High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection.

abstract：:The membrane fluidity of antigen-presenting cells (APCs) has a significant bearing on T-cell-stimulating ability and is dependent on the cholesterol content of the membrane. The relationship, if any, between membrane fluidity and defective cell-mediated immunity in visceral leishmaniasis has been investigated. Systemi...

journal_title：Infection and immunity

authors： Banerjee S,Ghosh J,Sen S,Guha R,Dhar R,Ghosh M,Datta S,Raychaudhury B,Naskar K,Haldar AK,Lal CS,Pandey K,Das VN,Das P,Roy S

更新日期：2009-06-01 00:00:00

abstract：:We have determined the nucleotide sequence of the 1.4-kilobase DNA fragment containing the plasminogen activator gene (pla) of Yersinia pestis, which determines both plasminogen activator and coagulase activities of the species. The sequence revealed the presence of a 936-base-pair open reading frame that constitutes ...

journal_title：Infection and immunity

authors： Sodeinde OA,Goguen JD

更新日期：1989-05-01 00:00:00

abstract：:Streptococcus iniae causes meningoencephalitis and death in commercial fish species and has recently been identified as an emerging human pathogen producing fulminant soft tissue infection. As identified by pulsed-field gel electrophoresis (PFGE), strains causing disease in either fish or humans belong to a single clo...

journal_title：Infection and immunity

authors： Fuller JD,Bast DJ,Nizet V,Low DE,de Azavedo JC

更新日期：2001-04-01 00:00:00

abstract：:The results of a test of endotoxic potency based upon the development of histamine hypersensitivity in mice were compared with the results obtained by testing the same materials for pyrogenicity in rabbits and lethality for chicken embryos (CELD50). The results of the histamine hypersensitization test (HHT) correlated...

journal_title：Infection and immunity

authors： Bergman RK,Milner KC,Munoz JJ

更新日期：1977-11-01 00:00:00

abstract：:Performing patch-clamp experiments on human macrophages, we show that the K(+) channel MaxiK is activated by lipopolysaccharide, peptidoglycan, and interleukin-1. Cytokine production initiated by several Toll-like receptor (TLR) ligands and by interleukin-1 is inhibited by MaxiK blockade. This provides evidence for fu...

journal_title：Infection and immunity

authors： Scheel O,Papavlassopoulos M,Blunck R,Gebert A,Hartung T,Zähringer U,Seydel U,Schromm AB

更新日期：2006-07-01 00:00:00

abstract：:Conjugated polysaccharide vaccines protect against serogroup C meningococci. However, this approach cannot be applied to serogroup B, which is still a major cause of meningitis. We evaluated the immunogenicity of three surface-exposed proteins from serogroup B Neisseria meningitidis (App, NhhA, and NadA) identified du...

journal_title：Infection and immunity

authors： Bowe F,Lavelle EC,McNeela EA,Hale C,Clare S,Arico B,Giuliani MM,Rae A,Huett A,Rappuoli R,Dougan G,Mills KH

更新日期：2004-07-01 00:00:00

abstract：:A recombinant 23-kDa protein (rBPI23) derived from human bactericidal/permeability-increasing protein (BPI) possesses potent endotoxin-neutralizing abilities in vitro and in vivo. Binding of rBPI23 to those endotoxins (lipopolysaccharides [LPSs]) encountered clinically would be a prerequisite for efficacy in decreasin...

journal_title：Infection and immunity

authors： Appelmelk BJ,An YQ,Thijs BG,MacLaren DM,de Graaff J

更新日期：1994-08-01 00:00:00

abstract：:We compared a cryptococcal culture filtrate antigen referred to as CneF with chemically defined cryptococcal antigen fractions isolated by Cherniak and co-workers by using double immunodiffusion gels, polyacrylamide gel electrophoresis, immunoblots, and footpad reactivity of immunized mice. The three previously descri...

journal_title：Infection and immunity

authors： Murphy JW,Mosley RL,Cherniak R,Reyes GH,Kozel TR,Reiss E

更新日期：1988-02-01 00:00:00

abstract：:Although it has been known for some time that Salmonella typhimurium is able to survive and even replicate in the normally bactericidal environment of the macrophage phagosome, the mechanisms by which this organism accomplishes this feat remain obscure. In this study, a murine macrophage cell line and confocal immunof...

journal_title：Infection and immunity

authors： Rathman M,Barker LP,Falkow S

更新日期：1997-04-01 00:00:00

abstract：:Vibrio mimicus 61892, isolated in 1977 from a case of watery diarrhea in Bangladesh, produces an enterotoxin which possesses activity in Y-1 mouse adrenal cells and in rabbit ileal loops which is identical to the prototype cholera toxin (CT) produced by Vibrio cholerae 569B. The neutralization of the adrenal cell acti...

journal_title：Infection and immunity

authors： Spira WM,Fedorka-Cray PJ

更新日期：1983-11-01 00:00:00

abstract：:Active immunization with Escherichia coli-expressed recombinant outer surface protein C (OspC) of Borrelia burgdorferi has been demonstrated to confer protection against a tick-transmitted infection on laboratory animals. A previous study in this laboratory showed that OspC antibody raised against a denatured immunoge...

journal_title：Infection and immunity

authors： Gilmore RD Jr,Mbow ML

更新日期：1999-10-01 00:00:00

abstract：:A mouse lacking CD28, a T-cell costimulatory molecule, and STAT6, a transcription factor that mediates interleukin-4 (IL-4) signaling, was developed from parental CD28- and STAT6-deficient mice. STAT6/CD28(-/-) BALB/c mice that were 8 weeks old had a normal phenotype, and IL-4 production was induced following infectio...

journal_title：Infection and immunity

authors： Liu Q,Arseculeratne C,Liu Z,Whitmire J,Grusby MJ,Finkelman FD,Darling TN,Cheever AW,Swearengen J,Urban JF,Gause WC

更新日期：2004-07-01 00:00:00

abstract：:Female C57BL/6J mice were infected with Trypanosoma cruzi and subsequently given macrophages or lymphocytes from syngeneic donors which had recovered from the acute infection. Mice which received immune peritoneal macrophages, splenic lymphocytes, or lymph node lymphocytes developed lower mean parasitemias and cumulat...

journal_title：Infection and immunity

authors： Burgess DE,Hanson WL

更新日期：1979-09-01 00:00:00

abstract：:We constructed hha derivatives from both a clinical uropathogenic Escherichia coli isolate (strain FVL4) and a wild E. coli strain causing bovine diarrhea (strain CCB21) and analyzed the effect of the hha allele on the expression of the different virulence factors exhibited by these strains. Expression of hemolysin an...

journal_title：Infection and immunity

authors： Mouriño M,Madrid C,Balsalobre C,Prenafeta A,Muñoa F,Blanco J,Blanco M,Blanco JE,Juarez A

更新日期：1996-07-01 00:00:00

abstract：:Iron is an important element for the growth of microorganisms as well as in the defense of the host by serving as a catalyst for the generation of free radicals via the Fenton/Haber-Weiss reactions. The iron transporter natural resistance-associated macrophage protein 1 (Nramp1) confers resistance to the growth of a v...

journal_title：Infection and immunity

authors： Zhong W,Lafuse WP,Zwilling BS

更新日期：2001-11-01 00:00:00

abstract：:Group A streptococcal pyrogenic exotoxins A, B, and C (also known as scarlet fever toxins and erythrogenic toxins) were evaluated for relatedness to another streptococcus-derived lymphocyte mitogen, blastogen A. Streptococcal pyrogenic exotoxin A and blastogen A were immunologically cross-reactive and shared the same ...

journal_title：Infection and immunity

authors： Schlievert PM,Gray ED

更新日期：1989-06-01 00:00:00

abstract：:The bacterium Neisseria meningitidis is the causative agent of meningitis and sepsis. A generally effective vaccine against N. meningitidis serogroup B is not yet available, but outer membrane vesicle vaccines are in development. These vaccines contain lipopolysaccharide (LPS). The inclusion of N. meningitidis wild-ty...

journal_title：Infection and immunity

authors： Fransen F,Boog CJ,van Putten JP,van der Ley P

更新日期：2007-12-01 00:00:00

abstract：:While the pathological events evoked by infection are commonly described, effective host responses to bacteria and their products should primarily be protective. Heat shock protein (Hsp) expression is upregulated by many stimuli and serves to maintain intracellular protein integrity. The ability of the prototypic supe...

journal_title：Infection and immunity

authors： Musch MW,Petrof EO,Kojima K,Ren H,McKay DM,Chang EB

更新日期：2004-06-01 00:00:00

abstract：:Adherence to fibrinogen and fibronectin plays a crucial role in Staphylococcus aureus experimental endocarditis. Previous genetic studies have shown that infection and carriage isolates do not systematically differ in their virulence-related genes, including genes conferring adherence, such as clfA and fnbA. We set ou...

journal_title：Infection and immunity

authors： Ythier M,Entenza JM,Bille J,Vandenesch F,Bes M,Moreillon P,Sakwinska O

更新日期：2010-04-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is an important component of the innate immune system. It binds to the arrays of sugars commonly presented by microorganisms and activates the complement system independently of antibody. Despite detailed knowledge of the stereochemical basis of MBL binding, relatively little is known abou...

journal_title：Infection and immunity

authors： Devyatyarova-Johnson M,Rees IH,Robertson BD,Turner MW,Klein NJ,Jack DL

更新日期：2000-07-01 00:00:00

abstract：:We developed an in vitro model to study the temperature-regulated cytotoxicity and intracellular growth of Mycobacterium haemophilum in cultured human epithelial and endothelial cells. M. haemophilum associated with human epithelial and endothelial cells at similar rates when incubated at 33 and 37 degrees C, but only...

journal_title：Infection and immunity

authors： Fischer LJ,Quinn FD,White EH,King CH

更新日期：1996-01-01 00:00:00

abstract：:The salivary and serum immune responses to orally administered glucosyltransferase antigen complex from Streptococcus mutants strain 6715 were investigated in hamsters. All enzyme-linked immunosorbent assay was used to measure the antibody quantity and isotype, and a [14C]glucosyl-labeled sucrose incorporation assay w...

journal_title：Infection and immunity

authors： Smith DJ,Taubman MA,Ebersole JL

更新日期：1980-05-01 00:00:00

abstract：:Alveolar macrophages are the effector cells largely responsible for clearance of Pneumocystis carinii from the lungs. Binding of organisms to beta-glucan and mannose receptors has been shown to stimulate phagocytosis of the organisms. To further define the mechanisms used by alveolar macrophages for clearance of P. ca...

journal_title：Infection and immunity

authors： Hollifield M,Bou Ghanem E,de Villiers WJ,Garvy BA

更新日期：2007-08-01 00:00:00

abstract：:In this study we found that serum inhibitory activity against Blastomyces dermatitidis was principally mediated by albumin. This was confirmed in experiments using albumin from several mammalian species. Analbuminemic rat serum did not inhibit B. dermatitidis growth in vivo; however, the addition of albumin restored i...

journal_title：Infection and immunity

authors： Giles S,Czuprynski C

更新日期：2003-11-01 00:00:00

abstract：:Escherichia coli heat-stable enterotoxin (ST) appears to cause intestinal fluid secretion by activating intestinal particulate guanylate cyclase. Recent studies suggest that chlorpromazine and quinacrine reduce the intestinal secretory response to ST and activation of guanylate cyclase by ST. We have examined the effe...

journal_title：Infection and immunity

authors： Greenberg RN,Murad F,Guerrant RL

更新日期：1982-02-01 00:00:00

abstract：:One aspect in a broad spectrum of possible mechanisms of cariostatic reactions of fluoride is its interaction with the metabolism of oral bacteria. Information on the mechanisms and kinetics of fluoride inhibition of essential enzymes of the glycolytic pathway of the relevant bacteria is lacking. In this work, the iso...

journal_title：Infection and immunity

authors： Hüther FJ,Psarros N,Duschner H

更新日期：1990-04-01 00:00:00

abstract：:Phase 1 and 2 clinical trials of group B streptococcal (GBS) capsular polysaccharide (CPS)-protein conjugate vaccines in healthy adults have demonstrated their safety and improved immunogenicity compared with uncoupled CPSs. Two recent trials sought to determine (i) whether adsorption of conjugate vaccine to aluminum ...

journal_title：Infection and immunity

authors： Paoletti LC,Rench MA,Kasper DL,Molrine D,Ambrosino D,Baker CJ

更新日期：2001-11-01 00:00:00

abstract：:Early-onset periodontitis (EOP) is characterized by rapidly progressive alveolar bone loss, chemotactic defects of neutrophils, and significant familial aggregation. We found immature myeloid lineage cells, defined as promyelocytes, in the peripheral blood in patients with EOP. A hematological examination of periphera...

journal_title：Infection and immunity

authors： Nemoto E,Nakamura M,Shoji S,Horiuchi H

更新日期：1997-09-01 00:00:00

abstract：:The gene encoding a nitric oxide reductase has been identified in Neisseria gonorrhoeae. The norB gene product shares significant identity with the nitric oxide reductases in Ralstonia eutropha and Synechocystis sp. and, like those organisms, the gonococcus lacks a norC homolog. The gonococcal norB gene was found to b...

journal_title：Infection and immunity

authors： Householder TC,Fozo EM,Cardinale JA,Clark VL

更新日期：2000-09-01 00:00:00

abstract：:Piglets suckled by dams that had been vaccinated with K88 antigen were significantly more resistant to deaths caused by neonatal diarrhea after challenge with a large dose of a K88-positive enteropathogenic strain of Escherichia coli than piglets suckled by control dams. The factors most likely to be involved in prote...

journal_title：Infection and immunity

authors： Rutter JM,Jones GW,Brown GT,Burrows MR,Luther PD

更新日期：1976-03-01 00:00:00