Abstract:
:A main feature in the pathogenesis of bacterial endocarditis is the activation of the coagulation system via the extrinsic pathway, resulting in the formation of infected endocardial vegetations. Earlier studies gave indirect evidence that monocytes play an important role in the procoagulant response during the course of the disease. In this study, we assessed the role of monocytes more directly. We compared weights and tissue factor activities (TFA) of endocardial vegetations of normal rabbits infected with Streptococcus sanguis with those of rabbits which were treated with the cytostatic drug etoposide (Vepesid; Bristol-Myers Squibb B.V.) to induce a selective monocytopenia. Furthermore, the importance of the presence of bacteria was determined through the influence of antibiotic treatment on TFA, vegetational weight, and infection of the vegetations. The TFA of the vegetations was measured chromogenically by monitoring the factor VII-dependent activation of factor X with an amidolytic assay for factor Xa. We found that the degree of infection and the weight of vegetations of rabbits treated with the cytostatic drug etoposide did not differ from that of untreated rabbits. Their TFA, however, was significantly lower than the TFA of vegetations of rabbits not treated with etoposide. We also found that, as with the monocytopenic rabbits, the weight of the vegetations was not reduced in penicillin G-treated rabbits. The degree of infection and TFA, however, were significantly lower. We conclude that monocytes indeed are involved in the activation of the coagulation system during the course of bacterial endocarditis and that the degree of infection is positively correlated to the TFA of the vegetations.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Bancsi MJ,Veltrop MH,Bertina RM,Thompson Jdoi
10.1128/IAI.64.2.448-451.1996subject
Has Abstractpub_date
1996-02-01 00:00:00pages
448-51issue
2eissn
0019-9567issn
1098-5522journal_volume
64pub_type
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.8.1924-1926.1987
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
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更新日期:1970-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.20.1.88-98.1978
更新日期:1978-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
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doi:10.1128/IAI.5.1.91-97.1972
更新日期:1972-01-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.33.1.275-284.1981
更新日期:1981-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
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doi:10.1128/IAI.63.1.212-223.1995
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.5.2051-2057.1994
更新日期:1994-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.27.2.297-301.1980
更新日期:1980-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.10.3823-3826.1991
更新日期:1991-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.51.1.31-36.1986
更新日期:1986-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.4.862-871.1974
更新日期:1974-10-01 00:00:00