Abstract:
:Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Collin M,Olsén Adoi
10.1128/IAI.69.11.7187-7189.2001keywords:
subject
Has Abstractpub_date
2001-11-01 00:00:00pages
7187-9issue
11eissn
0019-9567issn
1098-5522journal_volume
69pub_type
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