Novel role for albumin in innate immunity: serum albumin inhibits the growth of Blastomyces dermatitidis yeast form in vitro.

Abstract:

:In this study we found that serum inhibitory activity against Blastomyces dermatitidis was principally mediated by albumin. This was confirmed in experiments using albumin from several mammalian species. Analbuminemic rat serum did not inhibit B. dermatitidis growth in vivo; however, the addition of albumin restored inhibitory activity. Inhibitory activity does not require albumin domain III and appears to involve binding of a low-molecular-weight yeast-derived growth factor.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Giles S,Czuprynski C

doi

10.1128/iai.71.11.6648-6652.2003

keywords:

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

6648-52

issue

11

eissn

0019-9567

issn

1098-5522

journal_volume

71

pub_type

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