Cell-mediated immunity to Herpes simplex in humans: lymphocyte cytotoxicity measured by 51-Cr release from infected cells.

abstract：:Pasteurella multocida is the causative agent of fowl cholera in birds. In a previous study using signature-tagged mutagenesis, we identified a mutant, AL251, which was attenuated for virulence in mice and in the natural chicken host. Sequence analysis indicated that AL251 had an insertional inactivation of the gene wa...

journal_title：Infection and immunity

authors： Harper M,Cox AD,St Michael F,Wilkie IW,Boyce JD,Adler B

更新日期：2004-06-01 00:00:00

abstract：:In vivo administration of Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) to mice induced apoptosis before a specific immune response. Apoptosis was associated with the expression of immunoglobulin and Ia on B cells and of CD5 and several markers on T cells. Apoptosis peaked in the spleen and lymph nodes on day 2...

journal_title：Infection and immunity

authors： Isogai E,Isogal H,Kimura K,Fujii N,Takagi S,Hirose K,Hayashi M

更新日期：1996-04-01 00:00:00

abstract：:Macrophage-dependent killing of facultative intracellular bacteria was markedly impaired by overt erythrocytic Plasmodium yoelii or Plasmodium berghei infection of mice. P. yoelii infection was capable of ablating not only the macrophage microbicidal capacity of "normal" animals but also the bactericidal capacities of...

journal_title：Infection and immunity

authors： Murphy JR

更新日期：1981-01-01 00:00:00

abstract：:Pathogenic Yersinia species utilize a type III secretion system (T3SS) to translocate effectors called Yersinia outer proteins (Yops) into infected host cells. Previous studies demonstrated a role for effector Yops in the inhibition of caspase-1-mediated cell death and secretion of interleukin-1beta (IL-1beta) in naïv...

journal_title：Infection and immunity

authors： Lilo S,Zheng Y,Bliska JB

更新日期：2008-09-01 00:00:00

abstract：:The mouse humoral immune response toward native or detergent-extracted outer membrane vesicles (NOMVs and DOMVs, respectively) from Neisseria meningitidis was determined after intranasal immunization. Both preparations elicited high frequencies of NOMV-specific antibody-forming cells (AFCs) locally in the nasal associ...

journal_title：Infection and immunity

authors： Guthrie T,Wong SY,Liang B,Hyland L,Hou S,Høiby EA,Andersen SR

更新日期：2004-05-01 00:00:00

abstract：:A fibronectin (Fn)-binding adhesin of Staphylococcus aureus contains three tandem 37- or 38-amino-acid motifs (D1, D2, and D3), which function to bind Fn. Plasma from patients with S. aureus infections contain antibodies that preferentially recognize ligand induced binding sites in the D motifs and do not inhibit Fn b...

journal_title：Infection and immunity

authors： Huesca M,Sun Q,Peralta R,Shivji GM,Sauder DN,McGavin MJ

更新日期：2000-03-01 00:00:00

abstract：:The intravascular trematode Schistosoma mansoni is a causative agent of schistosomiasis, a disease that constitutes a major health problem globally. In this study we cloned and characterized the schistosome tegumental phosphodiesterase SmNPP-5 and evaluated its role in parasite virulence. SmNPP-5 is a 52.5-kDa protein...

journal_title：Infection and immunity

authors： Bhardwaj R,Krautz-Peterson G,Da'dara A,Tzipori S,Skelly PJ

更新日期：2011-10-01 00:00:00

abstract：:The relationship between hypersensitivity and cellular resistance to infection with facultative intracellular parasites was studied in mice by using infection-immunity in tularemia as a model system. Delayed hypersensitivity to antigenic fractions of Francisella tularensis was first detected 6 to 7 days after immuniza...

journal_title：Infection and immunity

authors： Claflin JL,Larson CL

更新日期：1972-03-01 00:00:00

abstract：:Gonococci from opaque colonies have cell wall outer membrane proteins that are lacking from organisms which form transparent colonies. These "colony opacity-associated" proteins are among a group of "minor" proteins that exhibit heat modification of their apparent subunit molecular sizes, are easily extracted by deoxy...

journal_title：Infection and immunity

authors： Swanson J

更新日期：1980-04-01 00:00:00

abstract：:The Mycobacterium tuberculosis exported repetitive protein (Erp) is a virulence determinant required for growth in cultured macrophages and in vivo. To better understand the role of Erp in Mycobacterium pathogenesis, we generated a mutation in the erp homologue of Mycobacterium marinum, a close genetic relative of M. ...

journal_title：Infection and immunity

authors： Cosma CL,Klein K,Kim R,Beery D,Ramakrishnan L

更新日期：2006-06-01 00:00:00

abstract：:Existing evidence suggests that oxidative insults and antioxidant defense mechanisms play a critical role in the host cell response during infection of endothelial cells by Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever. Heme oxygenase (HO), a rate-limiting enzyme in the pathway for heme ca...

journal_title：Infection and immunity

authors： Rydkina E,Sahni A,Silverman DJ,Sahni SK

更新日期：2002-08-01 00:00:00

abstract：:Pseudomonas aeruginosa is a gram-negative bacillus that is a major cause of morbidity and mortality in immunosuppressed patients, burn patients, and patients with cystic fibrosis. Although immunity to these bacteria has been associated with serum antibody, more recent evidence suggests that T-cell-mediated immunity ma...

journal_title：Infection and immunity

authors： Porwoll JM,Gebel HM,Rodey GE,Markham RB

更新日期：1983-05-01 00:00:00

abstract：:Yersinia enterocolitica serotype 9 contained an antigenic component giving a reaction of total identity with Brucella native hapten and polysaccharide B. This component was present in a phenol-water extract (fraction 5; M. Redfearn, Ph.D. Thesis, University of Wisconsin, Madison, 1960) along with the smooth lipopolysa...

journal_title：Infection and immunity

authors： Fernandez-Lago L,Moriyon I,Toyos J,Diaz R

更新日期：1982-11-01 00:00:00

abstract：:Human monocytes displayed increased expression of CD40 following infection with virulent Mycobacterium tuberculosis. Nevertheless, soluble CD40 ligand (CD40L; also designated CD154) had no effect on the intracellular growth of the organism. Restriction of the intracellular growth of M. tuberculosis by peripheral blood...

journal_title：Infection and immunity

authors： Larkin R,Benjamin CD,Hsu YM,Li Q,Zukowski L,Silver RF

更新日期：2002-08-01 00:00:00

abstract：:Lipopolysaccharides (LPS), either in the free form or complexed to CD14, a LPS receptor, are elicitors of the immune system. Lactoferrin (Lf), a LPS-chelating glycoprotein, protects animals against septic shock. Since optimal protection requires administration of Lf prior to lethal doses of LPS, we hypothesized that i...

journal_title：Infection and immunity

authors： Baveye S,Elass E,Fernig DG,Blanquart C,Mazurier J,Legrand D

更新日期：2000-12-01 00:00:00

abstract：:The purpose of the present study was to analyze Chlamydia pneumoniae-induced, antigen-specific, cell-mediated immunity. Peripheral blood mononuclear cells of four persons infected with C. pneumoniae Kajaani 6 and 17 healthy volunteers were stimulated with antigen composed of whole elementary bodies of C. pneumoniae Ka...

journal_title：Infection and immunity

authors： Surcel HM,Syrjälä H,Leinonen M,Saikku P,Herva E

更新日期：1993-05-01 00:00:00

abstract：:Previously, we identified five genes (Cj1321 to Cj1326, of which Cj1325 and Cj1326 are a single gene) in the O-linked flagellin glycosylation island that are highly prevalent in Campylobacter jejuni isolates from chickens. We report mutagenesis, functional, and structural data to confirm that this locus, and Cj1324 in...

journal_title：Infection and immunity

authors： Howard SL,Jagannathan A,Soo EC,Hui JP,Aubry AJ,Ahmed I,Karlyshev A,Kelly JF,Jones MA,Stevens MP,Logan SM,Wren BW

更新日期：2009-06-01 00:00:00

abstract：:A novel immunobiologically active fraction was prepared from a phenol-water extract of Prevotella intermedia ATCC 25611 by Sephadex G-100 column chromatography. The fraction consisted mainly of carbohydrate and protein and was devoid of fatty acid. The fraction showed high-molecular-weight bands (10,000 to 12,000) on ...

journal_title：Infection and immunity

authors： Iki K,Kawahara K,Sawamura S,Arakaki R,Sakuta T,Sugiyama A,Tamura H,Sueda T,Hamada S,Takada H

更新日期：1997-11-01 00:00:00

abstract：:Fourteen freshly isolated strains of Streptococcus sanguis were obtained from the dental plaque of five healthy adults. Whole saliva was collected concomitant with the plaque isolates from the five subjects, and a second whole saliva sample was collected 10 weeks later. All possible combinations of the first five sali...

journal_title：Infection and immunity

authors： Liljemark WF,Bloomquist CG,Ofstehage JC

更新日期：1979-12-01 00:00:00

abstract：:Plasmodium falciparum's ability to invade erythrocytes is essential for its survival within the human host. Immune mechanisms that impair this ability are therefore expected to contribute to immunity against the parasite. Plasma of humans who are naturally exposed to malaria has been shown to have growth-inhibitory ac...

journal_title：Infection and immunity

authors： Rono J,Färnert A,Olsson D,Osier F,Rooth I,Persson KE

更新日期：2012-05-01 00:00:00

abstract：:In order to plan for the wide-scale introduction of meningococcal C conjugate (MCC) vaccine for United Kingdom children up to 18 years old, phase II trials were undertaken to investigate whether there was any interaction between MCC vaccines conjugated to tetanus toxoid (TT) or a derivative of diphtheria toxin (CRM(19...

journal_title：Infection and immunity

authors： Burrage M,Robinson A,Borrow R,Andrews N,Southern J,Findlow J,Martin S,Thornton C,Goldblatt D,Corbel M,Sesardic D,Cartwight K,Richmond P,Miller E

更新日期：2002-09-01 00:00:00

abstract：:B-cell-deficient mice were prepared by administration of rabbit anti-mouse-mu antiserum to newborn animals within 12 h of birth onwards. Such immunodeficient animals, along with the normal controls, were infected intravenously with Cryptococcus neoformans. There was no difference in the mortality pattern, viable count...

journal_title：Infection and immunity

authors： Monga DP,Kumar R,Mohapatra LN,Malaviya AN

更新日期：1979-10-01 00:00:00

abstract：:The role of capsule in the adherence of Haemophilus influenzae type b to human epithelial cells in vitro was examined. A group of 30 nonadherent isolates did not differ in degree of encapsulation compared with their respective adherent variants. Furthermore, capsule-deficient mutants of both nonadherent and adherent v...

journal_title：Infection and immunity

authors： LiPuma JJ,Gilsdorf JR

更新日期：1987-09-01 00:00:00

abstract：:Three dominant proteins (41, 48, and 49 kDa) were detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in purified preparations of the extracellular aspartyl proteinase (AP) of Candida albicans. All three proteins bound to the specific carboxyl proteinase ligand, pepstatin A, and were assoc...

journal_title：Infection and immunity

authors： Morrison CJ,Hurst SF,Bragg SL,Kuykendall RJ,Diaz H,Pohl J,Reiss E

更新日期：1993-05-01 00:00:00

abstract：:We explored the role of urokinase and tissue-type plasminogen activators (uPA and tPA), as well as the uPA receptor (uPAR; CD87) in mouse severe malaria (SM), using genetically deficient (-/-) mice. The mortality resulting from Plasmodium berghei ANKA infection was delayed in uPA(-/-) and uPAR(-/-) mice but was simila...

journal_title：Infection and immunity

authors： Piguet PF,Da Laperrousaz C,Vesin C,Tacchini-Cottier F,Senaldi G,Grau GE

更新日期：2000-07-01 00:00:00

abstract：:T-cell-mediated immunity is an important determinant in protection against primary infection with Coccidioides immitis, a dimorphic fungal pathogen that causes the disease coccidioidomycosis. To determine if interleukin-12 (IL-12) gene therapy could potentiate host response against C. immitis, we constructed a single-...

journal_title：Infection and immunity

authors： Jiang C,Magee DM,Cox RA

更新日期：1999-06-01 00:00:00

abstract：:Escherichia coli O157:H7, a major Shiga toxin-producing pathogen, has a low infectious dose and causes serious illness in humans. The gastrointestinal tract of cattle is the primary reservoir of E. coli O157:H7, and thus, it is critical to eliminate or reduce E. coli O157:H7 gut colonization. Given that E. coli O157:H...

journal_title：Infection and immunity

authors： Xue Y,Zhang H,Wang H,Hu J,Du M,Zhu MJ

更新日期：2014-05-01 00:00:00

abstract：:Hookworm glutathione S-transferases (GSTs) are critical for parasite blood feeding and survival and represent potential targets for vaccination. Three cDNAs, each encoding a full-length GST protein from the human hookworm Necator americanus (and designated Na-GST-1, Na-GST-2, and Na-GST-3, respectively) were isolated ...

journal_title：Infection and immunity

authors： Zhan B,Perally S,Brophy PM,Xue J,Goud G,Liu S,Deumic V,de Oliveira LM,Bethony J,Bottazzi ME,Jiang D,Gillespie P,Xiao SH,Gupta R,Loukas A,Ranjit N,Lustigman S,Oksov Y,Hotez P

更新日期：2010-04-01 00:00:00

abstract：:Bordetella pertussis fimbriae are composed of a major subunit, Fim2 or Fim3, and the minor subunit FimD. Using immunoelectron microscopy, we provide evidence that FimD is located at the fimbrial tip. The role of FimD in colonization of the mouse respiratory tract was studied by using two fimbrial mutants: a mutant com...

journal_title：Infection and immunity

authors： Geuijen CA,Willems RJ,Bongaerts M,Top J,Gielen H,Mooi FR

更新日期：1997-10-01 00:00:00

abstract：:Genomics revealed the sequence of 3924 genes of the H37Rv strain of Mycobacterium tuberculosis. Proteomics complements genomics in showing which genes are really expressed, and here we show the expression of six genes not predicted by genomics, as proved by two-dimensional electrophoresis and matrix-assisted laser des...

journal_title：Infection and immunity

authors： Jungblut PR,Müller EC,Mattow J,Kaufmann SH

更新日期：2001-09-01 00:00:00