CD40 ligand (CD154) does not contribute to lymphocyte-mediated inhibition of virulent Mycobacterium tuberculosis within human monocytes.

Abstract:

:Human monocytes displayed increased expression of CD40 following infection with virulent Mycobacterium tuberculosis. Nevertheless, soluble CD40 ligand (CD40L; also designated CD154) had no effect on the intracellular growth of the organism. Restriction of the intracellular growth of M. tuberculosis by peripheral blood lymphocytes and antigen-specific CD4+ T-cell lines likewise was not reduced by blocking anti-CD40L monoclonal antibody 5c8.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Larkin R,Benjamin CD,Hsu YM,Li Q,Zukowski L,Silver RF

doi

10.1128/iai.70.8.4716-4720.2002

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

4716-20

issue

8

eissn

0019-9567

issn

1098-5522

journal_volume

70

pub_type

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