Virulent Shigella flexneri affects secretion, expression, and glycosylation of gel-forming mucins in mucus-producing cells.

abstract：:The coexistence of bacteria in natural environments can often be explained in terms of competition for a growth-limiting substrate(s), and the outcome of such competition depends upon relevant growth parameters such as substrate affinity and yield. Dental plaque bacteria are frequently carbon and energy limited. Growt...

journal_title：Infection and immunity

authors： Rogers AH,de Jong MH,Zilm PS,van der Hoeven JS

更新日期：1986-06-01 00:00:00

abstract：:Helicobacter mustelae, like Helicobacter pylori, possesses two flagellin proteins, FlaA and FlaB. Isogenic mutant strains of H. mustelae have been constructed by disruption of the flaA or flaB gene with a kanamycin resistance cassette or by introduction of both a kanamycin and a chloramphenicol resistance gene to prod...

journal_title：Infection and immunity

authors： Andrutis KA,Fox JG,Schauer DB,Marini RP,Li X,Yan L,Josenhans C,Suerbaum S

更新日期：1997-05-01 00:00:00

abstract：:Mice receiving a single injection of cyclophosphamide (150 mg/kg) 1 to 6 days before inoculation with viable Candida albicans showed an increased susceptibility to the challenge accompanied by a reduction in peripheral blood polymorphonuclear leukocytes and lymphocytes as well as in spleen cellularity. Several immunol...

journal_title：Infection and immunity

authors： Bistoni F,Baccarini M,Blasi E,Marconi P,Puccetti P,Garaci E

更新日期：1983-04-01 00:00:00

abstract：:The Lyme disease spirochete Borrelia burgdorferi reduces the expression of outer surface protein C (OspC) in response to the development of an anti-OspC humoral response, leading to the hypothesis that the ability to repress OspC expression is critical for the pathogen to proceed to chronic infection. B. burgdorferi w...

journal_title：Infection and immunity

authors： Xu Q,Seemanapalli SV,McShan K,Liang FT

更新日期：2006-09-01 00:00:00

abstract：:Previous studies have demonstrated that animals exposed to Streptococcus pneumoniae while recovering from influenza A virus infection exhibit exacerbated disease symptoms. However, many of the current animal models exploring dual viral and bacterial synergistic exacerbations of respiratory disease have utilized mouse-...

journal_title：Infection and immunity

authors： Speshock JL,Doyon-Reale N,Rabah R,Neely MN,Roberts PC

更新日期：2007-06-01 00:00:00

abstract：:Mucins are high-molecular-weight glycoproteins and major constituents of the mucus layer which covers the airway surface. We have studied the interactions between bacteria, mucins, and epithelial cells from the human respiratory tract. Nontypeable strains of Haemophilus influenzae were found to bind to purified airway...

journal_title：Infection and immunity

authors： Davies J,Carlstedt I,Nilsson AK,Håkansson A,Sabharwal H,van Alphen L,van Ham M,Svanborg C

更新日期：1995-07-01 00:00:00

abstract：:Previous studies demonstrated that Mycoplasma arthritidis strain 158 acquired a high degree of virulence upon lysogenization with bacteriophage MAV1. In the present study, the association between MAV1 and virulence was reexamined by creating new lysogens of 158 and of a relatively avirulent mutant, strain 158-1. In th...

journal_title：Infection and immunity

authors： Clapper B,Tu AH,Simmons WL,Dybvig K

更新日期：2004-12-01 00:00:00

abstract：:Salmonella enterica serovar Paratyphi A O-specific polysaccharide (O-SP) was activated with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) and bound to tetanus toxoid (TT) with adipic acid dihydrazide as a linker (SPA-TT(1)) or directly (SPA-TT(2)). In mice, these two conjugates elicited high levels of imm...

journal_title：Infection and immunity

authors： Konadu EY,Lin FY,Hó VA,Thuy NT,Van Bay P,Thanh TC,Khiem HB,Trach DD,Karpas AB,Li J,Bryla DA,Robbins JB,Szu SC

更新日期：2000-03-01 00:00:00

abstract：:Recent preclinical and epidemiologic studies have suggested that certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity. To investigate the strain specificity of BCG-induced protective respon...

journal_title：Infection and immunity

authors： Jeon BY,Derrick SC,Lim J,Kolibab K,Dheenadhayalan V,Yang AL,Kreiswirth B,Morris SL

更新日期：2008-11-01 00:00:00

abstract：:We show here that Helicobacter pylori broth culture supernatants disrupt the actin cytoskeleton of epithelial cell lines, leading to cell rounding and apoptosis through anoikis. We demonstrate that there are marked quantitative differences between strains and that there are different cell line sensitivities. By constr...

journal_title：Infection and immunity

authors： Bebb JR,Letley DP,Rhead JL,Atherton JC

更新日期：2003-06-01 00:00:00

abstract：:Most Escherichia coli isolates can express type 1 fimbriae with mannose-specific adhesins. These adhesins bind to the oligosaccharide chains of secretory immunoglobulin A (IgA). Thus, in addition to specific antibody activity, secretory IgA possesses a broad reactivity with bacteria expressing type 1 fimbriae. The abs...

journal_title：Infection and immunity

authors： Friman V,Adlerberth I,Connell H,Svanborg C,Hanson LA,Wold AE

更新日期：1996-07-01 00:00:00

abstract：:We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate ...

journal_title：Infection and immunity

authors： Delogu G,Sanguinetti M,Posteraro B,Rocca S,Zanetti S,Fadda G

更新日期：2006-05-01 00:00:00

abstract：:During the infection of mice with Listeria monocytogenes, there is a profound depletion of T (Thy-1+ Ig-) lymphocytes between days 1 and 4, followed by an increase in T cells to three times normal levels by day 9. The recovery of T cell numbers required cell proliferation, being sensitive to vinblastin and cyclophosph...

journal_title：Infection and immunity

authors： Chan YY,Cheers C

更新日期：1982-11-01 00:00:00

abstract：:Recombinant adenylate cyclase toxoids are shown to deliver inserted foreign CD4(+)-T-cell epitopes into the major histocompatibility complex class II presentation pathway, inducing a specific CD4(+)-T-cell response in vivo and yielding in vitro stimulation of specific CD4(+) T cells at a 100-times-higher molar efficie...

journal_title：Infection and immunity

authors： Loucká J,Schlecht G,Vodolánová J,Leclerc C,Sebo P

更新日期：2002-02-01 00:00:00

abstract：:Mouse spleen cultures were infected with murine cytomegalovirus, either before or after separating the cells into various classes, and the growth of virus and production of infectious centers were measured in each cell class. The separation techniques, which were used in various combinations, comprised: adherence to p...

journal_title：Infection and immunity

authors： Loh L,Hudson JB

更新日期：1979-12-01 00:00:00

abstract：:The microbicidal myeloperoxidase (MPO)-H2O2-chloride system strongly inhibits Escherichia coli DNA synthesis. Also, cell envelopes from MPO-treated E. coli cells lose their ability to interact with hemimethylated DNA sequences of oriC, the chromosomal origin of replication, raising the prospect that suppression of DNA...

journal_title：Infection and immunity

authors： Rosen H,Michel BR,vanDevanter DR,Hughes JP

更新日期：1998-06-01 00:00:00

abstract：:A large body of evidence has convincingly shown that Toll-like receptors are necessary sensors for infections with pathogens, but their activation was also suggested to generate autoimmunity. During experimental infections, the lack of these sensors or of their signaling molecules should lead to a deficient immune res...

journal_title：Infection and immunity

authors： Woods A,Soulas-Sprauel P,Jaulhac B,Arditi B,Knapp AM,Pasquali JL,Korganow AS,Martin T

更新日期：2008-04-01 00:00:00

abstract：:Random minitransposon mutagenesis was used to identify genes involved in the survival of Bordetella bronchiseptica within eukaryotic cells. One of the mutants which exhibited a reduced ability to survive intracellularly harbored a minitransposon insertion in a locus (ris) which displays a high degree of homology to tw...

journal_title：Infection and immunity

authors： Jungnitz H,West NP,Walker MJ,Chhatwal GS,Guzmán CA

更新日期：1998-10-01 00:00:00

abstract：:gamma delta T cells have variously been implicated in the protection against, and the pathogenesis of, malaria, but few studies have examined the gamma delta T-cell response to malaria in African children, who suffer the large majority of malaria-associated morbidity and mortality. This is unfortunate, since available...

journal_title：Infection and immunity

authors： Hviid L,Kurtzhals JA,Adabayeri V,Loizon S,Kemp K,Goka BQ,Lim A,Mercereau-Puijalon O,Akanmori BD,Behr C

更新日期：2001-05-01 00:00:00

abstract：:Borrelia burgdorferi elicits a potent cytokine response through activation of multiple signaling receptors on innate immune cells. Spirochetal lipoproteins initiate expression of NF-κB-dependent cytokines primarily via TLR2, whereas type I interferon (IFN) production is induced through the endosomal receptors TLR7 and...

journal_title：Infection and immunity

authors： Love AC,Schwartz I,Petzke MM

更新日期：2014-06-01 00:00:00

abstract：:The regulation of innate immune responses to pathogens occurs through the interaction of Toll-like receptors (TLRs) with pathogen-associated molecular patterns and the activation of several signaling pathways whose contribution to the overall innate immune response to pathogens is poorly understood. We demonstrate a m...

journal_title：Infection and immunity

authors： Izadi H,Motameni AT,Bates TC,Olivera ER,Villar-Suarez V,Joshi I,Garg R,Osborne BA,Davis RJ,Rincón M,Anguita J

更新日期：2007-10-01 00:00:00

abstract：:Immunization of BALB/c mice with a plasmid containing the gene for Trypanosoma cruzi trans-sialidase (TS) induced antibodies that inhibited TS enzymatic activity, CD4+ Th1 and CD8+ Tc1 cells, and protective immunity against infection. We used this model to obtain basic information on the requirement of CD4 or CD8 or B...

journal_title：Infection and immunity

authors： Fujimura AE,Kinoshita SS,Pereira-Chioccola VL,Rodrigues MM

更新日期：2001-09-01 00:00:00

abstract：:Individual strains of Staphylococcus aureus have different capacities to become internalized by osteoblasts. Here we report that the levels of sigma(B) expressed by S. aureus correlate with the capacity of this bacterium to be internalized by osteoblasts. However, sigma(B) is not essential for internalization and does...

journal_title：Infection and immunity

authors： Nair SP,Bischoff M,Senn MM,Berger-Bächi B

更新日期：2003-07-01 00:00:00

abstract：:The energy-dependent adsorption of radioiodinated rickettsiae to sheep erythrocytes was demonstrated. The iodination procedure, however, decreased the hemolytic activity of the rickettsiae. No desorption of rickettsiae from isolated rickettsia-erythrocyte complexes (prevented from lysing by NaF) could be measured. On ...

journal_title：Infection and immunity

authors： Winkler HH

更新日期：1977-09-01 00:00:00

abstract：:Peptide 9 (TDAYNQKLSERRAN) and peptide 10 (NATAEGRAINRRVE) represent surface-exposed epitopes of outer membrane protein F of Pseudomonas aeruginosa. Rats immunized with four intramuscular inoculations on days 0, 14, 28, and 42 with either peptide 9 or peptide 10 conjugated to keyhole limpet hemocyanin were afforded pr...

journal_title：Infection and immunity

authors： Gilleland LB,Gilleland HE Jr

更新日期：1995-06-01 00:00:00

abstract：:This study determined the role of crl in the production of curli by, the hemagglutination activity of, and fibronectin binding by avian pathogenic Escherichia coli chi 7122. Curli, an extracellular structure that binds fibronectin, was recently described (A. Olsén, A. Jonsson, and S. Normark, Nature [London] 338:652-6...

journal_title：Infection and immunity

authors： Provence DL,Curtiss R 3rd

更新日期：1992-11-01 00:00:00

abstract：:Intestinal epithelial cells (IECs), including secretory goblet cells, form essential physiochemical barriers that separate luminal bacteria from underlying immune cells in the intestinal mucosa. IECs are common targets for enteric bacterial pathogens, with hosts responding to these microbes through innate toll-like re...

journal_title：Infection and immunity

authors： Bhinder G,Stahl M,Sham HP,Crowley SM,Morampudi V,Dalwadi U,Ma C,Jacobson K,Vallance BA

更新日期：2014-09-01 00:00:00

abstract：:The action of injected bacterial lipopolysaccharide upon the uptake of cytophilic antibodies by macrophages was found to be unrelated either to changes in surface charge or to the rate of anaerobic glycolysis of these cells. It is apparently mediated by alterations in the levels of material in the serum which enhances...

journal_title：Infection and immunity

authors： Tizard IR

更新日期：1971-10-01 00:00:00

abstract：:Merozoite surface protein 2 (MSP2) is an abundant glycosylphosphatidylinositol (GPI)-anchored protein of Plasmodium falciparum, which is a potential component of a malaria vaccine. As all forms of MSP2 can be categorized into two allelic families, a vaccine containing two representative forms of MSP2 may overcome the ...

journal_title：Infection and immunity

authors： Adda CG,MacRaild CA,Reiling L,Wycherley K,Boyle MJ,Kienzle V,Masendycz P,Foley M,Beeson JG,Norton RS,Anders RF

更新日期：2012-12-01 00:00:00

abstract：:Actinobacillus pleuropneumoniae serotype 7 strains are shown to spontaneously lose cytolytic activity with a frequency of approximately 10(-4). The phenotypic change is associated with the loss of approximately 8.5 kbp of chromosomal DNA. A genomic fragment encoding the cytolysin and its flanking sequences was cloned ...

journal_title：Infection and immunity

authors： Anderson C,Potter AA,Gerlach GF

更新日期：1991-11-01 00:00:00