Abstract:
:We have previously shown that malaria parasites liberate exoantigens which, through a phospholipid component, stimulate mouse macrophages to secrete tumor necrosis factor (TNF), which are toxic to D-galactosamine-sensitized mice, and which therefore might be involved in pathology. Plasmodium yoelii exoantigens detoxified by dephosphorylation or digestion with lipases do not induce TNF production. However, these partial structures inhibited its production in response to the exoantigens, although not to bacterial lipopolysaccharide (LPS). When pure phospholipids were tested in a macrophage assay, none stimulated the production of TNF, but phosphatidylinositol (PI) inhibited TNF induction by P. yoelii exoantigens. Moreover, inositol monophosphate (IMP) was the only one of a number of monophosphate saccharides tested which was inhibitory; inositol was not. Macrophages pretreated with PI, IMP, or detoxified exoantigens and then incubated with parasite exoantigens also yielded much less TNF. PI, IMP, and lipase-digested exoantigens of P. yoelii similarly inhibited the TNF-inducing activity of exoantigens of the human parasites Plasmodium falciparum and Plasmodium vivax. Neither PI nor IMP diminished TNF production in response to LPS, in contrast to a platelet-activating factor antagonist [1-O-hexadecyl-2-acetyl- sn-glycero-3-phospho(N,N,N-trimethyl hexanolamine)] which inhibited both exoantigen- and LPS-induced production of TNF. We conclude that at least two different parts of the molecule are involved in the induction of TNF secretion by parasite exoantigens: one requires the presence of a phosphate bound to inositol, and, since dephosphorylated exoantigens were also inhibitory, one does not. It would seem that both affect interactions between parasite-derived exoantigens and the macrophage receptors.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Bate CA,Taverne J,Playfair JHdoi
10.1128/IAI.60.5.1894-1901.1992keywords:
subject
Has Abstractpub_date
1992-05-01 00:00:00pages
1894-901issue
5eissn
0019-9567issn
1098-5522journal_volume
60pub_type
杂志文章abstract::Interleukin-1 receptor (IL1R)-associated kinase 4 (IRAK4) is a member of the IRAK family and has an important role in inducing the production of inflammatory mediators. This kinase is downstream of MyD88, an adaptor protein essential for Toll-like receptor (TLR) function. We investigated the role of this kinase in IRA...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00328-12
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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更新日期:1983-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.3.1211-1215.1981
更新日期:1981-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.34.1.177-183.1981
更新日期:1981-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.3.1.141-148.1971
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.5.1051-1057.1987
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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doi:10.1128/IAI.1.6.587-594.1970
更新日期:1970-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.2.565-570.1992
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.7.4354-4362.2005
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更新日期:2011-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.37.2.558-567.1982
更新日期:1982-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.4.532-538.1973
更新日期:1973-04-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.39.1.463-465.1983
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.3.805-809.1989
更新日期:1989-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1987-10-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.60.9.3714-3718.1992
更新日期:1992-09-01 00:00:00
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更新日期:1998-02-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1996-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.1.124-129.1984
更新日期:1984-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01529-07
更新日期:2008-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.47.3.605-612.1985
更新日期:1985-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1976-02-01 00:00:00