Host-etiological agent interactions in intranasally and intraperitoneally induced Cryptococcosis in mice.

abstract：:Infection with gram-negative monocytotropic Ehrlichia strains results in a fatal toxic shock-like syndrome characterized by a decreased number of Ehrlichia-specific CD4(+) Th1 cells, the expansion of tumor necrosis factor alpha (TNF-alpha)-producing CD8(+) T cells, and the systemic overproduction of interleukin-10 (IL...

journal_title：Infection and immunity

authors： Ismail N,Crossley EC,Stevenson HL,Walker DH

更新日期：2007-09-01 00:00:00

abstract：:D-Amino acid oxidase (DAO) is a hydrogen peroxide-generating enzyme that uses a D-amino acid as a substrate. We hypothesized that DAO may protect against bacterial infection, because hydrogen peroxide is one of the most important molecules in the antibacterial defense systems in mammals. We show here that DAO suppress...

journal_title：Infection and immunity

authors： Nakamura H,Fang J,Maeda H

更新日期：2012-04-01 00:00:00

abstract：:Microbial heat shock proteins (HSP) are dominant antigens for the host immune response. Because of the high sequence homology between mammalian and microbial HSP, their value as component of a subunit vaccine has been the subject of controversy. Previous work from this laboratory, however, demonstrated for the first t...

journal_title：Infection and immunity

authors： Noll A,AutenriethIB

更新日期：1996-08-01 00:00:00

abstract：:Three open reading frames (ORFs) were identified by a genome walking strategy in the genomes of serotype M49 group A streptococcal (GAS) strains CS101 and 591. These ORFs were located between the mga core regulon and the dipeptide permease operon. The deduced amino acid (aa) sequences contained signature sequences ind...

journal_title：Infection and immunity

authors： Elsner A,Kreikemeyer B,Braun-Kiewnick A,Spellerberg B,Buttaro BA,Podbielski A

更新日期：2002-09-01 00:00:00

abstract：:A total of 224 strains were serogrouped by coagglutination (COA) and serotyped by protein I enzyme-linked immunosorbent assay (ELISA). Of these strains, 61 were from patients with disseminated gonococcal infection, 21 were from patients with pelvic inflammatory disease, and 115 were from patients with uncomplicated go...

journal_title：Infection and immunity

authors： Sandstrom EG,Knapp JS,Buchanan TB

更新日期：1982-01-01 00:00:00

abstract：:Production of group A streptococcal pyrogenic exotoxins (SPE) type A and C was transferred from toxigenic streptococcal strains to nontoxigenic strains by lysogeny. Lysogens were tested for SPE with Ouchterlony immunodiffusion on Todd-Hewitt agar plates; toxin diffusing from isolated colonies reacted with specific hyp...

journal_title：Infection and immunity

authors： Johnson LP,Schlievert PM,Watson DW

更新日期：1980-04-01 00:00:00

abstract：:Murine bone marrow-derived macrophages were infected with a panel of virulent isolates of Mycobacterium tuberculosis including laboratory strains Erdman and H37Rv and various clinical isolates in order to determine the sensitivity of each of these strains to the antimycobacterial activities of macrophage-generated rea...

journal_title：Infection and immunity

authors： Rhoades ER,Orme IM

更新日期：1997-04-01 00:00:00

abstract：:We identified and characterized a gene encoding a homologue of the B subunits of cholera toxin (CTB) and heat-labile enterotoxin (LTB) of Escherichia coli from a clinical isolate of Citrobacter freundii that was found to produce a factor in the culture supernatant that cross-reacted with antibodies to CTB and LTB when...

journal_title：Infection and immunity

authors： Karasawa T,Ito H,Tsukamoto T,Yamasaki S,Kurazono H,Faruque SM,Nair GB,Nishibuchi M,Takeda Y

更新日期：2002-12-01 00:00:00

abstract：:Fourteen strains of Escherichia coli were tested for ability to cause infective endocarditis in rabbits prepared by prior placement of an intracardiac catheter. Strains that were resistant to the bactericidal action of serum caused E. coli endocarditis in 91.4% of rabbits, whereas serum-sensitive strains usually faile...

journal_title：Infection and immunity

authors： Durack DT,Beeson PB

更新日期：1977-04-01 00:00:00

abstract：:Staphylococcus aureus is a pathogen often found in pneumonia and sepsis. In the context of the resistance of this organism to conventional antibiotics, an understanding of the regulation of natural endogenous antimicrobial molecules is of paramount importance. Previous studies have shown that both human and mouse airw...

journal_title：Infection and immunity

authors： McMichael JW,Maxwell AI,Hayashi K,Taylor K,Wallace WA,Govan JR,Dorin JR,Sallenave JM

更新日期：2005-06-01 00:00:00

abstract：:A major ceramide monohexoside (CMH) was purified from lipidic extracts of Cryptococcus neoformans. This molecule was analyzed by high-performance thin-layer chromatography (HPTLC), gas chromatography coupled with mass spectrometry, and fast atom bombardment-mass spectrometry. The cryptococcal CMH is a beta-glucosylcer...

journal_title：Infection and immunity

authors： Rodrigues ML,Travassos LR,Miranda KR,Franzen AJ,Rozental S,de Souza W,Alviano CS,Barreto-Bergter E

更新日期：2000-12-01 00:00:00

abstract：:The var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family is responsible for antigenic variation and sequestration of infected erythrocytes during malaria. We have previously grouped the 60 PfEMP1 variants of P. falciparum clone 3D7 into groups A and B/A (category A) and groups B, B/C, ...

journal_title：Infection and immunity

authors： Joergensen L,Turner L,Magistrado P,Dahlbäck MA,Vestergaard LS,Lusingu JP,Lemnge M,Salanti A,Theander TG,Jensen AT

更新日期：2006-12-01 00:00:00

abstract：:We reexamined the binding specificity of the Shiga-like toxin variant associated with porcine edema disease, SLT2e, which is reported to be more cytotoxic for Vero cells than for HeLa cells, by using receptor-deficient cells and a liposomal insertion system for purified glycolipids. We found that SLT2e preferentially ...

journal_title：Infection and immunity

authors： Keusch GT,Jacewicz M,Acheson DW,Donohue-Rolfe A,Kane AV,McCluer RH

更新日期：1995-03-01 00:00:00

abstract：:Streptococcus pneumoniae contains an inhibitor of human neutrophil elastase. The agent does not inhibit other proteases, including neutrophil cathepsin G and pancreatic elastase. It is active in the presence of insoluble elastin as well as synthetic elastase substrates. The inhibitor is present in the pneumococcal cel...

journal_title：Infection and immunity

authors： Vered M,Simon SR,Janoff A

更新日期：1985-07-01 00:00:00

abstract：:Streptococcus pneumoniae is a leading cause of bacterial pneumonia, meningitis, and sepsis in children. Human immunity to pneumococcal infections has been assumed to depend on anticapsular antibodies. However, recent findings from murine models suggest that alternative mechanisms, dependent on T helper cells, are also...

journal_title：Infection and immunity

authors： Olliver M,Hiew J,Mellroth P,Henriques-Normark B,Bergman P

更新日期：2011-10-01 00:00:00

abstract：:The intraerythrocytic apicomplexan Babesia microti, the primary causative agent of human babesiosis, is a major public health concern in the United States and elsewhere. Apicomplexans utilize a multiprotein complex that includes a type I membrane protein called apical membrane antigen 1 (AMA1) to invade host cells. We...

journal_title：Infection and immunity

authors： Moitra P,Zheng H,Anantharaman V,Banerjee R,Takeda K,Kozakai Y,Lepore T,Krause PJ,Aravind L,Kumar S

更新日期：2015-10-01 00:00:00

abstract：:Stimulated polymorphonuclear leukocytes have been shown by this laboratory to release a reactive-oxygen species (ROS) which is detectable in the supernatant and is capable of oxidizing reduced glutathione and reacting with methionine (Sagone et al., Blood 63:96-104, 1984). This ROS is dependent on H2O2 and heme for it...

journal_title：Infection and immunity

authors： Rao MK,Sagone AL Jr

更新日期：1984-03-01 00:00:00

abstract：:Two virulence factors of Listeria monocytogenes, listeriolysin O (LLO) and phosphatidylinositol-specific phospholipase C (PI-PLC), mediate escape of this pathogen from the phagocytic vacuole of macrophages, thereby allowing the bacterium access to the host cell cytosol for growth and spread to neighboring cells. We ch...

journal_title：Infection and immunity

authors： Wei Z,Schnupf P,Poussin MA,Zenewicz LA,Shen H,Goldfine H

更新日期：2005-10-01 00:00:00

abstract：:Peptide 9 (TDAYNQKLSERRAN) and peptide 10 (NATAEGRAINRRVE) represent surface-exposed epitopes of outer membrane protein F of Pseudomonas aeruginosa. Rats immunized with four intramuscular inoculations on days 0, 14, 28, and 42 with either peptide 9 or peptide 10 conjugated to keyhole limpet hemocyanin were afforded pr...

journal_title：Infection and immunity

authors： Gilleland LB,Gilleland HE Jr

更新日期：1995-06-01 00:00:00

abstract：:Cells of several strains of Streptococcus gordonii attached in much higher numbers to experimental pellicles formed from samples of submandibular or parotid saliva on hydroxyapatite (HA) beads than to buffer controls. The nature of the salivary components responsible were investigated by preparing experimental pellicl...

journal_title：Infection and immunity

authors： Gibbons RJ,Hay DI,Schlesinger DH

更新日期：1991-09-01 00:00:00

abstract：:Studies were carried out to determine whether treatment of mice with the synthetic adjuvant muramyl dipeptide afforded any resistance to infection with the obligate intracellular protozoan Toxoplasma gondii. Marked resistance to lethal challenge infection was observed in CBA but not C57BL/6 mice pretreated with muramy...

journal_title：Infection and immunity

authors： Krahenbuhl JL,Sharma SD,Ferraresi RW,Remington JS

更新日期：1981-02-01 00:00:00

abstract：:Cholera toxin (CT) and the type II heat-labile enterotoxins (HLT) LT-IIa and LT-IIb act as potent systemic and mucosal adjuvants and induce distinct T-helper (Th)-cell cytokine profiles. In the present study, CT and the type II HLT were found to differentially affect cytokine production by anti-CD3-stimulated human pe...

journal_title：Infection and immunity

authors： Martin M,Metzger DJ,Michalek SM,Connell TD,Russell MW

更新日期：2001-07-01 00:00:00

abstract：:Studies on the innate immune response against microbial infections in Drosophila melanogaster involve mutant strains and their reference strains that act as experimental controls. We used five standard D. melanogaster laboratory reference strains (Oregon R, w1118, Canton-S, Cinnabar Brown, and Yellow White [YW]) and i...

journal_title：Infection and immunity

authors： Eleftherianos I,More K,Spivack S,Paulin E,Khojandi A,Shukla S

更新日期：2014-10-01 00:00:00

abstract：:Interleukin-10 (IL-10)-producing B cells (B10 cells) play a critical role in the immune system balance by negatively regulating inflammatory responses. This study was conducted to determine the effect of local B10 cell induction on periodontal inflammation and bone loss in ligature-induced experimental periodontitis i...

journal_title：Infection and immunity

authors： Yu P,Hu Y,Liu Z,Kawai T,Taubman MA,Li W,Han X

更新日期：2016-12-29 00:00:00

abstract：:Heart and muscle tissues appear to be specific target organs for the in vivo inhibition of protein synthesis by diphtheria toxin. ...

journal_title：Infection and immunity

authors： Bowman CG,Imhoff JG,Bonventre PF

更新日期：1970-11-01 00:00:00

abstract：:Recent studies have shown that children with blood group A have increased susceptibility to enterotoxigenic Escherichia coli (ETEC) diarrhea and that Lewis blood group "a" antigen (Le(a)) may be a candidate receptor for ETEC colonization factor (CF) antigen I (CFA/I) fimbriae. Based on these findings, we have attempte...

journal_title：Infection and immunity

authors： Ahmed T,Lundgren A,Arifuzzaman M,Qadri F,Teneberg S,Svennerholm AM

更新日期：2009-05-01 00:00:00

abstract：:Plasmodium ookinetes secrete chitinases to penetrate the acellular, chitin-containing peritrophic matrix of the mosquito midgut en route to invasion of the epithelium. Chitinases are potentially targets that can be used to block malaria transmission. We demonstrate here that chitinases of Plasmodium falciparum and P. ...

journal_title：Infection and immunity

authors： Langer RC,Hayward RE,Tsuboi T,Tachibana M,Torii M,Vinetz JM

更新日期：2000-11-01 00:00:00

abstract：:Helicobacter pylori secretes a pore-forming VacA toxin that has structural features and activities substantially different from those of other known bacterial toxins. VacA can assemble into multiple types of water-soluble flower-shaped oligomeric structures, and most VacA activities are dependent on its capacity to ol...

journal_title：Infection and immunity

authors： González-Rivera C,Campbell AM,Rutherford SA,Pyburn TM,Foegeding NJ,Barke TL,Spiller BW,McClain MS,Ohi MD,Lacy DB,Cover TL

更新日期：2016-08-19 00:00:00

abstract：:Helicobacter infections are present in approximately 50% of humans, causing severe illnesses such as gastritis and malignancies. Dendritic cells (DC) are critical antigen-presenting cells which link innate and adaptive immune responses. The mechanism of dendritic cell regulation in Helicobacter-induced gastritis is po...

journal_title：Infection and immunity

authors： Drakes ML,Czinn SJ,Blanchard TG

更新日期：2006-08-01 00:00:00

abstract：:Factors in the queous humor capable of increasing the random migration and chemotaxis of monocytes were demonstrated during experimental uveitis in the rabbit. Injection of endotoxin-free human serum albumin into the vitreous produced a severe inflammation detectable after 7 days and maximal between 12 to 21 days. Aqu...

journal_title：Infection and immunity

authors： Sher NA,Foon KA,Fishman ML,Brown TM

更新日期：1976-04-01 00:00:00