Immunoglobulin A from bronchopulmonary secretions blocks bactericidal and opsonizing effects of antibody to nontypable Haemophilus influenzae.

abstract：:Pathogens produce virulence factors that interact directly with host molecules, but in many cases the host targets are unknown. The genetic and molecular identification of these orphan targets is often not feasible with mammalian experimental models. However, a substantial number of known targets are molecules and pat...

journal_title：Infection and immunity

authors： Darby C,Falkow S

更新日期：2001-10-01 00:00:00

abstract：:Leptospira interrogans is an important mammalian pathogen. Transmission from an environmental source requires adaptations to a range of new environmental conditions in the organs and tissues of the infected host. Since many pathogenic bacteria utilize temperature to discern their environment and regulate the synthesis...

journal_title：Infection and immunity

authors： Nally JE,Timoney JF,Stevenson B

更新日期：2001-01-01 00:00:00

abstract：:Using microarray technology, we studied the early differential expression of 3,528 genes in human meningothelial cells in response to meningococcal challenge. Thirty-two genes were up-regulated, and four were down-regulated. Those up-regulated included the tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-8 (b...

journal_title：Infection and immunity

authors： Wells DB,Tighe PJ,Wooldridge KG,Robinson K,Ala' Aldeen DA

更新日期：2001-04-01 00:00:00

abstract：:Mice were rendered deficient in B-cell activity by treatment with anti-mu antibody from birth. These animals were then infected intranasally with murine Chlamydia trachomatis (murine pneumonitis agent [MoPn]). They produced neither local nor systemic antibody to MoPn but had intact delayed-type hypersensitivity to MoP...

journal_title：Infection and immunity

authors： Williams DM,Grubbs B,Schachter J

更新日期：1987-10-01 00:00:00

abstract：:We wished to find a simple, biologically relevant method to evaluate the virulence of dengue viruses for human beings. Since cells of mononuclear phagocyte lineage may be important sites of dengue infection in primates, we evaluated the permissiveness of these cells to dengue virus as a correlate of virus virulence. T...

journal_title：Infection and immunity

authors： Halstead SB,Tom MC,Elm JL Jr

更新日期：1981-01-01 00:00:00

abstract：:Meningococcal sodC encodes periplasmic copper- and zinc-cofactored superoxide dismutase (Cu,Zn SOD) which catalyzes the conversion of the superoxide radical anion to hydrogen peroxide, preventing a sequence of reactions leading to production of toxic hydroxyl free radicals. From its periplasmic location, Cu,Zn SOD was...

journal_title：Infection and immunity

authors： Wilks KE,Dunn KL,Farrant JL,Reddin KM,Gorringe AR,Langford PR,Kroll JS

更新日期：1998-01-01 00:00:00

abstract：:Cord factor (trehalose 6,6'-dimycolate[TDM] ), a mixture of 6,6'-diesters of alpha, alpha-D-trehalose with natural mycolic acids, has been described as having immunoregulatory and antitumor activities in vivo, although the relevant mechanisms of action remain unelucidated. In this work, we measured the effects of TDM ...

journal_title：Infection and immunity

authors： Kierszenbaum F,Zenian A,Wirth JJ

更新日期：1984-02-01 00:00:00

abstract：:The importance of bacterial phospholipases during serum-mediated killing of Escherichia coli was examined by using wild-type DR+ DS+ and an isogenic phospholipase-deficient mutant DR- DS-. No difference in serum sensitivity was observed when the parental DR+ DS+ and mutant DR- DS- strains were exposed to various conce...

journal_title：Infection and immunity

authors： Kreutzer DL,Vandermaten M,Buller CS,Robertson DC,Hirata AA

更新日期：1977-10-01 00:00:00

abstract：:Challenges with the production and suboptimal immunogenicity of malaria vaccine candidates have slowed the development of a Plasmodium falciparum multiantigen vaccine. Attempting to resolve these issues, we focused on the use of highly immunogenic merozoite surface protein 8 (MSP8) as a vaccine carrier protein. Previo...

journal_title：Infection and immunity

authors： Parzych EM,Miura K,Ramanathan A,Long CA,Burns JM Jr

更新日期：2017-12-19 00:00:00

abstract：:A mouse lacking CD28, a T-cell costimulatory molecule, and STAT6, a transcription factor that mediates interleukin-4 (IL-4) signaling, was developed from parental CD28- and STAT6-deficient mice. STAT6/CD28(-/-) BALB/c mice that were 8 weeks old had a normal phenotype, and IL-4 production was induced following infectio...

journal_title：Infection and immunity

authors： Liu Q,Arseculeratne C,Liu Z,Whitmire J,Grusby MJ,Finkelman FD,Darling TN,Cheever AW,Swearengen J,Urban JF,Gause WC

更新日期：2004-07-01 00:00:00

abstract：:Decay-accelerating factor (DAF), a complement regulatory protein, also serves as a receptor for Dr adhesin-bearing Escherichia coli. The repeat three of DAF was shown to be important in Dr adhesin binding and complement regulation. However, Dr adhesins do not bind to red blood cells with the rare polymorphism of DAF, ...

journal_title：Infection and immunity

authors： Hasan RJ,Pawelczyk E,Urvil PT,Venkatarajan MS,Goluszko P,Kur J,Selvarangan R,Nowicki S,Braun WA,Nowicki BJ

更新日期：2002-08-01 00:00:00

abstract：:Membrane glycolipids contain the lactose sequence (galactose linked to glucose), and the oligosaccharide is variously extended such that there is a cell-type-specific repertoire. In this study, binding of Pseudomonas aeruginosa M35 to lipid-linked lactose (Gal beta 1-4Glc [structure 1]), lacto-N-neotetraose (Gal beta ...

journal_title：Infection and immunity

authors： Rosenstein IJ,Yuen CT,Stoll MS,Feizi T

更新日期：1992-12-01 00:00:00

abstract：:Although recent evidence suggests that fibronectin may be involved in the attachment of treponemes to mammalian cells, its possible role in promoting phagocytosis of Treponema pallidum has not been investigated. In the present study, we examined the antibody-independent interactions of fibronectin, C1q, and human poly...

journal_title：Infection and immunity

authors： Baughn RE

更新日期：1986-11-01 00:00:00

abstract：:Antimicrobial factors were analyzed in samples of whole saliva from 31 children, aged 0.8 to 3.8 years. When compared with the adult reference group, the children displayed similar levels of lysozyme, salivary peroxidase, and hypothiocyanite (OSCN-), whereas the amounts of immunoglobulins (isotypes A, G, and M), lacto...

journal_title：Infection and immunity

authors： Tenovuo J,Lehtonen OP,Aaltonen AS,Vilja P,Tuohimaa P

更新日期：1986-01-01 00:00:00

abstract：:Recombinant adenylate cyclase toxoids are shown to deliver inserted foreign CD4(+)-T-cell epitopes into the major histocompatibility complex class II presentation pathway, inducing a specific CD4(+)-T-cell response in vivo and yielding in vitro stimulation of specific CD4(+) T cells at a 100-times-higher molar efficie...

journal_title：Infection and immunity

authors： Loucká J,Schlecht G,Vodolánová J,Leclerc C,Sebo P

更新日期：2002-02-01 00:00:00

abstract：:Subtilase cytotoxin (SubAB) is a recently identified AB5 subunit toxin produced by Shiga-toxigenic Escherichia coli. The A subunit is thought to be a subtilase-like, serine protease, whereas the B subunit binds to the toxin receptor on the cell surface. We cloned the genes from a clinical isolate; the toxin was produc...

journal_title：Infection and immunity

authors： Morinaga N,Yahiro K,Matsuura G,Watanabe M,Nomura F,Moss J,Noda M

更新日期：2007-01-01 00:00:00

abstract：:During an etiological study of Kawasaki disease (mucocutaneous lymph node syndrome [MCLS]), we found that dominant viridans streptococcal strains on tooth surfaces and in the throat of both MCLS patients and non-MCLS control children formed erythrogenic and biologically active, extracellular products. In this study, w...

journal_title：Infection and immunity

authors： Takada H,Kawabata Y,Tamura M,Matsushita K,Igarashi H,Ohkuni H,Todome Y,Uchiyama T,Kotani S

更新日期：1993-12-01 00:00:00

abstract：:Infantile gastroenteritis virus (orbi-group) recovered from stools of infants with acute nonbacterial gastroenteritis was administered per os to germfree and conventional piglets. Virus was found subsequently in stools and in the mucosal epithelial cells of the small intestine of these animals. Some animals developed ...

journal_title：Infection and immunity

authors： Middleton PJ,Petric M,Szymanski MT

更新日期：1975-12-01 00:00:00

abstract：:Bordetella pertussis extract that contained adenylate cyclase toxin produced large increases in human neutrophil cyclic AMP levels and inhibited their oxidative burst, as reflected by luminol-enhanced chemiluminescence and superoxide release. The adenylate cyclase toxin-containing extract blocked neutrophil-mediated i...

journal_title：Infection and immunity

authors： Galgiani JN,Hewlett EL,Friedman RL

更新日期：1988-04-01 00:00:00

abstract：:The application of dissociation techniques, involving gel filtration in the presence of guanidine, to a semipurified preparation of Campylobacter jejuni heat-labile enterotoxin yielded a material whose functional and immunological properties resemble those of the B subunits of cholera toxin and Escherichia coli heat-l...

journal_title：Infection and immunity

authors： Klipstein FA,Engert RF

更新日期：1985-06-01 00:00:00

abstract：:We have developed an animal model for studying mycobacterial pathogenesis using Mycobacterium marinum and the goldfish, Carassius auratus. Goldfish are injected intraperitoneally with doses between 10(2) and 10(9) CFU of M. marinum organisms. Depending on the dose of M. marinum organisms administered, an acute or chro...

journal_title：Infection and immunity

authors： Talaat AM,Reimschuessel R,Wasserman SS,Trucksis M

更新日期：1998-06-01 00:00:00

abstract：:To explore the mechanisms underlying the eosinophil-mediated inflammation of tropical pulmonary eosinophilia (TPE), bronchoalveolar lavage (BAL) fluid, serum, and supernatants from pulmonary and blood leukocytes (WBC) from patients with acute TPE (n = 6) were compared with those obtained from healthy uninfected indivi...

journal_title：Infection and immunity

authors： O'Bryan L,Pinkston P,Kumaraswami V,Vijayan V,Yenokida G,Rosenberg HF,Crystal R,Ottesen EA,Nutman TB

更新日期：2003-03-01 00:00:00

abstract：:Theileria parasites infect and transform bovine leukocytes. We have analyzed laboratory-established Theileria sp.-infected leukocyte lines and observed that transformed macrophages express CD5. Low-level expression of CD5 by macrophages was further confirmed on three independent Theileria annulata clinical isolates fr...

journal_title：Infection and immunity

authors： Moreau MF,Thibaud JL,Miled LB,Chaussepied M,Baumgartner M,Davis WC,Minoprio P,Langsley G

更新日期：1999-12-01 00:00:00

abstract：:We describe here a Sprague-Dawley rat model for chronic osteomyelitis. Staphylococcus aureus and sodium morrhuate were implanted by either microdrilling or direct needle injection into the tibiae of rats. Of 107 rats, 87 (81%) developed osteomyelitis when a high-speed drill was used for implantation, and 27 (51%) of 5...

journal_title：Infection and immunity

authors： Rissing JP,Buxton TB,Weinstein RS,Shockley RK

更新日期：1985-03-01 00:00:00

abstract：:The expression of the Shigella flexneri chromosomal aerobactin genes during growth of the bacterium within tissue culture cells was assayed. During intracellular growth, aerobactin promoter activity was repressed relative to the level observed in bacteria grown extracellularly, even when the bacteria had been starved ...

journal_title：Infection and immunity

authors： Headley V,Hong M,Galko M,Payne SM

更新日期：1997-02-01 00:00:00

abstract：:Natural killer (NK) cells are considered to be key players in the early innate responses to protozoan infections, primarily indirectly by producing gamma interferon (IFN-gamma) in response to cytokines, like interleukin 12 (IL-12). We demonstrate that live, as well as heat-inactivated, tachyzoites of Neospora caninum,...

journal_title：Infection and immunity

authors： Boysen P,Klevar S,Olsen I,Storset AK

更新日期：2006-02-01 00:00:00

abstract：:Random minitransposon mutagenesis was used to identify genes involved in the survival of Bordetella bronchiseptica within eukaryotic cells. One of the mutants which exhibited a reduced ability to survive intracellularly harbored a minitransposon insertion in a locus (ris) which displays a high degree of homology to tw...

journal_title：Infection and immunity

authors： Jungnitz H,West NP,Walker MJ,Chhatwal GS,Guzmán CA

更新日期：1998-10-01 00:00:00

abstract：:Transgenic tobacco plants stably expressing recombinant FaeG, which is the major subunit and adhesin of K88ad fimbriae, were obtained. Analysis of sera from immunized mice indicates that in mice, the immunogenicity induced by plant-derived FaeG protein is comparable to that generated with traditional approaches. ...

journal_title：Infection and immunity

authors： Huang Y,Liang W,Pan A,Zhou Z,Huang C,Chen J,Zhang D

更新日期：2003-09-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) has been shown to be a central immunomodulator used by leishmaniae to escape effective mechanisms of protection in human and murine infections with these parasites. However, all the information is derived from studies of established infection, while little is known about TGF-...

journal_title：Infection and immunity

authors： Kariminia A,Bourreau E,Pascalis H,Couppié P,Sainte-Marie D,Tacchini-Cottier F,Launois P

更新日期：2005-09-01 00:00:00

abstract：:Localized juvenile periodontosis is associated with a defect of neutrophil chemotaxis that is characterized by selective depletion of a surface protein with a molecular mass of 110 kDa (GP110). Data on partial characterization of GP110 suggest that it is a glycoprotein which is enriched in Lys, Glu, His, Leu, and Ala ...

journal_title：Infection and immunity

authors： Tripathi SC,Van Dyke TE

更新日期：1992-07-01 00:00:00