Mitogenic activities of synthetic Escherichia coli lipid A and a synthetic partial structure (tripalmitoyl pentapeptide) of E. coli lipoprotein.

abstract：:As reported elsewhere, an enterotoxigenic strain of Escherichia coli serotype O25:K98:NM was epidemiologically incriminated as the etiological agent in a shipboard outbreak of diarrheal illness. This enterotoxigenic E. coli strain and possibly other enteric isolates were found to produce heat-labile toxin and not heat...

journal_title：Infection and immunity

authors： Wachsmuth K,Wells J,Shipley P,Ryder R

更新日期：1979-06-01 00:00:00

abstract：:Staphylococcus aureus experimental endocarditis relies on sequential fibrinogen binding (for valve colonization) and fibronectin binding (for endothelial invasion) conferred by peptidoglycan-attached adhesins. Fibronectin-binding protein A (FnBPA) reconciles these two properties--as well as elastin binding--and promot...

journal_title：Infection and immunity

authors： Piroth L,Que YA,Widmer E,Panchaud A,Piu S,Entenza JM,Moreillon P

更新日期：2008-08-01 00:00:00

abstract：:Streptococcus pneumoniae is a major cause of illness and death in children in developing countries. In these children, zinc deficiency is associated with an increased risk of acute respiratory tract infections, which can be reduced by daily zinc administration. Severe infections decrease zinc levels in plasma and may ...

journal_title：Infection and immunity

authors： Strand TA,Hollingshead SK,Julshamn K,Briles DE,Blomberg B,Sommerfelt H

更新日期：2003-04-01 00:00:00

abstract：:Staphylococcus aureus is an important pathogen of humans and other animals, causing bacteremia, abscesses, endocarditis, and other infectious syndromes. A signature-tagged mutagenesis (STM) system was adapted for use in studying the genes required for in vivo survival of S. aureus. An STM library was ultimately create...

journal_title：Infection and immunity

authors： Schwan WR,Coulter SN,Ng EY,Langhorne MH,Ritchie HD,Brody LL,Westbrock-Wadman S,Bayer AS,Folger KR,Stover CK

更新日期：1998-02-01 00:00:00

abstract：:The mechanisms that govern the initial interaction between Paracoccidioides brasiliensis, a primary dimorphic fungal pathogen, and cells of the innate immunity need to be clarified. Our previous studies showed that Toll-like receptor 2 (TLR2) and TLR4 regulate the initial interaction of fungal cells with macrophages a...

journal_title：Infection and immunity

authors： Loures FV,Pina A,Felonato M,Feriotti C,de Araújo EF,Calich VL

更新日期：2011-06-01 00:00:00

abstract：:Mice with a null deletion mutation in the gamma interferon (IFN-gamma) receptor gene were used to study the role of IFN-gamma responsiveness during experimental pulmonary cryptococcosis. Cryptococcus neoformans was inoculated intratracheally into mice lacking the IFN-gamma receptor gene (IFN-gammaR-/-) and into contro...

journal_title：Infection and immunity

authors： Chen GH,McDonald RA,Wells JC,Huffnagle GB,Lukacs NW,Toews GB

更新日期：2005-03-01 00:00:00

abstract：:Relapsing fever (RF) is a spirochetal infection characterized by relapses of a febrile illness and spirochetemia due to the sequential appearance and disappearance of isogenic serotypes in the blood. The only difference between isogenic serotypes is the variable major outer membrane lipoprotein. In the absence of spec...

journal_title：Infection and immunity

authors： Sethi N,Sondey M,Bai Y,Kim KS,Cadavid D

更新日期：2006-11-01 00:00:00

abstract：:Oral inoculation of calves and steers with 10(10) CFU of Escherichia coli O157:H7 induced prompt and sustained increases in serum antibodies to O157 lipopolysaccharide. Neutralizing antibodies to verotoxin 1 also increased rapidly in most steers but more gradually in calves. None of the animals developed neutralizing ...

journal_title：Infection and immunity

authors： Johnson RP,Cray WC Jr,Johnson ST

更新日期：1996-05-01 00:00:00

abstract：:We found that oral immunization with flagellum-defective mutant strains of Salmonella enterica serovar Typhimurium with the ClpXP-deficient background protected mice against oral challenge with the virulent strain. These data indicate that Salmonella flagellin is not a dominant protective antigen in oral immunization ...

journal_title：Infection and immunity

authors： Kodama C,Matsui H

更新日期：2004-04-01 00:00:00

abstract：:The diarrheagenic pathogen enteropathogenic Escherichia coli (EPEC) is responsible for significant infant mortality and morbidity, particularly in developing countries. EPEC pathogenesis relies on a type III secretion system-mediated transfer of virulence effectors into host cells. EPEC modulates host cell survival an...

journal_title：Infection and immunity

authors： Roxas JL,Koutsouris A,Viswanathan VK

更新日期：2007-05-01 00:00:00

abstract：:Spotted fever group rickettsiae are known to produce distinct plaque phenotypes. Strains that cause lytic infections in cell culture form clear plaques, while nonlytic strains form opaque plaques in which the cells remain intact. Clear plaques have historically been associated with more-virulent species or strains of ...

journal_title：Infection and immunity

authors： Clark TR,Ellison DW,Kleba B,Hackstadt T

更新日期：2011-04-01 00:00:00

abstract：:The gonococcal pilus is a primary virulence factor, providing the initial attachment of the bacterial cell to human mucosal tissues. Pilin, the major subunit of the pilus, can carry a wide spectrum of primary amino acid sequences which are generated by the action of a complex antigenic variation system. Changes in the...

journal_title：Infection and immunity

authors： Long CD,Madraswala RN,Seifert HS

更新日期：1998-05-01 00:00:00

abstract：:Isolated outer membranes of Borrelia burgdorferi 297 were utilized to obtain partial amino acid sequence information for a low-molecular-weight, outer membrane-associated polypeptide. Degenerate oligonucleotide primers based upon this information were used to amplify a 100-bp probe for detection of the corresponding f...

journal_title：Infection and immunity

authors： Lahdenne P,Porcella SF,Hagman KE,Akins DR,Popova TG,Cox DL,Katona LI,Radolf JD,Norgard MV

更新日期：1997-02-01 00:00:00

abstract：:Toxoplasma gondii is an obligate intracellular parasite that resides in the cytoplasm of its host in a unique membrane-bound vacuole known as the parasitophorous vacuole (PV). The membrane surrounding the parasite is remodeled by the dense granules, secretory organelles that release an array of proteins into the vacuo...

journal_title：Infection and immunity

authors： Rome ME,Beck JR,Turetzky JM,Webster P,Bradley PJ

更新日期：2008-11-01 00:00:00

abstract：:A preparation procedure for scanning electron microscopy was developed by which gononcoccal colonies can be studied directly on the agar surface. After glutaraldehyde fixation directly in petri dishes, small agar pieces were cut out and dehydrated stepwise in increasing concentrations of ethanol. The blocks were there...

journal_title：Infection and immunity

authors： Elmros T,Hörstedt P,Winblad B

更新日期：1975-09-01 00:00:00

abstract：:Dendritic cells (DC) suffer a maturation defect following interaction with erythrocytes infected with malaria parasites and become unable to induce protective malaria liver-stage immunity. Here we show that, by contrast, maturation-arrested DC in vitro are capable of the successful induction of antigen-specific gamma ...

journal_title：Infection and immunity

authors： Pouniotis DS,Proudfoot O,Bogdanoska V,Apostolopoulos V,Fifis T,Plebanski M

更新日期：2004-09-01 00:00:00

abstract：:Moraxella catarrhalis is a causative agent of otitis media in children and lower respiratory tract infections in adults suffering from chronic obstructive pulmonary disease (COPD). This strict human pathogen continues to be a significant cause of disease in this broad spectrum of patients because there is no available...

journal_title：Infection and immunity

authors： Schwingel JM,Edwards KJ,Cox AD,Masoud H,Richards JC,St Michael F,Tekwe CD,Sethi S,Murphy TF,Campagnari AA

更新日期：2009-10-01 00:00:00

abstract：:Salmonella enterica serovar Enteritidis (S. Enteritidis) is a major etiologic agent of nontyphoid salmonellosis in the United States. S. Enteritidis persistently and silently colonizes the intestinal and reproductive tract of laying hens, resulting in contaminated poultry products. The consumption of contaminated poul...

journal_title：Infection and immunity

authors： McKelvey JA,Yang M,Jiang Y,Zhang S

更新日期：2014-12-01 00:00:00

abstract：:No effective therapy exists for Cryptosporidium parvum, a coccidial protozoan parasite that causes severe diarrhea in patients with AIDS. The role of microtubules in parasite invasion of host cells was investigated by incubating 10(7) oocysts with a HT 29.74 cell line for 24 h in the presence of microtubule-disrupting...

journal_title：Infection and immunity

authors： Wiest PM,Johnson JH,Flanigan TP

更新日期：1993-11-01 00:00:00

abstract：:A recent study demonstrated that polyclonal antibodies to Rickettsia conorii and monoclonal antibodies to outer membrane proteins A (OmpA) and B (OmpB) provided effective, Fc-dependent, passive immunity, even in severe combined immunodeficient mice with an established infection. In order to determine the mechanism of ...

journal_title：Infection and immunity

authors： Feng HM,Whitworth T,Popov V,Walker DH

更新日期：2004-06-01 00:00:00

abstract：:Haemophilus ducreyi is resistant to killing by normal serum antibody and complement. We discovered an H. ducreyi outer membrane protein required for expression of serum resistance and termed it DsrA (for "ducreyi serum resistance A"). The dsrA locus was cloned, sequenced, and mutagenized. An isogenic mutant (FX517) of...

journal_title：Infection and immunity

authors： Elkins C,Morrow KJ Jr,Olsen B

更新日期：2000-03-01 00:00:00

abstract：:Sephadex G-200 filtration was used for fractionating dengue type 2 (DEN-2)-infected suckling mouse brain (SMB) supernatant fluids. The high-molecular-weight fraction, which was eluted in the void volume, showed no increase in type specificity when tested against immune ascitic fluid to the four prototype dengue viruse...

journal_title：Infection and immunity

authors： Cornesky RA,Hammon WM,Atchison RW,Sather GE

更新日期：1972-12-01 00:00:00

abstract：:A plaque assay system for pathogenic rickettsiae, which utilizes primary chick embryo tissue cultures, is described. It proved to be a highly reproducible measure of infectiousness for Rickettsia rickettsi and R. typhi, which were employed in most studies; as well as for R. canada, R. prowazeki, R. sibirica, R. akari,...

journal_title：Infection and immunity

authors： Wike DA,Tallent G,Peacock MG,Ormsbee RA

更新日期：1972-05-01 00:00:00

abstract：:An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of...

journal_title：Infection and immunity

authors： D'Avila H,Almeida PE,Roque NR,Castro-Faria-Neto HC,Bozza PT

更新日期：2007-03-01 00:00:00

abstract：:An immunomodulatory role of arthropod saliva has been well documented, but evidence for an effect on Plasmodium sp. infectiousness remains controversial. Mosquito saliva may orient the immune response toward a Th2 profile, thereby priming a Th2 response against subsequent antigens, including Plasmodium. Orientation to...

journal_title：Infection and immunity

authors： Lawaly R,Konate L,Marrama L,Dia I,Diallo D,Diène Sarr F,Schneider BS,Casademont I,Diallo M,Brey PT,Sakuntabhai A,Mecheri S,Paul R

更新日期：2012-06-01 00:00:00

abstract：:The immunoprophylactic effect of chemically inactivated Pseudomonas aeruginosa exotoxin A in experimental pseudomonas infections was studied. Exotoxin A toxoids were prepared by Formalin (f-TXD) or glutaraldehyde (g-TXD) treatment. Immunization of mice with three or four doses (10 micrograms each) of f-TXD and the syn...

journal_title：Infection and immunity

authors： Pavlovskis OR,Edman DC,Leppla SH,Wretlind B,Lewis LR,Martin KE

更新日期：1981-05-01 00:00:00

abstract：:By crossed immunoelectrophoresis and Western blotting (immunoblotting), it was shown that Borrelia burgdorferi expresses the 60-kilodalton Common Antigen (CA) that is cross-reactive with an equivalent antigen in a wide range of remotely related bacteria. B. burgdorferi CA is strongly immunogenic. A B. burgdorferi geno...

journal_title：Infection and immunity

authors： Hansen K,Bangsborg JM,Fjordvang H,Pedersen NS,Hindersson P

更新日期：1988-08-01 00:00:00

abstract：:Listeria monocytogenes is a ubiquitous potentially pathogenic organism requiring iron for growth and virulence. Although it does not produce siderophores, L. monocytogenes is able to obtain iron by using either exogenous siderophores produced by various microorganisms or natural catechol compounds widespread in the en...

journal_title：Infection and immunity

authors： Coulanges V,Andre P,Ziegler O,Buchheit L,Vidon DJ

更新日期：1997-07-01 00:00:00

abstract：:The chlamydial cryptic plasmid encodes eight putative open reading frames (ORFs), designated pORF1 to -8. Antibodies raised against these ORF proteins were used to localize the endogenous proteins during chlamydial infection. We found that the pORF5 protein (also known as pgp3) was detected mainly in the cytosol of Ch...

journal_title：Infection and immunity

authors： Li Z,Chen D,Zhong Y,Wang S,Zhong G

更新日期：2008-08-01 00:00:00

abstract：:The blood-stage development of malaria parasites is initiated by the invasion of merozoites into susceptible erythrocytes. Specific receptor-ligand interactions must occur for the merozoites to first attach to and then invade erythrocytes. Because the invasion process is essential for the parasite's survival and the m...

journal_title：Infection and immunity

authors： Tsuboi T,Kappe SH,al-Yaman F,Prickett MD,Alpers M,Adams JH

更新日期：1994-12-01 00:00:00