Participation of complement in host defense against encapsulated Haemophilus influenzae types a, c, and d.

abstract：:Rocky Mountain spotted fever, a systemic tick-borne illness caused by the obligate intracellular bacterium Rickettsia rickettsii, is associated with widespread infection of the vascular endothelium. R. rickettsii infection induces a biphasic pattern of the nuclear factor-kappaB (NF-kappaB) activation in cultured human...

journal_title：Infection and immunity

authors： Clifton DR,Rydkina E,Freeman RS,Sahni SK

更新日期：2005-01-01 00:00:00

abstract：:Placenta-sequestering Plasmodium falciparum involved in the pathogenesis of pregnancy-associated malaria (PAM) in otherwise clinically immune women expresses particular variant surface antigens (VSA(PAM)) on the surface of infected erythrocytes that differ from VSA found in parasitized nonpregnant individuals (non-PAM...

journal_title：Infection and immunity

authors： Megnekou R,Staalsoe T,Taylor DW,Leke R,Hviid L

更新日期：2005-07-01 00:00:00

abstract：:Infection with the protozoan parasite Toxoplasma gondii is transmitted to humans from infected animals by tissue cysts and oocysts excreted by cats. Immunization with inactivated parasites or recombinant proteins has at best shown partial protection. We constructed a plasmid expressing the SAG1 surface antigen of T. g...

journal_title：Infection and immunity

authors： Nielsen HV,Lauemøller SL,Christiansen L,Buus S,Fomsgaard A,Petersen E

更新日期：1999-12-01 00:00:00

abstract：:Members of our group reported recently that neisseria infection of human epithelial cells results in accelerated degradation of the major lysosomal integral membrane protein LAMP1 and that this is due to hydrolysis of this glycoprotein at its immunoglobulin A1 (IgA1)-like hinge by the neisseria type 2 IgA1 protease (L...

journal_title：Infection and immunity

authors： Ayala P,Lin L,Hopper S,Fukuda M,So M

更新日期：1998-10-01 00:00:00

abstract：:Mosquitoes are infected with Plasmodium falciparum by taking a blood meal from a gametocyte carrier. Since a mosquito takes a volume of 1 to 2 microl, a blood meal may contain 1 x 10(4) to 3 x 10(4) leukocytes (WBC). The majority of WBC are composed of neutrophils which may phagocytose and kill developing gametes insi...

journal_title：Infection and immunity

authors： Lensen AH,Bolmer-Van de Vegte M,van Gemert GJ,Eling WM,Sauerwein RW

更新日期：1997-09-01 00:00:00

abstract：:Increased incidence of bovine tuberculosis (TB) in the United Kingdom caused by infection with Mycobacterium bovis is a cause of considerable economic loss to farmers and the government. The Eurasian badger (Meles meles) represents a wildlife source of recurrent M. bovis infections of cattle in the United Kingdom, and...

journal_title：Infection and immunity

authors： Clark S,Cross ML,Nadian A,Vipond J,Court P,Williams A,Hewinson RG,Aldwell FE,Chambers MA

更新日期：2008-08-01 00:00:00

abstract：:Endotoxemia in rats is associated with the accumulation of neutrophils (polymorphonuclear leukocytes) within the airspaces of the lung. Polymorphonuclear leukocyte influx appears to be regulated by the intrapulmonary accumulation of chemotactic activity. Since alveolar macrophages (AMS) are prevalent cells in the airs...

journal_title：Infection and immunity

authors： Christman JW,Petras SF,Vacek PM,Davis GS

更新日期：1989-03-01 00:00:00

abstract：:Brucella abortus and polyacrylic acid, two agents whose interferon-inducing capacity in the mouse has been well established, failed to stimulate circulating interferon production in rabbits, yet protected rabbits against local vaccinia virus infection. ...

journal_title：Infection and immunity

authors： De Clercq E,De Somer P

更新日期：1973-10-01 00:00:00

abstract：:Haemophilus ducreyi, the causative agent of chancroid, produces a lipooligosaccharide (LOS) which terminates in N-acetyllactosamine. This glycoform can be further extended by the addition of a single sialic acid residue to the terminal galactose moiety. H. ducreyi does not synthesize sialic acid, which must be acquire...

journal_title：Infection and immunity

authors： Post DM,Mungur R,Gibson BW,Munson RS Jr

更新日期：2005-10-01 00:00:00

abstract：:The purpose of the present study was to evaluate the effectiveness of an attenuated Salmonella enterica serovar Typhimurium vaccine strain expressing the saliva-binding region (SBR) of the Streptococcus mutans antigen I/II adhesin, either alone or linked with the mucosal adjuvant cholera toxin A2 and B subunits (CTA2/...

journal_title：Infection and immunity

authors： Huang Y,Hajishengallis G,Michalek SM

更新日期：2001-04-01 00:00:00

abstract：:Fibrosis is a significant complication of intestinal disorders associated with microbial dysbiosis and pathobiont expansion, notably Crohn's disease (CD). Mechanisms that favor fibrosis are not well understood, and therapeutic strategies are limited. Here we demonstrate that colitis-susceptible Il10-deficient mice dev...

journal_title：Infection and immunity

authors： Ellermann M,Gharaibeh RZ,Fulbright L,Dogan B,Moore LN,Broberg CA,Lopez LR,Rothemich AM,Herzog JW,Rogala A,Gordon IO,Rieder F,Brouwer CR,Simpson KW,Jobin C,Sartor RB,Arthur JC

更新日期：2019-10-18 00:00:00

abstract：:On incubation of rabbit polymorphonuclear leukocytes with the S component of staphylococcal leukocidin at 37 degrees C, the 3H-labeled methyl group of S-adenosyl[methyl-3H]methionine was rapidly incorporated into phospholipid. Subsequently, the methylated phosphatidylcholine was degraded by activated phospholipase A2....

journal_title：Infection and immunity

authors： Noda M,Hirayama T,Matsuda F,Kato I

更新日期：1985-10-01 00:00:00

abstract：:The regulation of innate immune responses to pathogens occurs through the interaction of Toll-like receptors (TLRs) with pathogen-associated molecular patterns and the activation of several signaling pathways whose contribution to the overall innate immune response to pathogens is poorly understood. We demonstrate a m...

journal_title：Infection and immunity

authors： Izadi H,Motameni AT,Bates TC,Olivera ER,Villar-Suarez V,Joshi I,Garg R,Osborne BA,Davis RJ,Rincón M,Anguita J

更新日期：2007-10-01 00:00:00

abstract：:Pneumocystis carinii pneumonia (PcP) is a clinically important infection of immunocompromised patients. Although the interaction of Pneumocystis with the alveolar epithelium has been well documented, very little information regarding the epithelial response to Pneumocystis is currently available. In order to study Pne...

journal_title：Infection and immunity

authors： Wang J,Gigliotti F,Maggirwar S,Johnston C,Finkelstein JN,Wright TW

更新日期：2005-05-01 00:00:00

abstract：:Cryptococcus neoformans laccase expression during murine infection was investigated in lung tissue by immunohistochemistry and immunogold electron microscopy. Laccase was detected in the fungal cell cytoplasm, cell wall, and capsule in vivo. The amount of laccase found in different sites varied as a function of the ti...

journal_title：Infection and immunity

authors： Garcia-Rivera J,Tucker SC,Feldmesser M,Williamson PR,Casadevall A

更新日期：2005-05-01 00:00:00

abstract：:Galectin-3 (Gal-3) is a multifunctional beta-galactoside-binding lectin that senses self-derived and microbial glycoconjugates. Although Gal-3 is important in immune reactions and host defense in some experimental models, the function of Gal-3 during helminthic diseases (e.g., schistosomiasis) is still elusive. We sho...

journal_title：Infection and immunity

authors： Breuilh L,Vanhoutte F,Fontaine J,van Stijn CM,Tillie-Leblond I,Capron M,Faveeuw C,Jouault T,van Die I,Gosset P,Trottein F

更新日期：2007-11-01 00:00:00

abstract：:Although excystation is crucial to the initiation of infection by Giardia lamblia, little is known about the regulation of this important process. We have been able to reliably induce excystation in vitro by mimicking cyst passage through the stomach and upper small intestine by the exposure of in vitro-derived cysts ...

journal_title：Infection and immunity

authors： Meng TC,Hetsko ML,Gillin FD

更新日期：1996-06-01 00:00:00

abstract：:The suspected correlation between cessation of type C virus production and halt in immunoglobulin secretion by murine myeloma cells was studied. Employing two variants of the murine myeloma MOPC-315, immunoglobulin A-producing and nonproducing cells, we demonstrated that the two myelomas release similar levels of type...

journal_title：Infection and immunity

authors： Gazit A,Yaniv A,Halperin D,Ben-Efraim S

更新日期：1979-08-01 00:00:00

abstract：:Pathogenic biofilms have been associated with persistent infections due to their high resistance to antimicrobial agents, while commensal biofilms often fortify the host's immune system. Hence, controlling biofilm formation of both pathogenic bacteria and commensal bacteria is important in bacterium-related diseases. ...

journal_title：Infection and immunity

authors： Lee JH,Regmi SC,Kim JA,Cho MH,Yun H,Lee CS,Lee J

更新日期：2011-12-01 00:00:00

abstract：:We found that oral immunization with flagellum-defective mutant strains of Salmonella enterica serovar Typhimurium with the ClpXP-deficient background protected mice against oral challenge with the virulent strain. These data indicate that Salmonella flagellin is not a dominant protective antigen in oral immunization ...

journal_title：Infection and immunity

authors： Kodama C,Matsui H

更新日期：2004-04-01 00:00:00

abstract：:The fungus Cryptococcus neoformans has emerged as a major cause of meningoencephalitis worldwide. Host response to the fungus involves both innate and adaptive immunity, but fungal genes that modulate these processes are poorly understood. Previous studies demonstrated attenuated virulence of a mutant of a virulence-a...

journal_title：Infection and immunity

authors： Qiu J,Olszewski MA,Williamson PR

更新日期：2013-03-01 00:00:00

abstract：:Salmonella choleraesuis chi 3781, an attenuated [delta cya-12 delta(crp-cdt)19] mutant, was electroporated with the plasmid pBA31-R7, which codes for the expression of a 31-kDa protein from Brucella abortus (BCSP31). Recombinant S. choleraesuis chi 3781 stably maintained the pBA31-R7 plasmid and continued to express t...

journal_title：Infection and immunity

authors： Stabel TJ,Mayfield JE,Morfitt DC,Wannemuehler MJ

更新日期：1993-02-01 00:00:00

abstract：:Here we describe a protocol for purifying Borrelia burgdorferi from feeding ticks by velocity centrifugation and Percoll density gradient centrifugation. The purified spirochetes were motile and 10- to 20-fold purer than the bacteria in crude tick homogenates. The purified bacteria were present in sufficient quantity ...

journal_title：Infection and immunity

authors： Rathinavelu S,de Silva AM

更新日期：2001-06-01 00:00:00

abstract：:The immunopathology of Chagas' disease was studied in the experimental model of chronic infection in C57BL/10JT or mice. Sublethal infection with Trypanosoma cruzi, Y strain, induced specific antibodies and a delayed hypersensitivity response to parasite antigens. Mice developed chronic chagasic myocarditis but not sk...

journal_title：Infection and immunity

authors： Mortatti RC,Maia LC,de Oliveira AV,Munk ME

更新日期：1990-11-01 00:00:00

abstract：:Sepsis is both a common and, despite present-day therapy, a serious disease. The pathophysiology of the septic response is a complex, multifactorial phenomenon which in part involves the activation of complement by bacterial endotoxin. A monoclonal antibody to human complement factor B, code-named 1H5, which was capab...

journal_title：Infection and immunity

authors： Clardy CW

更新日期：1994-10-01 00:00:00

abstract：:A method was developed to study the adhesion of Streptococcus pneumoniae to human pharyngeal epithelial cells. Epithelial cells from healthy persons, pneumococcal strains from patients with otitis media, meningitis, or septicemia, and pneumococcal cells from the nasopharynx of healthy carriers were used. Adhesion was ...

journal_title：Infection and immunity

authors： Andersson B,Eriksson B,Falsen E,Fogh A,Hanson LA,Nylén O,Peterson H,Svanborg Edén C

更新日期：1981-04-01 00:00:00

abstract：:Representative strains of oral streptococci were tested for Fc immunoglobulin G (IgG) reactivity by two different techniques, agglutination of rabbit-IgG sensitized sheep erythrocytes and uptake of human and rabbit 125I-radiolabeled IgG. None of the S. mutans serotypes a through e reacted with the Fc region of either ...

journal_title：Infection and immunity

authors： Shea C,Ferretti JJ

更新日期：1981-12-01 00:00:00

abstract：:Bordetella bronchiseptica is closely related to Bordetella pertussis, which produces respiratory disease primarily in mammals other than humans. However, its importance as a human pathogen is being increasingly recognized. Although a large amount of research on Bordetella has been generated regarding protein virulence...

journal_title：Infection and immunity

authors： Sisti F,Fernández J,Rodríguez ME,Lagares A,Guiso N,Hozbor DF

更新日期：2002-04-01 00:00:00

abstract：:Polyinosinate-polycytidylate [poly(I).poly(C)]-induced interferon production in cultures of human foreskin fibroblast strains was increased by ultraviolet irradiation of cells at the time of exposure to inducer or at 2 h after induction. Incubation of cells with interferon prior to induction (priming) and ultraviolet ...

journal_title：Infection and immunity

authors： Mozes LW,Havell EA,Gradoville ML,Vilcek J

更新日期：1974-11-01 00:00:00

abstract：:Gardnerella vaginalis, the bacterial species most frequently isolated from women with bacterial vaginosis (BV), produces a cholesterol-dependent cytolysin (CDC), vaginolysin (VLY). At sublytic concentrations, CDCs may initiate complex signaling cascades crucial to target cell survival. Using live-cell imaging, we obse...

journal_title：Infection and immunity

authors： Randis TM,Zaklama J,LaRocca TJ,Los FC,Lewis EL,Desai P,Rampersaud R,Amaral FE,Ratner AJ

更新日期：2013-12-01 00:00:00