Selective pressures and lipopolysaccharide subunits as determinants of resistance of clinical isolates of gram-negative bacilli to human serum.

abstract：:A substance with potent decomplementation activity was isolated from staphylococcal culture supernatants by polyethylene glycol precipitation, DEAE-ion-exchange and Sephacryl chromatography, and preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The purified substance exhibited all the characterist...

journal_title：Infection and immunity

authors： Bhakdi S,Muhly M

更新日期：1985-01-01 00:00:00

abstract：:Fibronectin binds to Streptococcus pyogenes, and this binding is inhibited by lipoteichoic acid (LTA). Previous studies have shown that LTA can be released from S. pyogenes by treatment with penicillin. Penicillin released LTA from both S. pyogenes and Staphylococcus aureus; however, the binding of fibronectin correla...

journal_title：Infection and immunity

authors： Nealon TJ,Beachey EH,Courtney HS,Simpson WA

更新日期：1986-02-01 00:00:00

abstract：:Pneumocystis pneumonia (PcP) is a life-threatening infection that affects immunocompromised individuals. Nearly half of all PcP cases occur in those prescribed effective chemoprophylaxis, suggesting that additional preventive methods are needed. To this end, we have identified a unique mouse Pneumocystis surface prote...

journal_title：Infection and immunity

authors： Tesini BL,Wright TW,Malone JE,Haidaris CG,Harber M,Sant AJ,Nayak JL,Gigliotti F

更新日期：2017-03-23 00:00:00

abstract：:The mechanism by which capsular polysaccharides inhibit phagocytosis is not clearly understood. We investigated the association between a negative surface charge and inhibition of phagocytosis by the capsular polysaccharide of Cryptococcus neoformans. A two-polymer aqueous-phase system containing phosphate ions was us...

journal_title：Infection and immunity

authors： Kozel TR,Reiss E,Cherniak R

更新日期：1980-08-01 00:00:00

abstract：:The development and course of normally lethal parasitemias in mice inoculated intraperitoneally with erythrocytic stages of Plasmodium yoelii or Plasmodium berghei were markedly affected by treatment with the antilymphoid drug cyclosporin A (CS-A). When the first of four daily subcutaneous 25-mg/kg doses of CS-A was g...

journal_title：Infection and immunity

authors： Nickell SP,Scheibel LW,Cole GA

更新日期：1982-09-01 00:00:00

abstract：:Type II secretion (T2S) is one means by which Gram-negative pathogens secrete proteins into the extracellular milieu and/or host organisms. Based upon recent genome sequencing, it is clear that T2S is largely restricted to the Proteobacteria, occurring in many, but not all, genera in the Alphaproteobacteria, Betaprote...

journal_title：Infection and immunity

authors： Cianciotto NP,White RC

更新日期：2017-04-21 00:00:00

abstract：:Using fluorescent antibody techniques (FA) and light microscopy (LM) and electron microscopy (EM), this paper describes the morphological features of the ileum in the DK1 mouse orally challenged with adenovirus K87. At the peak of infection, virus is easily identified by FA in the epithelium of the villi and crypts of...

journal_title：Infection and immunity

authors： Takeuchi A,Hashimoto K

更新日期：1976-02-01 00:00:00

abstract：:Bordetella pertussis adenylate cyclase-hemolysin (AC-Hly), encoded by the cyaA gene, belongs to the RTX family of toxins with extensive glycine-rich repeats in the carboxy-terminal portion. AC-Hly possesses both adenylate cyclase toxic and hemolytic activities that depend on a posttranslational modification mediated b...

journal_title：Infection and immunity

authors： Betsou F,Sebo P,Guiso N

更新日期：1993-09-01 00:00:00

abstract：:Cells of the laboratory strain 3153A of Candida albicans can be stimulated to undergo high-frequency phenotypic switching by a low dose of UV. We have compared the adhesive properties of cells exhibiting the basic original smooth (o-smooth) phenotype and three switch phenotypes (star, irregular wrinkle, and revertant ...

journal_title：Infection and immunity

authors： Vargas K,Wertz PW,Drake D,Morrow B,Soll DR

更新日期：1994-04-01 00:00:00

abstract：:Bordetella pertussis fimbriae are composed of a major subunit, Fim2 or Fim3, and the minor subunit FimD. Using immunoelectron microscopy, we provide evidence that FimD is located at the fimbrial tip. The role of FimD in colonization of the mouse respiratory tract was studied by using two fimbrial mutants: a mutant com...

journal_title：Infection and immunity

authors： Geuijen CA,Willems RJ,Bongaerts M,Top J,Gielen H,Mooi FR

更新日期：1997-10-01 00:00:00

abstract：:Members of our group reported recently that neisseria infection of human epithelial cells results in accelerated degradation of the major lysosomal integral membrane protein LAMP1 and that this is due to hydrolysis of this glycoprotein at its immunoglobulin A1 (IgA1)-like hinge by the neisseria type 2 IgA1 protease (L...

journal_title：Infection and immunity

authors： Ayala P,Lin L,Hopper S,Fukuda M,So M

更新日期：1998-10-01 00:00:00

abstract：:A nasal vaccine, consisting of outer membrane vesicles (OMVs) from group B Neisseria meningitidis, was given to 12 volunteers in the form of nose drops or nasal spray four times at weekly intervals, with a fifth dose 5 months later. Each nasal dose consisted of 250 microg of protein, equivalent to 10 times the intramu...

journal_title：Infection and immunity

authors： Haneberg B,Dalseg R,Wedege E,Høiby EA,Haugen IL,Oftung F,Andersen SR,Naess LM,Aase A,Michaelsen TE,Holst J

更新日期：1998-04-01 00:00:00

abstract：:Pertussis toxin is secreted from Bordetella pertussis with the assistance of the Ptl transport system, a member of the type IV family of macromolecular transporters. The S1 subunit and the B oligomer combine to form the holotoxin prior to export from the bacterial cell, although the site of assembly is not known. To b...

journal_title：Infection and immunity

authors： Farizo KM,Fiddner S,Cheung AM,Burns DL

更新日期：2002-03-01 00:00:00

abstract：:Affinity-purified rabbit polyclonal (PAB96-1) and mouse monoclonal (1G9-1C2) antibodies to synthetic H-DDDDDDD-OH, an antimicrobial anionic peptide (AP) originally isolated from ovine pulmonary surfactant, were prepared and used to assess the concentrations of AP-like molecules in human respiratory tract samples. In b...

journal_title：Infection and immunity

authors： Brogden KA,Ackermann MR,McCray PB Jr,Huttner KM

更新日期：1999-08-01 00:00:00

abstract：:Interactions between bacteria and salivary components are thought to be important in the establishment and ecology of the oral microflora. alpha-Amylase, the predominant salivary enzyme in humans, binds to Streptococcus gordonii, a primary colonizer of the tooth. Previous studies have implicated this interaction in ad...

journal_title：Infection and immunity

authors： Rogers JD,Palmer RJ Jr,Kolenbrander PE,Scannapieco FA

更新日期：2001-11-01 00:00:00

abstract：:Three dominant proteins (41, 48, and 49 kDa) were detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in purified preparations of the extracellular aspartyl proteinase (AP) of Candida albicans. All three proteins bound to the specific carboxyl proteinase ligand, pepstatin A, and were assoc...

journal_title：Infection and immunity

authors： Morrison CJ,Hurst SF,Bragg SL,Kuykendall RJ,Diaz H,Pohl J,Reiss E

更新日期：1993-05-01 00:00:00

abstract：:Experiments were conducted in which rhesus monkeys were infected with mumps virus by inoculation into the parotid gland. Virus was isolated from buccal swab specimens from animals up to 6 days after inoculation. Immunofluorescence staining for mumps antigen was positive, and infectious virus was recovered from tissue ...

journal_title：Infection and immunity

authors： Flanagan TD,Andrada JA,Barron AL,Witebsky E

更新日期：1971-05-01 00:00:00

abstract：:Human gingival fibroblasts were exposed in culture to cell extracts of different black-pigmented Bacteroides species, and their growth was monitored by determining thymidine uptake and counting cells. Of the Bacteroides species tested (B. gingivalis, B. asaccharolyticus, and B. intermedius), B. gingivalis gave the ext...

journal_title：Infection and immunity

authors： Larjava H,Uitto VJ,Eerola E,Haapasalo M

更新日期：1987-01-01 00:00:00

abstract：:The var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family is responsible for antigenic variation and sequestration of infected erythrocytes during malaria. We have previously grouped the 60 PfEMP1 variants of P. falciparum clone 3D7 into groups A and B/A (category A) and groups B, B/C, ...

journal_title：Infection and immunity

authors： Joergensen L,Turner L,Magistrado P,Dahlbäck MA,Vestergaard LS,Lusingu JP,Lemnge M,Salanti A,Theander TG,Jensen AT

更新日期：2006-12-01 00:00:00

abstract：:Previous studies have suggested that the Pseudomonas aeruginosa PAK pilus adhesin moiety resides in an epithelial cell-binding domain located in the C-terminal region of the PAK pilin structural protein. Synthetic peptides Ac17red (a synthetic peptide with a sequence identical to that of PAK pilin residues 128 to 144,...

journal_title：Infection and immunity

authors： Irvin RT,Doig P,Lee KK,Sastry PA,Paranchych W,Todd T,Hodges RS

更新日期：1989-12-01 00:00:00

abstract：:We studied seven strains of group G streptococci isolated from clinically severe bacteremic infections in six intravenous drug abusers. These group G strains multiplied luxuriantly in fresh human blood. On electron microscopy, they exhibited surface fibrillae similar to those observed in M-protein-rich group A strepto...

journal_title：Infection and immunity

authors： Bisno AL,Craven DE,McCabe WR

更新日期：1987-03-01 00:00:00

abstract：:Bactericidal/permeability-increasing protein (BPI), a human neutrophil granule protein, has been shown to bind lipopolysaccharide (LPS) and neutralize LPS-mediated cytokine production in adherent monocytes and the whole-blood system. In this study we investigated the ability of recombinant human BPI (rBPI) to inhibit ...

journal_title：Infection and immunity

authors： Arditi M,Zhou J,Huang SH,Luckett PM,Marra MN,Kim KS

更新日期：1994-09-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium, similar to various facultative intracellular pathogens, has been shown to respond to the hostile conditions inside macrophages of the host organism by inducing stress proteins, such as DnaK. DnaK forms a chaperone machinery with the cochaperones DnaJ and GrpE. To elucidate the ...

journal_title：Infection and immunity

authors： Takaya A,Tomoyasu T,Matsui H,Yamamoto T

更新日期：2004-03-01 00:00:00

abstract：:The short-term kinetics of fluoride uptake by cells from 20- to 22-h cultures of Streptococcus mutans strain 6715 were studied using rapid filtration and centrifugation techniques. Saline-suspended organisms were diluted with fluoride-containing solutions buffered at four different pH values (2.0, 4.0, 5.5, and 8.2). ...

journal_title：Infection and immunity

authors： Whitford GM,Schuster GS,Pashley DH,Venkateswarlu P

更新日期：1977-12-01 00:00:00

abstract：:Cross-reactive humoral immune responses between antigens of different developmental stages of the worm Schistosoma mansoni have previously been demonstrated. In contrast, information on antigenic cross-reactivity at the T-cell level is still very sparse. The present study examined the cross-reactive T-cell responses t...

journal_title：Infection and immunity

authors： Lukacs NW,Boros DL

更新日期：1991-09-01 00:00:00

abstract：:In attempts to reactivate latent herpes simplex virus, we instilled Diplococcus pneumoniae intratracheally into mice harboring latent infections in sacrosciatic spinal ganglia. All mice developed a severe pneumonia within 24 h and were given penicillin therapy. Representative mice that survived the penumonia were sacr...

journal_title：Infection and immunity

authors： Stevens JG,Cook ML,Jordan MC

更新日期：1975-04-01 00:00:00

abstract：:G protein-coupled receptor kinase 5 (GRK5) is a serine/threonine kinase previously shown to mediate polymicrobial sepsis-induced inflammation. The goal of the present study was to examine the role of GRK5 in monomicrobial pulmonary infection by using an intratracheal Escherichia coli infection model of pneumonia. We u...

journal_title：Infection and immunity

authors： Packiriswamy N,Steury M,McCabe IC,Fitzgerald SD,Parameswaran N

更新日期：2016-04-22 00:00:00

abstract：:Neisseria meningitidis is a human-specific pathogen and leading cause of meningitis and septicemia. Factor H binding protein (fHbp), a virulence factor which protects N. meningitidis from innate immunity by binding the human complement regulator factor H (fH) with high affinity, is also a key antigen in vaccines being...

journal_title：Infection and immunity

authors： van der Veen S,Johnson S,Jongerius I,Malik T,Genovese A,Santini L,Staunton D,Ufret-Vincenty RL,Pickering MC,Lea SM,Tang CM

更新日期：2014-03-01 00:00:00

abstract：:The pattern of invasion of human hair in vitro by the dermatophyte Microsporum gypseum was studied by transmission and scanning electron microscopy. Mycelia that invaded the hair cortex through the edge of cuticles showed a flattened "frond" growth in contrast to the filamentous form seen on ordinary laboratory media....

journal_title：Infection and immunity

authors： Kanbe T,Tanaka K

更新日期：1982-11-01 00:00:00

abstract：:An apparent inhibition of induction of mouse hepatic tryptophan oxygenase by endotoxin has been reported previously, as evidenced by low catalytic activity. This could be due either to decreased tryptophan oxygenase levels or to inactivation of existing enzyme molecules. To resolve this question, the enzyme was quanti...

journal_title：Infection and immunity

authors： Rippe DF,Berry LJ

更新日期：1973-10-01 00:00:00