Abstract:
:The regulation of innate immune responses to pathogens occurs through the interaction of Toll-like receptors (TLRs) with pathogen-associated molecular patterns and the activation of several signaling pathways whose contribution to the overall innate immune response to pathogens is poorly understood. We demonstrate a mechanism of control of murine macrophage responses mediated by TLR1/2 heterodimers through c-Jun N-terminal kinase 1 (JNK1) activity. JNK controls tumor necrosis factor alpha production and TLR-mediated macrophage responses to Borrelia burgdorferi, the causative agent of Lyme disease, and the TLR1/TLR2-specific agonist PAM(3)CSK(4). JNK1, but not JNK2, activity regulates the expression of the tlr1 gene in the macrophage cell line RAW264.7, as well as in primary CD11b(+) cells. We also show that the proximal promoter region of the human tlr1 gene contains an AP-1 binding site that is subjected to regulation by the kinase and binds two complexes that involve the JNK substrates c-Jun, JunD, and ATF-2. These results demonstrate that JNK1 regulates the response to TLR1/2 ligands and suggest a positive feedback loop that may serve to increase the innate immune response to the spirochete.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Izadi H,Motameni AT,Bates TC,Olivera ER,Villar-Suarez V,Joshi I,Garg R,Osborne BA,Davis RJ,Rincón M,Anguita Jdoi
10.1128/IAI.00492-07subject
Has Abstractpub_date
2007-10-01 00:00:00pages
5027-34issue
10eissn
0019-9567issn
1098-5522pii
IAI.00492-07journal_volume
75pub_type
杂志文章abstract::Little data are available regarding L-form phagocyte interactions. Due to difficulty with more conventional methods, a serum-free technique of surface phagocytosis employing cellulose ester micropore filters, fluorochrome staining, and reflecting fluorescence microscopy was developed. Intracellular localization of L-f...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.5.6.976-981.1972
更新日期:1972-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.27.2.604-613.1980
更新日期:1980-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1995-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.19.2.457-461.1978
更新日期:1978-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.3.1017-1022.1998
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.20.1.73-77.1978
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.2.355-359.1975
更新日期:1975-02-01 00:00:00
abstract::Merozoite surface proteins of Plasmodium falciparum play a critical role in the invasion of human erythrocytes by the malaria parasite. Here we describe the identification of a novel protein with a molecular mass of 40 kDa that is found on the merozoite surface of P. falciparum. We call this protein merozoite surface ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.11.4460-4467.1997
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.10.3536-3546.1991
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.1.197-208.1996
更新日期:1996-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.4.764-765.1974
更新日期:1974-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.8.4603-4611.2004
更新日期:2004-08-01 00:00:00
abstract::The naturally antibiotic-resistant bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a disease with stubbornly high mortality and a complex, protracted treatment regimen. The worldwide incidence of melioidosis is likely grossly underreported, though it is known to be highly endemic in northern...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00938-17
更新日期:2018-04-23 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.12.7004-7012.2002
更新日期:2002-12-01 00:00:00