterial pneumonia, meningitis, and sepsis in children. Human immunity to pneumococcal infections has been assumed to depend on anticapsular antibodies. However, recent findings from murine models suggest that alternative mechanisms, dependent on T helper cells, are also...

journal_title：Infection and immunity

authors： Olliver M,Hiew J,Mellroth P,Henriques-Normark B,Bergman P

更新日期：2011-10-01 00:00:00