Serum antibody responses of cattle following experimental infection with Escherichia coli O157:H7.


:Oral inoculation of calves and steers with 10(10) CFU of Escherichia coli O157:H7 induced prompt and sustained increases in serum antibodies to O157 lipopolysaccharide. Neutralizing antibodies to verotoxin 1 also increased rapidly in most steers but more gradually in calves. None of the animals developed neutralizing antibodies to verotoxin 2. These serological responses were not correlated with elimination of infection in calves or steers or protection of calves against reinfection with the same strain.


Infect Immun


Infection and immunity


Johnson RP,Cray WC Jr,Johnson ST




Has Abstract


1996-05-01 00:00:00












  • Trafficking of porin-deficient Salmonella typhimurium mutants inside HeLa cells: ompR and envZ mutants are defective for the formation of Salmonella-induced filaments.

    abstract::Outer membrane porin genes of Salmonella typhimurium, including ompC, ompF, and tppB, are regulated by the products of ompB, a two-component regulatory locus encoding OmpR and EnvZ. S. typhimurium ompR mutants are attenuated in mice, but to date no one has studied the intracellular trafficking of S. typhimurium porin-...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Mills SD,Ruschkowski SR,Stein MA,Finlay BB

    更新日期:1998-04-01 00:00:00

  • Complement-mediated bactericidal activity of anti-factor H binding protein monoclonal antibodies against the meningococcus relies upon blocking factor H binding.

    abstract::Binding of the complement-downregulating protein factor H (fH) to the surface of the meningococcus is important for survival of the organism in human serum. The meningococcal vaccine candidate factor H binding protein (fHbp) is an important ligand for human fH. While some fHbp-specific monoclonal antibodies (MAbs) blo...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Giuntini S,Reason DC,Granoff DM

    更新日期:2011-09-01 00:00:00

  • Intestinal Epithelial Toll-Like Receptor 4 Signaling Affects Epithelial Function and Colonic Microbiota and Promotes a Risk for Transmissible Colitis.

    abstract::Evidence obtained from gene knockout studies supports the role of Toll-like receptor 4 (TLR4) in intestinal inflammation and microbiota recognition. Increased epithelial TLR4 expression is observed in patients with inflammatory bowel disease. However, little is known of the effect of increased TLR4 signaling on intest...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Dheer R,Santaolalla R,Davies JM,Lang JK,Phillips MC,Pastorini C,Vazquez-Pertejo MT,Abreu MT

    更新日期:2016-01-11 00:00:00

  • Localized expression of mRNA for phagocyte-specific chemotactic cytokines in human periodontal infections.

    abstract::In bacterial infections, mononuclear and polymorphonuclear phagocytes are key components of host defenses. Recent investigations have indicated that chemokines are able to recruit and activate phagocytes. In particular, interleukin-8 (IL-8) attracts polymorphonuclear leukocytes (PMNs), while monocyte chemoattractant p...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Tonetti MS,Imboden MA,Gerber L,Lang NP,Laissue J,Mueller C

    更新日期:1994-09-01 00:00:00

  • Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells.

    abstract::Experiments outlined here investigate the role of nitric oxide (NO) in the pathogenesis of Plasmodium falciparum-induced malarial anemia (MA). The results show that ex vivo and in vitro NO synthase (NOS) activity in peripheral blood mononuclear cells (PBMCs) is significantly elevated in children with MA and inversely ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Keller CC,Kremsner PG,Hittner JB,Misukonis MA,Weinberg JB,Perkins DJ

    更新日期:2004-08-01 00:00:00

  • Natural and experimental infection with an attaching and effacing strain of Escherichia coli in calves.

    abstract::Gnotobiotic calves were inoculated with an O5:K4:H-, urease-positive strain of Escherichia coli isolated from a 2-day-old calf with diarrhea. The calves developed elevated temperatures and passed loose mucoid feces, with or without blood. The E. coli strain was negative for heat-stable and heat-labile enterotoxins but...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Moxley RA,Francis DH

    更新日期:1986-08-01 00:00:00

  • Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.

    abstract::Genetic defects in the Rab27a or Munc13-4 gene lead to immunodeficiencies in humans, characterized by frequent viral and bacterial infections. However, the role of Rab27a and Munc13-4 in the regulation of systemic inflammation initiated by Gram-negative bacterium-derived pathogenic molecules is currently unknown. Usin...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Johnson JL,Hong H,Monfregola J,Catz SD

    更新日期:2011-09-01 00:00:00

  • PLC/PRF/5 (Alexander) hepatoma cell line: further characterization and studies of infectivity.

    abstract::The Alexander hepatoma cell line, PLC/PRF/5, was studied for evidence of hepatitis B virus markers and alpha-fetoprotein. Only hepatitis B surface antigen and alpha-fetoprotein were detected. Induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did n...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Daemer RJ,Feinstone SM,Alexander JJ,Tully JG,London WT,Wong DC,Purcell RH

    更新日期:1980-11-01 00:00:00

  • Mechanism of fibronectin enhancement of group B streptococcal phagocytosis by human neutrophils and culture-derived macrophages.

    abstract::In previous studies, we reported that fibronectin (FN) markedly enhances phagocytic uptake of antibody-coated group B streptococci (GBS) by human polymorphonuclear leukocytes. Furthermore, administration of FN along with a GBS type-specific monoclonal or polyclonal antibody to infected neonatal rats significantly enha...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Hill HR,Augustine NH,Williams PA,Brown EJ,Bohnsack JF

    更新日期:1993-06-01 00:00:00

  • Leishmania pifanoi proteoglycolipid complex P8 induces macrophage cytokine production through Toll-like receptor 4.

    abstract::The P8 proteoglycolipid complex (P8 PGLC) is a glyconjugate expressed by Leishmania mexicana complex parasites. We previously have shown that vaccination with P8 PGLC provides protection against cutaneous leishmaniasis in susceptible BALB/c mice. However, the biological importance of this complex remains unknown. Here...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Whitaker SM,Colmenares M,Pestana KG,McMahon-Pratt D

    更新日期:2008-05-01 00:00:00

  • Extracellular antigens from Salmonella enteritidis induce effective immune response in mice after oral vaccination.

    abstract::We have studied polyacryl starch microparticles as an adjuvant in oral vaccination in mice. Secreted antigens from Salmonella enterica serovar Enteritidis were administered covalently conjugated to microparticles, or as free antigens, orally or intramuscularly and evaluated for their immunogenicity and ability to elic...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Strindelius L,Degling Wikingsson L,Sjöholm I

    更新日期:2002-03-01 00:00:00

  • Predominant gram-positive bacteria in human feces: numbers, variety, and persistence.

    abstract::The predominant gram-positive bacteria in 47 fecal specimens from 10 healthy men were studied by microscopic and cultural counts, by the characterization and tentative identification of isolates, and by the use of fluorescein isothiocyanate (FITC)-conjugated globulins prepared using some of the isolates. Gram-positive...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Gossling J,Slack JM

    更新日期:1974-04-01 00:00:00

  • Identification of Specific Components of the Eicosanoid Biosynthetic and Signaling Pathway Involved in Pathological Inflammation during Intra-abdominal Infection with Candida albicans and Staphylococcus aureus.

    abstract::Polymicrobial intra-abdominal infections (IAIs) are a significant cause of morbidity and mortality, particularly when fungal pathogens are involved. Our experimental murine model of IAI involving intraperitoneal inoculation of Candida albicans and Staphylococcus aureus results in synergistic lethality (∼80%) due to ex...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Ikeh MAC,Fidel PL Jr,Noverr MC

    更新日期:2018-06-21 00:00:00

  • Allele specificity of naturally acquired antibody responses against Plasmodium falciparum apical membrane antigen 1.

    abstract::Antibody responses against proteins located on the surface or in the apical organelles of merozoites are presumed to be important components of naturally acquired protective immune responses against the malaria parasite Plasmodium falciparum. However, many merozoite antigens are highly polymorphic, and antibodies indu...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Cortés A,Mellombo M,Masciantonio R,Murphy VJ,Reeder JC,Anders RF

    更新日期:2005-01-01 00:00:00

  • Role of mycobactin in the growth and virulence of tubercle bacilli.

    abstract::Tubercle bacilli failed to grow in iron-void media enriched with solutions of iron-containing transferrin (Tr) or ferritin (F) because these substances do not provide the bacilli with iron, which is essential for their growth. Animal serum and macrophages possessed no iron carrier with an ability to satisfy the need o...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Golden CA,Kochan I,Spriggs DR

    更新日期:1974-01-01 00:00:00

  • The Escherichia coli heat-stable enterotoxin is a long-lived superagonist of guanylin.

    abstract::The mechanism by which bacterial heat-stable enterotoxins (ST I STA) cause diarrhea in humans and animals has been linked to the activation of an intestinal membrane-bound guanylate cyclase. Guanylin, a recently discovered rat intestinal peptide, is homologous in structure to ST I and can activate guanylate cyclase pr...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Carpick BW,Gariépy J

    更新日期:1993-11-01 00:00:00

  • Structural analysis of electrophoretic variation in the genome profiles of rotavirus field isolates.

    abstract::Detailed structural studies were undertaken on five isolates of bovine rotavirus which showed variability in the migration patterns of their genome segments on electrophoresis in polyacrylamide gels. The individual genome segments of each isolate were characterized by partial digestion of terminally radiolabeled RNA w...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Clarke IN,McCrae MA

    更新日期:1982-05-01 00:00:00

  • Demonstration of antigen-specific T cells and histopathological alterations in mice experimentally inoculated with Borrelia burgdorferi.

    abstract::Antigen-specific T-cell responses and histopathological changes were studied in mice experimentally inoculated with Borrelia burgdorferi B31. Inbred mice with different H-2 haplotypes and/or different genetic backgrounds were inoculated with B. burgdorferi organisms and tested for antigen-specific T-cell responses in ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Schaible UE,Kramer MD,Justus CW,Museteanu C,Simon MM

    更新日期:1989-01-01 00:00:00

  • Purification of staphylococcal alpha-toxin by adsorption chromatography on glass.

    abstract::Staphylococcal alpha-toxin was purified from Staphylococcus aureus growth medium using adsorption chromatography on controlled pore glass beads. Elution of alpha-toxin from the unmodified glass surface of the beads with various anions generally followed the chaotropic series. Alpha-toxin, purified by glass bead chroma...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Cassidy P,Harshman S

    更新日期:1976-03-01 00:00:00

  • Effect of tracheal cytotoxin from Bordetella pertussis on human neutrophil function in vitro.

    abstract::The infiltration of neutrophils which phagocytose and kill microorganisms is an important defense mechanism against infections of the airways. Bordetella pertussis is a human respiratory pathogen which colonizes ciliated epithelium, causing whooping cough. We have investigated the effects of the peptidoglycan fragment...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Cundell DR,Kanthakumar K,Taylor GW,Goldman WE,Flak T,Cole PJ,Wilson R

    更新日期:1994-02-01 00:00:00

  • Combined effects of blood and temperature shift on Borrelia burgdorferi gene expression as determined by whole genome DNA array.

    abstract::Borrelia burgdorferi undergoes differential gene expression during transmission from its tick vector to a vertebrate host. The addition of blood to a spirochete culture at 35 degrees C for 48 h had a dramatic effect on gene expression of this organism. Utilizing B. burgdorferi whole genome DNA arrays, we compared the ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Tokarz R,Anderton JM,Katona LI,Benach JL

    更新日期:2004-09-01 00:00:00

  • Mitogenic stimulation of murine spleen cells: relation to susceptibility to Salmonella infection.

    abstract::The screening of several inbred strains of mice suggested that the capacity of their spleen cells to respond to the mitogenic effect of lipopolysaccharide (LPS) of gram-negative bacteria was correlated with their resistance to intraperitoneal infection with Salmonella typhimurium. An infection of LPS into mice caused ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: von Jeney N,Günther E,Jann K

    更新日期:1977-01-01 00:00:00

  • Periplasmic superoxide dismutase in meningococcal pathogenicity.

    abstract::Meningococcal sodC encodes periplasmic copper- and zinc-cofactored superoxide dismutase (Cu,Zn SOD) which catalyzes the conversion of the superoxide radical anion to hydrogen peroxide, preventing a sequence of reactions leading to production of toxic hydroxyl free radicals. From its periplasmic location, Cu,Zn SOD was...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Wilks KE,Dunn KL,Farrant JL,Reddin KM,Gorringe AR,Langford PR,Kroll JS

    更新日期:1998-01-01 00:00:00

  • Localization of chlamydial group Antigen in McCoy cell monolayers infected with Chlamydia trachomatis or Chlamydia psittaci.

    abstract::Chlamydial inclusions were demonstrated by indirect immunofluorescence (IF) with antiserum to the chlamydial group antigen when McCoy cell monolayers infected with either Chlamydia trachomatis or Chlamydia psittaci were fixed in formaldehyde or paraformaldehyde, provided the monolayer was not allowed to dry. If these ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Richmond SJ,Stirling P

    更新日期:1981-11-01 00:00:00

  • Apparent role for Borrelia burgdorferi LuxS during mammalian infection.

    abstract::The Lyme disease spirochete, Borrelia burgdorferi, controls protein expression patterns during its tick-mammal infection cycle. Earlier studies demonstrated that B. burgdorferi synthesizes 4,5-dihydroxy-2,3-pentanedione (autoinducer-2 [AI-2]) and responds to AI-2 by measurably changing production of several infection-...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Arnold WK,Savage CR,Antonicello AD,Stevenson B

    更新日期:2015-04-01 00:00:00

  • Role of host factors in the pathogenesis of Salmonella-associated arthritis in rats.

    abstract::To evaluate the roles of the infectious agent and the host in the pathogensis of Salmonella-associated arthritis (SAA), 1O(3) to 10(6) heat-killed Salmonella enteritidis were injected directly into involved carpal joints in normal and actively immunized rats and in hosts adoptively immunized by the intravenous transfe...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Volkman A,Collins FM

    更新日期:1976-04-01 00:00:00

  • C2 toxicity in extract of Clostridium botulinum type C spores.

    abstract::Toxic protein(s) neutralized with anti-C2 toxic serum was extracted from Clostridium botulinum type C spores treated with an alkaline mercaptoethanol solution. C2 toxicity in the spores was located in the spore coat fraction and was more heat stable than that found in culture fluid. ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Yamakawa K,Nishida S,Nakamura S

    更新日期:1983-08-01 00:00:00

  • Immune response to the iron-deprivation-induced proteins of Salmonella typhi in typhoid fever.

    abstract::Iron starvation conditions limited the growth of Salmonella typhi, as evidenced by an increase in the lag phase of a culture and a decrease in the number of bacteria reached in the stationary phase. The analysis of the outer membrane of bacteria grown under these conditions identified new protein components with appar...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Fernandez-Beros ME,Gonzalez C,McIntosh MA,Cabello FC

    更新日期:1989-04-01 00:00:00

  • A globally disseminated M1 subclone of group A streptococci differs from other subclones by 70 kilobases of prophage DNA and capacity for high-frequency intracellular invasion.

    abstract::The M1inv+ subclone of M1 group A streptococci that spread globally in the late 1980s and early 1990s was previously identified by restriction fragment length polymorphism (RFLP), M protein, and SpeA exotoxin sequence analyses. Strains representing this subclone were characterized with regard to carriage of bacterioph...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Cleary PP,LaPenta D,Vessela R,Lam H,Cue D

    更新日期:1998-11-01 00:00:00

  • Bacteroides gingivalis vesicles bind to and aggregate Actinomyces viscosus.

    abstract::Isolated Bacteroides gingivalis 2561 vesicles aggregated suspensions of Actinomyces viscosus and Actinomyces naeslundii of all taxonomy clusters. Vesicles bound near A. viscosus cell walls and among its surface fibrils. Tritiated vesicles bound slightly better to saliva-coated hydroxyapatite (SHA) than to SHA coated w...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Ellen RP,Grove DA

    更新日期:1989-05-01 00:00:00