In vivo induction of apoptosis and immune responses in mice by administration of lipopolysaccharide from Porphyromonas gingivalis.


:In vivo administration of Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) to mice induced apoptosis before a specific immune response. Apoptosis was associated with the expression of immunoglobulin and Ia on B cells and of CD5 and several markers on T cells. Apoptosis peaked in the spleen and lymph nodes on day 2, and the second peak occurred in the thymus on day 9. Tumor necrosis factor alpha (TNF-alpha) could mediate apoptosis, because the serum TNF-alpha levels were significantly higher than those of controls at 1 day before apoptosis and recombinant murine TNF-alpha induced apoptosis. The apoptosis induced by Pg-LPS was similar to that induced by Escherichia coli LPS in its basic manner, but it was unique in the response of thymus T cells. It was suggested that Pg-LPS could induce apoptosis for the elimination of early nonspecific activated lymphocytes.


Infect Immun


Infection and immunity


Isogai E,Isogal H,Kimura K,Fujii N,Takagi S,Hirose K,Hayashi M




Has Abstract


1996-04-01 00:00:00












  • Motility is crucial for the infectious life cycle of Borrelia burgdorferi.

    abstract::The Lyme disease spirochete, Borrelia burgdorferi, exists in a zoonotic cycle involving an arthropod tick and mammalian host. Dissemination of the organism within and between these hosts depends upon the spirochete's ability to traverse through complex tissues. Additionally, the spirochete outruns the host immune cell...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sultan SZ,Manne A,Stewart PE,Bestor A,Rosa PA,Charon NW,Motaleb MA

    更新日期:2013-06-01 00:00:00

  • Expansion of gamma interferon-producing CD8+ T cells following secondary infection of mice immune to Leishmania major.

    abstract::Reinfection of immune mice with Leishmania major elicits a secondary gamma interferon (IFN-gamma) response to which specific CD8+ T cells are essential. We have shown previously that specific CD8+ T cells from reinfected immune mice release substantially higher levels of IFN-gamma, a cytokine essential for the efficie...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Müller I,Kropf P,Louis JA,Milon G

    更新日期:1994-06-01 00:00:00

  • Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum.

    abstract::Saccharomyces boulardii, a nonpathogenic yeast, is effective in treating some patients with Clostridium difficile diarrhea and colitis. We have previously reported that S. boulardii inhibits rat ileal secretion in response to C. difficile toxin A possibly by releasing a protease that digests the intestinal receptor fo...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Castagliuolo I,LaMont JT,Nikulasson ST,Pothoulakis C

    更新日期:1996-12-01 00:00:00

  • Inhibition of the secretory activity of Escherichia coli heat-stable enterotoxin by indomethacin.

    abstract::The effect of indomethacin on the net intestinal accumulation of fluid induced by Escherichia coli heat-stable (ST) enterotoxin in the infant mouse model was examined. Indomethacin, when administered with ST enterotoxin, caused a striking decrease in net intestinal fluid accumulation. This inhibition of ST activity wa...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Madsen GL,Knoop FC

    更新日期:1978-10-01 00:00:00

  • Antibody response in white-footed mice (Peromyscus leucopus) experimentally infected with the Lyme disease spirochete (Borrelia burgdorferi).

    abstract::White-footed mice (Peromyscus leucopus), the primary reservoir for Borrelia burgdorferi in the northern midwest and northeastern United States, were experimentally inoculated with an infectious strain or a noninfectious strain of the Lyme disease spirochete and examined for their specific antibody response with the en...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Schwan TG,Kime KK,Schrumpf ME,Coe JE,Simpson WJ

    更新日期:1989-11-01 00:00:00

  • Braun lipoprotein (Lpp) contributes to virulence of yersiniae: potential role of Lpp in inducing bubonic and pneumonic plague.

    abstract::Yersinia pestis evolved from Y. pseudotuberculosis to become the causative agent of bubonic and pneumonic plague. We identified a homolog of the Salmonella enterica serovar Typhimurium lipoprotein (lpp) gene in Yersinia species and prepared lpp gene deletion mutants of Y. pseudotuberculosis YPIII, Y. pestis KIM/D27 (p...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sha J,Agar SL,Baze WB,Olano JP,Fadl AA,Erova TE,Wang S,Foltz SM,Suarez G,Motin VL,Chauhan S,Klimpel GR,Peterson JW,Chopra AK

    更新日期:2008-04-01 00:00:00

  • Sigma B contributes to Listeria monocytogenes gastrointestinal infection but not to systemic spread in the guinea pig infection model.

    abstract::Contributions of the alternative sigma factor sigmaB to Listeria monocytogenes infection were investigated using strains bearing null mutations in sigB, prfA, or inlA or in selected inlA or prfA promoter regions. The DeltaP4inlA strain, which has a deletion in the sigmaB-dependent P4inlA promoter, and the DeltasigB st...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Garner MR,Njaa BL,Wiedmann M,Boor KJ

    更新日期:2006-02-01 00:00:00

  • Downmodulation of Effector Functions in NK Cells upon Toxoplasma gondii Infection.

    abstract::The obligate intracellular parasite Toxoplasma gondii can actively infect any nucleated cell type, including cells from the immune system. The rapid transfer of T. gondii from infected dendritic cells to effector natural killer (NK) cells may contribute to the parasite's sequestration and shielding from immune recogni...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sultana MA,Du A,Carow B,Angbjär CM,Weidner JM,Kanatani S,Fuks JM,Muliaditan T,James J,Mansfield IO,Campbell TM,Liu L,Kadri N,Lambert H,Barragan A,Chambers BJ

    更新日期:2017-09-20 00:00:00

  • Protective role of murine β-defensins 3 and 4 and cathelin-related antimicrobial peptide in Fusarium solani keratitis.

    abstract::Antimicrobial peptides (AMPs), such as β-defensins and cathelicidins, are essential components of innate and adaptive immunity owing to their extensive multifunctional activities. However, their role in fungal infection in vivo remains elusive. In this study, we investigated the protective effect of murine β-defensin ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kolar SS,Baidouri H,Hanlon S,McDermott AM

    更新日期:2013-08-01 00:00:00

  • Expression, Purification, and Biological Characterization of Babesia microti Apical Membrane Antigen 1.

    abstract::The intraerythrocytic apicomplexan Babesia microti, the primary causative agent of human babesiosis, is a major public health concern in the United States and elsewhere. Apicomplexans utilize a multiprotein complex that includes a type I membrane protein called apical membrane antigen 1 (AMA1) to invade host cells. We...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Moitra P,Zheng H,Anantharaman V,Banerjee R,Takeda K,Kozakai Y,Lepore T,Krause PJ,Aravind L,Kumar S

    更新日期:2015-10-01 00:00:00

  • Functional Analysis of the Role of Toxoplasma gondii Nucleoside Triphosphate Hydrolases I and II in Acute Mouse Virulence and Immune Suppression.

    abstract::Bioluminescent reporter assays have been widely used to study the effect of Toxoplasma gondii on host gene expression. In the present study, we extend these studies by engineering novel reporter cell lines containing a gamma-activated sequence (GAS) element driving firefly luciferase (FLUC). In RAW264.7 macrophages, T...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Olias P,Sibley LD

    更新日期:2016-06-23 00:00:00

  • Immunopathology of experimental Chagas' disease: binding of T cells to Trypanosoma cruzi-infected heart tissue.

    abstract::The immunopathology of Chagas' disease was studied in the experimental model of chronic infection in C57BL/10JT or mice. Sublethal infection with Trypanosoma cruzi, Y strain, induced specific antibodies and a delayed hypersensitivity response to parasite antigens. Mice developed chronic chagasic myocarditis but not sk...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Mortatti RC,Maia LC,de Oliveira AV,Munk ME

    更新日期:1990-11-01 00:00:00

  • Distinct cytokine regulation by cholera toxin and type II heat-labile toxins involves differential regulation of CD40 ligand on CD4(+) T cells.

    abstract::Cholera toxin (CT) and the type II heat-labile enterotoxins (HLT) LT-IIa and LT-IIb act as potent systemic and mucosal adjuvants and induce distinct T-helper (Th)-cell cytokine profiles. In the present study, CT and the type II HLT were found to differentially affect cytokine production by anti-CD3-stimulated human pe...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Martin M,Metzger DJ,Michalek SM,Connell TD,Russell MW

    更新日期:2001-07-01 00:00:00

  • The human P-glycoprotein transporter enhances the type I interferon response to Listeria monocytogenes infection.

    abstract::Human multidrug efflux transporters are known for their ability to extrude antibiotics and toxic compounds out of cells, yet accumulating data indicate they have additional functions in diverse physiological processes not related to drug efflux. Here, we show that the human multidrug transporter P-glycoprotein (P-gp) ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sigal N,Kaplan Zeevi M,Weinstein S,Peer D,Herskovits AA

    更新日期:2015-06-01 00:00:00

  • Nitric oxide levels regulate the immune response of Drosophila melanogaster reference laboratory strains to bacterial infections.

    abstract::Studies on the innate immune response against microbial infections in Drosophila melanogaster involve mutant strains and their reference strains that act as experimental controls. We used five standard D. melanogaster laboratory reference strains (Oregon R, w1118, Canton-S, Cinnabar Brown, and Yellow White [YW]) and i...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Eleftherianos I,More K,Spivack S,Paulin E,Khojandi A,Shukla S

    更新日期:2014-10-01 00:00:00

  • Distinct Morphological Fates of Uropathogenic Escherichia coli Intracellular Bacterial Communities: Dependency on Urine Composition and pH.

    abstract::Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections. These bacteria undertake a multistage infection cycle involving invasion of and proliferation within urinary tract epithelial cells, leading to the rupture of the host cell and dispersal of the bacteria, some of which have a highly...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Iosifidis G,Duggin IG

    更新日期:2020-08-19 00:00:00

  • Agonists of Toll-like receptors 3, 4, 7, and 9 are candidates for use as adjuvants in an outer membrane vaccine against Neisseria meningitidis serogroup B.

    abstract::The bacterium Neisseria meningitidis is the causative agent of meningitis and sepsis. A generally effective vaccine against N. meningitidis serogroup B is not yet available, but outer membrane vesicle vaccines are in development. These vaccines contain lipopolysaccharide (LPS). The inclusion of N. meningitidis wild-ty...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Fransen F,Boog CJ,van Putten JP,van der Ley P

    更新日期:2007-12-01 00:00:00

  • Effect of indomethacin on the incidence of experimental Escherichia coli pyelonephritis.

    abstract::In the presence of temporary obstruction (20 h), ascending Escherichia coli urinary infection leads to irreversible acute exudative pyelonephritis (AEP) in rats. The purpose of the present study was to investigate the early inflammatory events which take place in response to the presence of bacteria in the kidney pare...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Glauser MP,Francioli PB,Bille J,Bonard M,Meylan P

    更新日期:1983-05-01 00:00:00

  • Conservation and diversity of sap homologues and their organization among Campylobacter fetus isolates.

    abstract::Campylobacter fetus surface layer proteins (SLPs), encoded by sapA homologues, are important in virulence. In wild-type C. fetus strain 23D, all eight sapA homologues are located in the 54-kb sap island, and SLP expression reflects the position of a unique sapA promoter in relation to the sapA homologues. The extensiv...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Tu ZC,Hui J,Blaser MJ

    更新日期:2004-03-01 00:00:00

  • Cloning and genetic analysis of serotype 5 M protein determinant of group A streptococci: evidence for multiple copies of the M5 determinant in the Streptococcus pyogenes genome.

    abstract::A gene bank of group A Streptococcus strain Manfredo (M protein serotype 5) was constructed with a bacteriophage lambda vector-Escherichia coli K-12 host system and screened by immunoblotting hybrid phage plaques with antisera raised to purified pep M5 (serotype 5 M protein fragment released from the streptococcal cel...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kehoe MA,Poirier TP,Beachey EH,Timmis KN

    更新日期:1985-04-01 00:00:00

  • Protective role of nitric oxide in Staphylococcus aureus infection in mice.

    abstract::This study was carried out to determine the role of nitric oxide (NO) in Staphylococcus aureus infection in mice. NO production in spleen cell cultures was induced by heat-killed S. aureus. Expression of mRNA of the inducible isoform of NO synthase (iNOS) was induced in the spleens and kidneys of S. aureus-infected mi...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sasaki S,Miura T,Nishikawa S,Yamada K,Hirasue M,Nakane A

    更新日期:1998-03-01 00:00:00

  • Immunogenicity of Salmonella typhi Ty21a vaccine for young children.

    abstract::An attenuated Salmonella typhi Ty21a vaccine was administered to 18 infants and toddlers (less than or equal to 24 months old) to determine its safety and immunogenicity. The vaccination (10(9) CFU per dose, three doses) was well tolerated. However, after the vaccination there was no evidence of a humoral or cellular ...

    journal_title:Infection and immunity

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Murphy JR,Grez L,Schlesinger L,Ferreccio C,Baqar S,Muñoz C,Wasserman SS,Losonsky G,Olson JG,Levine MM

    更新日期:1991-11-01 00:00:00

  • Relationship between Habs serotypes and 2-amino sugar composition of Pseudomonas aeruginosa.

    abstract::Thirteen Habs-serotype strains could be classified into 11 groups depending on the characteristic patterns of 2-amino sugar composition; strains of serotypes 2, 5, and 7 had the same pattern, and each other serotype strain had its own distinctive pattern. In our classification, fucosamine and quinovosamine were of imp...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Suzuki N,Tsunematsu Y,Matsumoto H,Tazaki T

    更新日期:1977-03-01 00:00:00

  • Neutralization of lymphocyte immortalization by different strains of Epstein-Barr virus with a murine monoclonal antibody.

    abstract::A murine monoclonal antibody was raised against the B95-8 strain of Epstein-Barr virus (EBV), which was isolated from a case of mononucleosis after blood transfusion (Hoffman et al. Proc. Natl. Acad. Sci. U.S.A. 77:2979, 1980). We provide evidence that neutralization of immortalization by this monoclonal antibody is v...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Miller G,Heston L,Hoffman G

    更新日期:1982-09-01 00:00:00

  • Development of bactericidal capacity and phagocytosis-associated metabolism of fetal pig leukocytes.

    abstract::Evidence that the bactericidal ability and the stimulated oxidative metabolism of leukocytes appear in parallel during fetal development of the Minnesota Miniature pig has been obtained by application of the techniques applied to studies of human cells. It was demonstrated that leukocytes from 87- to 90-day fetuses we...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Holmes B,Day N,Haseman J,Good RA

    更新日期:1972-02-01 00:00:00

  • Isolation and partial characterization of staphylococcal decomplementation antigen.

    abstract::A substance with potent decomplementation activity was isolated from staphylococcal culture supernatants by polyethylene glycol precipitation, DEAE-ion-exchange and Sephacryl chromatography, and preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The purified substance exhibited all the characterist...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Bhakdi S,Muhly M

    更新日期:1985-01-01 00:00:00

  • Origins of a 350-kilobase genomic duplication in Mycobacterium tuberculosis and its impact on virulence.

    abstract::In the present study, we have investigated the evolution and impact on virulence of a 350-kb genomic duplication present in the most recently evolved members of the Mycobacterium tuberculosis East Asian lineage. In a mouse model of infection, comparing HN878 subclones HN878-27 (no duplication) and HN878-45 (with the 3...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Domenech P,Rog A,Moolji JU,Radomski N,Fallow A,Leon-Solis L,Bowes J,Behr MA,Reed MB

    更新日期:2014-07-01 00:00:00

  • Proinflammatory activation of neutrophils and monocytes by Helicobacter pylori in patients with different clinical presentations.

    abstract::Chronic Helicobacter pylori infection is associated with mucosal inflammation. The aim of the present study was to assess human neutrophil and monocyte activation by H. pylori strains obtained from patients with different clinical presentations. Bacterial sonicates from 12 strains were used to stimulate phagocyte upre...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Hansen PS,Go MF,Varming K,Andersen LP,Genta RM,Graham DY,Nielsen H

    更新日期:1999-06-01 00:00:00

  • A murine model for infection with Burkholderia cepacia with sustained persistence in the spleen.

    abstract::Burkholderia cepacia is an opportunistic pathogen that causes severe systemic infections in patients with chronic granulomatous disease (CGD) or with cystic fibrosis (CF), but its mechanisms of virulence are poorly understood. We developed a murine model of systemic infection in wild-type (WT) and gamma interferon kno...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Speert DP,Steen B,Halsey K,Kwan E

    更新日期:1999-08-01 00:00:00

  • Protection against colibacillosis in neonatal piglets by immunization of dams with procholeragenoid.

    abstract::Protection against colibacillosis in neonatal piglets was obtained by immunization of pregnant dams with procholeragenoid. Procholeragenoid is a stable high-molecular-weight aggregate of cholera toxin formed during the heating of cholera toxin. Procholeragenoid retained approximately 1% of the toxicity of native toxin...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Fürer E,Cryz SJ Jr,Dorner F,Nicolet J,Wanner M,Germanier R

    更新日期:1982-03-01 00:00:00