Abstract:
:Temperate bacteriophage can transfer toxin-encoding genes between bacteria, often resulting in acquired pathogenicity. However, little is known regarding the effects of the eukaryotic host on the phage-pathogen interaction. Using Streptococcus pyogenes as a model, we demonstrate, both in vitro and in vivo, that the eukaryote mediates the efficient induction of toxin-encoding temperate phage and the resultant conversion of Tox(-) flora to Tox(+). Furthermore, we show that both phage induction and subsequent conversion need not happen in the same mammalian host, as host-to-host phage transmission can result in toxigenic conversion within the secondary host. Ultimately, our findings demonstrate that the eukaryotic host serves as an essential component in the phage-mediated evolution of virulence within the microbial population.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Broudy TB,Fischetti VAdoi
10.1128/iai.71.7.3782-3786.2003keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
3782-6issue
7eissn
0019-9567issn
1098-5522journal_volume
71pub_type
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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更新日期:1988-05-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2003-03-01 00:00:00
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更新日期:2019-10-18 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1977-06-01 00:00:00