Receptor-binding function of type 1 pili effects bladder colonization by a clinical isolate of Escherichia coli.

Abstract:

:The role of type 1 pili in promoting bladder colonization was examined by constructing two mutant strains of a clinical Escherichia coli isolate. One mutant was isogenic to the parental strain save for a lesion in a gene required for pilus receptor binding; the other mutant was isogenic save for a lesion in the gene encoding the pilus structural subunit. Using mixed infections of the parental and mutant strains in an ascending rat cystitis model, we found that type 1-piliated mutants that lacked the receptor-binding function were as ineffective in bladder colonization as were mutants lacking the entire organelle.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Keith BR,Maurer L,Spears PA,Orndorff PE

doi

10.1128/IAI.53.3.693-696.1986

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

693-6

issue

3

eissn

0019-9567

issn

1098-5522

journal_volume

53

pub_type

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