In vivo induction of apoptosis and immune responses in mice by administration of lipopolysaccharide from Porphyromonas gingivalis.


:In vivo administration of Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) to mice induced apoptosis before a specific immune response. Apoptosis was associated with the expression of immunoglobulin and Ia on B cells and of CD5 and several markers on T cells. Apoptosis peaked in the spleen and lymph nodes on day 2, and the second peak occurred in the thymus on day 9. Tumor necrosis factor alpha (TNF-alpha) could mediate apoptosis, because the serum TNF-alpha levels were significantly higher than those of controls at 1 day before apoptosis and recombinant murine TNF-alpha induced apoptosis. The apoptosis induced by Pg-LPS was similar to that induced by Escherichia coli LPS in its basic manner, but it was unique in the response of thymus T cells. It was suggested that Pg-LPS could induce apoptosis for the elimination of early nonspecific activated lymphocytes.


Infect Immun


Infection and immunity


Isogai E,Isogal H,Kimura K,Fujii N,Takagi S,Hirose K,Hayashi M




Has Abstract


1996-04-01 00:00:00












  • Protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide in a modified model of endocarditis in rats.

    abstract::The protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide (CP5) was examined in a modified model of catheter-induced endocarditis. Rats were catheterized by surgically passing a polyethylene catheter through the right carotid artery and aortic valve into the left ventricle. The ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Lee JC,Park JS,Shepherd SE,Carey V,Fattom A

    更新日期:1997-10-01 00:00:00

  • Lymphocyte function-associated antigen 1 is a receptor for Pasteurella haemolytica leukotoxin in bovine leukocytes.

    abstract::Pasteurella (Mannheimia) haemolytica leukotoxin (Lkt) causes cell type- and species-specific effects in ruminant leukocytes. Recent studies indicate that P. haemolytica Lkt binds to bovine CD18, the common subunit of all beta2 integrins. We designed experiments with the following objectives: to identify which member o...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Jeyaseelan S,Hsuan SL,Kannan MS,Walcheck B,Wang JF,Kehrli ME,Lally ET,Sieck GC,Maheswaran SK

    更新日期:2000-01-01 00:00:00

  • Contribution of urease to colonization by Shiga toxin-producing Escherichia coli.

    abstract::Shiga toxin-producing Escherichia coli (STEC) is a food-borne pathogen with a low infectious dose that colonizes the colon in humans and can cause severe clinical manifestations such as hemolytic-uremic syndrome. The urease enzyme, encoded in the STEC chromosome, has been demonstrated to act as a virulence factor in o...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Steyert SR,Kaper JB

    更新日期:2012-08-01 00:00:00

  • Potentiation of human natural killer cell cytotoxicity by Salmonella bacteria is an interferon- and interleukin-2-independent process that utilizes CD2 and CD18 structures in the effector phase.

    abstract::Incubation of large granular lymphocytes (LGL) with glutaraldehyde-fixed bacteria stimulated in the supernatant the production of interferon (IFN), which proved to be mainly IFN-gamma. Even though IFN-gamma was produced upon exposure of LGL to bacteria, anti-IFN-gamma antibodies failed to interfere with induction of c...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Tarkkanen J,Saksela E

    更新日期:1991-08-01 00:00:00

  • Heterogeneic autoantibody against neurofilament protein in the sera of animals with experimental kuru and Creutzfeldt-Jakob disease and natural scrapie infection.

    abstract::Heterogeneic autoantibodies against axonal neurofilament proteins of mature mouse neurons grown in vitro were detected by the indirect immunofluorescence technique in 12.7% (9 of 71) of the sera from nonhuman primates infected with kuru, in 14.5% (17 of 117) and 4% (1 of 25), respectively, of the sera from nonhuman pr...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Aoki T,Gibbs CJ Jr,Sotelo J,Gajdusek DC

    更新日期:1982-10-01 00:00:00

  • Function of the fibronectin-binding serum opacity factor of Streptococcus pyogenes in adherence to epithelial cells.

    abstract::The serum opacity factor (SOF) of Streptococcus pyogenes is a serotyping tool and pathogenesis factor. Using SOF-coated latex beads in cell adherence assays and antiserum directed against SOF in S. pyogenes-HEp-2 cell adherence inhibition experiments, we demonstrate SOF involvement in the fibronectin-mediated adherenc...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Oehmcke S,Podbielski A,Kreikemeyer B

    更新日期:2004-07-01 00:00:00

  • Comparison of in vivo and in vitro multiplication rates of Haemophilus influenzae type b.

    abstract::A model of invasive Haemophilus influenzae type b disease in rats was used to compare the net in vivo and in vitro multiplication rates of this bacterium. In both the blood of rats and in vitro cultures (fresh rat blood or enriched broth) there was an exponential increase in the number of CFU per milliliter with calcu...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Rubin LG

    更新日期:1986-06-01 00:00:00

  • The twin arginine translocation system is essential for virulence of Yersinia pseudotuberculosis.

    abstract::Yersinia species pathogenic to humans have been extensively characterized with respect to type III secretion and its essential role in virulence. This study concerns the twin arginine translocation (Tat) pathway utilized by gram-negative bacteria to secrete folded proteins across the bacterial inner membrane into the ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Lavander M,Ericsson SK,Bröms JE,Forsberg A

    更新日期:2006-03-01 00:00:00

  • Structural and functional lesions in brush border of human polarized intestinal Caco-2/TC7 cells infected by members of the Afa/Dr diffusely adhering family of Escherichia coli.

    abstract::Diffusely adhering Escherichia coli (DAEC) strains expressing F1845 fimbrial adhesin or Dr hemagglutinin belonging to the Afa/Dr family of adhesins infect cultured polarized human intestinal cells through recognition of the brush border-associated decay-accelerating factor (DAF; CD55) as a receptor. The wild-type Afa/...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Peiffer I,Guignot J,Barbat A,Carnoy C,Moseley SL,Nowicki BJ,Servin AL,Bernet-Camard MF

    更新日期:2000-10-01 00:00:00

  • Immunoglobulin A from bronchopulmonary secretions blocks bactericidal and opsonizing effects of antibody to nontypable Haemophilus influenzae.

    abstract::Patients with chronic bronchitis are colonized by and may develop acute bronchopulmonary infection due to nontypable Haemophilus influenzae (NTHI) despite the presence of bactericidal and opsonizing antibody to the infecting organism. To test the hypothesis that secretory immunoglobulin A (IgA) interferes with host de...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Musher DM,Goree A,Baughn RE,Birdsall HH

    更新日期:1984-07-01 00:00:00

  • The type III secretion effector NleF of enteropathogenic Escherichia coli activates NF-κB early during infection.

    abstract::The enteric pathogens enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli employ a type 3 secretion system (T3SS) to manipulate the host inflammatory response during infection. Previously, it has been reported that EPEC, in a T3SS-dependent manner, induces an early proinflammatory response through a...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Pallett MA,Berger CN,Pearson JS,Hartland EL,Frankel G

    更新日期:2014-11-01 00:00:00

  • Division of single host cells after infection with chlamydiae.

    abstract::Mouse fibroblasts (L cells) were infected in suspension with Chlamydia psittaci (6BC) and then plated out on a solid substrate at a density of 80 cells per cm2 so that the effect of chlamydial infection on the division of single host cells and their progeny could be determined. Uninfected L cells multiplied with a mea...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Horoschak KD,Moulder JW

    更新日期:1978-01-01 00:00:00

  • Multiplicity of Scrapie virus in infected mouse spleen cells in vivo.

    abstract::Subpopulations of spleen cells from scrapie virus-infected mice were used to determine the average virus content of infected cells in vivo at a time when virus was rapidly increasing in titer in lymphoreticular tissues. Comparison of the mean lethal doses of lysed to intact cells indicated averages of 2 to 6 infectiou...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Lavelle GC

    更新日期:1973-06-01 00:00:00

  • Antibody formation to trehalose-6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis.

    abstract::A complex of trehalose-6, 6'-dimycolate (cord factor) and methylated bovine serum albumin was prepared, and its effect on the toxicity of cord factor in mice was studied. Either the active immunization with cord factor-methylated bovine serum albumin complex or the passive transfer of sera of rabbits vaccinated with t...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kato M

    更新日期:1972-02-01 00:00:00

  • Skin lesions produced by Staphylococcus aureus exfoliatin in hairless mice.

    abstract::Exfoliatin caused skin loss in hairless mutant mice only while they lacked hair, but older mice were more resistant to this effect than neonates. ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kapral FA,Miller MM

    更新日期:1972-11-01 00:00:00

  • Interleukin-6 production in a murine model of Pneumocystis carinii pneumonia: relation to resistance and inflammatory response.

    abstract::The production of interleukin-6 (IL-6) and its possible relationship to host resistance and inflammatory response to Pneumocystis carinii infection were examined in mice with severe combined immunodeficiency (SCID mice). IL-6 activity was detected in the serum and lungs of P. carinii-infected mice but not in mice free...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Chen W,Havell EA,Gigliotti F,Harmsen AG

    更新日期:1993-01-01 00:00:00

  • Variable adherence of fimbriated Haemophilus influenzae type b to human cells.

    abstract::The attachment of isogenic fimbriated and nonfimbriated Haemophilus influenzae type b variants to human cells was studied by using a radioactive assay and an indirect immunofluorescent assay. As described previously, fimbriated H. influenzae variants adhered to a greater extent than nonfimbriated variants to human buc...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sable NS,Connor EM,Hall CB,Loeb MR

    更新日期:1985-04-01 00:00:00

  • Virulence of Pseudomonas aeruginosa and spontaneous spread of pseudomonas pneumonia in a mink ranch.

    abstract::Comparative studies on the virulence of two strains of Pseudomonas aeruginosa isolated from otic pus and mink pneumonic lesion, respectively, were made by means of intranasal inoculation in mink. The minimal lethal dose of the former (strain NC-5, highly virulent for mice) was 10(10), and that of the latter (strain No...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Shimizu T,Homma JY,Aoyama T,Onodera T,Noda H

    更新日期:1974-07-01 00:00:00

  • Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 ligand(hi) population.

    abstract::In the lungs of mice vaccinated with Mycobacterium bovis BCG, there was an accumulation of CD4 cells expressing the activated effector phenotype CD44hi CD62 ligandlo) (CD62Llo) which were capable of secreting gamma interferon. Upon cell transfer, however, cells expressing a resting/naïve phenotype (CD44lo CD62Lhi) wer...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kipnis A,Irwin S,Izzo AA,Basaraba RJ,Orme IM

    更新日期:2005-11-01 00:00:00

  • Generalized infection and lack of delayed hypersensitivity in BALB/c mice infected with Leishmania tropica major.

    abstract::The susceptibility of a few strains of mice to a subcutaneous injection of Leishmania tropica major, the causative agent of cutaneous leishmaniasis in humans, was studied. The infection in six strains (CBA, AKR/J, AKR/cu, C57BL/6, A/J, and C3H) remained cutaneous, and the animals recovered within 3 to 4 months. In con...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Nasseri M,Modabber FZ

    更新日期:1979-11-01 00:00:00

  • Neisseria lactamica and Neisseria meningitidis share lipooligosaccharide epitopes but lack common capsular and class 1, 2, and 3 protein epitopes.

    abstract::Neisseria lactamica, a common human pharyngeal commensal, contributes to acquired immunity to Neisseria meningitidis. To define the surface antigens shared between these two species, we used monoclonal antibodies (MAbs) to study 35 N. lactamica strains isolated in various parts of the world for cross-reactivity with m...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kim JJ,Mandrell RE,Griffiss JM

    更新日期:1989-02-01 00:00:00

  • Purification and characterization of three types of proteases from culture supernatants of Porphyromonas gingivalis.

    abstract::Three types of caseinolytic proteases (Pase-A, Pase-B, and Pase-C) were isolated and purified from culture supernatants of Porphyromonas gingivalis 381 by the combined procedures of acetone precipitation, gel filtration, solubilization with octylthioglucoside followed by affinity chromatography on arginine-Sepharose 4...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Hinode D,Hayashi H,Nakamura R

    更新日期:1991-09-01 00:00:00

  • Cryptococcus neoformans enters the endolysosomal pathway of dendritic cells and is killed by lysosomal components.

    abstract::Cryptococcus neoformans is an opportunistic fungal pathogen that primarily causes disease in immunocompromised individuals. Dendritic cells (DCs) can phagocytose C. neoformans, present cryptococcal antigen, and kill C. neoformans. However, early events following C. neoformans phagocytosis by DCs are not well defined. ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Wozniak KL,Levitz SM

    更新日期:2008-10-01 00:00:00

  • Effects of cell source, mouse strain, and immunosuppressive treatment on production of virulent and attenuated murine cytomegalovirus.

    abstract::Murine cytomegalovirus pools from various in vitro and in vivo sources were compared for virulence in suckling mice in an effort to identify the conditions which were necessary for the production of virulent and attenuated viruses. Virus passaged in tracheal ring and salivary gland organ cultures, where virus is produ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Selgrade MK,Nedrud JG,Collier AM,Gardner DE

    更新日期:1981-09-01 00:00:00

  • Ribonucleic acid synthesis in normal and immune macrophages after antigenic stimulus.

    abstract::Macrophage ribonucleic acid (RNA) synthesis is an important metabolic process intimately related to the function of these cells. Mouse peritoneal macrophage RNA was extracted with phenol in the presence of bentonite and electrophoresed on composite agarose-polyacrylamide gels. The pulse-chase technique was used to fol...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Soderberg LS,Tewari RP,Solotorovsky M

    更新日期:1976-06-01 00:00:00

  • Effect of CpG oligodeoxynucleotides on the immunogenicity of Pfs25, a Plasmodium falciparum transmission-blocking vaccine antigen.

    abstract::Antibodies directed against Pfs25, a protein present on the surface of zygotes and ookinetes of Plasmodium falciparum, completely block pathogen transmission. We evaluated the immunomodulatory effect of CpG oligodeoxynucleotides (ODN) on the immunogenicity of recombinant Pfs25 (rPfs25) formulated in alum (Al). Immuniz...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Coban C,Ishii KJ,Stowers AW,Keister DB,Klinman DM,Kumar N

    更新日期:2004-01-01 00:00:00

  • Shift in ribonucleotide reductase gene expression in Pseudomonas aeruginosa during infection.

    abstract::The roles of different ribonucleotide reductases (RNRs) in bacterial pathogenesis have not been studied systematically. In this work we analyzed the importance of the different Pseudomonas aeruginosa RNRs in pathogenesis using the Drosophila melanogaster host-pathogen interaction model. P. aeruginosa codes for three d...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sjöberg BM,Torrents E

    更新日期:2011-07-01 00:00:00

  • Phage-dependent changes in Shigella flexneri type antigen synthesis.

    abstract::Lysogenic conversion of Shigella flexneri type antigens was studied with the aid of wild-type and thermosensitive mutant phages. With all wild-type phages, the appearance of glycosylated antigen was accompanied by the appearance of polyprenyl phosphate glucose synthetase activity. With some of the mutant phages, the a...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Financsek I,Ketyi I,Sasak W,Jankowski W,Janczura E,Chojnacki T

    更新日期:1976-12-01 00:00:00

  • Bacterial Nucleotidyl Cyclase Inhibits the Host Innate Immune Response by Suppressing TAK1 Activation.

    abstract::Exoenzyme Y (ExoY) is a type III secretion system effector found in 90% of the Pseudomonas aeruginosa isolates. Although it is known that ExoY is a soluble nucleotidyl cyclase that increases the cytoplasmic levels of nucleoside 3',5'-cyclic monophosphates (cNMPs) to mediate endothelial Tau phosphorylation and permeabi...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: He C,Zhou Y,Liu F,Liu H,Tan H,Jin S,Wu W,Ge B

    更新日期:2017-08-18 00:00:00

  • Reduction of Articular and Systemic Inflammation by Kava-241 in a Porphyromonas gingivalis-Induced Arthritis Murine Model.

    abstract::Rheumatoid arthritis (RA) is an inflammatory disease that has been linked to several risk factors, including periodontitis. Identification of new anti-inflammatory compounds to treat arthritis is needed. We had previously demonstrated the beneficial effect of Kava-241, a kavain-derived compound, in the management of P...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Huck O,You J,Han X,Cai B,Panek J,Amar S

    更新日期:2018-08-22 00:00:00