Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy.


:An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation.


Infect Immun


Infection and immunity


D'Avila H,Almeida PE,Roque NR,Castro-Faria-Neto HC,Bozza PT




Has Abstract


2007-03-01 00:00:00














  • Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization.

    abstract::In the murine model of urinary tract infections (UTI), cystitis by uropathogenic Escherichia coli (UPEC) occurs through an intimate relationship with the bladder superficial umbrella cell entailing cycles of adherence, invasion, intracellular bacterial community (IBC) formation, and dispersal (fluxing) from the intrac...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Wright KJ,Seed PC,Hultgren SJ

    更新日期:2005-11-01 00:00:00

  • Probable L-forms of Nocardia asteroides induced in cultured mouse peritoneal macrophages.

    abstract::Mouse peritoneal macrophages were infected with varying numbers of Nocardia asteroides 10905, and the fate of the ingested organisms was determined by viable plate count (VPC), light microscopy (LM), immunofluorescent microscopy (IM), and electron microscopy (EM). The results obtained with these methods differed. VPC ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Bourgeois L,Beaman BL

    更新日期:1974-03-01 00:00:00

  • Nutritional requirements for synthesis of heat-labile enterotoxin by enterotoxigenic strains of Escherichia coli.

    abstract::Optimal growth conditions have been established for production of heat-labile enterotoxin (LT) by both porcine and human strains of enterotoxigenic (ENT(+)) Escherichia coli. There were no unusual growth factor requirements, and some strains produced fairly high levels of LT in a basal salts medium containing 0.5% glu...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Gilligan PH,Robertson DC

    更新日期:1979-01-01 00:00:00

  • Moraxella catarrhalis bacterium without endotoxin, a potential vaccine candidate.

    abstract::Lipooligosaccharide (LOS) is a major surface component of Moraxella catarrhalis and a possible virulence factor in the pathogenesis of human infections caused by this organism. The presence of LOS on the bacterium is an obstacle to the development of vaccines derived from whole cells or outer membrane components of th...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Peng D,Hong W,Choudhury BP,Carlson RW,Gu XX

    更新日期:2005-11-01 00:00:00

  • Caspase and bid involvement in Clostridium difficile toxin A-induced apoptosis and modulation of toxin A effects by glutamine and alanyl-glutamine in vivo and in vitro.

    abstract::Clostridium difficile is the leading cause of nosocomial bacterial diarrhea. Glutamine and its stable and highly soluble derivative alanyl-glutamine, have been beneficial in models of intestinal injury. In this study, we extend our work on the mechanisms of Clostridium difficile toxin A (TxA)-induced apoptosis in huma...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Carneiro BA,Fujii J,Brito GA,Alcantara C,Oriá RB,Lima AA,Obrig T,Guerrant RL

    更新日期:2006-01-01 00:00:00

  • Antihistoplasma effect of activated mouse splenic macrophages involves production of reactive nitrogen intermediates.

    abstract::The mechanism by which recombinant murine gamma interferon (rMuIFN-gamma) and bacterial lipopolysaccharide (LPS) activate mouse resident splenic macrophages to inhibit the intracellular growth of the fungus Histoplasma capsulatum was examined. Growth inhibition depended on L-arginine metabolism. The growth inhibitory ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Lane TE,Wu-Hsieh BA,Howard DH

    更新日期:1994-05-01 00:00:00

  • Endogenous interleukin-10 is required for prevention of a hyperinflammatory intracerebral immune response in Listeria monocytogenes meningoencephalitis.

    abstract::To analyze the role of interleukin-10 (IL-10) in bacterial cerebral infections, we studied cerebral listeriosis in IL-10-deficient (IL-10(-/-)) and wild-type (WT) mice, the latter of which express high levels of IL-10 in both primary and secondary cerebral listeriosis. IL-10(-/-) mice succumbed to primary as well as s...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Deckert M,Soltek S,Geginat G,Lütjen S,Montesinos-Rongen M,Hof H,Schlüter D

    更新日期:2001-07-01 00:00:00

  • Complement C3 as a Prompt for Human Macrophage Death during Infection with Francisella tularensis Strain SCHU S4.

    abstract::Tularemia is caused by the Gram-negative bacterial pathogen Francisella tularensis Infection of macrophages and their subsequent death are believed to play important roles in the progression of disease. Because complement is a particularly effective opsonin for Francisella, we asked whether complement-dependent uptake...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Brock SR,Parmely MJ

    更新日期:2017-09-20 00:00:00

  • Defining the interaction of the Treponema pallidum adhesin Tp0751 with laminin.

    abstract::Various invasive pathogens attach to host tissues via the extracellular matrix component laminin, the major glycoprotein found within basement membranes. Previous investigations identified the laminin-binding adhesin Tp0751 within the spirochete bacterium Treponema pallidum. In the current study, Tp0751 was shown to a...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Cameron CE,Brouwer NL,Tisch LM,Kuroiwa JM

    更新日期:2005-11-01 00:00:00

  • Localization of translocating Escherichia coli, Proteus mirabilis, and Enterococcus faecalis within cecal and colonic tissues of monoassociated mice.

    abstract::Normal bacteria can translocate (migrate) across an intact intestinal mucosa, but the anatomical site of bacterial translocation has not been defined. Gastrointestinal (GI) cross-sections were obtained from mice monoassociated with high cecal concentrations of Escherichia coli, Proteus mirabilis, or Enterococcus faeca...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Wells CL,Erlandsen SL

    更新日期:1991-12-01 00:00:00

  • Potentiating effect of bile on enterotoxin-induced diarrhea.

    abstract::The influence of bile acids on adenosine 3',5'-phosphate-induced intestinal secretion was studied in mice. Bile flow was stopped by ligation of the common bile duct, and secretion was induced in ligated loops of the small intestine. The decrease of bile led to inhibition of hypersecretion after challenge with heat-lab...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Lange S,Lönnroth I

    更新日期:1982-02-01 00:00:00

  • Interaction of staphylococcal exfoliative toxin with concanavalin A.

    abstract::Treatment of mouse embryo fibroblasts (MEF) grown in vitro with purified staphylococcal exfoliative toxin (ET) increased the concanavalin A (Con A) agglutinability of MEF 3.5-fold over control cells. Possible explanations for this phenomenon were investigated. ET lacked proteolytic activity on denatured casein. Con A,...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Rogolsky M,Wiley BB,Keyhani M,Glasgow LA

    更新日期:1974-12-01 00:00:00

  • Antibodies to cell envelope proteins of Pseudomonas aeruginosa in cystic fibrosis patients.

    abstract::Many vaccines containing somatic and secreted antigens of Pseudomonas aeruginosa have been reported. The vaccines containing lipopolysaccharide have been found to provide type-specific protection, but the endotoxin content of these vaccines does not make it feasible to use them in patients who are already debilitated....

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Fernandes PB,Kim C,Cundy KR,Haung NN

    更新日期:1981-08-01 00:00:00

  • Susceptibility of inbred and outbred mouse strains to Sendai virus and prevalence of infection in laboratory rodents.

    abstract::Sendai virus is one of the more prevalent and serious virus infections of rodents. Infection was found in 66% of the mouse, 63% of the rat, 83% of the hamster, and 44% of the guinea pig colonies examined. Twenty-four inbred and outbred strains of mice were tested for their sensitivity to lethal Sendai virus infection....

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Parker JC,Whiteman MD,Richter CB

    更新日期:1978-01-01 00:00:00

  • Functional Analysis of the Role of Toxoplasma gondii Nucleoside Triphosphate Hydrolases I and II in Acute Mouse Virulence and Immune Suppression.

    abstract::Bioluminescent reporter assays have been widely used to study the effect of Toxoplasma gondii on host gene expression. In the present study, we extend these studies by engineering novel reporter cell lines containing a gamma-activated sequence (GAS) element driving firefly luciferase (FLUC). In RAW264.7 macrophages, T...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Olias P,Sibley LD

    更新日期:2016-06-23 00:00:00

  • Estimation of growth parameters for some oral bacteria grown in continuous culture under glucose-limiting conditions.

    abstract::The coexistence of bacteria in natural environments can often be explained in terms of competition for a growth-limiting substrate(s), and the outcome of such competition depends upon relevant growth parameters such as substrate affinity and yield. Dental plaque bacteria are frequently carbon and energy limited. Growt...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Rogers AH,de Jong MH,Zilm PS,van der Hoeven JS

    更新日期:1986-06-01 00:00:00

  • Macrophage Migration Inhibition Studies with Cells from Mice Vaccinated with Cell Walls of Mycobacterium bovis BCG: Characterization of the Experimental System.

    abstract::The macrophage migration inhibition test was applied to the study of delayed hypersensitivity in mice vaccinated intravenously with oil-treated cell walls of Mycobacterium bovis BCG. Migration inhibition of peritoneal exudate cells from sensitized mice was demonstrated directly upon incubation of the cells with purifi...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Yamamoto K,Anacker RL

    更新日期:1970-06-01 00:00:00

  • Occurrence of quinovosamine in lipopolysaccharides of Brucella species.

    abstract::Lipopolysaccharides obtained from Brucella abortus, B. melitensis, and B. suis, but not B. canis, were found to contain amino sugars identified as glucosamine and quinovosamine by cation exchange and thin-layer cellulose chromatography and ninhydrin degradation. ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Bowser DV,Wheat RW,Foster JW,Leong D

    更新日期:1974-04-01 00:00:00

  • Adhesion and ultrastructural properties of human enterotoxigenic Escherichia coli producing colonization factor antigens III and IV.

    abstract::Human enterotoxigenic Escherichia coli (ETEC) producing colonization factor antigen III (CFA/III) and coli surface antigens 4, 5, and 6 (CS4, CS5, and CS6) of CFA/IV were examined ultrastructurally and for ability to adhere to human small intestinal enterocytes and to cultured human intestinal mucosa. Strains of serot...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Knutton S,McConnell MM,Rowe B,McNeish AS

    更新日期:1989-11-01 00:00:00

  • Adherence of Candida albicans to endothelial cells is inhibited by prostaglandin I2.

    abstract::The adherence of Candida species yeast cells to bovine and human endothelium was measured. The adherence phenomenon is a saturable event which can be altered by the release of prostaglandin I2 (PGI2 or prostacyclin) by endothelial cells. Release of PGI2 by endothelium has a protective effect, reducing Candida albicans...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Klotz SA

    更新日期:1994-04-01 00:00:00

  • Potent immunoregulatory effects of Salmonella typhi flagella on antigenic stimulation of human peripheral blood mononuclear cells.

    abstract::A key function of monocytes/macrophages (Mphi) is to present antigens to T cells. However, upon interaction with bacteria, Mphi lose their ability to effectively present soluble antigens. This functional loss was associated with alterations in the expression of adhesion molecules and CD14 and a reduction in the uptake...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Wyant TL,Tanner MK,Sztein MB

    更新日期:1999-03-01 00:00:00

  • Redox balance via lactate dehydrogenase is important for multiple stress resistance and virulence in Enterococcus faecalis.

    abstract::Enterococcus faecalis is a highly stress resistant opportunistic pathogen. The intrinsic ruggedness of this bacterium is supposed to be the basis of its capacity to colonize the hostile environments of hospitals and to cause several kinds of infections. We show in this work that general resistance to very different en...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Rana NF,Sauvageot N,Laplace JM,Bao Y,Nes I,Rincé A,Posteraro B,Sanguinetti M,Hartke A

    更新日期:2013-08-01 00:00:00

  • Burkholderia cenocepacia ShvR-regulated genes that influence colony morphology, biofilm formation, and virulence.

    abstract::Burkholderia cenocepacia is an opportunistic pathogen that primarily infects cystic fibrosis (CF) patients. Previously, we reported that ShvR, a LysR regulator, influences colony morphology, virulence, and biofilm formation and regulates the expression of an adjacent 24-kb genomic region encoding 24 genes. In this stu...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Subramoni S,Nguyen DT,Sokol PA

    更新日期:2011-08-01 00:00:00

  • Analysis of the lytic activity of the Serpulina hyodysenteriae hemolysin.

    abstract::The hemolysins of Serpulina hyodysenteriae are active at 27 to 40 degrees C and pH 3 to 9 and are unaffected by enzymatic inhibitors. Pore formation was demonstrated by the inhibition of hemolysis with molecules of 2.0 to 2.3 nm in diameter and the release of 86rubidium from erythrocytes without hemoglobin release aft...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Hyatt DR,Joens LA

    更新日期:1997-11-01 00:00:00

  • Role of energy sensor TlpD of Helicobacter pylori in gerbil colonization and genome analyses after adaptation in the gerbil.

    abstract::Helicobacter pylori maintains colonization in its human host using a limited set of taxis sensors. TlpD is a proposed energy taxis sensor of H. pylori and dominant under environmental conditions of low bacterial energy yield. We studied the impact of H. pylori TlpD on colonization in vivo using a gerbil infection mode...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Behrens W,Schweinitzer T,Bal J,Dorsch M,Bleich A,Kops F,Brenneke B,Didelot X,Suerbaum S,Josenhans C

    更新日期:2013-10-01 00:00:00

  • Oral immunization of mice and swine with an attenuated Salmonella choleraesuis [delta cya-12 delta(crp-cdt)19] mutant containing a recombinant plasmid.

    abstract::Salmonella choleraesuis chi 3781, an attenuated [delta cya-12 delta(crp-cdt)19] mutant, was electroporated with the plasmid pBA31-R7, which codes for the expression of a 31-kDa protein from Brucella abortus (BCSP31). Recombinant S. choleraesuis chi 3781 stably maintained the pBA31-R7 plasmid and continued to express t...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Stabel TJ,Mayfield JE,Morfitt DC,Wannemuehler MJ

    更新日期:1993-02-01 00:00:00

  • Lon protease activity causes down-regulation of Salmonella pathogenicity island 1 invasion gene expression after infection of epithelial cells.

    abstract::Salmonella enterica serovar Typhimurium causes self-limiting gastroenteritis in humans and a typhoid-like disease in mice that serves as a model for typhoid infections in humans. A critical step in Salmonella pathogenesis is the invasion of enterocytes and M cells of the small intestine via expression of a type III se...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Boddicker JD,Jones BD

    更新日期:2004-04-01 00:00:00

  • Effect of lysozyme on glucose fermentation, cytoplasmic pH, and intracellular potassium concentrations in Streptococcus mutans 10449.

    abstract::Several previous findings have suggested that the cationic nature of lysozyme is a major factor in its bactericidal activity. Since a number of cationic proteins or peptides have been reported to cause membrane damage in bacteria, we investigated the effect of lysozyme on glucose fermentation and intracellular pH and ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Wang YB,Germaine GR

    更新日期:1991-02-01 00:00:00

  • Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene.

    abstract::Strains of Bacteroides fragilis that produce a ca. 20-kDa heat-labile protein toxin (termed B. fragilis toxin [BFT]) have been associated with diarrheal disease of animals and humans. BFT alters the morphology of intestinal epithelial cells both in vitro and in vivo and stimulates secretion in ligated intestinal segme...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Franco AA,Mundy LM,Trucksis M,Wu S,Kaper JB,Sears CL

    更新日期:1997-03-01 00:00:00

  • Adsorption of fibronectin onto polymethylmethacrylate and promotion of Staphylococcus aureus adherence.

    abstract::Recent data suggest that fibronectin may favor Staphylococcus aureus infection by promoting attachment to either injured tissues or implanted foreign bodies. We studied the quantitative adsorption of fibronectin onto polymethylmethacrylate (PMMA) cover slips by using a 125I-labeled preparation of the purified plasma g...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Vaudaux PE,Waldvogel FA,Morgenthaler JJ,Nydegger UE

    更新日期:1984-09-01 00:00:00