Immunization with Pneumocystis Cross-Reactive Antigen 1 (Pca1) Protects Mice against Pneumocystis Pneumonia and Generates Antibody to Pneumocystis jirovecii.

abstract：:Encapsulated Staphylococcus aureus strains are more virulent than unencapsulated staphylococci, and this phenomenon has been associated with decreased opsonization of encapsulated bacteria by normal human serum. Peptidoglycan, a major cell wall component of S. aureus, has been shown to promote opsonization of this bac...

journal_title：Infection and immunity

authors： Wilkinson BJ,Sisson SP,Kim Y,Peterson PK

更新日期：1979-12-01 00:00:00

abstract：:Spirochetes have been implicated as potential etiologic agents of periodontitis in humans. Murine monoclonal antibodies (MAbs) specific for a serogroup of Treponema denticola, an oral spirochete, were developed and characterized in this study. Antibodies secreted by clone IAA11 were judged to be the most useful, since...

journal_title：Infection and immunity

authors： Simonson LG,Rouse RF,Bockowski SW

更新日期：1988-01-01 00:00:00

abstract：:The membrane-damaging properties on human diploid embryonic lung fibroblasts of streptolysin O (from Streptococcus pyogenes) and theta-toxin (from Clostridium perfringens) were compared. The results are consistent with the suggested mechanism for hemolysis by streptolysin O involving one fixation site and one lytic si...

journal_title：Infection and immunity

authors： Thelestam M,Möllby R

更新日期：1980-09-01 00:00:00

abstract：:Streptococcus equi is the causative agent of strangles, the most frequently diagnosed infectious disease of horses worldwide. The disease is characterized by abscessation and swelling of the lymph nodes of the head and neck, which can literally strangle the horse to death. S. equi produces four recently acquired phage...

journal_title：Infection and immunity

authors： Paillot R,Robinson C,Steward K,Wright N,Jourdan T,Butcher N,Heather Z,Waller AS

更新日期：2010-04-01 00:00:00

abstract：:We previously showed the requirement of both T cells and gamma interferon (IFN-gamma)-producing non-T cells for the genetic resistance of BALB/c mice to the development of toxoplasmic encephalitis (TE). In order to define the role of IFN-gamma production and the perforin-mediated cytotoxicity of T cells in this resist...

journal_title：Infection and immunity

authors： Wang X,Kang H,Kikuchi T,Suzuki Y

更新日期：2004-08-01 00:00:00

abstract：:Female C57BL/6J mice were infected with Trypanosoma cruzi and subsequently given macrophages or lymphocytes from syngeneic donors which had recovered from the acute infection. Mice which received immune peritoneal macrophages, splenic lymphocytes, or lymph node lymphocytes developed lower mean parasitemias and cumulat...

journal_title：Infection and immunity

authors： Burgess DE,Hanson WL

更新日期：1979-09-01 00:00:00

abstract：:Pathogenicity of Rickettsia tsutsugamushi for laboratory mice is known to be influenced by at least three factors: (i) route of inoculation, (ii) antigenic strain, and (iii) natural resistance of the host. By using Karp, Gilliam, and Kato strains of R. tsutsugamushi, we examined the effect of these three pathogenicity...

journal_title：Infection and immunity

authors： Groves MG,Kelly DJ

更新日期：1989-05-01 00:00:00

abstract：:Borrelia burgdorferi, the agent of Lyme disease, is transmitted by ticks. During transmission from the tick to the host, spirochetes are delivered with tick saliva, which contains the salivary protein Salp15. Salp15 has been shown to protect spirochetes against B. burgdorferi-specific antibodies. We now show that Salp...

journal_title：Infection and immunity

authors： Schuijt TJ,Hovius JW,van Burgel ND,Ramamoorthi N,Fikrig E,van Dam AP

更新日期：2008-07-01 00:00:00

abstract：:The Lyme disease spirochete Borrelia burgdorferi reduces the expression of outer surface protein C (OspC) in response to the development of an anti-OspC humoral response, leading to the hypothesis that the ability to repress OspC expression is critical for the pathogen to proceed to chronic infection. B. burgdorferi w...

journal_title：Infection and immunity

authors： Xu Q,Seemanapalli SV,McShan K,Liang FT

更新日期：2006-09-01 00:00:00

abstract：:Binding of the complement-downregulating protein factor H (fH) to the surface of the meningococcus is important for survival of the organism in human serum. The meningococcal vaccine candidate factor H binding protein (fHbp) is an important ligand for human fH. While some fHbp-specific monoclonal antibodies (MAbs) blo...

journal_title：Infection and immunity

authors： Giuntini S,Reason DC,Granoff DM

更新日期：2011-09-01 00:00:00

abstract：:Staphylococcus aureus can produce a wide variety of exotoxins, including toxic shock syndrome toxin 1 (TSST-1), staphylococcal enterotoxins, and staphylococcal enterotoxin-like toxins. These toxins share superantigenic activity. To investigate the beta chain (Vbeta) specificities of each of these toxins, TSST-1 and al...

journal_title：Infection and immunity

authors： Thomas D,Dauwalder O,Brun V,Badiou C,Ferry T,Etienne J,Vandenesch F,Lina G

更新日期：2009-05-01 00:00:00

abstract：:Neisseria gonorrhoeae is an obligate human pathogen that causes the common sexually transmitted infection gonorrhea. Gonococcal infections cause significant morbidity, particularly among women, as the organism ascends to the upper reproductive tract, resulting in pelvic inflammatory disease, ectopic pregnancy, and inf...

journal_title：Infection and immunity

authors： Hollander A,Mercante AD,Shafer WM,Cornelissen CN

更新日期：2011-12-01 00:00:00

abstract：:Clostridium difficile is recognized as the major cause of antibiotic-associated colitis. C. difficile produces two toxins, A (enterotoxin) and B (cytotoxin), that are implicated in the pathogenesis of the colitis. We examined the dose responses, time course, and synergism of these two toxins in ligated rabbit intestin...

journal_title：Infection and immunity

authors： Lima AA,Lyerly DM,Wilkins TD,Innes DJ,Guerrant RL

更新日期：1988-03-01 00:00:00

abstract：:The interaction of plasma fibronectin with C1q of the complement system has been demonstrated in the past several years. In addition, the antibody-independent binding of C1q to bacteria, as well as the binding of plasma fibronectin to bacteria, is well documented. This study examines whether the binding of C1q to bact...

journal_title：Infection and immunity

authors： Sorvillo JM,Pearlstein E

更新日期：1985-09-01 00:00:00

abstract：:Clostridium botulinum serotype A produces a neurotoxin composed of a 100-kDa heavy chain and a 50-kDa light chain linked by a disulfide bond. This neurotoxin is part of a ca. 900-kDa complex, formed by noncovalent association with a single nontoxin, nonhemagglutinin subunit and a family of hemagglutinating proteins. P...

journal_title：Infection and immunity

authors： Maksymowych AB,Reinhard M,Malizio CJ,Goodnough MC,Johnson EA,Simpson LL

更新日期：1999-09-01 00:00:00

abstract：:Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglob...

journal_title：Infection and immunity

authors： Collin M,Olsén A

更新日期：2001-11-01 00:00:00

abstract：:Cells of the marine fish pathogen Vibrio anguillarum 775 harboring a plasmid associated with virulence can grow unaffected in the presence of iron-binding compounds such as transferrin. In contrast, the growth of isogenic plasmidless derivatives is inhibited by the presence of iron chelators. Radioactive from (55Fe3+)...

journal_title：Infection and immunity

authors： Crosa JH,Hodges LL

更新日期：1981-01-01 00:00:00

abstract：:The relationship between the selective abilities of bacteria to adhere and their predilections for colonizing different mammalian hosts was investigated by using bacteria indigenous to the tongue dorsum of humans and rats as models. Streptococcus salivarius and S. sanguis averaged 22.6 and 2.8%, respectively, of the c...

journal_title：Infection and immunity

authors： Gibbons RJ,Spinell DM,Skobe Z

更新日期：1976-01-01 00:00:00

abstract：:Pasteurella multocida is the causative agent of fowl cholera in birds. In a previous study using signature-tagged mutagenesis, we identified a mutant, AL251, which was attenuated for virulence in mice and in the natural chicken host. Sequence analysis indicated that AL251 had an insertional inactivation of the gene wa...

journal_title：Infection and immunity

authors： Harper M,Cox AD,St Michael F,Wilkie IW,Boyce JD,Adler B

更新日期：2004-06-01 00:00:00

abstract：:A Mycobacterium tuberculosis strain disrupted in the AraC homologue Rv1931c was isolated. The mutant strain exhibited reduced survival both in macrophages and in a mouse infection model, with survival being restored on complementation with the Rv1931c gene. These results suggest that Rv1931c regulates genes important ...

journal_title：Infection and immunity

authors： Frota CC,Papavinasasundaram KG,Davis EO,Colston MJ

更新日期：2004-09-01 00:00:00

abstract：:We investigated the effect of a pH 4-treated human immunoglobulin preparation for intravenous use (pH4-G) on the production of tumor necrosis factor alpha (TNF-alpha) in vivo. The level of TNF-alpha in the sera of rabbits receiving pH4-G before lipopolysaccharide (LPS) injection was lower than that in rabbits receivin...

journal_title：Infection and immunity

authors： Shimozato T,Iwata M,Tamura N

更新日期：1990-05-01 00:00:00

abstract：:Actinobacillus pleuropneumoniae can use porcine transferrin as the sole source of iron. Two proteins with molecular masses of approximately 60 kDa (TfbA) and 110 kDa have been shown to specifically bind porcine transferrin; from the TfbA protein, three isoforms from A. pleuropneumoniae serotypes 1, 5, and 7 have been ...

journal_title：Infection and immunity

authors： Strutzberg K,von Olleschik L,Franz B,Pyne C,Schmidt MA,Gerlach GF

更新日期：1995-10-01 00:00:00

abstract：:The amino acid sequence of heat-stable enterotoxin produced by enterotoxigenic Escherichia coli 18D has been revised. Amino acids originally assigned to positions 11 and 18, i.e., Tyr and Asn, respectively, were found to occupy positions 18 and 11, respectively. Thus all heat-stable enterotoxins composed of 18 amino a...

journal_title：Infection and immunity

authors： Thompson MR,Giannella RA

更新日期：1985-03-01 00:00:00

abstract：:Alveolar bone destruction is a characteristic feature of periodontitis. Treponema denticola is known to be involved in periodontitis. To elucidate the role of T. denticola in alveolar bone destruction in periodontitis, the effects of lipooligosaccharide (LOS) from T. denticola on osteoclast formation and on expression...

journal_title：Infection and immunity

authors： Choi BK,Lee HJ,Kang JH,Jeong GJ,Min CK,Yoo YJ

更新日期：2003-01-01 00:00:00

abstract：:In vitro, macrophages from normal strain BRVR mice killed Salmonella more quickly than did macrophages from normal strain BSVS mice. Salmonella injected intraperitoneally multiplied more quickly in BSVS mice than in BRVR mice. BRVR macrophages injected intraperitoneally into BSVS mice protected against Salmonella mult...

journal_title：Infection and immunity

authors： Maier T,Oels HC

更新日期：1972-10-01 00:00:00

abstract：:Streptococcus agalactiae (group B Streptococcus or GBS) is a common colonizer of the gastrointestinal and genital tracts and an important cause of invasive infections in newborn infants and in adults with predisposing chronic conditions or advanced age. Attachment to epithelial surfaces at mucosal sites is a critical ...

journal_title：Infection and immunity

authors： Park SE,Jiang S,Wessels MR

更新日期：2012-11-01 00:00:00

abstract：:We developed an in vitro model to study the temperature-regulated cytotoxicity and intracellular growth of Mycobacterium haemophilum in cultured human epithelial and endothelial cells. M. haemophilum associated with human epithelial and endothelial cells at similar rates when incubated at 33 and 37 degrees C, but only...

journal_title：Infection and immunity

authors： Fischer LJ,Quinn FD,White EH,King CH

更新日期：1996-01-01 00:00:00

abstract：:We constructed the expression vector pSK-SCP containing the streptococcal exotoxin B gene (spe b) which expressed protease activity. We showed that the recombinant streptococcal pyogenic exotoxin B/streptococcal cysteine protease (rSPE B/SCP) was secreted into the culture supernatant of the transformant and retained i...

journal_title：Infection and immunity

authors： Watanabe Y,Todome Y,Ohkuni H,Sakurada S,Ishikawa T,Yutsudo T,Fischetti VA,Zabriskie JB

更新日期：2002-07-01 00:00:00

abstract：:Local passive immunization with monoclonal antibodies (Mc Ab) to Streptococcus mutans was attempted as an alternative approach to active systemic immunization. We prepared an immunoglobulin G class Mc Ab to the cell surface protein determinant of streptococcal antigen I/II and applied it repeatedly to the teeth of rhe...

journal_title：Infection and immunity

authors： Lehner T,Caldwell J,Smith R

更新日期：1985-12-01 00:00:00

abstract：:A new strategy for rapidly selecting and testing genetic vaccines has been developed, in which a whole genome library is cloned into a bacteriophage lambda ZAP Express vector which contains both prokaryotic (P(lac)) and eukaryotic (P(CMV)) promoters upstream of the insertion site. The phage library is plated on Escher...

journal_title：Infection and immunity

authors： March JB,Jepson CD,Clark JR,Totsika M,Calcutt MJ

更新日期：2006-01-01 00:00:00