Nonfunctional variant 3 factor H binding proteins as meningococcal vaccine candidates.

abstract：:Colonization of the large bowel of healthy infants by Clostridium difficile was studied. Feces were collected from five breast-fed aand five formula-fed infants throughout the first year of life, and levels of C. difficile were quantitated. Three breast-fed and five formula-fed infants were colonized for periods of be...

journal_title：Infection and immunity

authors： Stark PL,Lee A,Parsonage BD

更新日期：1982-03-01 00:00:00

abstract：:Twenty monoclonal antibodies have been prepared to the erythrocytes from CBA/Ca mice infected with the rodent malaria Plasmodium chabaudi. By immunofluorescence, 15 of these antibodies recognized parasite antigens expressed only during the development of mature trophozoites to schizonts and merozoites, 2 recognized pa...

journal_title：Infection and immunity

authors： Boyle DB,Newbold CI,Smith CC,Brown KN

更新日期：1982-10-01 00:00:00

abstract：:Some strains of Streptococcus mutans were found to recognize and bind collagen type I. Binding of 125I-labeled collagen type I was specific in that collagen types I and II, but not unrelated proteins, were able to inhibit binding of the labeled ligand to bacteria. Collagen binding to S. mutans was partially reversible...

journal_title：Infection and immunity

authors： Switalski LM,Butcher WG,Caufield PC,Lantz MS

更新日期：1993-10-01 00:00:00

abstract：:The immunodominant proteins and glycoproteins of Borrelia burgdorferi were analyzed by one-dimensional (1D) and 2D gel electrophoresis. More than 100 polypeptide species could be detected on silver-stained 2D gels. Separation of sonic extracts of the organism by differential centrifugation (100,000 X g) revealed sever...

journal_title：Infection and immunity

authors： Luft BJ,Jiang W,Munoz P,Dattwyler RJ,Gorevic PD

更新日期：1989-11-01 00:00:00

abstract：:Chromosomal DNA from a uropathogenic strain of Escherichia coli was partially digested with the restriction enzyme EcoRI. The partial digests were ligated into a cosmid containing an ampicillin-resistant determinant and packaged into lambda phage particles. An ampicillin-resistant transductant of E. coli HB101 was fou...

journal_title：Infection and immunity

authors： Clegg S

更新日期：1982-11-01 00:00:00

abstract：:Western blot (immunoblot) analysis of sera from cattle vaccinated with Brucella abortus S19 exhibit an elevated serologic response to Hsp62, the GroEL homolog (BaGroEL). Serologic screening of individual cows vaccinated with B. abortus S19 revealed no correlation between the immune response to BaGroEL and protection a...

journal_title：Infection and immunity

authors： Lin J,Adams LG,Ficht TA

更新日期：1996-10-01 00:00:00

abstract：:A main feature in the pathogenesis of bacterial endocarditis is the activation of the coagulation system via the extrinsic pathway, resulting in the formation of infected endocardial vegetations. Earlier studies gave indirect evidence that monocytes play an important role in the procoagulant response during the course...

journal_title：Infection and immunity

authors： Bancsi MJ,Veltrop MH,Bertina RM,Thompson J

更新日期：1996-02-01 00:00:00

abstract：:The P8 proteoglycolipid complex (P8 PGLC) is a glyconjugate expressed by Leishmania mexicana complex parasites. We previously have shown that vaccination with P8 PGLC provides protection against cutaneous leishmaniasis in susceptible BALB/c mice. However, the biological importance of this complex remains unknown. Here...

journal_title：Infection and immunity

authors： Whitaker SM,Colmenares M,Pestana KG,McMahon-Pratt D

更新日期：2008-05-01 00:00:00

abstract：:The recently introduced choleragen-induced rat foot edema model has been employed as a bioassay for evaluating the immunogenicity of three purified preparations containing cholera exo-enterotoxin antigen, choleragen, choleragenoid, and Formalin-treated choleragen (formagen). The results indicated that choleragen evoke...

journal_title：Infection and immunity

authors： Finkelstein RA,Hollingsworth RC

更新日期：1970-05-01 00:00:00

abstract：:Infection with mycobacterial species, including Mycobacterium tuberculosis, has long been implicated in the etiopathology of rheumatoid arthritis (RA) on the basis of clinical and pathological similarities between tuberculosis and RA. Despite evidence of immune responses to mycobacterial antigens in RA patient synovia...

journal_title：Infection and immunity

authors： Kempsell KE,Cox CJ,McColm AA,Bagshaw JA,Reece R,Veale DJ,Emery P,Isaacs JD,Gaston JS,Crowe JS

更新日期：2001-03-01 00:00:00

abstract：:Wild-type isolates of Shigella flexneri bind the dye Congo red from solid media, thus producing red (Crb+) colonies. Mutants which fail to bind the dye produce white colonies (Crb-) and are avirulent in a variety of systems. In S. flexneri the ability to bind Congo red correlates with the ability to bind hemin and pro...

journal_title：Infection and immunity

authors： Daskaleros PA,Payne SM

更新日期：1987-06-01 00:00:00

abstract：:Vibrio cholerae V86 El Tor Inaba caused experimental cholera in germfree ICR suckling mice. Sucklings born of gnotobiotic mothers monoassociated with the same strain were completely protected against live oral homologous challenge. ...

journal_title：Infection and immunity

authors： Shimamura T,Tazume S,Hashimoto K,Sasaki S

更新日期：1981-10-01 00:00:00

abstract：:Adherence of erythrocytes infected with Plasmodium falciparum to microvascular endothelial cells (sequestration) is considered to play an important role in parasite virulence and pathogenesis. However, the real importance of sequestration for infection and disease has never been fully assessed. The absence of an appro...

journal_title：Infection and immunity

authors： Mota MM,Jarra W,Hirst E,Patnaik PK,Holder AA

更新日期：2000-07-01 00:00:00

abstract：:Neisseria gonorrhoeae releases peptidoglycan fragments during growth, and these molecules induce an inflammatory response in the human host. The proinflammatory molecules include peptidoglycan monomers, peptidoglycan dimers, and free peptides. These molecules can be released by the actions of lytic transglycosylases o...

journal_title：Infection and immunity

authors： Schaub RE,Perez-Medina KM,Hackett KT,Garcia DL,Dillard JP

更新日期：2019-01-24 00:00:00

abstract：:In this study, we investigated a potential requirement of two-component signal transduction systems for acid resistance in Helicobacter pylori. In comparison to a wild-type strain, isogenic strains with null mutations in either HP0165 or HP1364 histidine kinases were impaired in their ability to grow at pH 5.0. The gr...

journal_title：Infection and immunity

authors： Loh JT,Cover TL

更新日期：2006-05-01 00:00:00

abstract：:Infection by Shigella flexneri is characterized by infiltration of neutrophils in the intestinal mucosa and by a strong inflammatory reaction. Although neutrophils are constitutively programmed to die by apoptosis, we show that isolated human neutrophils undergo necrosis 2 h after infection with virulent S. flexneri s...

journal_title：Infection and immunity

authors： François M,Le Cabec V,Dupont MA,Sansonetti PJ,Maridonneau-Parini I

更新日期：2000-03-01 00:00:00

abstract：:Oligosaccharide (OS)-protein conjugates are promising candidate vaccines against encapsulated bacteria, such as Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae. Although the effects of several variables such as OS chain length and protein carrier have been studied, little is known about th...

journal_title：Infection and immunity

authors： Lefeber DJ,Benaissa-Trouw B,Vliegenthart JF,Kamerling JP,Jansen WT,Kraaijeveld K,Snippe H

更新日期：2003-12-01 00:00:00

abstract：:Pseudomonas aeruginosa is a gram-negative bacillus that is a major cause of morbidity and mortality in immunosuppressed patients, burn patients, and patients with cystic fibrosis. Although immunity to these bacteria has been associated with serum antibody, more recent evidence suggests that T-cell-mediated immunity ma...

journal_title：Infection and immunity

authors： Porwoll JM,Gebel HM,Rodey GE,Markham RB

更新日期：1983-05-01 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) is a leading diarrheagenic bacterial pathogen among travelers and children in resource-limited regions. Adherence to host intestinal cells mediated by ETEC fimbriae is believed to be a critical first step in ETEC pathogenesis. These fimbriae are categorized into related classes ...

journal_title：Infection and immunity

authors： Liu Y,Shahabudin S,Farid S,Lee LH,McVeigh AL,Maciel M Jr.,,Poole ST,Broadman M,Prouty MG,Savarino SJ

更新日期：2020-10-19 00:00:00

abstract：:Each of the serotypes of Haemophilus influenzae (types a to f) may colonize the respiratory tract of humans, but only type b strains commonly cause invasive systemic infections. To investigate the role of complement in immunity to encapsulated non-type b strains, rats were depleted of C3 with cobra venom factor and ch...

journal_title：Infection and immunity

authors： Corrall CJ,Winkelstein JA,Moxon ER

更新日期：1982-03-01 00:00:00

abstract：:Toxoplasma gondii infects both hematopoietic and nonhematopoietic cells and can cause cerebral and ocular toxoplasmosis, as a result of either congenital or postnatally acquired infections. Host protection likely acts at both cellular levels to control the parasite. CD40 is a key factor for protection against cerebral...

journal_title：Infection and immunity

authors： Van Grol J,Muniz-Feliciano L,Portillo JA,Bonilha VL,Subauste CS

更新日期：2013-06-01 00:00:00

abstract：:Merozoite surface proteins of Plasmodium falciparum play a critical role in the invasion of human erythrocytes by the malaria parasite. Here we describe the identification of a novel protein with a molecular mass of 40 kDa that is found on the merozoite surface of P. falciparum. We call this protein merozoite surface ...

journal_title：Infection and immunity

authors： Marshall VM,Silva A,Foley M,Cranmer S,Wang L,McColl DJ,Kemp DJ,Coppel RL

更新日期：1997-11-01 00:00:00

abstract：:Protective immunity against tuberculosis is considered to be essentially cell mediated, and an important role for CD8(+) T lymphocytes has been suggested by several studies of murine and human infections. The present work, using an experimental model of infection with Mycobacterium bovis in cattle, showed that live M....

journal_title：Infection and immunity

authors： Liébana E,Girvin RM,Welsh M,Neill SD,Pollock JM

更新日期：1999-03-01 00:00:00

abstract：:The in vivo role of endogenous interleukin 12 (IL-12) in modulating intrapulmonary growth of Legionella pneumophila was assessed by using a murine model of replicative L. pneumophila lung infection. Intratracheal inoculation of A/J mice with virulent bacteria (10(6) L. pneumophila cells per mouse) resulted in inductio...

journal_title：Infection and immunity

authors： Brieland JK,Remick DG,LeGendre ML,Engleberg NC,Fantone JC

更新日期：1998-01-01 00:00:00

abstract：:The attachment of isogenic fimbriated and nonfimbriated Haemophilus influenzae type b variants to human cells was studied by using a radioactive assay and an indirect immunofluorescent assay. As described previously, fimbriated H. influenzae variants adhered to a greater extent than nonfimbriated variants to human buc...

journal_title：Infection and immunity

authors： Sable NS,Connor EM,Hall CB,Loeb MR

更新日期：1985-04-01 00:00:00

abstract：:A toxin associated with Toxoplasma gondii infection was obtained from the trophozoites and culture medium used to propagate the parasite in cell cultures. The toxin, named Toxofactor (TF), administered parenterally or nonparenterally in adult mice, produces transient symptoms of lethargy, ruffled fur, and body weight ...

journal_title：Infection and immunity

authors： Grimwood B,O'Connor G,Gaafar HA

更新日期：1983-12-01 00:00:00

abstract：:No studies to date clearly define the interactions between Porphyromonas gingivalis and human peripheral blood polymorphonuclear leukocytes (PMN), nor has a protective role for antibody to P. gingivalis been defined. Using a fluorochrome phagocytosis microassay, we investigated PMN phagocytosis and killing of P. gingi...

journal_title：Infection and immunity

authors： Cutler CW,Kalmar JR,Arnold RR

更新日期：1991-06-01 00:00:00

abstract：:Whereas infections of macrophages by promastigote forms of Leishmania mexicana pifanoi induce the production of superoxide, infections by amastigotes barely induce superoxide production. Several approaches were employed to gain insight into the mechanism by which amastigotes avoid eliciting superoxide production. Firs...

journal_title：Infection and immunity

authors： Pham NK,Mouriz J,Kima PE

更新日期：2005-12-01 00:00:00

abstract：:Yersinia pestis evolved from Y. pseudotuberculosis to become the causative agent of bubonic and pneumonic plague. We identified a homolog of the Salmonella enterica serovar Typhimurium lipoprotein (lpp) gene in Yersinia species and prepared lpp gene deletion mutants of Y. pseudotuberculosis YPIII, Y. pestis KIM/D27 (p...

journal_title：Infection and immunity

authors： Sha J,Agar SL,Baze WB,Olano JP,Fadl AA,Erova TE,Wang S,Foltz SM,Suarez G,Motin VL,Chauhan S,Klimpel GR,Peterson JW,Chopra AK

更新日期：2008-04-01 00:00:00

abstract：:Legionella pneumophila organisms are able to infect and multiply within the ciliated protozoan Tetrahymena pyriformis. This ability may be associated with virulence, because an attenuated strain of L. pneumophila fails to multiply within this protozoan, whereas a virulent strain increases 10,000-fold in number when co...

journal_title：Infection and immunity

authors： Fields BS,Barbaree JM,Shotts EB Jr,Feeley JC,Morrill WE,Sanden GN,Dykstra MJ

更新日期：1986-09-01 00:00:00