Caspase and bid involvement in Clostridium difficile toxin A-induced apoptosis and modulation of toxin A effects by glutamine and alanyl-glutamine in vivo and in vitro.

abstract：:Internalization of Staphylococcus aureus in bovine endothelial cells (BEC) is increased by tumor necrosis factor alpha stimulation and NF-κB activation. Because the phosphoinositide-3-kinase (PI3K)-Akt signaling pathway also modulates NF-κB activity, we considered whether the internalization of S. aureus by BEC is ass...

journal_title：Infection and immunity

authors： Oviedo-Boyso J,Cortés-Vieyra R,Huante-Mendoza A,Yu HB,Valdez-Alarcón JJ,Bravo-Patiño A,Cajero-Juárez M,Finlay BB,Baizabal-Aguirre VM

更新日期：2011-11-01 00:00:00

abstract：:Germination of Bacillus anthracis Sterne and plasmidless Delta-Sterne endospores was dramatically enhanced in RAW264.7 macrophage-like cells, while germination of nonpathogenic Bacillus endospores was not. Elimination of gerS, a germinant receptor locus, caused a complete loss of cell-enhanced germination, implicating...

journal_title：Infection and immunity

authors： Ireland JA,Hanna PC

更新日期：2002-10-01 00:00:00

abstract：:In Shigella flexneri a 220-kilobase plasmid encodes the ability to invade nonprofessional phagocytes by a mechanism similar to phagocytosis. In this report, the continuous macrophage cell line J774 was used to study the intracellular fate of both invasive and noninvasive strains. pWR100, the virulence plasmid of S. fl...

journal_title：Infection and immunity

authors： Clerc PL,Ryter A,Mounier J,Sansonetti PJ

更新日期：1987-03-01 00:00:00

abstract：:The role of gamma-delta T cells in host resistance to Chlamydia trachomatis was characterized by using a murine model of pneumonia caused by the mouse pneumonitis agent (MoPn), murine C. trachomatis. At days 3 and 7 after infection, gamma-delta T-cell-deficient knockout mice had significantly higher levels of MoPn in ...

journal_title：Infection and immunity

authors： Williams DM,Grubbs BG,Kelly K,Pack E,Rank RG

更新日期：1996-09-01 00:00:00

abstract：:Leishmaniae are protozoans which, depending upon both the host and parasite species, can cause either a healing or nonhealing infection. While C57BL/10 mice are able to heal following infection with Leishmania major, they fail to heal following infection with Leishmania amazonensis. In order to address the role of Th1...

journal_title：Infection and immunity

authors： Afonso LC,Scott P

更新日期：1993-07-01 00:00:00

abstract：:Curli are thin, coiled fibers expressed on the surface of Escherichia coli that bind several matrix and plasma proteins such as fibronectin, laminin, plasminogen, tissue plasminogen activator, and H-kininogen. In this work, we examined the interactions between curli-expressing E. coli and human major histocompatibilit...

journal_title：Infection and immunity

authors： Olsén A,Wick MJ,Mörgelin M,Björck L

更新日期：1998-03-01 00:00:00

abstract：:The effects of cyclophosphamide (CY) treatment on acute murine cytomegalovirus (MCMV) infection were studied to explore the potential usefulness of MCMV as a means of detecting immune dysfunction and to identify host defense mechanisms important for protection against MCMV. Conditions found optimal for enhancing MCMV ...

journal_title：Infection and immunity

authors： Selgrade MK,Daniels MJ,Hu PC,Miller FJ,Graham JA

更新日期：1982-12-01 00:00:00

abstract：:Pseudomallei group Burkholderia species are facultative intracellular parasites that spread efficiently from cell to cell by a mechanism involving the fusion of adjacent cell membranes. Intercellular fusion requires the function of the cluster 5 type VI secretion system (T6SS-5) and its associated valine-glycine repea...

journal_title：Infection and immunity

authors： Toesca IJ,French CT,Miller JF

更新日期：2014-04-01 00:00:00

abstract：:Individuals with sickle cell anemia are subject to serious infections caused by a number of bacteria, including Salmonella species and Staphylococcus aureus. It has been suggested that in sickle cell anemia, extensive erythrophagocytosis by macrophages may interfere with their antibacterial function and thereby predis...

journal_title：Infection and immunity

authors： Hand WL,King-Thompson NL

更新日期：1983-06-01 00:00:00

abstract：:A nonproteolytic strain of Clostridium botulinum type B produces two toxins of different molecular weight (16S and 12S) that are indistinguishable from the corresponding toxins of a proteolytic strain in molecular weight and construction but differ in potential toxicity, activation ratio, and hemagglutinability. Succe...

journal_title：Infection and immunity

authors： Miyazaki S,Kozaki S,Sakaguchi S,Sakaguchi G

更新日期：1976-03-01 00:00:00

abstract：:Acute lethality was induced in rabbits by the sequential injection of Propionibacterium acnes and lipopolysaccharide (LPS). P. acnes induced the infiltration of inflammatory cells into the liver lobules during the early phase, and LPS in the late phase caused death in association with pathological changes mimicking he...

journal_title：Infection and immunity

authors： Ikeda N,Mukaida N,Kaneko S,Fujioka N,Su S,Nariuchi H,Unoura M,Harada K,Nakanuma Y,Kobayashi K

更新日期：1995-12-01 00:00:00

abstract：:The rfb region from Vibrio cholerae O139 strain MO45 was cloned from cosmid gene banks established in Escherichia coli HB101, using an immunoblot assay for screening of the correct clones. Immunoblot analysis of lipopolysaccharide (LPS) preparations revealed the presence of two types of positive clones: (i) those expr...

journal_title：Infection and immunity

authors： Favre D,Cryz SJ Jr,Viret JF

更新日期：1996-09-01 00:00:00

abstract：:A modified version of the Bacteroides fragilis transposon Tn4400, designated Tn4400', enabling rapid isolation and analysis of B. fragilis mutants has been constructed. To identify potential virulence factors, Tn4400'-generated mutants were screened by a new method; this resulted in the isolation of 21 mutant strains ...

journal_title：Infection and immunity

authors： Tang YP,Malamy MH

更新日期：2000-01-01 00:00:00

abstract：:Monoclonal antibodies were produced against the HAR-13 strain (A) of Chlamydia trachomatis. By an indirect immunofluorescence technique, three clones (1-7, 2-8, 9F) were found to produce antibody that reacted only with serotype A strains. Clone 3-5 produced antibody that cross-reacted with serotypes A, C, H, I, and J....

journal_title：Infection and immunity

authors： Clark RB,Nachamkin I,Schatzki PF,Dalton HP

更新日期：1982-12-01 00:00:00

abstract：:Oral or intravenous inoculation of previously unexposed juvenile and adult ferrets with Campylobacter jejuni uniformly resulted in intestinal colonization lasting 2 to 12 days. Disease varied from mild to moderate diarrhea, which resolved in 2 to 3 days. Orally infected animals developed agglutinin titers of 8 to 256 ...

journal_title：Infection and immunity

authors： Bell JA,Manning DD

更新日期：1990-06-01 00:00:00

abstract：:Genetic defects in the Rab27a or Munc13-4 gene lead to immunodeficiencies in humans, characterized by frequent viral and bacterial infections. However, the role of Rab27a and Munc13-4 in the regulation of systemic inflammation initiated by Gram-negative bacterium-derived pathogenic molecules is currently unknown. Usin...

journal_title：Infection and immunity

authors： Johnson JL,Hong H,Monfregola J,Catz SD

更新日期：2011-09-01 00:00:00

abstract：:Cattle are an important reservoir of Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC) O157:H7 strains, foodborne pathogens that cause hemorrhagic colitis and hemolytic uremic syndrome in humans. EHEC O157:H7 strains are not pathogenic in calves >3 weeks old. Our objective was to determine if EHEC O157:H...

journal_title：Infection and immunity

authors： Dean-Nystrom EA,Bosworth BT,Cray WC Jr,Moon HW

更新日期：1997-05-01 00:00:00

abstract：:The Escherichia coli genome varies in size from 4.5 to 5.5 Mb. It is unclear whether this variation may be distributed finely throughout the genome or is concentrated at just a few chromosomal loci or on plasmids. Further, the functional correlates of size variation in different genome copies are largely unexplored. W...

journal_title：Infection and immunity

authors： Rode CK,Melkerson-Watson LJ,Johnson AT,Bloch CA

更新日期：1999-01-01 00:00:00

abstract：:This study examined apoptotic cell death associated with Shiga-like toxin (Stx)-producing Escherichia coli. Renal cortices from three children with postenteropathic hemolytic-uremic syndrome (HUS) and from mice infected with E. coli O157:H7 and pediatric renal tubular epithelial cells stimulated with Stx and E. coli O...

journal_title：Infection and immunity

authors： Karpman D,Håkansson A,Perez MT,Isaksson C,Carlemalm E,Caprioli A,Svanborg C

更新日期：1998-02-01 00:00:00

abstract：:Studies have implicated Gardnerella vaginalis as an important etiological agent in bacterial vaginosis (BV). It produces a cholesterol-dependent cytolysin, vaginolysin (VLY). In this study, we sought to characterize the interaction between vaginal epithelium, G. vaginalis, and VLY using EpiVaginal tissues from MatTek....

journal_title：Infection and immunity

authors： Garcia EM,Kraskauskiene V,Koblinski JE,Jefferson KK

更新日期：2019-03-25 00:00:00

abstract：:Many pathogenic Escherichia coli produce the toxin alpha-hemolysin (Hly), and lipopolysaccharide (LPS), interleukin-1 (IL-1), and tumor necrosis factor (TNF) have all been recognized as important effector molecules during infections by gram-negative organisms. Despite the characterization of many in vitro effects of h...

journal_title：Infection and immunity

authors： Gleason TG,Houlgrave CW,May AK,Crabtree TD,Sawyer RG,Denham W,Norman JG,Pruett TL

更新日期：1998-09-01 00:00:00

abstract：:Proteins were extracted at pH 2.5 from carefully washed brain homogenates of patients with subacute sclerosing panencephalitis. Immunoglobulin G was isolated from the extracts by gel filtration and immunoadsorbent chromatography and was 125I radioiodinated. The labeled immunoglobulin G was reacted with purified measle...

journal_title：Infection and immunity

authors： Weil ML,Norrby E,Itabashi HH,Wilson R,Tourtellotte WW,Heiner DC

更新日期：1979-04-01 00:00:00

abstract：:The stimulation of mononuclear phagocytes by lipopolysaccharide (LPS) is facilitated by the binding of complexes of LPS and LPS-binding protein to CD14. Although it is clear that CD14 is involved in LPS-induced signaling, other investigators have hypothesized the existence of additional signaling pathways in macrophag...

journal_title：Infection and immunity

authors： Lynn WA,Liu Y,Golenbock DT

更新日期：1993-10-01 00:00:00

abstract：:Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role in natural killer cell activation and the T helper 1 (Th1) cell response, particularly in collaboration with IL-12. Since Th1 cells play a pivotal role in the host defense against infection with intracellular microbes, such as Leishmania...

journal_title：Infection and immunity

authors： Ohkusu K,Yoshimoto T,Takeda K,Ogura T,Kashiwamura S,Iwakura Y,Akira S,Okamura H,Nakanishi K

更新日期：2000-05-01 00:00:00

abstract：:We investigated the effect of the extracellular protease of Serratia marcescens on human serum constituents such as immunoglobulins, fibronectin, alpha 1-protease inhibitor, alpha 2-macroglobulin, lysozyme, and transferrin. At a very low concentration of Serratia 56-kilodalton protease (56K protease), purified human p...

journal_title：Infection and immunity

authors： Molla A,Matsumoto K,Oyamada I,Katsuki T,Maeda H

更新日期：1986-09-01 00:00:00

abstract：:Bordetella bronchiseptica secreted a hydroxamate siderophore when grown in Fe-depleted medium. A Tn5lac insertion mutant of B. bronchiseptica, DBB22, did not produce this hydroxamate siderophore and was incapable of using lactoferrin as an Fe source. Our data suggest that B. bronchiseptica uses a siderophore for remov...

journal_title：Infection and immunity

authors： Foster LA,Dyer DW

更新日期：1993-06-01 00:00:00

abstract：:An improved enterocyte adhesion assay has been used to examine a collection of 44 strains of enterotoxigenic Escherichia coli (ETEC) for their ability to adhere to the brush border of isolated human duodenal enterocytes. Fourteen strains showed good adhesion; in each case the ability to adhere correlated with the prod...

journal_title：Infection and immunity

authors： Knutton S,Lloyd DR,Candy DC,McNeish AS

更新日期：1985-06-01 00:00:00

abstract：:Streptococcus suis is one of the most important pathogens affecting the swine industry and is also an emerging zoonotic agent for humans. Two-component signaling systems (TCSs) play important roles in the adaptation of pathogenic bacteria to host environments. In this study, we identified a novel TCS, named TCS09HKRR,...

journal_title：Infection and immunity

authors： Zhong X,Zhang Y,Zhu Y,Dong W,Ma J,Pan Z,Yao H

更新日期：2019-08-21 00:00:00

abstract：:We isolated a monoclonal antibody directed against the ferric complex of aerobactin purified from Escherichia coli KH576. This antibody, which we designated MAb AERO1, was identified as an immunoglobulin G, subtype 2. A competitive enzyme-linked immunosorbent assay with MAb AERO1 had a limit of 10 nM for the detection...

journal_title：Infection and immunity

authors： le Roy D,Expert D,Razafindratsita A,Deroussent A,Cosme J,Bohuon C,Andremont A

更新日期：1992-03-01 00:00:00

abstract：:Mucin glycoproteins are secreted in large amounts by the intestinal epithelium and constitute an efficient component of innate immune defenses to promote homeostasis and protect against enteric pathogens. In this study, our objective was to investigate how the bacterial enteropathogen Shigella flexneri, which causes b...

journal_title：Infection and immunity

authors： Sperandio B,Fischer N,Joncquel Chevalier-Curt M,Rossez Y,Roux P,Robbe Masselot C,Sansonetti PJ

更新日期：2013-10-01 00:00:00