Abstract:
:We investigated the effect of a pH 4-treated human immunoglobulin preparation for intravenous use (pH4-G) on the production of tumor necrosis factor alpha (TNF-alpha) in vivo. The level of TNF-alpha in the sera of rabbits receiving pH4-G before lipopolysaccharide (LPS) injection was lower than that in rabbits receiving only LPS. Similarly, the in vitro production of TNF-alpha was suppressed by pH4-G. Rabbit peritoneal exudate cells stimulated with LPS in the presence of pH4-G produced less TNF-alpha than did those stimulated only with LPS. pH4-G, however, had no effect on various TNF-alpha activities, such as cytotoxicity against tumorigenic murine fibroblasts (L929 cells), induction of interleukin-1 production, or fever induction. These results indicate that pH4-G suppresses TNF-alpha production without affecting TNF-alpha activities. A suppressive effect on the expression of TNF-alpha mRNA was also observed.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Shimozato T,Iwata M,Tamura Ndoi
10.1128/IAI.58.5.1384-1390.1990subject
Has Abstractpub_date
1990-05-01 00:00:00pages
1384-90issue
5eissn
0019-9567issn
1098-5522journal_volume
58pub_type
杂志文章abstract::In this study we found that serum inhibitory activity against Blastomyces dermatitidis was principally mediated by albumin. This was confirmed in experiments using albumin from several mammalian species. Analbuminemic rat serum did not inhibit B. dermatitidis growth in vivo; however, the addition of albumin restored i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.11.6648-6652.2003
更新日期:2003-11-01 00:00:00
abstract::The three most abundant extracellular proteins of Mycobacterium tuberculosis, the 30-, 32-, and 16-kDa major extracellular proteins, are particularly promising vaccine candidates. We have mapped T-cell epitopes of these three proteins in outbred guinea pigs by immunizing the animals with each protein and assaying sple...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.5.2665-2670.1999
更新日期:1999-05-01 00:00:00
abstract::The dispersed gene family 1 (DGF-1) is the fifth largest gene family in the Trypanosoma cruzi genome, with over 500 members (11). Many of the predicted DGF-1 protein products have several transmembrane domains and N-glycosylation and phosphorylation sites and were thought to localize in the plasma membrane. Here, we r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00780-09
更新日期:2010-01-01 00:00:00
abstract::Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role in natural killer cell activation and the T helper 1 (Th1) cell response, particularly in collaboration with IL-12. Since Th1 cells play a pivotal role in the host defense against infection with intracellular microbes, such as Leishmania...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.5.2449-2456.2000
更新日期:2000-05-01 00:00:00
abstract::Alternate modalities for the treatment of Mycobacterium tuberculosis are needed due to the rise in numbers of immunosuppressed individuals at risk for serious disease and the increasing prevalence of multidrug-resistant isolates. Interleukin-12 (IL-12) has been shown to improve immune responses against M. tuberculosis...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.5.2976-2988.2004
更新日期:2004-05-01 00:00:00
abstract::Salmonella is a widespread zoonotic enteropathogen that causes gastroenteritis and fatal typhoidal disease in mammals. During systemic infection of mice, Salmonella enterica serovar Typhimurium resides and replicates in macrophages within the "Salmonella-containing vacuole" (SCV). It is surprising that the substrates ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00093-09
更新日期:2009-07-01 00:00:00
abstract::K99 prepared by acid precipitation hemagglutinated guinea pig erythrocytes, whereas K99 prepared by chromatography on diethylaminoethyl-Sephadex did not. K99 purified by either procedure hemagglutinated horse erythrocytes. K99 prepared by acid precipitation contained a second antigen not presnet in the K99 prepared by...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.22.2.555-559.1978
更新日期:1978-11-01 00:00:00
abstract::Pseudomonas aeruginosa, an important opportunistic pathogen of humans, exploits epithelial damage to establish infection. We have rigorously explored the role of N-glycoproteins and heparan sulfate proteoglycans (HSPGs) in P. aeruginosa-mediated attachment and subsequent downstream events at the apical (AP) and basola...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01215-09
更新日期:2010-03-01 00:00:00
abstract::Although nasal vaccination has emerged as an interesting alternative to systemic or oral vaccination, knowledge is scarce about the immune responses after such immunization in humans. In the present study, we have compared the kinetics and organ distribution of the antibody responses after nasal and oral vaccination. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.7.3390-3396.1998
更新日期:1998-07-01 00:00:00
abstract::Shiga toxin-producing Escherichia coli (STEC) strains are responsible for causing hemolytic-uremic syndrome (HUS), and systemic administration of Shiga toxin (Stx)-specific human monoclonal antibodies (HuMAbs) is considered a promising approach for prevention or treatment of the disease in children. The goal of the pr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.6.3125-3130.2003
更新日期:2003-06-01 00:00:00
abstract::Purified Escherichia coli type 1 fimbriae have been shown previously to stimulate T-cell-independent proliferation of human B lymphocytes. The response is mediated by the mannose-specific, lectin-like adhesin protein FimH. Here we show that type 1 fimbriae also stimulate immunoglobulin (Ig) secretion by B cells. The r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.12.5197-5203.1992
更新日期:1992-12-01 00:00:00
abstract::The plasma level of the chemokine CCL3 is elevated in patients with chronic severe schistosomiasis mansoni. We have previously shown that CCL3(-/-) mice with experimental infection showed diminished pathology and worm burden compared to those of wild-type (WT) mice. To elucidate further the role of CC chemokines durin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00502-10
更新日期:2011-04-01 00:00:00
abstract::Serum from rabbits immunized with either heat-killed or live nonencapsulated Staphylococcus aureus failed further to enhance phagocytosis and intracellular killing of the homologous organism by either normal rabbit polymorphonuclear leukocytes or monocytes, when compared with normal rabbit serum. These immune sera did...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.2.6.742-749.1970
更新日期:1970-12-01 00:00:00
abstract::Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha 2-fucosyltransferase, and alpha 3-fucosyltransferase activity of rat liver. Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized and secreted by the liver dur...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.29.1.114-118.1980
更新日期:1980-07-01 00:00:00
abstract::Polymorphoneutrophils (PMNs) are important effector cells in host defense against pneumonia. However, PMNs can also induce inflammation and tissue damage. To investigate the contribution of PMNs to host defense against pneumococcal pneumonia, we determined the effect of the PMN-depleting rat monoclonal antibody RB6-8C...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01579-06
更新日期:2007-04-01 00:00:00
abstract::Cryptococcus neoformans NIH 409 was cultured in a defined medium containing D-[1-13C]xylose (Xyl), D-[1-13C]mannose (Man), or D-[1-13C]mannitol as the sole carbon source. The distribution of 13C in the Man, Xyl, glucuronic acid (GlcA), and O-acetyl constituents of native and de-O-acetylated glucuronoxylomannan (GXM) w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.6.2996-2998.1998
更新日期:1998-06-01 00:00:00
abstract::The absolute requirement for elemental iron and the porphyrin nucleus for growth of Haemophilus influenzae led us to investigate the role of iron and hemin in regulation of expression of the H. influenzae transferrin receptor. H. influenzae type b strain H1689 was grown in brain heart infusion broth supplemented with ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.10.4033-4037.1993
更新日期:1993-10-01 00:00:00
abstract::Otitis media developed in 67% of chinchillas inoculated intranasally with type 7 Streptococcus pneumoniae and influenza A virus. Only 4% of chinchillas inoculated with influenza alone and 21% of chinchillas inoculated with S. pneumoniae alone developed otitis media. Among the chinchillas that developed otitis media af...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-11-01 00:00:00
abstract::Serum amyloid A protein (SAA) elevation accompanies induction of secondary amyloidosis in mice given Mycobacterium butyricum in Freund adjuvant. The synthesis of SAA by cultured hepatocytes is induced by a macrophage-derived mediator, which has been identified as interleukin 1. In these studies, SAA synthesis has been...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.39.3.1147-1154.1983
更新日期:1983-03-01 00:00:00
abstract::Toxoplasma gondii infects both hematopoietic and nonhematopoietic cells and can cause cerebral and ocular toxoplasmosis, as a result of either congenital or postnatally acquired infections. Host protection likely acts at both cellular levels to control the parasite. CD40 is a key factor for protection against cerebral...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01145-12
更新日期:2013-06-01 00:00:00
abstract::Brucella species can cause brucellosis, a zoonotic disease that causes serious livestock economic losses and represents a public health threat. The mechanism of virulence of Brucella spp. is not yet fully understood. Therefore, it is crucial to identify new molecules that serve as virulence factors to better understan...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02790-14
更新日期:2015-04-01 00:00:00
abstract::Cutaneous lesions of the human sexually transmitted genital ulcer disease chancroid are characterized by the presence of intraepidermal pustules, keratinocyte cytopathology, and epidermal and dermal erosion. These lesions are replete with neutrophils, macrophages, and CD4(+) T cells and contain very low numbers of cel...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.9.4963-4967.1999
更新日期:1999-09-01 00:00:00
abstract::The addition of inhibitors of cell wall biosynthesis to exponential-phase cultures of Streptococcus mutans may do one of three things, depending on the concentrations used: (i) prevent cell division at a time coincident with the onset of chromosome replication, (ii) prevent cell division later in the cell cycle coinci...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.1.28-32.1983
更新日期:1983-07-01 00:00:00
abstract::Very little is known about the host response to chlamydial genital infection in the male, particularly about the nature of the local response in the urethra. In this study, the pathological and immunologic responses to urethral infection of the male guinea pig with Chlamydia caviae (Chlamydophila caviae) were characte...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01339-09
更新日期:2010-04-01 00:00:00
abstract::Mycoplasma salivarium cells propagated in PPLO broth (Difco Laboratories, Detroit, Mich.) supplemented with rabbit serum (10% [vol/vol]) and harvested by centrifugation were shown to contain rabbit immunoglobulin G (IgG) (approximately 4 to 10% of total cell proteins) and to produce IgM autoantibodies to IgG when inoc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.1.263-265.1987
更新日期:1987-01-01 00:00:00
abstract::Staphylococcal alpha-toxin was purified from Staphylococcus aureus growth medium using adsorption chromatography on controlled pore glass beads. Elution of alpha-toxin from the unmodified glass surface of the beads with various anions generally followed the chaotropic series. Alpha-toxin, purified by glass bead chroma...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.3.982-986.1976
更新日期:1976-03-01 00:00:00
abstract::The filarial nematode Onchocerca volvulus is the causative organism of river blindness. Our previous studies demonstrated an essential role for endosymbiotic Wolbachia bacteria in corneal disease, which is characterized by neutrophil infiltration into the corneal stroma and the development of corneal haze. To determin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00991-07
更新日期:2007-12-01 00:00:00
abstract::Immunization of mice with Plasmodium berghei or Plasmodium yoelii synthetic linear peptide chimeras (LPCs) based on the circumsporozoite protein protects against experimental challenge with viable sporozoites. The immunogenicity of LPCs is significantly enhanced by spontaneous polymerization. To better understand the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00470-08
更新日期:2009-05-01 00:00:00
abstract::Experiments were performed to study the effect of antibody to Streptococcus mutans glucosyltransferase (GTF) on the implantation of these organisms in hamsters. Salivary (immunoglobulin A) and serum (immunoglobulin G) antibodies to GTF and GTF-inhibiting activity were elicited by injection of GTF in Freund complete ad...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.37.2.656-661.1982
更新日期:1982-08-01 00:00:00
abstract::Staphylococcus aureus infections are an important public health concern due to their increasing incidence and high rates of mortality. The success of S. aureus as a pathogen is highly related to its enormous capacity to evade the host immune response. The critical role of tumor necrosis factor alpha (TNF-α) in the ini...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00593-13
更新日期:2013-11-01 00:00:00