Mutant of Bordetella pertussis which lacks ability to produce filamentous hemagglutinin.

abstract：:Levels of interferon in adult bovine serum and in fetal bovine serum and tissues were examined during the course of transplacental bovine viral diarrhea virus infection. The cows produced circulating interferon between 2 and 9 days after viral inoculation, with mean peak levels in the serum on day 4. Interferon could ...

journal_title：Infection and immunity

authors： Rinaldo CR Jr,Isackson DW,Overall JC Jr,Glasgow LA,Brown TT,Bistner SI,Gillespie JH,Scott FW

更新日期：1976-09-01 00:00:00

abstract：:The effect of bile on the expression of cholera toxin (CT) and the major subunit of the toxin-coregulated pilus (TcpA) and on motility was examined in the Vibrio cholerae O1 classical-biotype strains 0395 and 569B. Although the motility of the cells increased significantly in the presence of bile, transcription of the...

journal_title：Infection and immunity

authors： Gupta S,Chowdhury R

更新日期：1997-03-01 00:00:00

abstract：:Mycobacterium tuberculosis grows within the phagocytic vacuoles of macrophages, where it encounters a moderately acidic and possibly nutrient-restricted environment. Other mycobacterial species encounter acidic conditions in soil and aquatic environments. We have evaluated the influence of pH and divalent cation level...

journal_title：Infection and immunity

authors： Piddington DL,Kashkouli A,Buchmeier NA

更新日期：2000-08-01 00:00:00

abstract：:The addition of a sonic extract of Capnocytophaga sputigena to the culture fluid to human fibroblasts resulted in an inhibition of cell proliferation. The inhibition was dose-related (200 micrograms/ml caused a 90% inhibition, and 1,000 micrograms/ml caused a complete cessation of growth). The growth inhibition was no...

journal_title：Infection and immunity

authors： Stevens RH,Sela MN,Shapira J,Hammond BF

更新日期：1980-01-01 00:00:00

abstract：:Protective immunity against pulmonary tuberculosis (TB) is characterized by the formation in the lungs of granulomas consisting of macrophages and activated T cells producing tumor necrosis factor alpha and gamma interferon, both required for the activation of the phagocytes. In 90% of immunocompetent humans, this res...

journal_title：Infection and immunity

authors： Kaplan G,Post FA,Moreira AL,Wainwright H,Kreiswirth BN,Tanverdi M,Mathema B,Ramaswamy SV,Walther G,Steyn LM,Barry CE 3rd,Bekker LG

更新日期：2003-12-01 00:00:00

abstract：:Cultures of Serpulina pilosicoli 95/1000, isolated from a pig with porcine intestinal spirochetosis (PIS), and S. pilosicoli WesB, isolated from an Aboriginal child with diarrhea, were used to infect 5-week-old newly weaned pigs. Four of 12 pigs infected with strain 95/1000 and 2 of 12 pigs infected with strain WesB b...

journal_title：Infection and immunity

authors： Trott DJ,Huxtable CR,Hampson DJ

更新日期：1996-11-01 00:00:00

abstract：:In Vibrio cholerae, the transmembrane DNA binding proteins, ToxR and TcpP, activate expression of the regulatory gene toxT in response to specific environmental signals. The resulting enhanced level of ToxT leads to a coordinated increase in the production of a subset of virulence factors, including cholera toxin (CT)...

journal_title：Infection and immunity

authors： Krishnan HH,Ghosh A,Paul K,Chowdhury R

更新日期：2004-07-01 00:00:00

abstract：:The attachment of radioisotope-labeled Mycoplasma pneumoniae to hamster tracheal rings in organ culture was examined by radioautography and liquid scintillation counting. Radioautographs of individual rings exposed for 8 h to (3H) thymidine-labeled virulent M. pneumoniae revealed a dense extracellular collection of em...

journal_title：Infection and immunity

authors： Powell DA,Hu PC,Wilson M,Collier AM,Baseman JB

更新日期：1976-03-01 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) is a major cause of traveler's diarrhea as well as of endemic diarrhea and stunting in children in developing areas. However, a small-mammal model has been badly needed to better understand and assess mechanisms, vaccines, and interventions. We report a murine model of ETEC diar...

journal_title：Infection and immunity

authors： Bolick DT,Medeiros PHQS,Ledwaba SE,Lima AAM,Nataro JP,Barry EM,Guerrant RL

更新日期：2018-06-21 00:00:00

abstract：:The effect of indomethacin on the net intestinal accumulation of fluid induced by Escherichia coli heat-stable (ST) enterotoxin in the infant mouse model was examined. Indomethacin, when administered with ST enterotoxin, caused a striking decrease in net intestinal fluid accumulation. This inhibition of ST activity wa...

journal_title：Infection and immunity

authors： Madsen GL,Knoop FC

更新日期：1978-10-01 00:00:00

abstract：:We investigated the role of bacterial mannose-resistant fimbriation of S fimbriae (Fim), mannose-resistant hemagglutination (S-Mrh), and hemolysin (Hly) production by an Escherichia coli parent and genetically cloned strains as regards their effect on histamine release from rat mast cells and generation of the chemilu...

journal_title：Infection and immunity

authors： König B,König W,Scheffer J,Hacker J,Goebel W

更新日期：1986-12-01 00:00:00

abstract：:Transposon Tn916 was used to insertionally inactivate a coaggregation-relevant locus of Streptococcus gordonii DL1 (Challis). One mutant (F11) was isolated that lost the ability to coaggregate with the streptococcal partners of DL1 but retained the ability to coaggregate with partners belonging to other genera. A prob...

journal_title：Infection and immunity

authors： Whittaker CJ,Clemans DL,Kolenbrander PE

更新日期：1996-10-01 00:00:00

abstract：:Actinobacillus actinomycetemcomitans is the etiologic agent of localized aggressive periodontitis, a rapidly progressing oral disease that occurs in adolescents. A. actinomycetemcomitans can also cause systemic disease, including infective endocarditis. In early work on A. actinomycetemcomitans workers concluded that ...

journal_title：Infection and immunity

authors： Balashova NV,Crosby JA,Al Ghofaily L,Kachlany SC

更新日期：2006-04-01 00:00:00

abstract：:It is currently accepted that malaria-parasitized red blood cells (pRBC) are eliminated, like senescent erythrocytes, phagocytically by macrophages in the red pulp of the spleen. Here, however, we show that self-healing Plasmodium chabaudi malaria activates spleen closure in C57BL/6 mice. Confocal laser scanning micro...

journal_title：Infection and immunity

authors： Krücken J,Mehnert LI,Dkhil MA,El-Khadragy M,Benten WP,Mossmann H,Wunderlich F

更新日期：2005-10-01 00:00:00

abstract：:The glycolipid haptens of Mycoplasma pneumoniae became immunogenic when bound to membrane proteins of Acholeplasma laidlawii by reaggregation. This process consisted of the solubilization of lipid-depleted A. laidlawii membranes and M. pneumoniae glycolipids in 20 mm sodium dodecyl sulfate and dialysis of the mixed so...

journal_title：Infection and immunity

authors： Razin S,Prescott B,James WD,Caldes G,Valdesuso J,Chanock RM

更新日期：1971-03-01 00:00:00

abstract：:A total of 133 Listeria monocytogenes isolates were characterized by ribotyping and allelic analysis of the virulence genes hly, actA, and inlA to uncover linkages between independent phylogenetic and specific virulence markers. PCR-restriction fragment length polymorphisms revealed 8 hly, 11 inl4, and 2 actA alleles....

journal_title：Infection and immunity

authors： Wiedmann M,Bruce JL,Keating C,Johnson AE,McDonough PL,Batt CA

更新日期：1997-07-01 00:00:00

abstract：:Cryptosporidial infections were established in five young foals with severe combined immunodeficiency following oral administration of 10(8) Cryptosporidium parvum oocysts. All foals shed oocysts (average of 8 x 10(6) to 2 x 10(8)/g of feces) until death. Inflammation and C. parvum organisms were observed in the commo...

journal_title：Infection and immunity

authors： Bjorneby JM,Leach DR,Perryman LE

更新日期：1991-10-01 00:00:00

abstract：:Four glycoproteins of Treponema pallidum were identified by intrinsic [14C]glucosamine labeling. Only two glycoproteins were demonstrated in T. phagedenis biotype Reiter with the same technique. Glycoproteins of both treponemes were characterized as antigens and shown to be localized within the outer membranes of the ...

journal_title：Infection and immunity

authors： Moskophidis M,Müller F

更新日期：1984-12-01 00:00:00

abstract：:To study the immunological activity of proteins secreted by Mycobacterium tuberculosis, we carried out comparative studies in guinea pigs infected intravenously with 2.5 x 10(3) CFU of this organism or with 2.5 x 10(4) CFU of Mycobacterium bovis BCG. Groups of infected guinea pigs were skin tested with fractions of se...

journal_title：Infection and immunity

authors： Hasløv K,Andersen A,Nagai S,Gottschau A,Sørensen T,Andersen P

更新日期：1995-03-01 00:00:00

abstract：:In vitro studies have shown that enterotoxigenic Escherichia coli (ETEC) strains are capable of invading cultured epithelial cells derived from the human ileum and colon. Two separate invasion loci (tia and tib) have previously been isolated from the classical ETEC strain H10407. The tia locus has been shown to direct...

journal_title：Infection and immunity

authors： Mammarappallil JG,Elsinghorst EA

更新日期：2000-12-01 00:00:00

abstract：:This study investigates the role of CD4+ T cells in host defense against cholera enterotoxin-induced diarrhea. Antitoxin immunoglobulin A formation and gut protection against cholera toxin (CT) following oral immunizations with CT were evaluated in normal mice and mice that had been depleted of CD4+ T cells by in vivo...

journal_title：Infection and immunity

authors： Hörnqvist E,Goldschmidt TJ,Holmdahl R,Lycke N

更新日期：1991-10-01 00:00:00

abstract：:We have mapped a group of virulence genes of Porphyromonas gingivalis to a single large fragment of the genome. These genes (rgpA, kgp, and hagA) all contain a consensus repeat sequence (HArep). rgpA and kgp encode cysteine proteases with Arg-X and Lys-X specificity, respectively, and hagA encodes a hemagglutinin. Gen...

journal_title：Infection and immunity

authors： Lewis JP,Macrina FL

更新日期：1999-05-01 00:00:00

abstract：:Burkholderia cepacia is an opportunistic pathogen that causes severe systemic infections in patients with chronic granulomatous disease (CGD) or with cystic fibrosis (CF), but its mechanisms of virulence are poorly understood. We developed a murine model of systemic infection in wild-type (WT) and gamma interferon kno...

journal_title：Infection and immunity

authors： Speert DP,Steen B,Halsey K,Kwan E

更新日期：1999-08-01 00:00:00

abstract：:Neisseria meningitidis is the causative agent of meningococcal disease. Onset of meningococcal disease can be extremely rapid and can kill within a matter of hours. However, although a much-feared pathogen, Neisseria meningitidis is frequently found in the nasopharyngeal mucosae of healthy carriers. The bacterial fact...

journal_title：Infection and immunity

authors： Ren X,MacKichan JK

更新日期：2014-12-01 00:00:00

abstract：:The absolute requirement for elemental iron and the porphyrin nucleus for growth of Haemophilus influenzae led us to investigate the role of iron and hemin in regulation of expression of the H. influenzae transferrin receptor. H. influenzae type b strain H1689 was grown in brain heart infusion broth supplemented with ...

journal_title：Infection and immunity

authors： Morton DJ,Musser JM,Stull TL

更新日期：1993-10-01 00:00:00

abstract：:Fimbrial adhesins that mediate attachment to host cells are produced by most virulent Escherichia coli isolates. These virulence factors play an important role in the initial stages of bacterial colonization and also in determination of the host and tissue specificity. Isolates belonging to serotype O78 are known to c...

journal_title：Infection and immunity

authors： Babai R,Stern BE,Hacker J,Ron EZ

更新日期：2000-10-01 00:00:00

abstract：:Purified Escherichia coli type 1 fimbriae have been shown previously to stimulate T-cell-independent proliferation of human B lymphocytes. The response is mediated by the mannose-specific, lectin-like adhesin protein FimH. Here we show that type 1 fimbriae also stimulate immunoglobulin (Ig) secretion by B cells. The r...

journal_title：Infection and immunity

authors： Ponniah S,Abraham SN,Endres RO

更新日期：1992-12-01 00:00:00

abstract：:The availability of relevant and useful animal models is critical for progress in the development of effective vaccines and therapeutics. The infection of rabbits and non-human primates with fully virulent Bacillus anthracis spores provides two excellent models of anthrax disease. However, the high cost of procuring a...

journal_title：Infection and immunity

authors： Loving CL,Kennett M,Lee GM,Grippe VK,Merkel TJ

更新日期：2007-06-01 00:00:00

abstract：:The Re mutant of Salmonella minnesota adheres in much greater numbers than the wild type to endothelial cells derived from the bovine pulmonary artery. Since the Re mutant is distinguished from wild-type S. minnesota by its ability to bind C1q and since endothelial cells possess receptors for C1q, we examined the role...

journal_title：Infection and immunity

authors： Ryan US,Schultz DR,Goodwin JD,Vann JM,Selvaraj MP,Hart MA

更新日期：1989-05-01 00:00:00

abstract：:Mucin glycoproteins are secreted in large amounts by the intestinal epithelium and constitute an efficient component of innate immune defenses to promote homeostasis and protect against enteric pathogens. In this study, our objective was to investigate how the bacterial enteropathogen Shigella flexneri, which causes b...

journal_title：Infection and immunity

authors： Sperandio B,Fischer N,Joncquel Chevalier-Curt M,Rossez Y,Roux P,Robbe Masselot C,Sansonetti PJ

更新日期：2013-10-01 00:00:00