Antibody recognition and isoelectrofocusing of antigens of the malaria parasite Plasmodium yoelii.

abstract：:We report on the identification of a surface-exposed, highly conserved, immunogenic nontypeable Haemophilus influenzae (NTHi) protein, which elicits cross-reactive bactericidal antibodies against NTHi. The protein was extracted from NTHi strain P860295 with KSCN and purified; it migrated as a single band on a sodium d...

journal_title：Infection and immunity

authors： Zagursky RJ,Ooi P,Jones KF,Fiske MJ,Smith RP,Green BA

更新日期：2000-05-01 00:00:00

abstract：:Salmonella strains that lack or overproduce DNA adenine methylase (Dam) elicit a protective immune response to different Salmonella species. To generate vaccines against other bacterial pathogens, the dam genes of Yersinia pseudotuberculosis and Vibrio cholerae were disrupted but found to be essential for viability. O...

journal_title：Infection and immunity

authors： Julio SM,Heithoff DM,Provenzano D,Klose KE,Sinsheimer RL,Low DA,Mahan MJ

更新日期：2001-12-01 00:00:00

abstract：:Escherichia coli strains isolated from newborn infants were injected intraperitoneally into infant rats. Strains possessing the K1 capsular polysaccharide antigen were significantly more virulent than strains lacking this antigen. When 5-day-old animals were injected with 1.2 X 10(1) colony forming units of a K1 E. co...

journal_title：Infection and immunity

authors： Bortolussi R,Ferrieri P,Wannamaker LW

更新日期：1978-11-01 00:00:00

abstract：:TB10.4 is a newly identified antigen of Mycobacterium tuberculosis recognized by human and murine T cells upon mycobacterial infection. Here, we show that immunization with Mycobacterium bovis BCG induces a strong, genetically controlled, Th1 immune response against TB10.4 in mice. BALB/c and C57BL/6 strains behave as...

journal_title：Infection and immunity

authors： Hervas-Stubbs S,Majlessi L,Simsova M,Morova J,Rojas MJ,Nouzé C,Brodin P,Sebo P,Leclerc C

更新日期：2006-06-01 00:00:00

abstract：:An apparent inhibition of induction of mouse hepatic tryptophan oxygenase by endotoxin has been reported previously, as evidenced by low catalytic activity. This could be due either to decreased tryptophan oxygenase levels or to inactivation of existing enzyme molecules. To resolve this question, the enzyme was quanti...

journal_title：Infection and immunity

authors： Rippe DF,Berry LJ

更新日期：1973-10-01 00:00:00

abstract：:A total of 224 strains were serogrouped by coagglutination (COA) and serotyped by protein I enzyme-linked immunosorbent assay (ELISA). Of these strains, 61 were from patients with disseminated gonococcal infection, 21 were from patients with pelvic inflammatory disease, and 115 were from patients with uncomplicated go...

journal_title：Infection and immunity

authors： Sandstrom EG,Knapp JS,Buchanan TB

更新日期：1982-01-01 00:00:00

abstract：:Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or diphosphates showed high activities in most in vitro assays, and the lethality of a diphosphate derivative to galactosami...

journal_title：Infection and immunity

authors： Kotani S,Takada H,Tsujimoto M,Ogawa T,Harada K,Mori Y,Kawasaki A,Tanaka A,Nagao S,Tanaka S

更新日期：1984-07-01 00:00:00

abstract：:Intracellular multiplication of virulent Legionella pneumophila serogroup 1 was inhibited by human monocyte-derived macrophages activated by a glycoprotein extract of Klebsiella pneumoniae, RU 41.740. Macrophage cultures were infected with L. pneumophila in the presence of immune antibodies on day 7 of culture. Extrac...

journal_title：Infection and immunity

authors： Rajagopalan P,Dournon E,Vildé JL,Pocidalo JJ

更新日期：1987-09-01 00:00:00

abstract：:The study of how bacteria respond to and obtain divalent metal ions provides insight into the regulation of virulence factors in the host environment. Regulation of metal permease operons in gram-positive bacteria may involve the binding of metal-responsive repressors to palindromic domains in their control regions. T...

journal_title：Infection and immunity

authors： Oetjen J,Fives-Taylor P,Froeliger EH

更新日期：2002-10-01 00:00:00

abstract：:The Alexander hepatoma cell line, PLC/PRF/5, was studied for evidence of hepatitis B virus markers and alpha-fetoprotein. Only hepatitis B surface antigen and alpha-fetoprotein were detected. Induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did n...

journal_title：Infection and immunity

authors： Daemer RJ,Feinstone SM,Alexander JJ,Tully JG,London WT,Wong DC,Purcell RH

更新日期：1980-11-01 00:00:00

abstract：:In order to evaluate during experimental Trypanosoma brucei infections the potential role of tumor necrosis factor alpha (TNF-alpha) in the host-parasite interrelationship, C57BL/6 TNF-alpha knockout mice (TNF-alpha-/-) as well as C57BL/6 wild-type mice were infected with pleomorphic T. brucei AnTat 1.1 E parasites. I...

journal_title：Infection and immunity

authors： Magez S,Radwanska M,Beschin A,Sekikawa K,De Baetselier P

更新日期：1999-06-01 00:00:00

abstract：:Bordetella pertussis, a causative agent of whooping cough, expresses BrkA, which confers serum resistance, but the closely related human pathogen that also causes whooping cough, Bordetella parapertussis, does not. Interestingly, B. parapertussis, but not B. pertussis, produces an O antigen, a factor shown in other mo...

journal_title：Infection and immunity

authors： Goebel EM,Wolfe DN,Elder K,Stibitz S,Harvill ET

更新日期：2008-04-01 00:00:00

abstract：:The importance of bacterial phospholipases during serum-mediated killing of Escherichia coli was examined by using wild-type DR+ DS+ and an isogenic phospholipase-deficient mutant DR- DS-. No difference in serum sensitivity was observed when the parental DR+ DS+ and mutant DR- DS- strains were exposed to various conce...

journal_title：Infection and immunity

authors： Kreutzer DL,Vandermaten M,Buller CS,Robertson DC,Hirata AA

更新日期：1977-10-01 00:00:00

abstract：:In bacterial infections, mononuclear and polymorphonuclear phagocytes are key components of host defenses. Recent investigations have indicated that chemokines are able to recruit and activate phagocytes. In particular, interleukin-8 (IL-8) attracts polymorphonuclear leukocytes (PMNs), while monocyte chemoattractant p...

journal_title：Infection and immunity

authors： Tonetti MS,Imboden MA,Gerber L,Lang NP,Laissue J,Mueller C

更新日期：1994-09-01 00:00:00

abstract：:The NikR protein is a nickel-dependent regulatory protein which is a member of the ribbon-helix-helix family of transcriptional regulators. The gastric pathogen Helicobacter pylori expresses a NikR ortholog, which was previously shown to mediate regulation of metal metabolism and urease expression, but the mechanism g...

journal_title：Infection and immunity

authors： Ernst FD,Kuipers EJ,Heijens A,Sarwari R,Stoof J,Penn CW,Kusters JG,van Vliet AH

更新日期：2005-11-01 00:00:00

abstract：:We examined the effect of protein kinase C (PKC) activation on the cyclic GMP response to heat-stable enterotoxin (STa) in a colonic carcinoma intestinal epithelial cell line, T84 cells. Our results demonstrate that the active phorbol ester analog, phorbol dibutyrate, but not the inactive alpha-phorbol dibutyrate, act...

journal_title：Infection and immunity

authors： Weikel CS,Spann CL,Chambers CP,Crane JK,Linden J,Hewlett EL

更新日期：1990-05-01 00:00:00

abstract：:Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA fragmentation characteristic of apoptosis. Macrophage lysis was dependent on a subset of caspases and an intact sipB gene...

journal_title：Infection and immunity

authors： Watson PR,Gautier AV,Paulin SM,Bland AP,Jones PW,Wallis TS

更新日期：2000-06-01 00:00:00

abstract：:A hemagglutinin with an M(r) of 67,000 (pMGA) from Mycoplasma gallisepticum S6 was purified by using monoclonal antibody affinity chromatography. Purified pMGA was treated with a number of enzymes, the resultant peptides were purified, and their amino acid sequence was determined by using an Applied Biosystems (model ...

journal_title：Infection and immunity

authors： Markham PF,Glew MD,Whithear KG,Walker ID

更新日期：1993-03-01 00:00:00

abstract：:A previously undescribed, immunoreactive, membranous spherule outer wall (SOW) fraction produced by Coccidioides immitis (strains 634 and 735) grown in culture was isolated. Both this fraction and intact spherules were reactive with sera from coccidioidomycosis patients, as demonstrated by immunofluorescence microscop...

journal_title：Infection and immunity

authors： Cole GT,Seshan KR,Franco M,Bukownik E,Sun SH,Hearn VM

更新日期：1988-10-01 00:00:00

abstract：:Cholera toxin (CT) is a potent adjuvant for mucosal vaccination; however, its mechanism of action has not been clarified completely. It is well established that peripheral monocytes differentiate into dendritic cells (DCs) both in vitro and in vivo and that monocytes are the in vivo precursors of mucosal CD103(-) proi...

journal_title：Infection and immunity

authors： Veglia F,Sciaraffia E,Riccomi A,Pinto D,Negri DR,De Magistris MT,Vendetti S

更新日期：2011-03-01 00:00:00

abstract：:Bacillus anthracis, the causal agent of anthrax, synthesizes two surface layer (S-layer) proteins, EA1 and Sap, which account for 5 to 10% of total protein and are expressed in vivo. A recombinant B. anthracis strain was constructed by integrating into the chromosome a translational fusion harboring the DNA fragments ...

journal_title：Infection and immunity

authors： Mesnage S,Weber-Levy M,Haustant M,Mock M,Fouet A

更新日期：1999-09-01 00:00:00

abstract：:The unique permissiveness of A/J mouse macrophages for replication of Legionella pneumophila is caused by a deficiency in the Nod-like receptor (NLR) protein and intracellular sensor for L. pneumophila flagellin (Naip5). The signaling pathways and proteins activated by Naip5 sensing in macrophages were investigated. T...

journal_title：Infection and immunity

authors： Fortier A,Doiron K,Saleh M,Grinstein S,Gros P

更新日期：2009-11-01 00:00:00

abstract：:Yersinia enterocolitica is a human pathogen that is ubiquitous in livestock, especially pigs. The bacteria are able to colonize the intestinal tract of a variety of mammalian hosts, but the severity of induced gut-associated diseases (yersiniosis) differs significantly between hosts. To gain more information about the...

journal_title：Infection and immunity

authors： Schaake J,Kronshage M,Uliczka F,Rohde M,Knuuti T,Strauch E,Fruth A,Wos-Oxley M,Dersch P

更新日期：2013-11-01 00:00:00

abstract：:We have constructed an improved recombination-based in vivo expression technology (RIVET) and used it as a screening method to identify Vibrio cholerae genes that are transcriptionally induced during infection of infant mice. The improvements include the introduction of modified substrate cassettes for resolvase that ...

journal_title：Infection and immunity

authors： Osorio CG,Crawford JA,Michalski J,Martinez-Wilson H,Kaper JB,Camilli A

更新日期：2005-02-01 00:00:00

abstract：:Phagocytosis and mechanisms of killing of Aspergillus fumigatus conidia by murine alveolar macrophages (AM), which are the main phagocytic cells of the innate immunity of the lung, were investigated. Engulfment of conidia by murine AM lasts 2 h. Killing of A. fumigatus conidia by AM begins after 6 h of phagocytosis. S...

journal_title：Infection and immunity

authors： Philippe B,Ibrahim-Granet O,Prévost MC,Gougerot-Pocidalo MA,Sanchez Perez M,Van der Meeren A,Latgé JP

更新日期：2003-06-01 00:00:00

abstract：:An antiserum, C16, was raised in cattle against freeze-thawed extracts of sporozoites of Theileria parva (Muguga). This antiserum, which neutralizes sporozoite infectivity in vitro, identified theileria-specific antigens having approximate molecular masses of 105, 90, 85, 69, 67, 52, 47, and 43 kilodaltons (kDa) on We...

journal_title：Infection and immunity

authors： Iams KP,Hall R,Webster P,Musoke AJ

更新日期：1990-06-01 00:00:00

abstract：:Helicobacter pylori infection is thought to be involved in the development of several gastric diseases. Two H. pylori virulence factors (vacuolating cytotoxin A and cytotoxin-associated gene A) reportedly interact with lipid rafts in gastric epithelial cells. The role of Toll-like receptor (TLR)-mediated signaling in ...

journal_title：Infection and immunity

authors： Lu DY,Chen HC,Yang MS,Hsu YM,Lin HJ,Tang CH,Lee CH,Lai CK,Lin CJ,Shyu WC,Lin FY,Lai CH

更新日期：2012-05-01 00:00:00

abstract：:To analyze the role of interleukin-10 (IL-10) in bacterial cerebral infections, we studied cerebral listeriosis in IL-10-deficient (IL-10(-/-)) and wild-type (WT) mice, the latter of which express high levels of IL-10 in both primary and secondary cerebral listeriosis. IL-10(-/-) mice succumbed to primary as well as s...

journal_title：Infection and immunity

authors： Deckert M,Soltek S,Geginat G,Lütjen S,Montesinos-Rongen M,Hof H,Schlüter D

更新日期：2001-07-01 00:00:00

abstract：:As reported elsewhere, an enterotoxigenic strain of Escherichia coli serotype O25:K98:NM was epidemiologically incriminated as the etiological agent in a shipboard outbreak of diarrheal illness. This enterotoxigenic E. coli strain and possibly other enteric isolates were found to produce heat-labile toxin and not heat...

journal_title：Infection and immunity

authors： Wachsmuth K,Wells J,Shipley P,Ryder R

更新日期：1979-06-01 00:00:00

abstract：:Obligate vacuolar pathogens produce proteins that localize to the host cell-derived membranes of the vacuoles in which they reside, yielding unique organelles that are optimally suited for pathogen survival. Anaplasma phagocytophilum is an obligate vacuolar bacterium that infects neutrophils and causes the emerging an...

journal_title：Infection and immunity

authors： Huang B,Troese MJ,Ye S,Sims JT,Galloway NL,Borjesson DL,Carlyon JA

更新日期：2010-05-01 00:00:00