Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy.

Abstract:

:An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

D'Avila H,Almeida PE,Roque NR,Castro-Faria-Neto HC,Bozza PT

doi

10.1128/IAI.01326-06

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

1507-11

issue

3

eissn

0019-9567

issn

1098-5522

pii

IAI.01326-06

journal_volume

75

pub_type

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