Recovery from T cell depletion during murine listeriosis and effect on a T-dependent antibody response.

Abstract:

:During the infection of mice with Listeria monocytogenes, there is a profound depletion of T (Thy-1+ Ig-) lymphocytes between days 1 and 4, followed by an increase in T cells to three times normal levels by day 9. The recovery of T cell numbers required cell proliferation, being sensitive to vinblastin and cyclophosphamide. Adult thymectomy 6 months before infection had no effect on recovery. The repopulating cells were no more sensitive than normal T cells to hydrocortisone. B lymphocytes (Ig+ cells) and null (Thy-1-Ig-) cells increased from day 1 after the injection of either live or (in contrast to T cells) killed Listeria organisms. Their increase was inhibited by vinblastin and cyclophosphamide. Despite T cell depletion, no depression of the antibody response to the T-dependent antigen, sheep erythrocytes, occurred during infection or when spleen cells were adoptively transferred from infected mice to irradiated recipients.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Chan YY,Cheers C

doi

10.1128/IAI.38.2.694-698.1982

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

694-8

issue

2

eissn

0019-9567

issn

1098-5522

journal_volume

38

pub_type

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