In vivo induction of apoptosis and immune responses in mice by administration of lipopolysaccharide from Porphyromonas gingivalis.

Abstract:

:In vivo administration of Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) to mice induced apoptosis before a specific immune response. Apoptosis was associated with the expression of immunoglobulin and Ia on B cells and of CD5 and several markers on T cells. Apoptosis peaked in the spleen and lymph nodes on day 2, and the second peak occurred in the thymus on day 9. Tumor necrosis factor alpha (TNF-alpha) could mediate apoptosis, because the serum TNF-alpha levels were significantly higher than those of controls at 1 day before apoptosis and recombinant murine TNF-alpha induced apoptosis. The apoptosis induced by Pg-LPS was similar to that induced by Escherichia coli LPS in its basic manner, but it was unique in the response of thymus T cells. It was suggested that Pg-LPS could induce apoptosis for the elimination of early nonspecific activated lymphocytes.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Isogai E,Isogal H,Kimura K,Fujii N,Takagi S,Hirose K,Hayashi M

doi

10.1128/IAI.64.4.1461-1466.1996

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

1461-6

issue

4

eissn

0019-9567

issn

1098-5522

journal_volume

64

pub_type

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