Micronemal transport of Plasmodium ookinete chitinases to the electron-dense area of the apical complex for extracellular secretion.

abstract：:Spirochetes have been implicated as potential etiologic agents of periodontitis in humans. Murine monoclonal antibodies (MAbs) specific for a serogroup of Treponema denticola, an oral spirochete, were developed and characterized in this study. Antibodies secreted by clone IAA11 were judged to be the most useful, since...

journal_title：Infection and immunity

authors： Simonson LG,Rouse RF,Bockowski SW

更新日期：1988-01-01 00:00:00

abstract：:Previous studies indicated that inorganic pyrophosphatase of Ascaris suum (AsPPase) plays an important role in larval survival in the host. Here we describe a precise role for AsPPase in larval molting and development and also describe the potential role of recombinant AsPPase (rAsPPase) in protective immunity to A. s...

journal_title：Infection and immunity

authors： Islam MK,Miyoshi T,Yamada M,Tsuji N

更新日期：2005-04-01 00:00:00

abstract：:Scrub typhus is a potentially lethal infection that is caused by the obligate intracellular bacterium Orientia tsutsugamushi The roles of Toll-like receptor 2 (TLR2) and TLR4 in innate recognition of O. tsutsugamushi have not been elucidated. By overexpression of TLR2 or TLR4 in HEK293 cells, we demonstrated that TLR2...

journal_title：Infection and immunity

authors： Gharaibeh M,Hagedorn M,Lilla S,Hauptmann M,Heine H,Fleischer B,Keller C

更新日期：2016-11-18 00:00:00

abstract：:Staphylococcus aureus is a pathogen often found in pneumonia and sepsis. In the context of the resistance of this organism to conventional antibiotics, an understanding of the regulation of natural endogenous antimicrobial molecules is of paramount importance. Previous studies have shown that both human and mouse airw...

journal_title：Infection and immunity

authors： McMichael JW,Maxwell AI,Hayashi K,Taylor K,Wallace WA,Govan JR,Dorin JR,Sallenave JM

更新日期：2005-06-01 00:00:00

abstract：:Francisella tularensis is the causative agent of zoonotic tularemia, a severe pneumonia in humans, and Francisella novicida causes a similarly severe tularemia in mice upon inhalation. The correlates of protective immunity, as well as the virulence mechanisms of this deadly pathogen, are not well understood. In the pr...

journal_title：Infection and immunity

authors： Sharma J,Li Q,Mishra BB,Georges MJ,Teale JM

更新日期：2009-10-01 00:00:00

abstract：:Infection of resistant or susceptible mice with Trichuris muris provokes mesenteric lymph node responses which are polarized towards Th2 or Th1, respectively. These responses are well documented in the literature. In contrast, little is known about the local responses occurring within the infected intestine. Through m...

journal_title：Infection and immunity

authors： Datta R,deSchoolmeester ML,Hedeler C,Paton NW,Brass AM,Else KJ

更新日期：2005-07-01 00:00:00

abstract：:Toxin preparations were obtained by growing Clostridium difficile VPI strain 10463 in 2-liter brain heart infusion dialysis flasks at 37 degrees C for 3 days. The initial step of the purification scheme involved ultrafiltration through an XM-100 membrane filter. Two toxic activities, designated toxins A and B, were se...

journal_title：Infection and immunity

authors： Sullivan NM,Pellett S,Wilkins TD

更新日期：1982-03-01 00:00:00

abstract：:Escherichia coli containing the K1 capsule is the leading cause of gram-negative meningitis, but the pathogenesis of this disease is not completely understood. Recent microarray experiments in which we compared the gene expression profile of E. coli K1 associated with human brain microvascular endothelial cells (HBMEC...

journal_title：Infection and immunity

authors： Parthasarathy G,Yao Y,Kim KS

更新日期：2007-06-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is a major metabolic end product detected in deep periodontal pockets that is produced by resident periodontopathic microbiota associated with the progression of periodontitis. Treponema denticola, a member of the subgingival biofilm at disease sites, produces cystalysin, an enzyme that catabo...

journal_title：Infection and immunity

authors： Chu L,Dong Z,Xu X,Cochran DL,Ebersole JL

更新日期：2002-03-01 00:00:00

abstract：:UV-inactivated Sendai virus is mitogenic for murine splenocytes, whereas infectious Sendai virus kills spleen cells in vitro. The isolated hemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins of Sendai virus are also mitogenic for cultured mouse spleen cells. A mixture of these glycoproteins (1 microgram/well...

journal_title：Infection and immunity

authors： Kizaka S,Goodman-Snitkoff G,McSharry JJ

更新日期：1983-05-01 00:00:00

abstract：:A concentrated bacterial culture supernatant from the hemolytic Moraxella bovis strain UQV 148NF was used to immunize mice and generate monoclonal antibodies (MAbs). One, MAb G3/D7, neutralized the hemolytic activity of M. bovis and recognized a 94-kDa protein by Western blot analysis in hemolytic M. bovis strains rep...

journal_title：Infection and immunity

authors： Billson FM,Harbour C,Michalski WP,Tennent JM,Egerton JR,Hodgson JL

更新日期：2000-06-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO), a tryptophan-degrading enzyme, is inducible by various interferons (IFNs). IDO-mediated tryptophan degradation, but not the formation of IDO-catalyzed tryptophan metabolites, has been suggested as a mechanism for the antiparasitic action of IFN-gamma. To determine whether the IFN-gam...

journal_title：Infection and immunity

authors： Habara-Ohkubo A,Shirahata T,Takikawa O,Yoshida R

更新日期：1993-05-01 00:00:00

abstract：:As an intracellular protozoan parasite, Toxoplasma gondii is likely to exploit proteases for host cell invasion, acquisition of nutrients, avoidance of host protective responses, escape from the parasitophorous vacuole, differentiation, and other activities. T. gondii serine protease inhibitor 1 (TgPI1) is the most ab...

journal_title：Infection and immunity

authors： Pszenny V,Davis PH,Zhou XW,Hunter CA,Carruthers VB,Roos DS

更新日期：2012-03-01 00:00:00

abstract：:In bacterial infections, mononuclear and polymorphonuclear phagocytes are key components of host defenses. Recent investigations have indicated that chemokines are able to recruit and activate phagocytes. In particular, interleukin-8 (IL-8) attracts polymorphonuclear leukocytes (PMNs), while monocyte chemoattractant p...

journal_title：Infection and immunity

authors： Tonetti MS,Imboden MA,Gerber L,Lang NP,Laissue J,Mueller C

更新日期：1994-09-01 00:00:00

abstract：:Three antigenic determinants were revealed in H3 hemagglutinin of influenza A viruses isolated from 1968 to 1975. One of them was common for all viruses, and two others specified differences between the viruses possessing H3 hemagglutinin. ...

journal_title：Infection and immunity

authors： Rovnova ZI,Kosyakov PN,Berezina ON,Isayeva EI,Zhdanov VM

更新日期：1979-06-01 00:00:00

abstract：:Cutaneous lesions of the human sexually transmitted genital ulcer disease chancroid are characterized by the presence of intraepidermal pustules, keratinocyte cytopathology, and epidermal and dermal erosion. These lesions are replete with neutrophils, macrophages, and CD4(+) T cells and contain very low numbers of cel...

journal_title：Infection and immunity

authors： San Mateo LR,Toffer KL,Orndorff PE,Kawula TH

更新日期：1999-09-01 00:00:00

abstract：:This study examined apoptotic cell death associated with Shiga-like toxin (Stx)-producing Escherichia coli. Renal cortices from three children with postenteropathic hemolytic-uremic syndrome (HUS) and from mice infected with E. coli O157:H7 and pediatric renal tubular epithelial cells stimulated with Stx and E. coli O...

journal_title：Infection and immunity

authors： Karpman D,Håkansson A,Perez MT,Isaksson C,Carlemalm E,Caprioli A,Svanborg C

更新日期：1998-02-01 00:00:00

abstract：:Oligopeptides play important roles in bacterial nutrition and signaling. Using sequences from the available genome database for Mycobacterium tuberculosis H37Rv, the oligopeptide permease operon (oppBCDA) of Mycobacterium bovis BCG was cloned from a cosmid library. An opp mutant strain was constructed by homologous re...

journal_title：Infection and immunity

authors： Green RM,Seth A,Connell ND

更新日期：2000-02-01 00:00:00

abstract：:Uropathogenic Escherichia coli strain J96 carries multiple determinants for fimbrial adhesins. The regulatory protein PapB of P fimbriae has previously been implicated in potential coregulatory events. The focB gene of the F1C fimbria determinant is highly homologous to papB; the translated sequences share 81% identit...

journal_title：Infection and immunity

authors： Lindberg S,Xia Y,Sondén B,Göransson M,Hacker J,Uhlin BE

更新日期：2008-02-01 00:00:00

abstract：:The attachment and invasion of chicken ovarian granulosa cells by Salmonella enteritidis was examined in vitro. The attachment was inhibited by preincubation of granulosa cells with anti-chicken fibronectin antibody (approximately 70% reduction in attachment) or preincubation with a 14-kDa fimbrial protein isolated fr...

journal_title：Infection and immunity

authors： Thiagarajan D,Saeed M,Turek J,Asem E

更新日期：1996-12-01 00:00:00

abstract：:The Duffy binding protein (DBP) is a vital ligand for Plasmodium vivax blood-stage merozoite invasion, making the molecule an attractive vaccine candidate against vivax malaria. Similar to other blood-stage vaccine candidates, DBP allelic variation eliciting a strain-specific immunity may be a major challenge for deve...

journal_title：Infection and immunity

authors： Ntumngia FB,Schloegel J,Barnes SJ,McHenry AM,Singh S,King CL,Adams JH

更新日期：2012-03-01 00:00:00

abstract：:The relationship between the selective abilities of bacteria to adhere and their predilections for colonizing different mammalian hosts was investigated by using bacteria indigenous to the tongue dorsum of humans and rats as models. Streptococcus salivarius and S. sanguis averaged 22.6 and 2.8%, respectively, of the c...

journal_title：Infection and immunity

authors： Gibbons RJ,Spinell DM,Skobe Z

更新日期：1976-01-01 00:00:00

abstract：:The viaB locus coding for the Vi antigen of Salmonella typhi Ty2 was cloned on a 40.6-kilobase fragment into the cosmid vector pHC79. The live, oral, attenuated Vi-negative S. typhi Ty21a vaccine strain was transformed with the recombinant cosmid encoding the viaB locus. Homologous recombination of the viaB locus into...

journal_title：Infection and immunity

authors： Cryz SJ Jr,Fürer E,Baron LS,Noon KF,Rubin FA,Kopecko DJ

更新日期：1989-12-01 00:00:00

abstract：:Representative strains of serogroup A Neisseria meningitidis were chosen from all major meningitis epidemics worldwide since 1960 and subjected to analysis for the electrophoretic variation of 15 cytoplasmic allozymes and four outer membrane proteins. The 290 strains defined 84 unique electrophoretic types which were ...

journal_title：Infection and immunity

authors： Wang JF,Caugant DA,Li X,Hu X,Poolman JT,Crowe BA,Achtman M

更新日期：1992-12-01 00:00:00

abstract：:Pathogens produce virulence factors that interact directly with host molecules, but in many cases the host targets are unknown. The genetic and molecular identification of these orphan targets is often not feasible with mammalian experimental models. However, a substantial number of known targets are molecules and pat...

journal_title：Infection and immunity

authors： Darby C,Falkow S

更新日期：2001-10-01 00:00:00

abstract：:L-phase variants and small colony (G-phase) variants derived from penicillinase-producing Staphylococcus aureus strains were tested for penicillinase (beta lactamase) production. A refined variation of the modified Gots test for penicillinase was used to demonstrate penicillinase synthesis. Penicillinase synthesis was...

journal_title：Infection and immunity

authors： Simon HJ,Yin EJ

更新日期：1970-11-01 00:00:00

abstract：:Peripheral leukocytes from 16 Thai children with dengue hemorrhagic fever were examined to determine the leukocyte composition on the day of presentation and on convalescent days 15 and 30. Mononuclear cells were isolated each time, and the concentrations of T, B, Fc receptor-bearing, and "null" cells were determined....

journal_title：Infection and immunity

authors： Wells RA,Scott RM,Pavanand K,Sathitsathein V,Cheamudon U,Macdermott RP

更新日期：1980-05-01 00:00:00

abstract：:Mice were vaccinated with plasmid DNA (pDNA) encoding antigen 85A (Ag85A), Ag85B, or PstS-3 from Mycobacterium tuberculosis either in saline or formulated for intramuscular injections in VC1052:DPyPE (aminopropyl-dimethyl-myristoleyloxy-propanaminium bromide-diphytanoylphosphatidyl-ethanolamine) (Vaxfectin; Vical, Inc...

journal_title：Infection and immunity

authors： D'Souza S,Rosseels V,Denis O,Tanghe A,De Smet N,Jurion F,Palfliet K,Castiglioni N,Vanonckelen A,Wheeler C,Huygen K

更新日期：2002-07-01 00:00:00

abstract：:Proliferation of Bordetella pertussis in the lungs of infant mice challenged by the intranasal route was examined. The bacteria rapidly proliferated in the lungs of mice challenged with a sublethal dose of a wild-type strain (BP338) or a filamentous hemagglutinin mutant (BPM409) from 500 at day 0 to 10(7) at day 15. T...

journal_title：Infection and immunity

authors： Goodwin MS,Weiss AA

更新日期：1990-10-01 00:00:00

abstract：:Fusobacterium nucleatum is closely associated with human periodontal diseases and may also be a causative agent in other infections, such as pericarditis, septic arthritis, and abscesses of tonsils and liver. Initiation and outcome of infective diseases depend critically on the host cell signaling system altered by th...

journal_title：Infection and immunity

authors： Uitto VJ,Baillie D,Wu Q,Gendron R,Grenier D,Putnins EE,Kanervo A,Firth JD

更新日期：2005-02-01 00:00:00