Abstract:
:Natural killer (NK) cells are critically involved in the early immune response against various intracellular pathogens, including Coxiella burnetii and Chlamydia psittaciChlamydia-infected NK cells functionally mature, induce cellular immunity, and protect themselves by killing the bacteria in secreted granules. Here, we report that infected NK cells do not allow intracellular multiday growth of Coxiella, as is usually observed in other host cell types. C. burnetii-infected NK cells display maturation and gamma interferon (IFN-γ) secretion, as well as the release of Coxiella-containing lytic granules. Thus, NK cells possess a potent program to restrain and expel different types of invading bacteria via degranulation. Strikingly, though, in contrast to Chlamydia, expulsed Coxiella organisms largely retain their infectivity and, hence, escape the cell-autonomous self-defense mechanism in NK cells.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Matthiesen S,Zaeck L,Franzke K,Jahnke R,Fricke C,Mauermeir M,Finke S,Lührmann A,Knittler MRdoi
10.1128/IAI.00172-20subject
Has Abstractpub_date
2020-10-19 00:00:00issue
11eissn
0019-9567issn
1098-5522pii
IAI.00172-20journal_volume
88pub_type
杂志文章abstract::Strains of Bacteroides fragilis that produce a ca. 20-kDa heat-labile protein toxin (termed B. fragilis toxin [BFT]) have been associated with diarrheal disease of animals and humans. BFT alters the morphology of intestinal epithelial cells both in vitro and in vivo and stimulates secretion in ligated intestinal segme...
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更新日期:1978-03-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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更新日期:1988-02-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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更新日期:1977-09-01 00:00:00