Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease.

abstract：:The development of vaccines for prevention of diseases caused by pathogenic species can encounter major obstacles if high sequence diversity is observed between individual strains. Therefore, development might be restricted either to conserved antigens, which are often rare, or to multivalent vaccines, which renders t...

journal_title：Infection and immunity

authors： Nayak A,Schüler W,Seidel S,Gomez I,Meinke A,Comstedt P,Lundberg U

更新日期：2020-03-23 00:00:00

abstract：:Lipid compositions of 40 patient isolates of Mycobacterium tuberculosis derived from Madras, Burma, Rangoon, and East Africa were studied, and two major populations of tubercle bacilli were distinguished. Nearly all of the strains previously designated as attenuated for the guinea pig (D. A. Mitchison) are characteriz...

journal_title：Infection and immunity

authors： Goren MB,Brokl O,Schaefer WB

更新日期：1974-01-01 00:00:00

abstract：:An extracellular cytolysin produced by Vibrio metschnikovii was purified by acid precipitation, phenyl-Sepharose CL-4B chromatography, and rechromatography on a phenyl-Sepharose CL-4B column and high-performance liquid chromatography on a Mono Q (anion-exchange) column. The purified cytolysin had a molecular weight of...

journal_title：Infection and immunity

authors： Miyake M,Honda T,Miwatani T

更新日期：1988-04-01 00:00:00

abstract：:Current efforts to develop plague vaccines focus on LcrV, a polypeptide that resides at the tip of type III secretion needles. LcrV-specific antibodies block Yersinia pestis type III injection of Yop effectors into host immune cells, thereby enabling phagocytes to kill the invading pathogen. Earlier work reported that...

journal_title：Infection and immunity

authors： Miller NC,Quenee LE,Elli D,Ciletti NA,Schneewind O

更新日期：2012-04-01 00:00:00

abstract：:To evaluate the enteropathogenicity of Aeromonas hydrophila and Plesiomonas shigelloides, the rate of isolation of these organisms was compared among individuals with and without diarrhea in Thailand. In two groups of American travelers, A. hydrophila, but not P. shigelloides, was associated with episodes of travelers...

journal_title：Infection and immunity

authors： Pitarangsi C,Echeverria P,Whitmire R,Tirapat C,Formal S,Dammin GJ,Tingtalapong M

更新日期：1982-02-01 00:00:00

abstract：:Increased incidence of bovine tuberculosis (TB) in the United Kingdom caused by infection with Mycobacterium bovis is a cause of considerable economic loss to farmers and the government. The Eurasian badger (Meles meles) represents a wildlife source of recurrent M. bovis infections of cattle in the United Kingdom, and...

journal_title：Infection and immunity

authors： Clark S,Cross ML,Nadian A,Vipond J,Court P,Williams A,Hewinson RG,Aldwell FE,Chambers MA

更新日期：2008-08-01 00:00:00

abstract：:Accurate diagnosis and early treatment of tuberculosis (TB) and latent TB infection (LTBI) are vital to prevent and control TB. The lack of specific biomarkers hinders these efforts. This study's purpose was to screen immunological markers that discriminate Mycobacterium tuberculosis infection outcomes in a setting wh...

journal_title：Infection and immunity

authors： Teklu T,Kwon K,Wondale B,HaileMariam M,Zewude A,Medhin G,Legesse M,Pieper R,Ameni G

更新日期：2018-03-22 00:00:00

abstract：:Secretion of immunoglobulin A1 (IgA1) proteases is a characteristic of Haemophilus influenzae and several other bacterial pathogens causing infectious diseases, including meningitis. Indirect evidence suggests that the proteases are important virulence factors. In this study, we cloned the iga gene encoding immunoglob...

journal_title：Infection and immunity

authors： Poulsen K,Brandt J,Hjorth JP,Thøgersen HC,Kilian M

更新日期：1989-10-01 00:00:00

abstract：:Subtilase cytotoxin (SubAB) is a recently identified AB5 subunit toxin produced by Shiga-toxigenic Escherichia coli. The A subunit is thought to be a subtilase-like, serine protease, whereas the B subunit binds to the toxin receptor on the cell surface. We cloned the genes from a clinical isolate; the toxin was produc...

journal_title：Infection and immunity

authors： Morinaga N,Yahiro K,Matsuura G,Watanabe M,Nomura F,Moss J,Noda M

更新日期：2007-01-01 00:00:00

abstract：:Individuals living in areas where malaria is endemic are repeatedly exposed to many different malaria parasite antigens. Studies on naturally acquired antibody-mediated immunity to clinical malaria have largely focused on the presence of responses to individual antigens and their associations with decreased morbidity....

journal_title：Infection and immunity

authors： Osier FH,Fegan G,Polley SD,Murungi L,Verra F,Tetteh KK,Lowe B,Mwangi T,Bull PC,Thomas AW,Cavanagh DR,McBride JS,Lanar DE,Mackinnon MJ,Conway DJ,Marsh K

更新日期：2008-05-01 00:00:00

abstract：:Bovine mastitis continues to be the most detrimental factor for profitable dairying. Recent research conducted within our laboratory has identified a genetic marker in the CXCR2 gene associated with mastitis susceptibility. The objective of the present study was to evaluate the migratory ability of neutrophils from co...

journal_title：Infection and immunity

authors： Rambeaud M,Pighetti GM

更新日期：2005-08-01 00:00:00

abstract：:The major antigenic determinants of the lipoglycans from Acholeplasma granularum and Acholeplasma axanthum were found to be the oligosaccharide sequences Glcp(beta 1 leads to 2)-Glcp(alpha 1 leads to 4)-Glcp and Glcp(beta 1 leads to 2)-Glcp(beta 1 leads to 2)-Glcp, respectively. The disaccharides sophorose and maltose...

journal_title：Infection and immunity

authors： Al-Samarrai TH,Smith PF,Lynn RJ

更新日期：1983-05-01 00:00:00

abstract：:IL12RB1 is a human gene that is important for resistance to Mycobacterium tuberculosis infection. IL12RB1 is expressed by multiple leukocyte lineages, and encodes a type I transmembrane protein (IL12Rβ1) that associates with IL12p40 and promotes the development of host-protective T(H)1 cells. Recently, we observed tha...

journal_title：Infection and immunity

authors： Ray AA,Fountain JJ,Miller HE,Cooper AM,Robinson RT

更新日期：2015-02-01 00:00:00

abstract：:Both interleukin-17A (IL-17A) and IL-17F are proinflammatory cytokines that have an important role in intestinal homeostasis via receptor signaling. These cytokines have been characterized in chickens, but very little is known about their receptors and their functional activity. We provide here the first description o...

journal_title：Infection and immunity

authors： Kim WH,Jeong J,Park AR,Yim D,Kim S,Chang HH,Yang SH,Kim DH,Lillehoj HS,Min W

更新日期：2014-09-01 00:00:00

abstract：:Neisseria meningitidis is a human-specific pathogen and leading cause of meningitis and septicemia. Factor H binding protein (fHbp), a virulence factor which protects N. meningitidis from innate immunity by binding the human complement regulator factor H (fH) with high affinity, is also a key antigen in vaccines being...

journal_title：Infection and immunity

authors： van der Veen S,Johnson S,Jongerius I,Malik T,Genovese A,Santini L,Staunton D,Ufret-Vincenty RL,Pickering MC,Lea SM,Tang CM

更新日期：2014-03-01 00:00:00

abstract：:Phenethyl alcohol, at the maximum concentration which did not inhibit growth (0.3% [vol/vol]), inhibited the production of alpha-lysin and exoproteases but not that of delta-lysin in Staphylococcus aureus Wood 46. The inhibition of alpha-lysin was reversible, and transient accumulation of cell-associated alpha-lysin o...

journal_title：Infection and immunity

authors： Lee KY,Birkbeck TH

更新日期：1985-01-01 00:00:00

abstract：:The macrophage has previously been implicated in contributing to the renal inflammation associated with hemolytic-uremic syndrome (HUS). However, there is currently no in vivo model detailing the contribution of the renal macrophage to the kidney disease associated with HUS. Therefore, renal macrophage recruitment and...

journal_title：Infection and immunity

authors： Keepers TR,Gross LK,Obrig TG

更新日期：2007-03-01 00:00:00

abstract：:A hemolysin that appears to be responsible for the zones of beta-hemolysis surrounding colonies of group B streptococci (Streptococcus agalactiae) on blood agar plates has been isolated and partially purified. No soluble hemolysin was detectable in the supernatants of streptococcal cultures grown in several types of m...

journal_title：Infection and immunity

authors： Marchlewicz BA,Duncan JL

更新日期：1980-12-01 00:00:00

abstract：:We have determined the nucleotide sequence of the 1.4-kilobase DNA fragment containing the plasminogen activator gene (pla) of Yersinia pestis, which determines both plasminogen activator and coagulase activities of the species. The sequence revealed the presence of a 936-base-pair open reading frame that constitutes ...

journal_title：Infection and immunity

authors： Sodeinde OA,Goguen JD

更新日期：1989-05-01 00:00:00

abstract：:The affinity of uropathogenic Escherichia coli to kidneys and bladders of experimentally infected mice was shown to be determined in part by the adhesive properties of the infecting bacteria. Mice were infected with various pairwise combinations of two homogeneic sets of bacteria: (i) mutants derived from a human pyel...

journal_title：Infection and immunity

authors： Hagberg L,Hull R,Hull S,Falkow S,Freter R,Svanborg Edén C

更新日期：1983-04-01 00:00:00

abstract：:Monoclonal antibodies have been generated to the unique distal sugar epitopes on the oligosaccharide haptens of the glycopeptidolipid antigens of clinically prominent members of the Mycobacterium avium serocomplex. Thus, antibodies are described that recognize the distal O-acetyl-alpha-L-rhamnopyranosyl residue of the...

journal_title：Infection and immunity

authors： Rivoire B,Ranchoff BJ,Chatterjee D,Gaylord H,Tsang AY,Kolk AH,Aspinall GO,Brennan PJ

更新日期：1989-10-01 00:00:00

abstract：:The C-terminal 19-kDa domain of merozoite surface protein 1 (MSP1₁₉) is the target of protective antibodies but alone is poorly immunogenic. Previously, using the Plasmodium yoelii murine model, we fused P. yoelii MSP1₁₉ (PyMSP1₁₉) with full-length P. yoelii merozoite surface protein 8 (MSP8). Upon immunization, the M...

journal_title：Infection and immunity

authors： Alaro JR,Angov E,Lopez AM,Zhou H,Long CA,Burns JM Jr

更新日期：2012-07-01 00:00:00

abstract：:Bacteroides fragilis with enterotoxin-like activity (BFEL) was isolated from the feces of 24- to 48-h-old lambs with acute diarrheal disease on three different sheep ranches in the Northern Rocky Mountain region of the United States. The lamb intestinal loop test was used to enrich for the bacterium before its initial...

journal_title：Infection and immunity

authors： Myers LL,Firehammer BD,Shoop DS,Border MM

更新日期：1984-05-01 00:00:00

abstract：:Four strains of Staphylococcus aureus of a phage type other than the second group, isolated from patients with impetigo and Ritter's disease, were found to produce an exotoxin similar to those reported by Melish et al. (1972), Kapral and Miller (1971), and Arbuthnott et al. (1973). This toxin could elicit a general ex...

journal_title：Infection and immunity

authors： Kondo I,Sakurai S,Sarai Y

更新日期：1974-10-01 00:00:00

abstract：:During the systemic phase of murine infection with Salmonella enterica serovar Typhimurium, bacterial virulence is correlated with the ability to grow and survive within host macrophages. Salmonella pathogenicity island 2 (SPI-2), encoding a type three secretion system, has emerged as an important contributor to Salmo...

journal_title：Infection and immunity

authors： Linehan SA,Rytkönen A,Yu XJ,Liu M,Holden DW

更新日期：2005-07-01 00:00:00

abstract：:The present study examined the role of endogenous gamma interferon (IFN-gamma) in the formation of granulomas in mice which had been given a single intravenous injection of glycolipid-containing mycolic acid (trehalose 2,3,6'-trimycolate) purified from cell walls of Rhodococcus aurantiacus (Gordona aurantiaca) (GaGM) ...

journal_title：Infection and immunity

authors： Asano M,Nakane A,Minagawa T

更新日期：1993-07-01 00:00:00

abstract：:Natural heterogeneity in the structure of the lipid A portion of lipopolysaccharide (LPS) produces differential effects on the innate immune response. Gram-negative bacterial species produce LPS structures that differ from the classic endotoxic LPS structures. These differences include hypoacylation and hypophosphoryl...

journal_title：Infection and immunity

authors： Chilton PM,Hadel DM,To TT,Mitchell TC,Darveau RP

更新日期：2013-09-01 00:00:00

abstract：:Gamma interferon (IFN-γ) drives antiparasite responses and immunopathology during infection with Plasmodium species. Immunity-related GTPases (IRGs) are a class of IFN-γ-dependent proteins that are essential for cell autonomous immunity to numerous intracellular pathogens. However, it is currently unknown whether IRGs...

journal_title：Infection and immunity

authors： Guo J,McQuillan JA,Yau B,Tullo GS,Long CA,Bertolino P,Roediger B,Weninger W,Taylor GA,Hunt NH,Ball HJ,Mitchell AJ

更新日期：2015-04-01 00:00:00

abstract：:Plasmodium falciparum apical membrane antigen 1 (AMA1) is a leading malaria vaccine candidate whose function has not been unequivocally defined. Partial complementation of function can be achieved by exchanging the AMA1 of P. falciparum (PfAMA1) with that of P. chabaudi (PcAMA1). In this study, parasites expressing ch...

journal_title：Infection and immunity

authors： Healer J,Triglia T,Hodder AN,Gemmill AW,Cowman AF

更新日期：2005-04-01 00:00:00

abstract：:Schistosomiasis affects nearly 40 million women of reproductive age. Many of these women are infected while pregnant and lactating. Several studies have demonstrated transplacental trafficking of schistosome antigens; however, little is known regarding how these antigens affect the developing fetus and placenta. To ev...

journal_title：Infection and immunity

authors： McDonald EA,Kurtis JD,Acosta L,Gundogan F,Sharma S,Pond-Tor S,Wu HW,Friedman JF

更新日期：2013-03-01 00:00:00