Abstract:
:Several immunological, hematological, and pathological responses associated with Marek's disease were determined. Four-week-old Marek's disease-infected and control chickens were injected with Salmonella pullorum antigen. About one-half of all infected chickens tested were unresponsive to antigenic challenge. Antibody titers in responsive infected chickens were significantly depressed at 1 and 2 weeks post-inoculation when compared to controls. Total white blood cell counts of control and control-antigen chickens were significantly lower than counts in infected chickens. Based on response to antigenic challenge, 24% of the responsive group had leukemia compared to 54% of the unresponsive chickens. The predominant cell populations in these two groups responsible for the mononuclear cell leukemia were large lymphocytes and blast cells. These cell increases were significantly greater in unresponsive chickens. Also, transient increases in the granulocytic elements were observed in some infected chickens. Large fluctuations in hematocrit values were observed in Marek's disease-infected chickens. As many as 30% of the infected chickens were anemic throughout the testing periods. Infected chickens which did not receive antigen had lower incidences of mortality and gross lesions than similarly treated chickens which did receive antigen. In addition, those chickens which were unresponsive to antigenic challenge had a higher mortality rate and increased percentages of gross lesions when compared with responsive chickens.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Evans DL,Patterson LTdoi
10.1128/IAI.4.5.567-574.1971subject
Has Abstractpub_date
1971-11-01 00:00:00pages
567-74issue
5eissn
0019-9567issn
1098-5522journal_volume
4pub_type
杂志文章abstract::Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonize...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.8.5212-5215.2001
更新日期:2001-08-01 00:00:00
abstract::Vibrio cholerae neuraminidase (NANase) is hypothesized to act synergistically with cholera toxin (CT) and increase the severity of a secretory response by increasing the binding and penetration of CT to enterocytes. To test this hypothesis, the NANase gene (nanH) from V. cholerae Ogawa 395 was first cloned and sequenc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.2.406-415.1992
更新日期:1992-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.4.1258-1266.1997
更新日期:1997-04-01 00:00:00
abstract::Saliva-binding molecules of Streptococcus sanguis and their receptors were investigated. Streptococcal cell surfaces were extracted with a barbital buffer and examined immunochemically. Strains G9B and Blackburn, which adhere specifically to saliva-coated hydroxyapatite via immunologically related adhesins, possess 80...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.1.64-70.1988
更新日期:1988-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05806-11
更新日期:2011-12-01 00:00:00
abstract::The reproducibility of an experimental result is a fundamental assumption in science. Yet, results that are merely confirmatory of previous findings are given low priority and can be difficult to publish. Furthermore, the complex and chaotic nature of biological systems imposes limitations on the replicability of scie...
journal_title:Infection and immunity
pub_type: 社论
doi:10.1128/IAI.00908-10
更新日期:2010-12-01 00:00:00
abstract::Little is known about Zn homeostasis in Yersinia pestis, the plague bacillus. The Znu ABC transporter is essential for zinc (Zn) uptake and virulence in a number of bacterial pathogens. Bioinformatics analysis identified ZnuABC as the only apparent high-affinity Zn uptake system in Y. pestis. Mutation of znuACB caused...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00732-10
更新日期:2010-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00648-09
更新日期:2009-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.24.1.276-281.1979
更新日期:1979-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.20.1.130-135.1978
更新日期:1978-04-01 00:00:00
abstract::The unique permissiveness of A/J mouse macrophages for replication of Legionella pneumophila is caused by a deficiency in the Nod-like receptor (NLR) protein and intracellular sensor for L. pneumophila flagellin (Naip5). The signaling pathways and proteins activated by Naip5 sensing in macrophages were investigated. T...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01546-08
更新日期:2009-11-01 00:00:00
abstract::The ultrastructural appearance of the "halozone" formed at the interface between the spotted fever agent Rickettsia rickettsii and the cytoplasm of persistently infected cultured vole cells (Microtus pennsylvanicus) was studied by transmission electron microscopy. In sections of epoxy-embedded specimens stained with u...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.3.1252-1260.1983
更新日期:1983-09-01 00:00:00
abstract::Strains of Bacteroides fragilis associated with diarrhea in children (termed enterotoxigenic B. fragilis, or ETBF) produce a heat-labile ca. 20-kDa protein toxin (BFT). The purpose of this study was to examine the activity of BFT on polarized monolayers of human intestinal epithelial cells (T84 cells). In Ussing chamb...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.9.3561-3570.1997
更新日期:1997-09-01 00:00:00
abstract::Streptococcus mutans, a major pathogen of dental caries, is considered one of the causative agents of infective endocarditis (IE). Recently, bacterial DNA encoding 120-kDa cell surface collagen-binding proteins (CBPs) has frequently been detected from S. mutans-positive IE patients. In addition, some of the CBP-positi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00401-17
更新日期:2017-11-17 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.2.4.387-391.1970
更新日期:1970-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.6.3172-3179.2000
更新日期:2000-06-01 00:00:00
abstract::Herein we report an important role for the ferric uptake regulator (Fur) in the resistance of Salmonella enterica serovar Typhimurium to the reactive nitrogen species produced by inducible nitric oxide (NO) synthase in an NRAMP1(r) murine model of acute systemic infection. The expression of fur protected Salmonella gr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01201-13
更新日期:2014-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.12.5161-5165.1996
更新日期:1996-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.3.805-809.1989
更新日期:1989-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.3.1018-1023.1982
更新日期:1982-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.20.3.776-781.1978
更新日期:1978-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.8.3199-3208.1993
更新日期:1993-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.21.3.966-972.1978
更新日期:1978-09-01 00:00:00
abstract::In mice infected with virulent blood (trypomastigote) forms of Trypanosoma cruzi, complement depletion with cobra venom factor caused a marked exacerbation of the disease evidenced by significantly increased parasitemia levels and early mortality as compared with those of untreated infected animals. The effect was gre...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.1.86-91.1975
更新日期:1975-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.3.1588-1596.2006
更新日期:2006-03-01 00:00:00
abstract::Sonicated preparations of capsulated Haemophilus influenzae type b, two of its spontaneous mutants, one containing patches of capsules (class I variant) and the other noncapsulated (class II variant), and a noncapsulated strain of H. influenzae type d were analyzed by crossed-immunoelectrophoresis using unadsorbed ant...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.6.1733-1742.1976
更新日期:1976-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.4.1329-1335.1995
更新日期:1995-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.2.448-451.1996
更新日期:1996-02-01 00:00:00
abstract::Spleen cell cultures from guinea pigs given legionella pneumophila vaccine in complete Freund adjuvant or as a sublethal infection were inhibited in their migration activity in vitro when incubated with specific antigen. Both direct and indirect migration inhibition assays revealed sensitization of the guinea pigs to ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.3.1132-1137.1983
更新日期:1983-09-01 00:00:00
abstract::Disruption of neutrophils causes the release of a cytoplasmic protein which can inhibit the growth of Candida albicans without killing the organisms. The present study was undertaken with a combined system in which candidacidal and candidastatic activities of human neutrophils could be compared. In this system it was ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.8.2696-2698.1990
更新日期:1990-08-01 00:00:00