Abstract:
:Infection of resistant or susceptible mice with Trichuris muris provokes mesenteric lymph node responses which are polarized towards Th2 or Th1, respectively. These responses are well documented in the literature. In contrast, little is known about the local responses occurring within the infected intestine. Through microarray analyses, we demonstrate that the gene expression profile of infected gut tissue differs according to whether the parasite is expelled or not. Genes differentially regulated postinfection in resistant BALB/c mice include several antimicrobial genes, in particular, intelectin (Itln). In contrast, analyses in AKR mice which ultimately progress to chronic infection provide evidence for a Th1-dominated mucosa with up-regulated expression of genes regulated by gamma interferon. Increases in the expression of genes associated with tryptophan metabolism were also apparent with the coinduction of tryptophanyl tRNA synthetase (Wars) and indoleamine-2,3-dioxygenase (Indo). With the emerging literature on the role of these gene products in the suppression of T-cell responses in vitro and in vivo, their up-regulated expression here may suggest a role for tryptophan metabolism in the parasite survival strategy.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Datta R,deSchoolmeester ML,Hedeler C,Paton NW,Brass AM,Else KJdoi
10.1128/IAI.73.7.4025-4033.2005keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
4025-33issue
7eissn
0019-9567issn
1098-5522pii
73/7/4025journal_volume
73pub_type
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.3.565-577.1974
更新日期:1974-09-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.11.2.330-333.1975
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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doi:10.1128/IAI.37.1.209-215.1982
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1992-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.12.5078-5084.1992
更新日期:1992-12-01 00:00:00
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更新日期:2009-04-01 00:00:00
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更新日期:2001-03-01 00:00:00