Abstract:
:The relationship between hypersensitivity and cellular resistance to infection with facultative intracellular parasites was studied in mice by using infection-immunity in tularemia as a model system. Delayed hypersensitivity to antigenic fractions of Francisella tularensis was first detected 6 to 7 days after immunization with viable F. tularensis vaccine, at which time immunity against challenge infection developed. Both immunity and delayed-type sensitivity reached maximal levels by 9 to 10 days. Immediate hypersensitivity occurred after immunization with both viable and nonviable tularemia vaccines but could not be correlated with resistance since nonviable antigens were not protective. Attempts to relate resistance to F. tularensis with nonspecific immunity factors were unsuccessful. Immunization of mice with BCG vaccine stimulated protection against infection with F. novicida and Salmonella typhimurium but provided no protection against infection with F. tularensis. Moreover, viable tularemia vaccine, while inducing marked protection against challenge with specific organisms, afforded no protection against infection with S. typhimurium or S. enteritidis. It is concluded that cellular immunity in tularemia involves an immunologically specific component.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Claflin JL,Larson CLdoi
10.1128/IAI.5.3.311-318.1972subject
Has Abstractpub_date
1972-03-01 00:00:00pages
311-8issue
3eissn
0019-9567issn
1098-5522journal_volume
5pub_type
杂志文章abstract::The ability of hemagglutinating and poorly hemagglutinating strains of the gastroduodenal pathogen Helicobacter pylori to bind 125I-radiolabelled laminin was quantitated in a liquid phase assay. Although all strains bound laminin, some hemagglutinating strains were good binders of laminin (maximum of 31% binding), whe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.9.3640-3648.1994
更新日期:1994-09-01 00:00:00
abstract::Rickettsia rickettsii and R. australis formed infectious antibody complexes when reacted with homologous convalescent serum. The addition of antiglobulin to these complexes showed neutralization of plaques proportional to the concentration of rickettsial immune serum. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.5.966-968.1974
更新日期:1974-05-01 00:00:00
abstract::The glucosyltransferases (GTFs) of viridans streptococci, common pathogens of infective endocarditis, are extracellular proteins that convert sucrose into exopolysaccharides and glucans. GTFs B, C, and D of Streptococcus mutans are modulins that induce, in vitro and in vivo, the production of cytokines, in particular ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.6.3261-3270.2005
更新日期:2005-06-01 00:00:00
abstract::Three open reading frames (ORFs) were identified by a genome walking strategy in the genomes of serotype M49 group A streptococcal (GAS) strains CS101 and 591. These ORFs were located between the mga core regulon and the dipeptide permease operon. The deduced amino acid (aa) sequences contained signature sequences ind...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.9.4859-4869.2002
更新日期:2002-09-01 00:00:00
abstract::A recent study demonstrated that polyclonal antibodies to Rickettsia conorii and monoclonal antibodies to outer membrane proteins A (OmpA) and B (OmpB) provided effective, Fc-dependent, passive immunity, even in severe combined immunodeficient mice with an established infection. In order to determine the mechanism of ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.6.3524-3530.2004
更新日期:2004-06-01 00:00:00
abstract::Contributions of the alternative sigma factor sigmaB to Listeria monocytogenes infection were investigated using strains bearing null mutations in sigB, prfA, or inlA or in selected inlA or prfA promoter regions. The DeltaP4inlA strain, which has a deletion in the sigmaB-dependent P4inlA promoter, and the DeltasigB st...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.2.876-886.2006
更新日期:2006-02-01 00:00:00
abstract::The urease gene of Staphylococcus saprophyticus CCM883 was cloned and expressed in Staphylococcus carnosus TM300. In vitro translation of the cloned DNA sequences revealed six polypeptides (of 70, 47, 29, 27, 20, and 17 kilodaltons) that were associated with enzyme activity. Introduction of the cloned genes into a ure...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.10.2998-3002.1989
更新日期:1989-10-01 00:00:00
abstract::The nitrate dissimilation pathway is important for anaerobic growth in Pseudomonas aeruginosa. In addition, this pathway contributes to P. aeruginosa virulence by using the nematode Caenorhabditis elegans as a model host, as well as biofilm formation and motility. We used a set of nitrate dissimilation pathway mutants...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00822-09
更新日期:2009-10-01 00:00:00
abstract::We examined the secretion of antimicrobial proteins and peptides into surgically isolated and continuously perfused segments of rat small intestine. Up to nine discrete antimicrobial molecules appeared in the intestinal perfusates following intravenous administration of bethanechol, a cholinergic agonist, or intralume...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.12.5161-5165.1996
更新日期:1996-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.4.2015-2021.2006
更新日期:2006-04-01 00:00:00
abstract::Brazilian purpuric fever (BPF)-associated Haemophilus influenzae biogroup aegyptius strain F3031 contains two identical copies of a five gene cluster (hifA to hifE) encoding pili similar to well-characterized Hif fimbriae of H. influenzae type b. HifE, the putative pilus tip adhesin of F3031, shares only 40% amino aci...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.4.1622-1631.1998
更新日期:1998-04-01 00:00:00
abstract::Immunoglobulin G (IgG)- and IgM-specific antibody titers against Salmonella typhi Ty2 porins have been measured in 30 paired typhoid sera by enzyme-linked immunosorbent assay. These studies have found that IgG serum titers of acute and convalescent sera were 625 and 5,000 times higher, respectively than the control se...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.52.1.209-212.1986
更新日期:1986-04-01 00:00:00
abstract::A recent study found that group A Streptococcus (GAS) expresses a cell surface protein with similarity to human collagen (S. Lukomski, K. Nakashima, I. Abdi, V. J. Cipriano, R. M. Ireland, S. R. Reid, G. G. Adams, and J. M. Musser, Infect. Immun. 68:6542-6553, 2000). This streptococcal collagen-like protein (Scl) cont...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.3.1729-1738.2001
更新日期:2001-03-01 00:00:00
abstract::Previously, in our laboratory, we established a two-chamber system to study translocation of Enterococcus faecalis across monolayers of polarized human colon carcinoma-derived T84 cells. By using the same system in the present study, we now show that disruption of gelE of strain OG1RF, which also has a polar effect on...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.3.1606-1612.2005
更新日期:2005-03-01 00:00:00
abstract::The compositions of lipopolysaccharides I and II, isolated from Coxiella burnetii phase I and pure phase II cells, respectively, showed drastic and clear-cut differences. Lipopolysaccharide II exhibited a comparatively simple composition. It contained, in addition to glucosamine (from lipid A) and a 2-keto-3-deoxyoctu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.1.53-57.1982
更新日期:1982-10-01 00:00:00
abstract::The antigenicities of Mycobacterium bovis strain BCG and an isoniazid (INH) - resistant mutant were compared. Sonic extracts of heat-killed, washed bacteria were injected into rabbits, and antisera were produced (anti-BCG and anti-BCG-R). The sonic extracts were also subjected to ultracentrifugation, and test antigens...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.3.4.524-529.1971
更新日期:1971-04-01 00:00:00
abstract::The ability of various strains of rats to produce interferon in response to polyriboinosinic-polyribocytodilic acid was investigated. ACI and DA (RT-1a), BN (RT-1n), Buffalo (RT-1b), August (RT-1c), and GH (RT-1l) strains produced low levels of interferon in response to intraperitoneal administration of polyriboinosin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.43.2.580-583.1984
更新日期:1984-02-01 00:00:00
abstract::Three groups of cattle, each group comprising six animals, were inoculated intravenously with populations of bloodstream forms of Trypanosoma vivax. The first group received T. vivax clone ILDat 1.3 derived from an isolate from Nigeria, while the other two received T. vivax stocks IL 1875 or IL 2133 isolated from Coas...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.54.2.444-447.1986
更新日期:1986-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.9.2892-2900.1991
更新日期:1991-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.5.1384-1390.1990
更新日期:1990-05-01 00:00:00
abstract::Although there is substantial evidence that type IV pili purified from diarrhea-associated Aeromonas species (designated Bfp for bundle-forming pilus) are intestinal colonization factors (S. M. Kirov, L. A. O'Donovan, and K. Sanderson, Infect. Immun. 67:5447-5454, 1999), nothing is known regarding the function of a se...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.7.4040-4048.2000
更新日期:2000-07-01 00:00:00
abstract::Oral inoculation of calves and steers with 10(10) CFU of Escherichia coli O157:H7 induced prompt and sustained increases in serum antibodies to O157 lipopolysaccharide. Neutralizing antibodies to verotoxin 1 also increased rapidly in most steers but more gradually in calves. None of the animals developed neutralizing ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.5.1879-1883.1996
更新日期:1996-05-01 00:00:00
abstract::Intravenous injection of rat anti-mouse gamma interferon (IFN-gamma) monoclonal antibody as well as rabbit anti-mouse tumor necrosis factor (TNF) antibody into mice which had received a sublethal infection with Listeria monocytogenes cells resulted in acceleration of listeriosis. Endogenous IFN-gamma seemed to be prod...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.11.3331-3337.1989
更新日期:1989-11-01 00:00:00
abstract::Previous studies have reported that human vascular endothelial cells lack the membrane-bound lipopolysaccharide (LPS) receptor, CD14 (mCD14). By optimizing assay conditions, including the selection of anti-CD14 monoclonal antibody, we now demonstrate that human umbilical vein endothelial cells (HUVEC) express CD14 on ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.1.479-485.2001
更新日期:2001-01-01 00:00:00
abstract::The effects of tolerance to Escherichia coli endotoxin on the phagocytic and bactericidal activity of the hepatic reticuloendothelial system against viable E. coli were examined using ex vivo perfused rat livers. Livers were isolated from control and endotoxin-tolerant rats and perfused with a medium containing 5% hom...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.27.3.798-803.1980
更新日期:1980-03-01 00:00:00
abstract::The importance of intact host defense mechanisms for successful antimicrobial therapy was investigated in an animal model. Recovery from lobar pneumococcal pneumonia as a result of penicillin therapy was studied in normal rats and in rats treated with cobra venom factor. This factor was used to selectively suppress th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.25.1.366-375.1979
更新日期:1979-07-01 00:00:00
abstract::This study was undertaken to ascertain the relationship between complement-derived chemotactic factors and complement component 1 inactivator (C1INA) enhancement of neutrophil chemotaxis. Studies were also designed to determine whether the C1s- reactive or binding site on C1INA was functional in altering chemotactic r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::Our previous studies demonstrated that Mycobacterium bovis bacillus Calmette-Guérin (BCG) can directly interact with human NK cells and induce the proliferation, gamma interferon production, and cytotoxic activity of such cells without the need for accessory cells. Thus, the aim of the present study was to identify th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00870-07
更新日期:2008-04-01 00:00:00
abstract::Fimbriae are colonization factors of the human pathogen Haemophilus influenzae in that they mediate bacterial adherence to human eukaryotic cells. The contribution of the major (HifA) and putative minor (HifD and HifE) subunits of H. influenzae fimbriae to fimbria-specific adherence was studied by using mutants that w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.12.4883-4889.1995
更新日期:1995-12-01 00:00:00
abstract::Recognition of microbial patterns by host receptors is the first step in a multistep sequence leading to neutrophil-dependent host resistance. Although the role of membrane-bound sensors in bacterial recognition has been examined in detail, the importance of cytosolic sensors in the lungs is largely unexplored. In thi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05641-11
更新日期:2011-11-01 00:00:00