Control of Leishmania infantum infection is associated with CD8(+) and gamma interferon- and interleukin-5-producing CD4(+) antigen-specific T cells.

abstract：:Monoclonal antibody MASC1-MR9 of isotype immunoglobulin M was generated in LOU/C rats by immunization with heat-killed Salmonella thompson (serogroup C1, O-antigen 6,7 lipopolysaccharide) bacteria which had been further enriched for O-antigen by coating with homologous lipopolysaccharide. Eight monoclonal antibodies w...

journal_title：Infection and immunity

authors： Nnalue NA,Weintraub A,Lindberg AA

更新日期：1991-01-01 00:00:00

abstract：:Pneumolysin, the cholesterol-dependent cytolysin of Streptococcus pneumoniae, induces inflammatory and apoptotic events in mammalian cells. Toll-like receptor 4 (TLR4) confers resistance to pneumococcal infection via its interaction with pneumolysin, but the underlying mechanisms remain to be identified. In the presen...

journal_title：Infection and immunity

authors： Srivastava A,Henneke P,Visintin A,Morse SC,Martin V,Watkins C,Paton JC,Wessels MR,Golenbock DT,Malley R

更新日期：2005-10-01 00:00:00

abstract：:Escherichia coli strains produce at least two heat-stable enterotoxins, STa and STb. STa is well known to be important in the pathogenesis of human diarrheal disease; the role of STb has not been defined. Fifty-two E. coli strains recovered from human diarrheal illness in northeast Brazil or Bangladesh were examined i...

journal_title：Infection and immunity

authors： Weikel CS,Tiemens KM,Moseley SL,Huq IM,Guerrant RL

更新日期：1986-04-01 00:00:00

abstract：:Antigenic competition between bovine gamma globulin (BGG) and endotoxin from a smooth strain (S-ET) and a rough (R-ET) heptoseless mutant strain of Salmonella minnesota was studied in mice. Both endotoxins acted as adjuvants for enhancing the antibody response to BGG. However, other work showed that the R-ET had minim...

journal_title：Infection and immunity

authors： Leong DL,Rudbach JA

更新日期：1971-02-01 00:00:00

abstract：:An improved enterocyte adhesion assay has been used to examine a collection of 44 strains of enterotoxigenic Escherichia coli (ETEC) for their ability to adhere to the brush border of isolated human duodenal enterocytes. Fourteen strains showed good adhesion; in each case the ability to adhere correlated with the prod...

journal_title：Infection and immunity

authors： Knutton S,Lloyd DR,Candy DC,McNeish AS

更新日期：1985-06-01 00:00:00

abstract：:Myeloid differentiation protein 88 (MyD88) is a general adaptor for the signaling cascade through receptors of the Toll/IL-1R family. When infected with Leishmania major parasites, MyD88-deficient mice displayed a dramatically enhanced parasite burden in their tissues similar to that found in susceptible BALB/c mice. ...

journal_title：Infection and immunity

authors： Debus A,Gläsner J,Röllinghoff M,Gessner A

更新日期：2003-12-01 00:00:00

abstract：:The adhesion of gram-positive bacteria to extracellular matrix (ECM) proteins is regarded as an important determinant of pathogenicity. A comparison of the adhesion of Streptococcus agalactiae strain O90R to different ECM proteins showed that the most pronounced binding could be observed for immobilized fibrinogen. To...

journal_title：Infection and immunity

authors： Spellerberg B,Rozdzinski E,Martin S,Weber-Heynemann J,Lütticken R

更新日期：2002-05-01 00:00:00

abstract：:Bacillus anthracis is surrounded by a polypeptide capsule composed of poly-gamma-d-glutamic acid (gammaDPGA). In a previous study, we reported that a monoclonal antibody (MAb F26G3) reactive with the capsular polypeptide is protective in a murine model of pulmonary anthrax. The present study examined a library of six ...

journal_title：Infection and immunity

authors： Kozel TR,Thorkildson P,Brandt S,Welch WH,Lovchik JA,AuCoin DP,Vilai J,Lyons CR

更新日期：2007-01-01 00:00:00

abstract：:Chronic infections play a significant role in the morbidity and mortality of patients with chronic airflow limitation. By stimulating airway inflammation, persistent infection has the potential to cause airway fibrosis. However, in patient this condition is most typically found in lungs damaged by other factors, such ...

journal_title：Infection and immunity

authors： McIntosh JC,Simecka JW,Ross SE,Davis JK,Miller EJ,Cassell GH

更新日期：1992-07-01 00:00:00

abstract：:Protection by surface antigen TF1.17 of Tritrichomonas foetus was investigated because it reacted with a monoclonal antibody which immobilized and mediated complement killing of the organism and prevented adherence to vaginal epithelial cells. This monoclonal antibody was used to demonstrate conservation of the antige...

journal_title：Infection and immunity

authors： BonDurant RH,Corbeil RR,Corbeil LB

更新日期：1993-04-01 00:00:00

abstract：:The role of CD19(+) CD5(+) and CD19(+) CD5(-) B cell subpopulations in the antibody response to pneumococcal capsular polysaccharides (caps-PSs) is controversial. In the present study, we evaluated the role of human CD19(+) CD5(+) and CD19(+) CD5(-) cell populations in the serotype-specific antibody response to caps-P...

journal_title：Infection and immunity

authors： Moens L,Verbinnen B,Covens K,Wuyts G,Johnson M,Roalfe L,Goldblatt D,Meyts I,Bossuyt X

更新日期：2015-07-01 00:00:00

abstract：:The urease gene cluster from the virulent Actinobacillus pleuropneumoniae serotype 1 strain CM5 was cloned and sequenced. The urease activity was associated with a 6.3-kbp region which contains eight long open reading frames (ORFs). The structural genes, ureABC, are separated from the accessory genes, ureEFGD, by a 61...

journal_title：Infection and immunity

authors： Bossé JT,MacInnes JI

更新日期：1997-11-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in controlling several aspects of immune responses, including the activation and differentiation of specific T cell subsets and antigen-presenting cells, thought to be relevant in the context of experimental Trypanosoma cruzi infec...

journal_title：Infection and immunity

authors： Barroso A,Gualdrón-López M,Esper L,Brant F,Araújo RR,Carneiro MB,Ávila TV,Souza DG,Vieira LQ,Rachid MA,Tanowitz HB,Teixeira MM,Machado FS

更新日期：2016-09-19 00:00:00

abstract：:Two glucosyltransferase genes from Streptococcus mutans GS-5, gtfB and gtfC, have been previously isolated and sequenced in this laboratory. In the present communication a third gtf gene, gtfD, was isolated and characterized. Isolation of the gene involved a novel procedure utilizing the integration plasmid pVA891. A ...

journal_title：Infection and immunity

authors： Hanada N,Kuramitsu HK

更新日期：1989-07-01 00:00:00

abstract：:Tritium-labeled, water-soluble components of Streptococcus pyogenes type M6 absorbed to cardiac tissue in vitro. Tissue binding was time dependent, saturable, and reversible. Chromatography of the crude bacterial extract on Bio-Gel P-300 indicated a molecular weight greater than 300,000 for the heart-binding component...

journal_title：Infection and immunity

authors： Stinson MW,Bergey EJ

更新日期：1982-01-01 00:00:00

abstract：:The kinetics of cytotoxic T lymphocyte antigen 4 (CTLA-4) expression on T cells responding to Cryptococcus neoformans and its role in regulating the T-cell response were examined. Using peripheral blood mononuclear cells stimulated with encapsulated or acapsular C. neoformans we showed that (i) the encapsulated strain...

journal_title：Infection and immunity

authors： Pietrella D,Perito S,Bistoni F,Vecchiarelli A

更新日期：2001-03-01 00:00:00

abstract：:It was previously demonstrated that avirulent Mycoplasma gallisepticum strain R(high) (passage 164) is lacking three proteins that are expressed in its virulent progenitor, strain R(low) (passage 15). These proteins were identified as the cytadhesin molecule GapA, the putative cytadhesin-related molecule CrmA, and a c...

journal_title：Infection and immunity

authors： Papazisi L,Frasca S Jr,Gladd M,Liao X,Yogev D,Geary SJ

更新日期：2002-12-01 00:00:00

abstract：:Guinea pig peritoneal or alveolar macrophages were inoculated with Mycoplasma pneumoniae cells. Extracellular mycoplasms were killed by complement treatment, and the effect of macrophage action on the number of the remaining viable mycoplasmas was observed. The complement killing was to some extent inhibited by the pr...

journal_title：Infection and immunity

authors： Erb P,Bredt W

更新日期：1979-07-01 00:00:00

abstract：:Macrophages can undergo apoptosis after infection with Mycobacterium tuberculosis. This macrophage response deprives the bacillus of its niche cell and supports the host response through better antigen presentation. The intracellular pathways of apoptosis that elaborate this macrophage response are not well understood...

journal_title：Infection and immunity

authors： O'Sullivan MP,O'Leary S,Kelly DM,Keane J

更新日期：2007-04-01 00:00:00

abstract：:Previous studies demonstrated that Mycoplasma arthritidis strain 158 acquired a high degree of virulence upon lysogenization with bacteriophage MAV1. In the present study, the association between MAV1 and virulence was reexamined by creating new lysogens of 158 and of a relatively avirulent mutant, strain 158-1. In th...

journal_title：Infection and immunity

authors： Clapper B,Tu AH,Simmons WL,Dybvig K

更新日期：2004-12-01 00:00:00

abstract：:Many pathogenic Escherichia coli produce the toxin alpha-hemolysin (Hly), and lipopolysaccharide (LPS), interleukin-1 (IL-1), and tumor necrosis factor (TNF) have all been recognized as important effector molecules during infections by gram-negative organisms. Despite the characterization of many in vitro effects of h...

journal_title：Infection and immunity

authors： Gleason TG,Houlgrave CW,May AK,Crabtree TD,Sawyer RG,Denham W,Norman JG,Pruett TL

更新日期：1998-09-01 00:00:00

abstract：:An antigenic complex has been isolated in a highly purified from from the Melvin strain of Neisseria gonorrhoeae. The complex has a molecular weight of 9.3 x 10(6) and on sodium dodecyl sulfate-polyacrylamide gel electrophoresis was found to consist of several subunits; the most predominant had the following molecular...

journal_title：Infection and immunity

authors： Karkhanis YD,Anderson RL,Zeltner JY,Carlo DJ,Stoudt TH

更新日期：1979-08-01 00:00:00

abstract：:Infection of C3H mice with Borrelia burgdorferi, the causative agent of Lyme disease, reliably produces an infectious arthritis and carditis that peak around 3 weeks postinfection and then spontaneously resolve. Macrophage polarization has been suggested to drive inflammation, the clearance of bacteria, and tissue rep...

journal_title：Infection and immunity

authors： Lasky CE,Olson RM,Brown CR

更新日期：2015-07-01 00:00:00

abstract：:Borrelia burgdorferi-induced arthritis in mice is characterized by tendonitis, synovitis, and inflammatory-cell infiltrate, predominantly of neutrophils. Because genetic deficiency in E and P selectins results in delayed recruitment of neutrophils to sites of inflammation, mice with this deficiency were tested for the...

journal_title：Infection and immunity

authors： Seiler KP,Ma Y,Weis JH,Frenette PS,Hynes RO,Wagner DD,Weis JJ

更新日期：1998-09-01 00:00:00

abstract：:A number of studies have substantiated the pivotal role of innate defense mechanisms in protection against invasive aspergillosis. However, experiments demonstrating increased resistance to lethal intravenous (i.v.) infection with Aspergillus fumigatus conidia in cortisone-treated or untreated mice preinfected with a ...

journal_title：Infection and immunity

authors： de Repentigny L,Petitbois S,Boushira M,Michaliszyn E,Sénéchal S,Gendron N,Montplaisir S

更新日期：1993-09-01 00:00:00

abstract：:The adherence mechanism of Aeromonas caviae Sch3N to HEp-2 cells was initially investigated through four mini-Tn5 mutants that showed a 10-fold decrease in adherence. These mutants lost motility, flagella, and their lipopolysaccharide (LPS) O antigen (O-Ag). Three genes, flmB-neuA-flmD, were found to be interrupted by...

journal_title：Infection and immunity

authors： Gryllos I,Shaw JG,Gavín R,Merino S,Tomás JM

更新日期：2001-01-01 00:00:00

abstract：:MAEBL is a type 1 membrane protein that is implicated in the merozoite invasion of erythrocytes and sporozoite invasion of mosquito salivary glands. This apical organelle protein is structurally similar to the ebl erythrocyte binding proteins, such as EBA-175, except that the tandem ligand domains of MAEBL are similar...

journal_title：Infection and immunity

authors： Preiser P,Rénia L,Singh N,Balu B,Jarra W,Voza T,Kaneko O,Blair P,Torii M,Landau I,Adams JH

更新日期：2004-06-01 00:00:00

abstract：:Several studies have demonstrated roles for eosinophils during innate and adaptive immune responses to helminth infections. However, evidence that eosinophils are capable of initiating an immune response to parasite antigens is lacking. The goal of the present in vitro study was to investigate the potential of eosinop...

journal_title：Infection and immunity

authors： Padigel UM,Lee JJ,Nolan TJ,Schad GA,Abraham D

更新日期：2006-06-01 00:00:00

abstract：:The efficacy of the innate immune system depends on its ability to mount an appropriate response to diverse infections and damaging agents. Key components of this system are pattern recognition receptors that detect pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs). Nlrp1b is a pattern rec...

journal_title：Infection and immunity

authors： Liao KC,Mogridge J

更新日期：2013-02-01 00:00:00

abstract：:The bacterial pathogen Listeria monocytogenes causes foodborne systemic disease in pregnant women, which can lead to preterm labor, stillbirth, or severe neonatal disease. Colonization of the maternal decidua appears to be an initial step in the maternal component of the disease as well as bacterial transmission to th...

journal_title：Infection and immunity

authors： Rizzuto G,Tagliani E,Manandhar P,Erlebacher A,Bakardjiev AI

更新日期：2017-07-19 00:00:00