Inhibition of the secretory activity of Escherichia coli heat-stable enterotoxin by indomethacin.

abstract：:Regulation of the synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi, is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some serotype Typhi strains exhibit overexpression of Vi polysaccharide, which masks cl...

journal_title：Infection and immunity

authors： Santander J,Wanda SY,Nickerson CA,Curtiss R 3rd

更新日期：2007-03-01 00:00:00

abstract：:The production of interleukin-6 (IL-6) and its possible relationship to host resistance and inflammatory response to Pneumocystis carinii infection were examined in mice with severe combined immunodeficiency (SCID mice). IL-6 activity was detected in the serum and lungs of P. carinii-infected mice but not in mice free...

journal_title：Infection and immunity

authors： Chen W,Havell EA,Gigliotti F,Harmsen AG

更新日期：1993-01-01 00:00:00

abstract：:CD8 T cells are effective mediators of specific immunity to infection by Listeria monocytogenes, a bacterial pathogen that initially infects macrophages in the spleen and liver and subsequently spreads to hepatocytes and unidentified parenchymal cells in the spleen. To identify the in vivo target cells of L. monocytog...

journal_title：Infection and immunity

authors： Harty JT,Bevan MJ

更新日期：1996-09-01 00:00:00

abstract：:Francisella tularensis is a facultative intracellular bacterial pathogen and the causative agent of tularemia. After infection of macrophages, the organism escapes from its phagosome and replicates to high density in the cytosol, but the bacterial factors required for these aspects of virulence are incompletely define...

journal_title：Infection and immunity

authors： Long ME,Lindemann SR,Rasmussen JA,Jones BD,Allen LA

更新日期：2013-03-01 00:00:00

abstract：:Highly purified protein antigens are usually poor immunogens; in practice, adjuvants are needed to obtain satisfactory immune responses. Plasmodium yoelii 19-kDa merozoite surface protein 1 (MSP1(19)) is a weak antigen, but mice vaccinated with this antigen in strong adjuvants can survive an otherwise lethal parasite ...

journal_title：Infection and immunity

authors： Ogun SA,Dumon-Seignovert L,Marchand JB,Holder AA,Hill F

更新日期：2008-08-01 00:00:00

abstract：:The initial encounter of Leishmania cells and cells from the immune system is fundamentally important in the outcome of infection and determines disease development or resistance. We evaluated the anti-Leishmania amazonensis response of naive volunteers by using an in vitro priming (IVP) system and comparing the respo...

journal_title：Infection and immunity

authors： Pompeu MM,Brodskyn C,Teixeira MJ,Clarêncio J,Van Weyenberg J,Coelho IC,Cardoso SA,Barral A,Barral-Netto M

更新日期：2001-12-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) isolated from human blood were exposed to various levels of hydrogen sulfide. The effect on respiratory burst, myeloperoxidase activity, and capacity to phagocytose and kill bacteria were studied. A 1-h exposure of the PMN to 1 mM sulfide did not decrease their myeloperoxidase activi...

journal_title：Infection and immunity

authors： Claesson R,Granlund-Edstedt M,Persson S,Carlsson J

更新日期：1989-09-01 00:00:00

abstract：:Streptococcus equi and Streptococcus zooepidemicus are major etiological agents of upper and lower airway disease in horses. Despite the considerable animal suffering and economic burden associated with these diseases, the factors that contribute to the virulence of these equine pathogens have not been extensively inv...

journal_title：Infection and immunity

authors： Harrington DJ,Greated JS,Chanter N,Sutcliffe IC

更新日期：2000-10-01 00:00:00

abstract：:Comparisons of the course of coccidioidomycosis in two strains of inbred mice established that BALB/c mice are significantly more susceptible to pulmonary infection with Coccidioides immitis than are DBA/2 mice. The susceptibility of BALB/c mice does not reside in their inability to mount a delayed-type hypersensitivi...

journal_title：Infection and immunity

authors： Cox RA,Kennell W,Boncyk L,Murphy JW

更新日期：1988-01-01 00:00:00

abstract：:Based upon the lipopolysaccharide (LPS) structure and antigenicity of Shigella group B, a strategy for broad cross-protection against 14 Shigella flexneri serotypes was designed. This strategy involves the use of two S. flexneri serotypes (2a and 3a), which together bear the all of the major antigenic group factors of...

journal_title：Infection and immunity

authors： Noriega FR,Liao FM,Maneval DR,Ren S,Formal SB,Levine MM

更新日期：1999-02-01 00:00:00

abstract：:Human genital Chlamydia infection is a major public health concern due to the serious reproductive system complications. Chlamydia binds several receptor tyrosine kinases (RTKs) on host cells, including the epidermal growth factor receptor (EGFR), and activates cellular signaling cascades for host invasion, cytoskelet...

journal_title：Infection and immunity

authors： Igietseme JU,Partin J,George Z,Omosun Y,Goldstein J,Joseph K,Ellerson D,Eko FO,Pohl J,Bandea C,Black CM

更新日期：2020-03-23 00:00:00

abstract：:Although the opportunistic bacterial pathogen Enterococcus faecium is a leading source of nosocomial infections, it appears to lack many of the overt virulence factors produced by other bacterial pathogens, and the underlying mechanism of pathogenesis is not clear. Using E. faecium-mediated killing of the nematode wor...

journal_title：Infection and immunity

authors： Moy TI,Mylonakis E,Calderwood SB,Ausubel FM

更新日期：2004-08-01 00:00:00

abstract：:A recent study found that group A Streptococcus (GAS) expresses a cell surface protein with similarity to human collagen (S. Lukomski, K. Nakashima, I. Abdi, V. J. Cipriano, R. M. Ireland, S. R. Reid, G. G. Adams, and J. M. Musser, Infect. Immun. 68:6542-6553, 2000). This streptococcal collagen-like protein (Scl) cont...

journal_title：Infection and immunity

authors： Lukomski S,Nakashima K,Abdi I,Cipriano VJ,Shelvin BJ,Graviss EA,Musser JM

更新日期：2001-03-01 00:00:00

abstract：:A live, attenuated, recombinant influenza vaccine (Alice strain) administered intranasally was evaluated in high school students and compared with intranasal placebo and subcutaneous, inactivated, bivalent influenza vaccine. The Alice strain was antigenic, increasing the geometric mean titer (GMT) from a prestudy leve...

journal_title：Infection and immunity

authors： Schiff GM,Linnemann CC Jr,shea L,Lange B,Rotte T

更新日期：1975-04-01 00:00:00

abstract：:Inbred CBA/J mice were used in developing a defined in vivo model for studying host-parasite relationships in cryptococcosis. Mice were infected either intranasally or intraperitoneally with 10(3) viable Cryptococcus neoformans cells. At weekly intervals over a 92-day period, C. neoformans growth profiles in the lungs...

journal_title：Infection and immunity

authors： Lim TS,Murphy JW,Cauley LK

更新日期：1980-08-01 00:00:00

abstract：:Antibiotic-resistant Klebsiella pneumoniae isolates constitute a great clinical challenge. One important resistance mechanism in K. pneumoniae is the metallo-β-lactamases (MBLs), which require zinc for their function. Thus, zinc chelation could be a strategy to resensitize K. pneumoniae to β-lactams. However, the pote...

journal_title：Infection and immunity

authors： Karadottir H,Coorens M,Liu Z,Wang Y,Agerberth B,Giske CG,Bergman P

更新日期：2019-12-17 00:00:00

abstract：:We report on the identification of a surface-exposed, highly conserved, immunogenic nontypeable Haemophilus influenzae (NTHi) protein, which elicits cross-reactive bactericidal antibodies against NTHi. The protein was extracted from NTHi strain P860295 with KSCN and purified; it migrated as a single band on a sodium d...

journal_title：Infection and immunity

authors： Zagursky RJ,Ooi P,Jones KF,Fiske MJ,Smith RP,Green BA

更新日期：2000-05-01 00:00:00

abstract：:A new strategy for rapidly selecting and testing genetic vaccines has been developed, in which a whole genome library is cloned into a bacteriophage lambda ZAP Express vector which contains both prokaryotic (P(lac)) and eukaryotic (P(CMV)) promoters upstream of the insertion site. The phage library is plated on Escher...

journal_title：Infection and immunity

authors： March JB,Jepson CD,Clark JR,Totsika M,Calcutt MJ

更新日期：2006-01-01 00:00:00

abstract：:The Legionella pneumophila major secretory protein (Msp) is a Zn2+ metalloprotease whose function in pathogenesis is unknown. The structural gene for the Msp protease, mspA, was isolated from an L. pneumophila genomic library. In Escherichia coli which contain plasmids with the mspA gene, Msp protein and activity are ...

journal_title：Infection and immunity

authors： Szeto L,Shuman HA

更新日期：1990-08-01 00:00:00

abstract：:Bordetella pertussis adenylate cyclase-hemolysin (AC-Hly), encoded by the cyaA gene, belongs to the RTX family of toxins with extensive glycine-rich repeats in the carboxy-terminal portion. AC-Hly possesses both adenylate cyclase toxic and hemolytic activities that depend on a posttranslational modification mediated b...

journal_title：Infection and immunity

authors： Betsou F,Sebo P,Guiso N

更新日期：1993-09-01 00:00:00

abstract：:Obligate vacuolar pathogens produce proteins that localize to the host cell-derived membranes of the vacuoles in which they reside, yielding unique organelles that are optimally suited for pathogen survival. Anaplasma phagocytophilum is an obligate vacuolar bacterium that infects neutrophils and causes the emerging an...

journal_title：Infection and immunity

authors： Huang B,Troese MJ,Ye S,Sims JT,Galloway NL,Borjesson DL,Carlyon JA

更新日期：2010-05-01 00:00:00

abstract：:The antigenicity of Erysipelothrix rhusiopathiae T28 (serotype 2) was investigated. Antigens were solubilized from the cell surface with detergents. By means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting it was shown that the molecular weight of the main antigenic component--a nonprot...

journal_title：Infection and immunity

authors： Lachmann PG,Deicher H

更新日期：1986-06-01 00:00:00

abstract：:During the course of infection of rabbits with vaccinia virus, macrophages obtained from the peritoneal cavity develop bactericidal activity and the replication of vaccinia virus becomes restricted in these cells. The abortive replication of vaccinia virus in the activated macrophages was characterized in the present ...

journal_title：Infection and immunity

authors： Buchmeier NA,Gee SR,Murphy FA,Rawls WE

更新日期：1979-10-01 00:00:00

abstract：:Trypanosoma brucei subsp. brucei and T. congolense incubated in homologous antibody at 0 degrees C for 30 min were lysed by subsequent addition of guinea pig complement. Trypanosomes incubated in antibody at 37 degrees C before complement treatment remained intact. Parasites bearing adsorbed antibody also remained int...

journal_title：Infection and immunity

authors： Balber AE,Bangs JD,Jones SM,Proia RL

更新日期：1979-06-01 00:00:00

abstract：:The addition of a sonic extract of Capnocytophaga sputigena to the culture fluid to human fibroblasts resulted in an inhibition of cell proliferation. The inhibition was dose-related (200 micrograms/ml caused a 90% inhibition, and 1,000 micrograms/ml caused a complete cessation of growth). The growth inhibition was no...

journal_title：Infection and immunity

authors： Stevens RH,Sela MN,Shapira J,Hammond BF

更新日期：1980-01-01 00:00:00

abstract：:In this study we demonstrate the capability of Chlamydia trachomatis to infect cultured human mesothelial cell (MC) monolayers and to induce the production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-8. Seventy-two hours after initial infection, both the procoagulant activity of MC and the act...

journal_title：Infection and immunity

authors： van Westreenen M,Pronk A,Diepersloot RJ,de Groot PG,Leguit P

更新日期：1998-05-01 00:00:00

abstract：:We investigated the biological properties of a novel staphylococcal enterotoxin (SE)-like toxin type P (SElP). SElP induced a substantial proliferative response and the production of cytokines interleukin-2, gamma interferon, tumor necrosis factor alpha, and interleukin-4 from human T cells when administered at a conc...

journal_title：Infection and immunity

authors： Omoe K,Imanishi K,Hu DL,Kato H,Fugane Y,Abe Y,Hamaoka S,Watanabe Y,Nakane A,Uchiyama T,Shinagawa K

更新日期：2005-09-01 00:00:00

abstract：:In an earlier report, we had described the isolation and characterization of autolysis-defective mutants of Staphylococcus aureus (N. Mani, P. Tobin, and R.K. Jayaswal, J. Bacteriol. 175:1493-1499, 1993). In the study reported here, an autolysis-defective mutant showed attenuated virulence in a rat model of experiment...

journal_title：Infection and immunity

authors： Mani N,Baddour LM,Offutt DQ,Vijaranakul U,Nadakavukaren MJ,Jayaswal RK

更新日期：1994-04-01 00:00:00

abstract：:The indigenous microbial flora of the middle ear cavity of Mongolian gerbils, Meriones unguiculatus, was isolated, characterized, and identified, showing it to be sparse and transitory. Organisms, when found in the middle ear cavity, were most likely to be Staphylococcus epidermidis-like organisms. Cerumen from the ex...

journal_title：Infection and immunity

authors： Thompson TA,Gardner D,Fulghum RS,Daniel HJ,Allen WE,Worthington JM,Williams PP

更新日期：1981-06-01 00:00:00

abstract：:Moraxella (Branhamella) catarrhalis is an important bacterial cause of otitis media in children and lower respiratory tract infections in adults. In this study, we describe the presence of a novel high-molecular-weight outer membrane protein (HMW-OMP). This protein varies from 350 to 720 kDa in apparent molecular mass...

journal_title：Infection and immunity

authors： Klingman KL,Murphy TF

更新日期：1994-04-01 00:00:00